Mitochondrial Suppliers USA
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Product | Description | |
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Mitochondrial ATF Translocator, SBI-0087702 (N- ( (4-methoxynaphthalen-1-yl) methyl) -2- (4-methoxyphenyl) ethanamine, SBI0087702, SBI 0087702) Quick inquiry Where to buy Suppliers range | A cell permeable naphthalene derivative that promotes the translocation of ATF2 from nucleus to mitochondria via PKCe that results in mitochondrial membrane leakage and cell death in melanoma cells (WM793 and UACC903). Diminishes cell motility and anchorage-free growth in melanoma cells (<90% at 10uM) and reduces their migration in an ATF2-dependent manner. Shown to reduce ATF2 phosphorylation on Thr52, 69, and 71. However, it does not affect the activity of Erk1/2, Akt, pan-PKC. Cells expressing ATF2T52E do not exhibit any loss of mitochondrial membrane potential. Does not induce apoptosis in normal melanocytes even at high concentrations (~20 mM) and has no effect on the localization or translocation of p53, STAT3, or b-catenin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Mitochondrial Fusion Promoter, M1 ( (E) -4-Chloro-2- (1- (2- (2, 4, 6-trichlorophenyl) hydrazono) ethyl) phenol) Quick inquiry Where to buy Suppliers range | A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50=5.3 and 4.42 mM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5uM 24h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5uM 24h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin at 5uM is shown to completely offset the mitochondrial fusion effect by 5uM M1 in Mfn1 knockout MEF. Comparing to mdivi-1, M1 exerts its effect via promoting fusion rather than inhibiting fission or division. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Mitochondrial Pyruvate Carrier Inhibitor, UK5099 ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023) Quick inquiry Where to buy Suppliers range | A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Group: Biochemicals. Grades: Highly Purified. CAS No. 56396-35-1. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
39S ribosomal protein L34, mitochondrial (58-66) Quick inquiry Where to buy Suppliers range | 39S ribosomal protein L34, mitochondrial. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-070. | |
MitoBloCK-6 (2- ( ( (4-Anilinophenyl) imino) methyl) -4, 6-dichlorophenol, 2, 4-Dichloro-6- ( ( ( ( (phenylamino) phenyl) imino) methyl) phenol) , Mitochondrial Protein Import Blocker from the Carla Koehler Laboratory, MB6, MB-6) Quick inquiry Where to buy Suppliers range | A cell-permeable, stable dichlorosalicylalde hyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700nM, 900nM, and 1.4uM for ALR, Erv1, and Erv2, respectively). Significantly reduces the import of CX9 proteins, Erv1, Tim23, and ADP/ATP carrier (AAC). However, it does not affect mitochondrial membrane integrity as evidenced by the lack of aconitase, AAC, Tim54, Mia40, and cytochrome c release. Has no effect on protein disulfide isomerase, flavin adenine dinucleotide, and succinate dehydrogenase activities and does not disrupt mitochondrial net work or reduce viability of cells even at high concentrations (~100uM in HeLa and HEK293 cells). Reported to specifically cause cytochrome c release, activate caspase-3, and induce apoptosis in human embryonic stem cells (~20uM), but not in differentiated cells. Reversibly impairs cardiac development and reduces heart rate in zebra fish that is attributed to mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??Cl?N?O, Primary Target: Erv1. US Biological Life Sciences. | Worldwide |
MitoHunt Red Mitochondrial Superoxide Indicator Quick inquiry Where to buy Suppliers range | MitoHunt Red Mitochondrial Superoxide Indicator is a red-fluorescent probe that can be used for monitoring ROS in live cells. Molecular formula: C43H43IN3P. Mole weight: 759.71. | |
Peroxiredoxin-5, mitochondrial (163-172) Quick inquiry Where to buy Suppliers range | Peroxiredoxin-5, mitochondrial (163-172) is a truncated fragment of Peroxiredoxin-5, mitochondrial. Peroxiredoxin-5 interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. Synonyms: Peroxisomal Antioxidant Enzyme (163-172); Thioredoxin Peroxidase PMP20 (163-172); Antioxidant Enzyme B166 (163-172). | |
Peroxiredoxin-5, mitochondrial (163-172) Quick inquiry Where to buy Suppliers range | Peroxiredoxin-5, mitochondrial. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-230. | |
