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| Product | Description | |
|---|---|---|
| 1-Methyladenine | 100mg Pack Size. Group: Biochemicals, Building Blocks, Organics. Formula: C6H7N5. CAS No. 5142-22-3. Prepack ID 90025004-100mg. Molecular Weight 149.15. See USA prepack pricing. |  |
| 3-Methyladenine | 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-MA. CAS No. 5142-23-4. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-19312. |  |
| 3-Methyladenine | 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K. Group: Inhibitors. Alternative Names: 3-Methylpurin-6-amine. CAS No. 5142-23-4. Molecular formula: C6H7N5. Mole weight: 149.15. Appearance: White powder. Purity: 0.98. IUPACName: 3-Methyl-7h-purin-6-imine. Canonical SMILES: CN1C=NC(=N)C2=C1N=CN2. Density: 1.60 g/cm³. Catalog: ACM5142234. |  |
| 3-Methyladenine | 3-Methyladenine Inhibitor. Uses: Scientific use. Product Category: T1879. CAS No. 5142-23-4. |  |
| 3-Methyladenine | 3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Synonyms: NSC 66389; NSC-66389; NSC66389; 6-Amino-3-methylpurine; 3-MA; 3H-Purin-6-amine, 3-methyl-; 3-Methyl Adenine; 3-Methyl-6-aminopurine; N3-Methyladenine. Grades: ≥98% by HPLC. CAS No. 5142-23-4. Molecular formula: C6H7N5. Mole weight: 149.15. |  |
| 3-Methyladenine | A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50=4.5mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 and Wortmannin.Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Group: Biochemicals. Alternative Names: 3-Methyl-3H-purin-6-amine; 3-Methyl-6-aminopurine; 3-Methyladenine; 6-Amino-3-methylpurine; N3-Methyladenine; NSC 66389. Grades: Highly Purified. CAS No. 5142-23-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C6H7N5 0.1H2O, Molecular Weight: 150.95. US Biological Life Sciences. |  Worldwide |
| 6-Amino-9-methylpurine (9-Methyladenine) | 6-Amino-9-methylpurine (9-Methyladenine). Group: Biochemicals. Alternative Names: 9-Methyladenine. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 7-Methyladenine | 7-Methyladenine is a compound that can be isolated from Isodictya erinacea [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N7-Methyladenine. CAS No. 935-69-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116496. | |
| 9-Methyladenine | A receptor adenine derivative binding membrane brain animal cell line. Synonyms: N9-Methyladenine; 6-Amino-9-methylpurine; 9-Methyl Adenine; 9-Methyl-9H-purin-6-amine; NSC 7843; 9-Methyl-9H-adenine; 9-methyl-9H-purin-6-ylamine. Grades: ≥95% by HPLC. CAS No. 700-00-5. Molecular formula: C6H7N5. Mole weight: 149.15. | |
| DNA-3-methyladenine glycosylase I | Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase). Group: Enzymes. Synonyms: deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I. Enzyme Commission Number: EC 3.2.2.20. CAS No. 89287-37-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3974; DNA-3-methyladenine glycosylase I; EC 3.2.2.20; 89287-37-6; deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I. Cat No: EXWM-3974. |  |
| DNA-3-methyladenine glycosylase II | Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase). Group: Enzymes. Synonyms: deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA. Enzyme Commission Number: EC 3.2.2.21. CAS No. 89287-38-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3975; DNA-3-methyladenine glycosylase II; EC 3.2.2.21; 89287-38-7; deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA. Cat No: EXWM-3975. | |
| DNA N6-methyladenine demethylase | Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome. Group: Enzymes. Synonyms: ALKBH1. Enzyme Commission Number: EC 1.14.11.51. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0670; DNA N6-methyladenine demethylase; EC 1.14.11.51; ALKBH1. Cat No: EXWM-0670. | |
| mRNA N1-methyladenine demethylase | Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA. Group: Enzymes. Synonyms: ALKBH3. Enzyme Commission Number: EC 1.14.11.54. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0673; mRNA N1-methyladenine demethylase; EC 1.14.11.54; ALKBH3. Cat No: EXWM-0673. | |
| mRNA N6-methyladenine demethylase | Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA with low activity. Group: Enzymes. Synonyms: ALKBH5; FTO. Enzyme Commission Number: EC 1.14.11.53. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0672; mRNA N6-methyladenine demethylase; EC 1.14.11.53; ALKBH5; FTO. Cat No: EXWM-0672. | |
