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| Product | Description | |
|---|---|---|
| Methylglyoxal 1,1-dimethyl acetal | Methylglyoxal 1,1-dimethyl acetal. Uses: Designed for use in research and industrial production. Product Category: Ortho Esters. CAS No. 6342-56-9. Molecular formula: C5H10O3. Mole weight: 118.13. Purity: 0.98. Product ID: ACM6342569. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Methylglyoxal bis-(guanylhydrazone)*dihy drochloride | Methylglyoxal bis-(guanylhydrazone)*dihy drochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Methylglyoxalbis(guanylhydrazone)hydratedihydrochloride;2,2-(1-Methyl-1,2-ethanediylidene) bis(hydrazinecarboximidamide) dihydrochloride hydrate. CAS No. 332360-02-8. Molecular formula: CH3C[=NNHC(=NH)NH2]CH[=NNHC(=NH)NH2]2HClxH2O. Mole weight: 0. Purity: 0.96. Product ID: ACM332360028. Alfa Chemistry ISO 9001:2015 Certified. | |
| methylglyoxal reductase (NADH) | This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH-dependent), by its coenzyme requirement, reaction direction, and enantiomeric preference. Group: Enzymes. Synonyms: methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent). Enzyme Commission Number: EC 1.1.1.78. CAS No. 37250-16-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0361; methylglyoxal reductase (NADH); EC 1.1.1.78; 37250-16-1; methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent). Cat No: EXWM-0361. |  |
| methylglyoxal reductase (NADPH) | The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1-phenylpropan-1-one. The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference. Group: Enzymes. Synonyms: lactaldehyde dehydrogenase (NADP+); GRE2 (gene name); methylglyoxal reductase (NADPH-dependent); lactaldehyde:NADP+ oxidoreductase. Enzyme Commission Number: EC 1.1.1.283. CAS No. 78310-66-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0191; methylglyoxal reductase (NADPH); EC 1.1.1.283; 78310-66-4; lactaldehyde dehydrogenase (NADP+); GRE2 (gene name); methylglyoxal reductase (NADPH-dependent); lactaldehyde:NADP+ oxidoreductase. Cat No: EXWM-0191. | |
| methylglyoxal synthase | Does not act on D-glyceraldehyde 3-phosphate. Group: Enzymes. Synonyms: methylglyoxal synthetase; glycerone-phosphate phospho-lyase. Enzyme Commission Number: EC 4.2.3.3. CAS No. 37279-01-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5187; methylglyoxal synthase; EC 4.2.3.3; 37279-01-9; methylglyoxal synthetase; glycerone-phosphate phospho-lyase. Cat No: EXWM-5187. | |
| 1-Aminoacetone Hydrochloride | Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases.1 It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients.2 As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells.2 Aminoacetone is used as a growth substrate for Pseudomonas.3. Group: Biochemicals. Alternative Names: 1-Amino-2-propanone Hydrochloride; 2-Oxopropylammonium Chloride; Aminoacetone Hydrochloride. Grades: Highly Purified. CAS No. 7737-17-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C3H8ClNO, Molecular Weight: 109.55. US Biological Life Sciences. |  Worldwide |
| 2-Methylimidazole | DryPowder; OtherSolid. Group: Hydrogen storage materials metal organic frameworks (mofs). Alternative Names: 2-Methylglyoxaline. CAS No. 693-98-1. Product ID: 2-methyl-1H-imidazole. Molecular formula: 82.11. Mole weight: C4H6N2. CC1=NC=CN1. 1S/C4H6N2/c1-4-5-2-3-6-4/h2-3H, 1H3, (H, 5, 6). LXBGSDVWAMZHDD-UHFFFAOYSA-N. 99%. |  |
| 2-oxoaldehyde dehydrogenase (NAD+) | Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+). Group: Enzymes. Synonyms: α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NAD+-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NAD+-dependent α-ketoaldehyde dehydrogenase. Enzyme Commission Number: EC 1.2.1.23. CAS No. 37250-91-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1129; 2-oxoaldehyde dehydrogenase (NAD+); EC 1.2.1.23; 37250-91-2; α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NAD+-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NAD+-dependent α-ketoaldehyde dehydrogenase. Cat No: EXWM-1129. | |
| 2-oxoaldehyde dehydrogenase (NADP+) | Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+). Group: Enzymes. Synonyms: α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NADP+-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NADP+-dependent α-ketoaldehyde dehydrogenase. Enzyme Commission Number: EC 1.2.1.49. CAS No. 83588-97-0, 97162-76-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1152; 2-oxoaldehyde dehydrogenase (NADP+); EC 1.2.1.49; 83588-97-0, 97162-76-0; α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NADP+-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NADP+-dependent α-ketoaldehyde dehydrogenase. Cat No: EXWM-1152. | |