10-(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl Methanesulfonate Quick inquiry Where to buy Suppliers range | 10-(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl Methanesulfonate is an intermediate in the synthesis of Mitoquinol (M372210), an antioxidant mitochondrial-targeted coenzyme Q analog with neuroprotective effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 845959-53-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H32O7S. US Biological Life Sciences. | Worldwide |
1,1,1,3,3,3-Hexafluoro-2-methoxypropane Quick inquiry Where to buy Suppliers range | 1,1,1,3,3,3-Hexafluoro-2-methoxypropane is a volatile inhalation anaesthetic affection mitochondrial respiration. Related compound to Sevoflurane (H291050). Group: Biochemicals. Grades: Highly Purified. CAS No. 13171-18-1. Pack Sizes: 100mg, 2.5g. Molecular Formula: C4H4F6O. US Biological Life Sciences. | Worldwide |
1-[1,1'-Bicyclopropyl]-2-yl-2-chlorobenzene (Mixture) Quick inquiry Where to buy Suppliers range | 1-[1,1'-Bicyclopropyl]-2-yl-2-chlorobenzene is an intermediate in synthesizing Sedaxane (S242000), a broad-spectrum seed treatment fungicide used for control of seed- and soil-borne diseases in a broad range of crops. It inhibits fungal respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C12H13Cl. US Biological Life Sciences. | Worldwide |
12- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) dodecanoic Acid Quick inquiry Where to buy Suppliers range | 12- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) dodecanoic Acid has been used as a reactant for the preparation of pro-apoptotic peptide functionalized gold nanoparticles as a new anti-cancer strategy of damaging mitochondria. Group: Biochemicals. Grades: Highly Purified. CAS No. 128917-74-8. Pack Sizes: 500mg, 1 g. Molecular Formula: C27H35NO4, Molecular Weight: 437.57. US Biological Life Sciences. | Worldwide |
1,2-Bis[4-(bromomethyl)phenyl]-1,2-diphenylethene Quick inquiry Where to buy Suppliers range | 1,2-Bis[4-(bromomethyl)phenyl]-1,2-diphenylethene. Uses: TPE-MB is an intermediate of aggregation-induced emission (AIE) material used in the synthesis of blue mitochondrial dyes for bio-imaging. TPE-MB may be used in the preparation of aggregation induced emission (AIE) probes for the fluorescence detection of mercury(II) and glutathione. Group: Halogen MOFs Ligands. Alternative Names: Benzene, 1,1'-(1,2-diphenyl-1,2-ethenediyl)bis[4-(bromomethyl)-. Grades: 95%. CAS No. 1053241-67-0. Product ID: ACM1053241670-3. Molecular formula: C28H22Br2. Mole weight: 518.28. IUPAC Name: 1-(bromomethyl)-4-[(E)-2-[4-(bromomethyl)phenyl]-1,2-diphenylethenyl]benzene. SMILES: BrCC (C=C1)=CC=C1/C (C2=CC=CC=C2)=C (C3=CC=CC=C3)/C4=CC=C (CBr)C=C4. | |
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine Quick inquiry Where to buy Suppliers range | 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine with lauric acid. Phosphatidylethanolamine is a phospholipid found in all living organisms, particularly in nervous tissue. It serves as a precursor of phosphatidylcholine, and promotes membrane fusion, oxidative phosphorylation, mitochondrial biogenesis, and autophagy. Synonyms: DLEA; DLPE; Dilauroyl phosphatidylethanolamine; PE(12:0/12:0); 1,2-didodecanoyl-sn-glycero-3-phosphoethanolamine. Grades: ≥98%. CAS No. 42436-56-6. Molecular formula: C29H58NO8P. Mole weight: 579.76. | |
14:0 Cardiolipin (TMCL) Liposomes Quick inquiry Where to buy Suppliers range | Cardiolipin is an essential phospholipid. It is the only known dimeric phospholipid, and its unique structure plays a major role in maintaining the function of membrane-associated proteins in the mitochondria. Cardiolipin is negatively charged in physiological pH. The studies of pharmacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved the antitumor activity of doxorubicin. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
1,5-Isoquinolinediol Quick inquiry Where to buy Suppliers range | 1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. 1,5-Isoquinolinediol is also an inducible nitric oxide synthase (NOS2) inhibitor. 1,5-Isoquinolinediol significantly inhibited mitochondrial membrane potential loss, AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: 1,5-Dihydroxyisoquinoline; Isoquinoline-1,5-diol; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisocarbostyril. Grades: 99%. CAS No. 5154-2-9. Molecular formula: C9H7NO2. Mole weight: 161.16. | |
18:1 Cardiolipin (TOCL) Liposomes Quick inquiry Where to buy Suppliers range | Cardiolipin is an essential phospholipid. It is the only known dimeric phospholipid, and its unique structure plays a major role in maintaining the function of membrane-associated proteins in the mitochondria. Cardiolipin is negatively charged in physiological pH. The studies of pharmacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved the antitumor activity of doxorubicin. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
