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| Product | Description | |
|---|---|---|
| 3-(3-Methyl-1,6-naphthyridin-2-yl)-1,2,4-thiadiazol-5-amine | 3-(3-Methyl-1,6-naphthyridin-2-yl)-1,2,4-thiadiazol-5-amine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(3-methyl-1,6-naphthyridin-2-yl)-1,2,4-thiadiazol-5-amine, AKOS015842316, DB-061114, KB-232966, TC-067833, 1179360-49-6. Product Category: Heterocyclic Organic Compound. CAS No. 1179360-49-6. Molecular formula: C11H9N5S. Mole weight: 243.287660 [g/mol]. Purity: 0.96. IUPACName: 3-(3-methyl-1,6-naphthyridin-2-yl)-1,2,4-thiadiazol-5-amine. Canonical SMILES: CC1=C(N=C2C=CN=CC2=C1)C3=NSC(=N3)N. Product ID: ACM1179360496. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Epetirimod | Epetirimod is a small-molecule immune-response modifier intended for the topical treatment of cervical human papilloma virus (HPV) infection and cervical dysplasia. Synonyms: S-30563; S 30563; S30563; 1-(2-methylpropyl)imidazo[4,5-c][1,5]naphthyridin-4-amine; Epetirimod. Grades: >98%. CAS No. 227318-71-0. Molecular formula: C13H15N5. Mole weight: 241.298. |  |
| 1-? (Phenyl methyl ) ?-?2-? [ (tri phenylphosphora?nylide ne ) ?amino] ?-1H-?indole-?3-?carboxalde hyde | 1-? (Phenyl methyl ) ?-?2-? [ (tri phenylphosphora?nylide ne ) ?amino] ?-1H-?indole-?3-?carboxalde hyde is an intermediate in synthesizing 2,3,4,10-Tetrahydro-1H-indolo[2,3-b][1,8]naphthyridin-2-ol (T294270), a derivative of 6, 7, 8, 9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3, 2:4, 5]imidazo[1, 2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metabolism. Created through the heat processing of food. Group: Biochemicals. Grades: Highly Purified. CAS No. 134370-12-0. Pack Sizes: 50mg, 100mg. Molecular Formula: C34H27N2OP. US Biological Life Sciences. |  Worldwide |
| 2-?Amino-?1-?(phenylmethyl)?-1H-?indole-?3-?carboxaldehyde | 2-?Amino-?1-?(phenylmethyl)?-1H-?indole-?3-?carboxaldehyde is an intermediate in synthesizing 2,3,4,10-Tetrahydro-1H-indolo[2,3-b][1,8]naphthyridin-2-ol (T294270), a derivative of 6, 7, 8, 9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3, 2:4, 5]imidazo[1, 2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metabolism. Created through the heat processing of food. Group: Biochemicals. Grades: Highly Purified. CAS No. 126177-49-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H14N2O. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-methylnicotinaldehyde | 2-Amino-5-methylnicotinaldehyde is a reactant used in the preparation of naphthyridines by Cu-catalyzed hydroamination / Friedlander reaction with terminal alkynes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1023814-35-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C7H8N2O, Molecular Weight: 136.15. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-methylnicotinaldehyde | A reagent used in the preparation of naphthyridines by Cu-catalyzed hydroamination/Friedlander reaction with terminal alkynes. Synonyms: 2-amino-5-methylpyridine-3-carbaldehyde. CAS No. 1023814-35-8. Molecular formula: C7H8N2O. Mole weight: 136.15. | |
| 2-Amino-6-methyl-1,8-naphthyridine-3-carbonitrile | 2-Amino-6-methyl-1,8-naphthyridine-3-carbonitrile. Group: Biochemicals. Grades: Highly Purified. CAS No. 1203499-48-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H8N4, Molecular Weight: 184.2. US Biological Life Sciences. | Worldwide |
| 2-? Amino-? 7-? chloro-? 1-? ethyl-? N-? methyl-? 4-? oxo-? 1, ? 4-? dihydro-? 1, ? 8-? naphthyridine-? 3-? carboxamide | 2-Amino-7-chloro-1-ethyl-1,4-dihydro-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide is an intermediate in the synthesis of SAR131675 (S139510), is a potent and selective VEGFR-3 inhibitor. Group: Biochemicals. Alternative Names: 2-Amino-7-chloro-1-ethyl-1,4-dihydro-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide. Grades: Highly Purified. CAS No. 1092523-24-4. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 7-Amino-4-methyl-[1,8]naphthyridin-2-ol | 7-Amino-4-methyl-[1,8]naphthyridin-2-ol. Group: Biochemicals. Grades: Highly Purified. CAS No. 1569-15-9. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Afabicin | Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Afabicin; Debio 1450; Debio-1450; Debio1450; AFN-1720; AFN 1720; AFN1720. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1518800-35-5. Molecular formula: C23H24N3O7P. Mole weight: 485.43. Purity: >98%. IUPACName: (E)-(6-(3-(methyl((3-methylbenzofuran-2-yl)methyl)amino)-3-oxoprop-1-en-1-yl)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)methyl dihydrogen phosphate. Canonical SMILES: O=P(O)(OCN1C(CCC2=CC(/C=C/C(N(C)CC(O3)=C(C)C4=C3C=CC=C4)=O)=CN=C12)=O)O. Product ID: ACM1518800355. Alfa Chemistry ISO 9001:2015 Certified. | |