| N6-Methyladenine | N6-Methyladenine. Group: Biochemicals. Alternative Names: 6-(Methylamino)purine. Grades: Highly Purified. CAS No. 443-72-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C6H7N5. US Biological Life Sciences. | Worldwide |
| N6-Methyladenine | N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication [1]. Uses: Scientific research. Group: Natural products. CAS No. 443-72-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-116887. | |
| N9-Methyladenine | N9-Methyladenine. Group: Biochemicals. Alternative Names: 6-Amino-9-methylpurine. Grades: Highly Purified. CAS No. 700-00-5. Pack Sizes: 1g, 2g, 5g, 10g. Molecular Formula: C6H7N5. US Biological Life Sciences. | Worldwide |
| 1-Me-dA-CE Phosphoramidite | 1-Me-dA-CE Phosphoramidite, an essential resource in the realm of biomedical research, holds particular significance in the field of DNA synthesis and modification. Its primary purpose lies in integrating 1-Methyladenine (1-Me-dA) modifications into nucleic acid sequences. Its unblemished purity and adaptability to diverse synthesizers empower scientists to effectuate meticulous modifications, fueling the investigation of DNA-protein interactions, epigenetics, and DNA repair mechanisms. Synonyms: 5'-Monomethoxytrityl-N6-chloroacetyl-1-methyl-2'-deoxyAdenosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N-[9-[3-O-[(Diisopropylamino)(2-cyanoethoxy)phosphino]-5-O-(4-methoxytrityl)-2-deoxy-beta-D-ribofuranosyl]-1-methyl-1,6-dihydro-9H-purine-6-ylidene]chloroacetamide. Molecular formula: C42H49ClN7O6P. Mole weight: 814.31. | |
| 23S rRNA (adenine2503-C8)-methyltransferase | This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the appended methyl group. It contains an [4Fe-S] cluster. Cfr is an plasmid-acquired methyltransferase that protects cells from the action of antibiotics. The enzyme methylates adenosine at position 2503 of 23S rRNA by a radical mechanism, transferring a CH2 group from S-adenosyl-L-methionine while retaining the hydrogen at the C-8 position of the adenine. Cfr first transfers an CH2 group to a conserved cysteine (Cys338 in Staphylococcus aureus), the generated radical from a second S-adenosyl-L-methionine then attacks the methyl group, exctracting a hydrogen. The formed radical forms a covalent intermediate with the adenine group of the tRNA. The enzyme will also methylate 2-methyladenine produced by the action of EC 2.1.1.192 [23S rRNA (adenine2503-C2)-methyltransferase]. Group: Enzymes. Synonyms: Cfr (gene name). Enzyme Commission Number: EC 2.1.1.224. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1827; 23S rRNA (adenine2503-C8)-methyltransferase; EC 2.1.1.224; Cfr (gene name). Cat No: EXWM-1827. | |
| 5'-O-[Bis (4-methoxyphenyl) phenylmethyl]-2'-deoxy-N-methyladenosine | 5'-O-[Bis (4-methoxyphenyl) phenylmethyl]-2'-deoxy-N-methyladenosine is a 5-O- (4, 4'-Dimethoxytri phenylmethy) substitued derivative of the 2-deoxy N-methyl analogue of Adenosine. It is used in the preparation of oligonucleotides containing N6-methyladenine residues in the GATC site. Group: Biochemicals. Alternative Names: 5-O- (4, 4'-Dimethoxytriphenyl methyl ) -N6- methyl -2'-deoxyadenosine; 5'-O-DMT-2'-deoxy-N-methyl-adenosine; 5'-O-DMT-N6-methyl-2'-deoxyadenosine. Grades: Highly Purified. CAS No. 98056-69-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyladenosine | 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyladenosine is a 5'-O-(4,4'-Dimethoxytriphenylmethy) substitued derivative of the 2'-deoxy N-methyl analogue of Adenosine. It is used in the preparation of oligonucleotides containing N6-methyladenine residues in the GATC site. Synonyms: 5'-O-DMTr-N6-methyl-2'-deoxyadenosine; 5'-O-(4,4'-Dimethoxytriphenylmethyl)-N6-methyl-2'-deoxyadenosine; 5'-O-DMT-2'-deoxy-N-methyl-adenosine; (2R, 3S, 5R)-2- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-5- (6- (methylamino)-9H-purin-9-yl)tetrahydrofuran-3-ol; N6-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine. Grades: ≥95%. CAS No. 98056-69-0. Molecular formula: C32H33N5O5. Mole weight: 567.63. | |