1-Des(3,4-dimethoxybenzyl) 1-Methoxymethyl 3,4-Dihydropapaverine Quick inquiry Where to buy Suppliers range | 1-Des(3,4-dimethoxybenzyl) 1-Methoxymethyl 3,4-Dihydropapaverine is derived from Homoveratrylamine (H669540), which is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinsons disease studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 107415-83-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H17NO3, Molecular Weight: 235.28. US Biological Life Sciences. | Worldwide |
1-O-Methylsulfonyl 3-O-Trityl-(S,S)-Chloramphenicol Quick inquiry Where to buy Suppliers range | 1-O-Methylsulfonyl 3-O-Trityl-(S,S)-Chloramphenicol is an intermediate in the synthesis of L-erythro-Chloramphenicol (C325015), which functions as a potent inhibitor of electron transport in the mitochondria in biological studies. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 250mg. Molecular Formula: C31H28Cl2N2O7S. US Biological Life Sciences. | Worldwide |
1-O-Methylsulfonyl (S,S)-Chloramphenicol Quick inquiry Where to buy Suppliers range | 1-O-Methylsulfonyl (S,S)-Chloramphenicol is an intermediate in the synthesis of L-erythro-Chloramphenicol (C325015), which functions as a potent inhibitor of electron transport in the mitochondria in biological studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 400835-38-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C12H14Cl2N2O7S. US Biological Life Sciences. | Worldwide |
(1S, 4S)-2, 5-Diazabicyclo[2. 2. 1]heptane Dihydrobromide Quick inquiry Where to buy Suppliers range | (1S, 4S)-2, 5-Diazabicyclo[2. 2. 1]heptane Dihydrobromide acts as a reagent for the synthesis and characterization of new piperazine-type inhibitors for mitochondrial ubiquinone reductase, preparation of heterocyclic compounds as chemokine receptor inhibitors useful in treatment of CXCR4-mediated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 132747-20-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H10N2; 2HBr, Molecular Weight: 98.1516182. US Biological Life Sciences. | Worldwide |
1-?tert-?Butyl-?3,?5-?dimethylbenzene Quick inquiry Where to buy Suppliers range | 1-?tert-?Butyl-?3,?5-?dimethylbenzene (Xylometazoline EP Impurity D) is a reagent used in the synthesis of polyarenes as oligonapthalene derivatives as well as in the preparation of arylsulfur trifluorides from diaryl disulfides. Xylometazoline derivative, a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the the ability to shift energy metabolism from mitochondrial to glycolysis (2). Group: Biochemicals. Grades: Highly Purified. CAS No. 98-19-1. Pack Sizes: 100g, 250g. Molecular Formula: C12H18, Molecular Weight: 162.27. US Biological Life Sciences. | Worldwide |
1-[trans-4- (4-Chlorophenyl) cyclohexyl] Ester Ethanedioic Acid-d5 Quick inquiry Where to buy Suppliers range | 1-[trans-4- (4-Chlorophenyl) cyclohexyl] Ester Ethanedioic Acid-d5 is an intermediate in the synthesis of Atovaquone-d5 (A793502), which is a hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H15ClO4. US Biological Life Sciences. | Worldwide |
2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-4H-1-benzopyran-4-one Quick inquiry Where to buy Suppliers range | 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-4H-1-benzopyran-4-one is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Group: Biochemicals. Grades: Highly Purified. CAS No. 498548-17-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C35H24O7. US Biological Life Sciences. | Worldwide |
2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-3,7-bis(phenylmethoxy)-4H-1-benzopyran-4-one Quick inquiry Where to buy Suppliers range | 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-3,7-bis(phenylmethoxy)-4H-1-benzopyran-4-one is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C42H30O7. US Biological Life Sciences. | Worldwide |
2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-3-phenylmethoxy-4H-1-benzopyran-4-one 7-O- β-D-Glucuronide Quick inquiry Where to buy Suppliers range | 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-3-phenylmethoxy-4H-1-benzopyran-4-one 7-O- β-D-Glucuronide is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C41H32O13. US Biological Life Sciences. | Worldwide |