| FGFR4-IN-1 | FGFR4-IN-1 is a potent and selective FGFR4 inhibitor. FGFR4 may be a novel therapeutic target for gastric cancer. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1708971-72-5. Molecular formula: C24H27N7O5. Mole weight: 493.52. Purity: >98%. IUPACName: N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide. Canonical SMILES: O=C(N1CCCC2=CC(CN3C(COCC3)=O)=C(C=O)N=C12)NC4=NC=C(C#N)C(NCCOC)=C4. Product ID: ACM1708971725. Alfa Chemistry ISO 9001:2015 Certified. | |
| FGFR4-IN-1 | FGFR4-IN-1 is a potent and selective FGFR4 inhibitor with potential for the treatment of gastric cancer. Synonyms: N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide; FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1. CAS No. 1708971-72-5. Molecular formula: C24H27N7O5. Mole weight: 493.52. | |
| INCB086550 | INCB086550 is A Potent and Novel Small-Molecule PD-L1 Inhibitor. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INCB086550; INCB-086550; INCB 086550; INCB86550; INCB-86550; INCB 86550; PD-1; PD-L1-IN-8. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2230911-59-6. Molecular formula: C41H39N7O4. Mole weight: 693.81. Purity: >98%. IUPACName: 1-((7-cyano-2-(3'-((3-((3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-yl)amino)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid. Canonical SMILES: CC1=C(C=CC=C1C2=NC3=CC(=CC(=C3O2)C#N)CN4CCC(C4)C(=O)O)C5=C(C(=CC=C5)NC6=NC=CC7=CC(=CN=C76)CN8CCC(C8)O)C. Product ID: ACM2230911596. Alfa Chemistry ISO 9001:2015 Certified. | |
| OTSSP167 | OTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells. Synonyms: 1- (6- (3, 5-dichloro-4-hydroxyphenyl) -4- ( ( (1r, 4r) -4- ( (dimethylamino) methyl) cyclohexyl) amino) -1, 5-naphthyridin-3-yl) ethanone; OTSSP167 free base; OTSSP 167; OTSSP-167; OTS167; OTS-167; OTS 167. Grades: 0.98. CAS No. 1431697-89-0. Molecular formula: C25H28Cl2N4O2. Mole weight: 487.425. | |
| OTSSP167 hydrochloride | OTSSP167 is a potent inhibitor of Maternal embryonic leucine zipper kinase (MELK) which regulates neural stem cell selfrenewal through control of the cell cycle. Synonyms: 4-[7-acetyl-8-[[4-[ (dimethylamino) methyl]cyclohexyl]amino]-1H-1, 5-naphthyridin-2-ylidene]-2, 6-dichlorocyclohexa-2, 5-dien-1-one hydrochloride; OTSSP167 (hydrochloride); UNII-65P731R507; 65P731R507; OTSSP167 HCl; OTS-167 monohydrochloride; HY-15512A; AKOS025117447. CAS No. 1431698-10-0. Molecular formula: C25H29Cl3N4O2. Mole weight: 523.9. | |
| PD-138312 | PD-138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a difluorophenyl substitution or a cyclopropyl at the 1 positions, respectively. It has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens in vitro activity. It was evaluated for its in vivo potencies against acute systemic infections and pneumococcal in mice pneumonia model. Uses: Pd-138312 has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens. Synonyms: PD-138312; PD138312; PD 138312;7-(3-(2-Aminopropan-2-yl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;7-(3-(1-Amino-1-methylethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Grades: >98%. CAS No. 107334-06-5. Molecular formula: C19H23FN4O3. Mole weight: 374.41. | |
| SAR131675 | SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20 nM. Synonyms: (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-. Grades: >98%. CAS No. 1433953-83-3. Molecular formula: C18H22N4O4. Mole weight: 358.39. | |
| SAR131675 | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. Group: Biochemicals. Alternative Names: 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide. Grades: Highly Purified. CAS No. 1092538-80-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 358.39. US Biological Life Sciences. | Worldwide |
| SAR131675 (Racemate) | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nmol/L, respectively. Synonyms: (Rac)-SAR131675; 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-, (±)-. Grades: ≥95%. CAS No. 1092539-44-0. Molecular formula: C18H22N4O4. Mole weight: 358.40. | |
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