| 6-Amino-2-chloro-9-methylpurine | 6-Amino-2-chloro-9-methylpurine. Group: Biochemicals. Alternative Names: 9-Methyl-2-chloroadenine; 2-Chloro-9-methyladenine. Grades: Highly Purified. CAS No. 7013-21-0. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C6H6ClN5. US Biological Life Sciences. | Worldwide |
| 6-Methylaminopurine arabinoside | 6-Methylaminopurine arabinoside, a nucleoside analogue lauded for its capacity in effectively treating viral infections, whether sly herpes simplex virus (HSV) or varicella-zoster virus (VZV) infections, reaps its rewards by preventing viral DNA synthesis and replication. Its impacts are significant in thwarting a multitude of diseases. Synonyms: 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-N-methyl-; Ara-map; 9-β-D-arabinofuranosyl-N-methyladenine; NSC 409168; 9-beta-D-Arabinofuranosyl-N-methyl-9H-purin-6-amine; 9H-Purin-6-amine, 9-β-D-arabinofuranosyl-N-methyl-. Grades: ≥95% by HPLC. CAS No. 60209-41-8. Molecular formula: C11H15N5O4. Mole weight: 281.27. | |
| 9H-Purin-6-amine,N-cyclopentyl-9-methyl- | Heterocyclic Organic Compound. Alternative Names: Lopac-N-154; N-Cyclopentyl-9-methyladenine; N6-Cyclopentyl-9-methyladenine; N-0840; n-cyclopentyl-9-methyl-9h-purin-6-amine. CAS No. 109292-91-3. Molecular formula: C11H15N5. Mole weight: 217.2703. Purity: 0.96. IUPACName: N-cyclopentyl-9-methylpurin-6-amine. Canonical SMILES: CN1C=NC2=C1N=CN=C2NC3CCCC3. Density: 1.42 g/cm³. Catalog: ACM109292913. | |
| Autophagy Inhibitor IV, Cpd18 (3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18) | A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10mM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Chloroquine Diphosphate Salt | Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine. Group: Biochemicals. Alternative Names: N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate Salt; Aralen Diphosphate; Aralen Phosphate; Arechin; Avloclor; Bemaphate; Chingamin; Chingamin Phosphate; SN 7618; Sanoquin; Tanakan. Grades: Highly Purified. CAS No. 50-63-5. Pack Sizes: 1g, 5g, 10g, 25g. Molecular Formula: C??H??ClN?O?P?, Molecular Weight: 515.86. US Biological Life Sciences. | Worldwide |
| DNA oxidative demethylase | Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA. Group: Enzymes. Synonyms: alkylated DNA repair protein; α-ketoglutarate-dependent dioxygenase ABH1; alkB (gene name). Enzyme Commission Number: EC 1.14.11.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0651; DNA oxidative demethylase; EC 1.14.11.33; alkylated DNA repair protein; α-ketoglutarate-dependent dioxygenase ABH1; alkB (gene name). Cat No: EXWM-0651. | |
| methylated-DNA-[protein]-cysteine S-methyltransferase | This protein is involved in the repair of alkylated DNA. It acts only on the alkylated DNA (cf. EC 3.2.2.20, DNA-3-methyladenine glycosidase I and EC 3.2.2.21, DNA-3-methyladenine glycosidase II). This enzyme catalyses only one turnover and therefore is not strictly catalytic. Group: Enzymes. Enzyme Commission Number: EC 2.1.1.63. CAS No. 77271-19-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1965; methylated-DNA-[protein]-cysteine S-methyltransferase; EC 2.1.1.63; 77271-19-3. Cat No: EXWM-1965. | |
| Olaquindox | Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induced apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway. Besides, Olaquindox also induces autophagy in HepG2 cells and that Olaquindox-induced apoptosis can be enhanced by 3-methyladenine. Olaquindox-induced autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK. Uses: Antimicrobial growth accelerant. Synonyms: N-(2-HYDROXYETHYL)-3-METHYL-2-QUINOXALINECARBOXAMIDE 1,4-DIOXIDE;OLAGUINDOX; OLAQUINDOX;2-(n-(2-hydroxyethyl)karbamoyl)-3-methylchinoxalin-1,4-dioxid; 2-quinoxalinecarboxamide,n-(2-hydroxyethyl)-3-methyl-,1,4-dioxide;bayernox;bayonox; bisergon. Grades: >98%. CAS No. 23696-28-8. Molecular formula: C12H13N3O4. Mole weight: 263.25. | |
| tRNA (adenine57-N1/adenine58-N1)-methyltransferase | The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNAAsp). Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs. Group: Enzymes. Synonyms: TrmI; PabTrmI; AqTrmI; MtTrmI. Enzyme Commission Number: EC 2.1.1.219. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1821; tRNA (adenine57-N1/adenine58-N1)-methyltransferase; EC 2.1.1.219; TrmI; PabTrmI; AqTrmI; MtTrmI. Cat No: EXWM-1821. | |
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