2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-2-oxoacetic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | 2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-2-oxoacetic Acid Methyl Ester is an intermediate in the synthesis of (Z)-Azoxystrobin (A965155), a fungicide that inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Group: Biochemicals. Grades: Highly Purified. CAS No. 143130-93-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H13N3O5. US Biological Life Sciences. | Worldwide |
2,2-dimethyldodecanoic Acid Quick inquiry Where to buy Suppliers range | 2,2-Dimethyldodecanoic acid, an intriguing biochemical, has emerged as a promising therapeutic candidate for the treatment of neurological disorders and diabetes. As a modulator of the mitochondrial membrane, this compound has garnered attention for its ability to enhance insulin sensitivity and glucose tolerance in experimental subjects, showcasing its therapeutic potential in metabolic disorders. Furthermore, preclinical investigations have yielded encouraging results, highlighting its potential to serve as a potent anxiolytic and antidepressant agent, rendering it a prime target for future research. Synonyms: 2,2-dimethyllauric acid. Grades: 95%. CAS No. 2874-73-9. Molecular formula: C14H28O2. Mole weight: 228.37. | |
2, 3-Dimethoxy-5-methyl-6-[10-[ (methylsulfonyl) oxy]decyl]-1, 4-benzenediol Quick inquiry Where to buy Suppliers range | 2, 3-Dimethoxy-5-methyl-6-[10-[ (methylsulfonyl) oxy]decyl]-1, 4-benzenediol is an intermediate in the synthesis of Mitoquinol (M372210), an antioxidant mitochondrial-targeted coenzyme Q analog with neuroprotective effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 845959-54-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H34O7S. US Biological Life Sciences. | Worldwide |
2-(3-Oxobutyl)-2-azaspiro[4.5]decan-3-one Quick inquiry Where to buy Suppliers range | 2-(3-Oxobutyl)-2-azaspiro[4.5]decan-3-one is a derivative of Gabapentin Lactam (G117275); a compound that reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntingtons disease. Gabapentin Lactam also opens mitochondrial ATP-dependent potassium channels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 250mg. Molecular Formula: C13H21NO2, Molecular Weight: 223.31. US Biological Life Sciences. | Worldwide |
2-(3-Oxobutyl)-2-azaspiro[4.5]decan-3-one-d6 Quick inquiry Where to buy Suppliers range | 2-(3-Oxobutyl)-2-azaspiro[4.5]decan-3-one-d6 is the isotope labelled analog of 2-(3-Oxobutyl)-2-azaspiro[4.5]decan-3-one (O848400); a derivative of Gabapentin Lactam (G117275) which is a compound that reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntingtons disease. Gabapentin Lactam also opens mitochondrial ATP-dependent potassium channels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C13H15D6NO2, Molecular Weight: 229.35. US Biological Life Sciences. | Worldwide |
2,4-Dinitrofluorobenzene Quick inquiry Where to buy Suppliers range | A substituted benzene use in polypeptide sequencing (also referred to as Sangers reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria. Group: Biochemicals. Alternative Names: 1-Fluoro-2,4-dinitrobenzene; 2,4-Dinitrobenzene fluoride; 4-Fluoro-1,3-dinitrobenzene; DFB; DNFB; FDNB; Fluorodinitrobenzene; NSC 33519. Grades: Highly Purified. CAS No. 70-34-8. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
2,4-Dinitrophenol-13C6 Quick inquiry Where to buy Suppliers range | 2,4-Dinitrophenol-13C6 is an lsotope labelled compound of 2,4-Dinitrophenol (D479945). 2,4-Dinitrophenol has potential application in the treatment of obesity via mitochondrial uncoupling. It is also used in the synthesis of coumarins and in the preparation of chloroformates as pharmaceutical reagents. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: 13C6H4N2O5, Molecular Weight: 190.06. US Biological Life Sciences. | Worldwide |
2,?6-?Dimethyl-?4-?tert-?butylphenylacetic Acid Quick inquiry Where to buy Suppliers range | 2,?6-?Dimethyl-?4-?tert-?butylphenylacetic Acid is an impurity of Xylometazoline (X749950), a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the the ability to shift energy metabolism from mitochondrial to glycolysis (2). Group: Biochemicals. Grades: Highly Purified. CAS No. 854646-92-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H14O2, Molecular Weight: 178.23. US Biological Life Sciences. | Worldwide |
2-Deoxy-5-hydroxyuridine Quick inquiry Where to buy Suppliers range | 2-Deoxy-5-hydroxyuridine is involved in the base excision repair (BER) mechanism in mitochondria. Group: Biochemicals. Grades: Highly Purified. CAS No. 5168-36-5. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C9H12N2O6, Molecular Weight: 244.2. US Biological Life Sciences. | Worldwide |