| 3,3'-(1-Methylethane-1,2-diylidene)dicarbazamidine dihydrochloride | 3,3'-(1-Methylethane-1,2-diylidene)dicarbazamidine dihydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Guanylhydrazone, Methyl-Gag, Methyl-G, Methyl GAG, MGBG, MGGH, MITOGUAZONE, NSC32946, NSC69432, CID5351153, Methylglyoxal bis(guanylhydrazone) dihydrochloride, Methylglyoxal bis(guanylhydrazone)dihydrochloride, Methyl glyoxal bis(amidinohydrazone) dihydrochloride, Guanidine, 1,1-methylethanediylidenedinitrilo)di-, dihydrochloride, 7059-23-6, Guanidine, 1,1-[(methylethanediylidene)dinitrilo]di-, dihydrochloride, Guanidine, 1,1-[(methylethanediylidene)dinitrilo]di-, dihydrochloride, monohydrate, Hydrazinecarboximidamide, 2,2-(1-methyl-1,2-ethanediylidene)bis-, dihydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 7059-23-6. Molecular formula: C5H12N8.2HCl. Mole weight: 219.655380 [g/mol]. Purity: 0.96. IUPACName: 2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine chloride. Product ID: ACM7059236. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-hexulose-6-phosphate synthase | Requires Mg2+ or Mn2+ for maximal activity. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily. Group: Enzymes. Synonyms: D-arabino-3-hexulose 6-phosphate formaldehyde-lyase; 3-hexulosephosphate synthase; 3-hexulose phosphate synthase; HPS. Enzyme Commission Number: EC 4.1.2.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4879; 3-hexulose-6-phosphate synthase; EC 4.1.2.43; D-arabino-3-hexulose 6-phosphate formaldehyde-lyase; 3-hexulosephosphate synthase; 3-hexulose phosphate synthase; HPS. Cat No: EXWM-4879. | |
| D-lactate dehydratase | The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase). Group: Enzymes. Synonyms: glyoxylase III. Enzyme Commission Number: EC 4.2.1.130. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4971; D-lactate dehydratase; EC 4.2.1.130; glyoxylase III. Cat No: EXWM-4971. | |
| D/L-glyceraldehyde reductase | The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction. Group: Enzymes. Synonyms: gld1 (gene name); gaaD (gene name). Enzyme Commission Number: EC 1.1.1.372. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0290; D/L-glyceraldehyde reductase; EC 1.1.1.372; gld1 (gene name); gaaD (gene name). Cat No: EXWM-0290. | |
| Glyoxalase I from Human, Recombinant | Glyoxalase I is universally expressed and involved in the protection against cellular damage due to cytotoxic metabolites such as advanced glycation end products (AGEs). It is an integral component of the detoxification system, catalyzing the conversion of reactive, acyclic a-oxoaldehydes into the corresponding a-hydroxyacids in a glutathione-dependent manner. Group: Enzymes. Synonyms: lactoylglutathione lyase; EC 4.4.1.5; methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing); 9033-12-9. Enzyme Commission Number: EC 4.4.1.5. Purity: > 90% by SDS-PAGE. Glyoxalase I. Mole weight: 20.7 kDa. Activity: >0.4 units/mg. Storage: Glyoxalase-I Human Recombinant although stable at 4 °C for weeks, should be stored desiccated below -18 °C. Please prevent freeze/thaw cycles. Form: Glyoxalase-1 solution containing 20 mM Tris pH-8, 1mM DTT and 10% glycerol. Source: E. coli. Species: Human. lactoylglutathione lyase; EC 4.4.1.5; methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing); 9033-12-9. Cat No: NATE-1651. | |
| Glyoxalase II from Human, Recombinant | The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis. Glx ii amino acid 14-308 (295 amino acids) with a c-terminal 6x his-tag. Group: Enzymes. Synonyms: Hydroxyacylglutathione hydrolase; mitochondrial; HAGH1; GLO2. Enzyme Commission Number: EC 3.1.2.6. Purity: > 90% by SDS-PAGE. Mole weight: 32.4 kDa. Activity: >10 U/mg. Storage: Store at -20 ?C for at least two years. Avoid repeated freeze thaw cycles. Form: Liquid. Source: E. coli. Species: Human. Hydroxyacylglutathione hydrolase; mitochondrial; HAGH1; GLO2; Glyoxalase II; Glx II; Glyoxalase. Cat No: NATE-1650. | |
| lactoylglutathione lyase | Also acts on 3-phosphoglycerol-glutathione. Group: Enzymes. Synonyms: methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing). Enzyme Commission Number: EC 4.4.1.5. CAS No. 9033-12-9. Glyoxalase I. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5339; lactoylglutathione lyase; EC 4.4.1.5; 9033-12-9; methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing). Cat No: EXWM-5339. | |