(2E)-3-(2-Chlorophenyl)-1-cyclopropyl-2-propen-1-one Quick inquiry Where to buy Suppliers range | (2E)-3-(2-Chlorophenyl)-1-cyclopropyl-2-propen-1-one is an intermediate in synthesizing Sedaxane (S242000), a broad-spectrum seed treatment fungicide used for control of seed- and soil-borne diseases in a broad range of crops. It inhibits fungal respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Group: Biochemicals. Grades: Highly Purified. CAS No. 928264-57-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C12H11ClO. US Biological Life Sciences. | Worldwide |
2-Isopropyl-4-pentenamide Quick inquiry Where to buy Suppliers range | 2-Isopropyl-4-pentenamide is a porphyrinogenic agent used in studies to determine the involvement of mice brain mitochondrial and microsomal Phase I drug metabolizing system. Group: Biochemicals. Grades: Highly Purified. CAS No. 299-78-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H15NO, Molecular Weight: 141.21. US Biological Life Sciences. | Worldwide |
2-Nicotinamide-b-D-riboside sulfate Quick inquiry Where to buy Suppliers range | 2-Nicotinamide-b-D-riboside sulfate, a supplement compound extensively applied in the biomedicine sector, is commonly used for treating age-related illnesses like Alzheimer's, Parkinson's, and cardiovascular diseases. What makes it noteworthy is its ability to enhance mitochondrial function alongside an increase in energy metabolism, thereby promoting better health and a longer lifespan. Synonyms: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide sulfate. CAS No. 1713228-05-7. Molecular formula: C22H30N4O14S. Mole weight: 606.60. | |
(2R)-Octyl-α-hydroxyglutarate Quick inquiry Where to buy Suppliers range | (2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-67-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5, Molecular Weight: 260.33. US Biological Life Sciences. | Worldwide |
(2R)-Octyl-α-hydroxyglutarate-d17 Quick inquiry Where to buy Suppliers range | (2R)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. | Worldwide |
(2S)-Octyl-α-hydroxyglutarate-d17 Quick inquiry Where to buy Suppliers range | (2S)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. | Worldwide |
3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) Quick inquiry Where to buy Suppliers range | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
[3-(Carboxybenzhydryl)-2 3-[3- (tert-Butyldimethylsilyloxy) prop-1-yl]dimethyl Trideuterio Methyl Ammonium Iodide Quick inquiry Where to buy Suppliers range | [3-(Carboxybenzhydryl)-2 3-[3- (tert-Butyldimethylsilyloxy) prop-1-yl]dimethyl Trideuterio Methyl Ammonium Iodide is an intermediate in the synthesis of 3-Hydroxy-9-hexadecenoyl-L-carnitine-d3 (H825457). 3-Hydroxy-9-hexadecenoyl-L-carnitine-d3 chloride is the labeled analog of 3-Hydroxy-9-hexadecenoyl-L-carnitine chloride (H825455) an analogue of 3- hydroxyhexadecanoyl carnitine Inner Salt (H943005), a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3- hydroxyhexadecanoyl carnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C42H65D3INO5Si. US Biological Life Sciences. | Worldwide |
(3-Carboxypropyl)triphenylphosphonium Bromide Quick inquiry Where to buy Suppliers range | (3-Carboxypropyl)triphenylphosphonium Bromide is a reagent used for the preparation of sphingosine 1-phosphate-1 receptor antagonists, as well as for the synthesis of mitochondrial vitamin E metabolites and other mitochondrial targets in the study of mitochodrial functions. Synonyms: (4-Hydroxy-4-oxobutyl)triphenylphosphonium Bromide; Phosphonium, (3-carboxypropyl)triphenyl-, bromide (1:1). Grades: ≥95%. CAS No. 17857-14-6. Molecular formula: C22H22BrO2P. Mole weight: 429.29. | |
3-Chloro-1,4-dihydro-1,4-dioxo-2-naphthalenecarboxylic Acid 4- (4-Chlorophenyl) cyclohexyl Ester Quick inquiry Where to buy Suppliers range | 3-Chloro-1,4-dihydro-1,4-dioxo-2-naphthalenecarboxylic Acid 4- (4-Chlorophenyl) cyclohexyl Ester is an impurity in the synthesis of Atovaquone-d5 (A793502), which is an hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic. Group: Biochemicals. Grades: Highly Purified. CAS No. 215672-88-1. Pack Sizes: 50mg, 250mg. Molecular Formula: C23H18Cl2O4. US Biological Life Sciences. | Worldwide |
3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid Quick inquiry Where to buy Suppliers range | 3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid is an intermediate in synthesizing Sedaxane (S242000), a broad-spectrum seed treatment fungicide used for control of seed- and soil-borne diseases in a broad range of crops. It inhibits fungal respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Group: Biochemicals. Grades: Highly Purified. CAS No. 151734-02-0. Pack Sizes: 2.5g, 5g. Molecular Formula: C6H6F2N2O2. US Biological Life Sciences. | Worldwide |
3-Hydroxy-1-methylpyridinium Iodide Quick inquiry Where to buy Suppliers range | 3-Hydroxy-1-methylpyridinium Iodide is a hydroxypyridine derivative showed protective effects of human erythrocytes against hemolysis from mechanical trauma. 3-Hydroxy-1-methylpyridinium Iodide is an antioxidant that showed inhibitory activity towards respiratory chain mitochondria. Group: Biochemicals. Alternative Names: 1-Methyl-3-hydroxypyridinium Iodide; 3-Hydroxypyridinium Methiodide. Grades: Highly Purified. CAS No. 7500-5-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
3- hydroxyhexadecanoyl carnitine Quick inquiry Where to buy Suppliers range | 3- hydroxyhexadecanoyl carnitine inner salt is a carnitine derivative, an essential cofactor of the the fatty acid metabolism that is required for the transport of fatty acirds through the inner mitochondrial membrane. Group: Biochemicals. Alternative Names: 3- hydroxypalmitoyl carnitine; (2R)-3-Carboxy-2-[(3-hydroxy-1-oxohexadecyl)oxy]-N,N,N-trimethyl-1-propanaminiumInner Salt, [1(R)]-3-Carboxy-2-[(3-hydroxy-1-oxohexadecyl)oxy]-N,N,N-trimethyl-1-propanaminium Inner Salt. Grades: Highly Purified. CAS No. 195207-76-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
3-Nitropropionic acid (3-NP) Quick inquiry Where to buy Suppliers range | A plant and fungal toxin, 3-nitropropionic acid acts as an irreversible inactivator of succinate dehydrogenase. Selectively inhibits succinic dehydrogenase complex (Complex II) in the mitochondrial electron transport chain. Also shown to cause brain lesions similar to those of Huntington?s disease. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
3-Nitrotetrazolium blue chloride Quick inquiry Where to buy Suppliers range | 3-Nitrotetrazolium blue chloride, a commonly utilized reagent within the biomedical sector, has proven essential in discerning cell viability and metabolic activity. Its prevalent application lies in assessing the effectiveness of antineoplastic drugs and their cytotoxic impact on tumor cells. Furthermore, it serves as a diagnostic instrument for evaluating mitochondrial function in a multitude of ailments, including cancer and neurodegenerative disorders. Synonyms: 2H-Tetrazolium, 3,3'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[2-(3-nitrophenyl)-5-phenyl-, chloride (1:2); 2H-Tetrazolium, 3,3'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[2-(3-nitrophenyl)-5-phenyl-, dichloride; 3,3'-(3,3'-Dimethoxy-4,4'-biphenylylene)bis[5-(m-nitrophenyl)-2-phenyl-2H-tetrazolium chloride]; m-NBT; m-Nitro Blue Tetrazolium Chloride; m-Nitrotetrazolium blue; NSC 90435. Grades: ≥95%. CAS No. 38184-50-8. Molecular formula: C40H30Cl2N10O6. Mole weight: 817.64. | |
4-(4-Hydroxy-1-butynyl)benzoic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | A reactant used in organic synthesis. Can be used in the preparation of mitochondrial complex 1 inhibitor as potential cardiac PET tracer and antifolate drugs. Group: Biochemicals. Alternative Names: 4-(4-Hydroxy-1-butyn-1-yl)-benzoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 123910-86-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
4-Hydroxyisoleucine Quick inquiry Where to buy Suppliers range | 4-Hydroxyisoleucine, which comes from the seeds of Trigonella foenum-graecum L, could inhibit palmitate-induced, ROS-associated inflammation and restored insulin sensitivity through regulating IRS-1 function. It acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats. Besides, 4-Hydroxyisoleucine could remarkably improve high glucose-induced IR in 3T3-L1 adipocytes. Meanwhile, 4-HIL could inhibit the secretion of TNF-alpha. Synonyms: 4-HYDROXY-L-ISOLEUCINE; (2S,3R)-2-aMino-4-hydroxy-3-Methylpentanoic acid. Grades: >98%. CAS No. 781658-23-9. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
4-Hydroxyquinazoline Quick inquiry Where to buy Suppliers range | 4-HQN is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50 = 9.5 μM). 4-HQN exhibits antianti-ischemic activity and reduces ROS production, subsequent mitochondrial and cell damage in rat heart. It also blocks NF-κB and AP-1 activation. Synonyms: 3H-quinazolin-4-one. Grades: ≥ 99 % by HPLC. CAS No. 491-36-1. Molecular formula: C8H6N2O. Mole weight: 146.15. | |
4-Phenylpyridine Quick inquiry Where to buy Suppliers range | 4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice. Group: Biochemicals. Alternative Names: NSC 70375; NSC 77935; p-Phenylpyridine; γ-Phenylpyridine. Grades: Highly Purified. CAS No. 939-23-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