| L-glycol dehydrogenase | The 2-hydroxycarbonyl compound formed can be further oxidized to a vicinal dicarbonyl compound. In the reverse direction, vicinal diketones, glyceraldehyde, glyoxal, methylglyoxal, 2-oxo-hydroxyketones and 2-ketoacid esters can be reduced. Group: Enzymes. Synonyms: glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase; L-(+)-glycol:NAD(P) oxidoreductase; L-glycol:NAD(P) dehydrogenase. Enzyme Commission Number: EC 1.1.1.185. CAS No. 77967-75-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0087; L-glycol dehydrogenase; EC 1.1.1.185; 77967-75-0; glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase; L-(+)-glycol:NAD(P) oxidoreductase; L-glycol:NAD(P) dehydrogenase. Cat No: EXWM-0087. | |
| Mitoguazone | Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG. CAS No. 459-86-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-106634. |  |
| Mitoguazone dihydrochloride monohydrate | Mitoguazone dihydrochloride monohydrate (CAS# 332360-02-8 ) is a useful research chemical. Synonyms: Methylglyoxal bis(guanylhydrazone) hydrate dihydrochloride; 2,2'-(1-Methyl-1,2-ethanediylidene) bis(hydrazinecarboximidamide) dihydrochloride hydrate; Methylglyoxal bis(guanylhydrazone) dihydrochloride hydrate; Methyl GAG dihydrochloride monohydrate; Methylglyoxal bis(guanylhydrazone) dihydrochloride monohydrate; 2,2'-(Propane-1,2-diylidene)di(hydrazine-1-carboximidamide)-hydrogen chloride-water. CAS No. 332360-02-8. Molecular formula: C5H16Cl2N8O. Mole weight: 275.14. |  |
| Native Saccharomyces cerevisiae Glyoxalase I | Glyoxalase I is universally expressed and involved in the protection against cellular damage due to cytotoxic metabolites such as advanced glycation end products (AGEs). It is an integral component of the detoxification system, catalyzing the conversion of reactive, acyclic a-oxoaldehydes into the corresponding a-hydroxyacids in a glutathione-dependent manner. Glyoxalase detoxification system consists of glyoxalase (glo)-i and glo-ii. glo-i is a cytosolic, 42 kda, dimeric zn2+ metalloenzyme. Group: Enzymes. Synonyms: lactoylglutathione lyase; EC 4.4.1.5; methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing); 9033-12-9. Enzyme Commission Number: EC 4.4.1.5. CAS No. 9033-12-9. Glyoxalase I. Mole weight: 42 kDa. Activity: > 400 units/mg protein. Storage: 2-8°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol, 0.4 M (NH4)2SO4 and 0.002 M KH2PO4 pH 6.5. Source: Saccharomyces cerevisiae. lactoylglutathione lyase; EC 4.4.1.5; methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing); 9033-12-9. Cat No: NATE-0308. | |
| Pyruvaldehyde bis(n4-methylthiosemicarbazone) | Pyruvaldehyde bis(n4-methylthiosemicarbazone). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Hydrazinecarbothioamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis[N-methyl-Pyruvaldehyde, bis(4-methyl-3-thiosemicarbazone) Semicarbazide, 1,1'-(methylethanediylidene)bis[4-methyl-3-thio-;Pyruvaldehyde bis(N4-methylthiosemicarbazone) Methylglyoxal bis-4-me. Product Category: Heterocyclic Organic Compound. CAS No. 673-68-7. Molecular formula: C7H14N6S2. Product ID: ACM673687. Alfa Chemistry ISO 9001:2015 Certified. | |
| Sardomozide | Sardomozide, also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. The in vivo phosphorylation of p53 at residues Ser(46)/Ser(392) and Mdm2 at residue Ser(166) was observed. SAM486A may be effective alternative agents for the treatment of NBs with or without MYCN amplification. Uses: Antineoplastic agents. Synonyms: CGP 48664; CGP-48664; CGP48664; SAM 486A; SAM-486A; SAM486A. Grades: >98%. CAS No. 149400-88-4. Molecular formula: C11H14N6. Mole weight: 230.27. | |
| Triosephosphate isomerase 1 (23-37) | Triosephosphate isomerase 1 (23-37) is a fragment of TPI1. Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. Synonyms: Triose-phosphate isomerase (23-37); Methylglyoxal synthase (23-37). | |
| Methyl Pyruvate | Methyl Pyruvate. Group: Biochemicals. Alternative Names: 2-Oxo-propionic Acid Methyl Ester; 2-Oxopropanoic Acid Methyl Ester; Methyl 2-Oxopropanoate; Methyl 2-Oxopropionate; Methyl Acetoformate; Methyl Methoxycarbonyl Ketone; Methyl Pyroracemate; Methyl Pyruvate; Methylglyoxylic Acid Methyl Ester; NSC 65430; Pyroracemic Acid Methyl Ester. Grades: Highly Purified. CAS No. 600-22-6. Pack Sizes: 50g. Molecular Formula: C4H6O3, Molecular Weight: 102.09. US Biological Life Sciences. | Worldwide |
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