5-(2-Hydroxyethyl)uridine Quick inquiry Where to buy Suppliers range | 5-(2-Hydroxyethyl)uridine, a modified nucleoside commonly used in RNA research, exhibits excellent RNA stability and translation efficiency, rendering it valuable for gene expression studies. In addition to its utility in the laboratory, recent studies revealed promising therapeutic potential for treating mitochondrial illnesses. Synonyms: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione; Uridine, 5-(2-hydroxyethyl)-. Grades: ≥95%. CAS No. 102691-28-1. Molecular formula: C11H16N2O7. Mole weight: 288.25. | |
5-Formyl-2',3'-O-(1-methylethylidene)-cytidine Quick inquiry Where to buy Suppliers range | 5-Formyl-2',3'-O-(1-methylethylidene)-cytidine is an intermediate in 5-Formylcytidine synthesis. 5-Formylcytidine is a modified nucleoside found at the first position of the anticodon of bovine mitochondrial tRNAMet. Synonyms: 5-Formyl-2',3'-O-(1-methylethylidene)cytidine; Furo[3,4-d]-1,3-dioxole Cytidine Deriv. CAS No. 153535-36-5. Molecular formula: C13H17N3O6. Mole weight: 311.29. | |
5-formylcytidine Quick inquiry Where to buy Suppliers range | 5-Formylcytidine is a modified nucleoside found at the first position of the anticodon of bovine mitochondrial tRNAMet. Synonyms: Cytidine, 5-formyl-; 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidine-5-carbaldehyde; cytidine, 6-formyl-. Grades: 98%. CAS No. 148608-53-1. Molecular formula: C10H13N3O6. Mole weight: 271.23. | |
5-(Hydroxymethyl)-2',3'-O-(1-methylethylidene)cytidine Quick inquiry Where to buy Suppliers range | 5-(Hydroxymethyl)-2',3'-O-(1-methylethylidene)cytidine is used in the synthesis of tRNA's anticodon stem and loop domain containing the 5-formylcytidine modification. Also, it is an intermediate used in 5-Formylcytidine synthesis, which is a modified nucleoside found at the first position of the anticodon of bovine mitochondrial tRNAMet. Synonyms: Furo[3,4-d]-1,3-dioxole Cytidine Deriv. CAS No. 72472-12-9. Molecular formula: C13H19N3O6. Mole weight: 313.31. | |
5'-Tetrachloro-Fluorescein CE Phosphoramidite(6-TET) Quick inquiry Where to buy Suppliers range | 5'-Tetrachloro-Fluorescein CE Phosphoramidite (6-TET) is an exceptional nucleoside derivatizing reagent. Significantly, its high sensitivity and specificity are beneficial for the fluorescence-based detection methods when examining single nucleotide polymorphisms, gene expression, or DNA sequencing. Moreover, novel investigations show that it could be imperative when studying mitochondrial DNA damages commonly implicated in both cancer and neurological disorders. Synonyms: 6-[(4,7,2',7'-Tetrachloro-3',6'-dipivaloylfluoresceinyl)-carboxamido]-hexyl-1-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Grades: >97% by HPLC. Molecular formula: C46H54CI4N3O10P. Mole weight: 981.73. | |
6-Methylnicotinamide Quick inquiry Where to buy Suppliers range | A nicotinamide derivative that inhibits state 3 respiration in isolated rat liver mitochondria. It is toxic to rat B65 neuroblastoma cells and is used in studies associated with early symptoms of Parkinson's disease. Group: Biochemicals. Alternative Names: 6-Methyl-3-Pyridinecarboxamide; 6-Methylnicotinic Acid Amide; 6-Methylpyridine-3-carboxamide. Grades: Highly Purified. CAS No. 6960-22-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
7-Doxyl Stearic Acid Quick inquiry Where to buy Suppliers range | A spin-labeled fatty acid. The reduction of doxylstearates takes place at the level of the ubiquinone in the respiratory chain in mitochondria in these cells. Group: Biochemicals. Alternative Names: 2-(5-Carboxypentyl)-4,4-dimethyl-2-undecyl-. Grades: Highly Purified. CAS No. 40951-82-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
8-[(6-Amino)hexyl]-amino-ATP - ATTO-665 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-ATP - ATTO-665 is a fluorescent probe used in live cell imaging to monitor ATP-dependent biological processes. It is commonly used to track mitochondrial function and ATP synthesis in cells. ATTO-665 is also used to detect drug interactions with ATP-binding proteins, such as kinases, in drug discovery research. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-5'-triphosphate, labeled with ATTO 665, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O13P3- ATTO 665 (free acid). Mole weight: 1225.37 (free acid). | |
8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101, an essential fluorescent dye for investigating GTPase activity and binding in biological assays, is an exquisite addition to scientific experimentation. The dye is particularly valuable when coupled with Rho GTPases that yield intriguing insights into important cellular activities such as cytoskeletal rearrangement and cell migration. Moreover, the dye's versatility is a cause for praise as it can be employed to label and visualize subcellular structures, including but not limited to mitochondria. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho101, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C53H67N10O17P3 (free acid). Mole weight: 1208.39 (free acid). | |
Acequinocyl-d25 Quick inquiry Where to buy Suppliers range | Isotope labelled Acequinocyl is an inhibitor of mitochondrial electron transport in complex III and used to control phytophagous mites. Used in Pesticide detection. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C24H7D25O4, Molecular Weight: 409.66. US Biological Life Sciences. | Worldwide |
Acetyl-L-carnitine-[13C2] hydrochloride Quick inquiry Where to buy Suppliers range | Acetyl-L-carnitine-[13C2] hydrochloride is the carbon-13 labelled edition of Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is an acetic acid ester of L-carnitine that transports fatty acids into the mitochondria. It was demonstrated that exhibits antidepressant and neuroprotective activity, and it can upregulate metabotropic glutamate receptor 2 (mGlu2). Synonyms: Acetyl-13C2-L-carnitine hydrochloride; (2R)-3-Carboxy-2-[(13C2)ethanoyloxy]-N,N,N-trimethylpropan-1-aminium chloride. Grades: 99% atom 13C. CAS No. 1219093-38-5. Molecular formula: C7[13C]2H18ClNO4. Mole weight: 241.68. | |
Acetyl-L-carnitine-[d3] hydrochloride Quick inquiry Where to buy Suppliers range | Acetyl-L-carnitine-[d3] hydrochloride is the deuterium labelled edition of Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is an acetic acid ester of L-carnitine that transports fatty acids into the mitochondria. It was demonstrated that exhibits antidepressant and neuroprotective activity, and it can upregulate metabotropic glutamate receptor 2 (mGlu2). Synonyms: Acetyl-L-carnitine-(N-methyl-d3) hydrochloride. Grades: 98% (CP); 99% atom D. CAS No. 1334532-17-0. Molecular formula: C9H15D3ClNO4. Mole weight: 242.72. | |
Acridine Orange 10-nonyl bromide Quick inquiry Where to buy Suppliers range | Acridine orange 10-nonyl is a metachromatic dye that is used to analyze mitochondria by flow cytometry, characterize multidrug resistance, and measure changes in mitochondrial mass during apoptosis in rat thymocytes. Synonyms: 10-nonyl Acridine Orange; Nonylacridine Orange; 3,6-bis(dimethylamino)-10-nonyl-acridinium bromide. Grades: ≥90%. CAS No. 75168-11-5. Molecular formula: C26H38BrN3. Mole weight: 472.5. | |
Adenosine 5'-diphosphate Disodium Salt Quick inquiry Where to buy Suppliers range | Adenosine 5'-diphosphate Disodium Salt, a paramount biochemical compound widely employed in the biomedical sector, assumes a pivotal function in energy metabolism, serving as a precursor for ATP synthesis. Its applications encompass extensive research endeavors investigating cellular energetics and pathologies linked to energy insufficiency, notably metabolic disorders and mitochondrial dysfunction. Synonyms: Adenosine 5'-(trihydrogen diphosphate) Disodium Salt; ADP Disodium; ADP Disodium Salt; Disodium 5'-ADP; Disodium ADP; Disodium Adenosine 5'-Diphosphate; 5'-ADP-Na2; ADP-Na2; Adenosine diphosphate disodium salt. Grades: ≥95%. CAS No. 16178-48-6. Molecular formula: C10H13N5Na2O10P2. Mole weight: 471.16. | |
Adenosine-5'-O-diphosphoribose phosphate Quick inquiry Where to buy Suppliers range | Adenosine-5'-O-diphosphoribose phosphate (ADRP) is a highly significant biomolecule that participates in a myriad of intricate cellular processes. Its paramount importance stems from being an essential substrate for a class of enzymes known as poly(ADP-ribose) polymerases (PARPs), which undertake the arduous tasks of DNA repair and modification. Remarkably, ADRP assumes a pivotal role in combating diseases associated with DNA damage, most notably cancer. Furthermore, it assumes an indispensable function in orchestrating the intricate mechanisms governing cellular metabolism and the highly intricate machinery of mitochondrial function. Synonyms: ADPRP. Grades: 95%. CAS No. 53595-18-9. Molecular formula: C15H24N5O17P3. Mole weight: 639.30. | |
Adenosine Receptor Agonist, NECA ( (2S, 3S, 4R, 5R) -5- (6-amino-9H-purin-9-yl) -N-ethyl-3, 4-di hydroxytetra hydrofuran-2-carboxamide ) Quick inquiry Where to buy Suppliers range | A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14nM, 20nM, 2.4uM and 6.2nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1uM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 35920-39-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |