Mitochonic Acid Suppliers USA
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Product | Description | |
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Mitochonic Acid 5 Quick inquiry Where to buy Suppliers range | Mitochonic Acid 5 is an effective mitochondrial ATP production enhancer. It binds to mitochondria and improves renal tubular and cardiomyocyte damage. Synonyms: Mitochonic Acid 5(MA-5); SCHEMBL15747705; MA-5; MA 5; MA5. Grades: 98%. CAS No. 1354707-41-7. Molecular formula: C18H13F2NO3. Mole weight: 329.3. | |
Mitochonic Acid 5, 99% Quick inquiry Where to buy Suppliers range | Mitochonic Acid 5, 99%. Group: Cancer Research. CAS No. 1354707-41-7. Pack Sizes: 5mg. ID EBT920. | |
12- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) dodecanoic Acid Quick inquiry Where to buy Suppliers range | 12- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) dodecanoic Acid has been used as a reactant for the preparation of pro-apoptotic peptide functionalized gold nanoparticles as a new anti-cancer strategy of damaging mitochondria. Group: Biochemicals. Grades: Highly Purified. CAS No. 128917-74-8. Pack Sizes: 500mg, 1 g. Molecular Formula: C27H35NO4, Molecular Weight: 437.57. US Biological Life Sciences. | Worldwide |
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine Quick inquiry Where to buy Suppliers range | 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine with lauric acid. Phosphatidylethanolamine is a phospholipid found in all living organisms, particularly in nervous tissue. It serves as a precursor of phosphatidylcholine, and promotes membrane fusion, oxidative phosphorylation, mitochondrial biogenesis, and autophagy. Synonyms: DLEA; DLPE; Dilauroyl phosphatidylethanolamine; PE(12:0/12:0); 1,2-didodecanoyl-sn-glycero-3-phosphoethanolamine. Grades: ≥98%. CAS No. 42436-56-6. Molecular formula: C29H58NO8P. Mole weight: 579.76. | |
1-[trans-4- (4-Chlorophenyl) cyclohexyl] Ester Ethanedioic Acid-d5 Quick inquiry Where to buy Suppliers range | 1-[trans-4- (4-Chlorophenyl) cyclohexyl] Ester Ethanedioic Acid-d5 is an intermediate in the synthesis of Atovaquone-d5 (A793502), which is a hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H15ClO4. US Biological Life Sciences. | Worldwide |
2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-2-oxoacetic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | 2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-2-oxoacetic Acid Methyl Ester is an intermediate in the synthesis of (Z)-Azoxystrobin (A965155), a fungicide that inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Group: Biochemicals. Grades: Highly Purified. CAS No. 143130-93-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H13N3O5. US Biological Life Sciences. | Worldwide |
2,2-dimethyldodecanoic Acid Quick inquiry Where to buy Suppliers range | 2,2-Dimethyldodecanoic acid, an intriguing biochemical, has emerged as a promising therapeutic candidate for the treatment of neurological disorders and diabetes. As a modulator of the mitochondrial membrane, this compound has garnered attention for its ability to enhance insulin sensitivity and glucose tolerance in experimental subjects, showcasing its therapeutic potential in metabolic disorders. Furthermore, preclinical investigations have yielded encouraging results, highlighting its potential to serve as a potent anxiolytic and antidepressant agent, rendering it a prime target for future research. Synonyms: 2,2-dimethyllauric acid. Grades: 95%. CAS No. 2874-73-9. Molecular formula: C14H28O2. Mole weight: 228.37. | |
2,?6-?Dimethyl-?4-?tert-?butylphenylacetic Acid Quick inquiry Where to buy Suppliers range | 2,?6-?Dimethyl-?4-?tert-?butylphenylacetic Acid is an impurity of Xylometazoline (X749950), a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the the ability to shift energy metabolism from mitochondrial to glycolysis (2). Group: Biochemicals. Grades: Highly Purified. CAS No. 854646-92-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H14O2, Molecular Weight: 178.23. US Biological Life Sciences. | Worldwide |
(2R)-Octyl-α-hydroxyglutarate Quick inquiry Where to buy Suppliers range | (2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-67-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5, Molecular Weight: 260.33. US Biological Life Sciences. | Worldwide |
(2R)-Octyl-α-hydroxyglutarate-d17 Quick inquiry Where to buy Suppliers range | (2R)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. | Worldwide |
(2S)-Octyl-α-hydroxyglutarate-d17 Quick inquiry Where to buy Suppliers range | (2S)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. | Worldwide |
[3-(Carboxybenzhydryl)-2 3-[3- (tert-Butyldimethylsilyloxy) prop-1-yl]dimethyl Trideuterio Methyl Ammonium Iodide Quick inquiry Where to buy Suppliers range | [3-(Carboxybenzhydryl)-2 3-[3- (tert-Butyldimethylsilyloxy) prop-1-yl]dimethyl Trideuterio Methyl Ammonium Iodide is an intermediate in the synthesis of 3-Hydroxy-9-hexadecenoyl-L-carnitine-d3 (H825457). 3-Hydroxy-9-hexadecenoyl-L-carnitine-d3 chloride is the labeled analog of 3-Hydroxy-9-hexadecenoyl-L-carnitine chloride (H825455) an analogue of 3- hydroxyhexadecanoyl carnitine Inner Salt (H943005), a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3- hydroxyhexadecanoyl carnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C42H65D3INO5Si. US Biological Life Sciences. | Worldwide |
3-Chloro-1,4-dihydro-1,4-dioxo-2-naphthalenecarboxylic Acid 4- (4-Chlorophenyl) cyclohexyl Ester Quick inquiry Where to buy Suppliers range | 3-Chloro-1,4-dihydro-1,4-dioxo-2-naphthalenecarboxylic Acid 4- (4-Chlorophenyl) cyclohexyl Ester is an impurity in the synthesis of Atovaquone-d5 (A793502), which is an hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic. Group: Biochemicals. Grades: Highly Purified. CAS No. 215672-88-1. Pack Sizes: 50mg, 250mg. Molecular Formula: C23H18Cl2O4. US Biological Life Sciences. | Worldwide |
3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid Quick inquiry Where to buy Suppliers range | 3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid is an intermediate in synthesizing Sedaxane (S242000), a broad-spectrum seed treatment fungicide used for control of seed- and soil-borne diseases in a broad range of crops. It inhibits fungal respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Group: Biochemicals. Grades: Highly Purified. CAS No. 151734-02-0. Pack Sizes: 2.5g, 5g. Molecular Formula: C6H6F2N2O2. US Biological Life Sciences. | Worldwide |
3- hydroxyhexadecanoyl carnitine Quick inquiry Where to buy Suppliers range | 3- hydroxyhexadecanoyl carnitine inner salt is a carnitine derivative, an essential cofactor of the the fatty acid metabolism that is required for the transport of fatty acirds through the inner mitochondrial membrane. Group: Biochemicals. Alternative Names: 3- hydroxypalmitoyl carnitine; (2R)-3-Carboxy-2-[(3-hydroxy-1-oxohexadecyl)oxy]-N,N,N-trimethyl-1-propanaminiumInner Salt, [1(R)]-3-Carboxy-2-[(3-hydroxy-1-oxohexadecyl)oxy]-N,N,N-trimethyl-1-propanaminium Inner Salt. Grades: Highly Purified. CAS No. 195207-76-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
3-Nitropropionic acid (3-NP) Quick inquiry Where to buy Suppliers range | A plant and fungal toxin, 3-nitropropionic acid acts as an irreversible inactivator of succinate dehydrogenase. Selectively inhibits succinic dehydrogenase complex (Complex II) in the mitochondrial electron transport chain. Also shown to cause brain lesions similar to those of Huntington?s disease. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
4-(4-Hydroxy-1-butynyl)benzoic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | A reactant used in organic synthesis. Can be used in the preparation of mitochondrial complex 1 inhibitor as potential cardiac PET tracer and antifolate drugs. Group: Biochemicals. Alternative Names: 4-(4-Hydroxy-1-butyn-1-yl)-benzoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 123910-86-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
4-Hydroxyisoleucine Quick inquiry Where to buy Suppliers range | 4-Hydroxyisoleucine, which comes from the seeds of Trigonella foenum-graecum L, could inhibit palmitate-induced, ROS-associated inflammation and restored insulin sensitivity through regulating IRS-1 function. It acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats. Besides, 4-Hydroxyisoleucine could remarkably improve high glucose-induced IR in 3T3-L1 adipocytes. Meanwhile, 4-HIL could inhibit the secretion of TNF-alpha. Synonyms: 4-HYDROXY-L-ISOLEUCINE; (2S,3R)-2-aMino-4-hydroxy-3-Methylpentanoic acid. Grades: >98%. CAS No. 781658-23-9. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
6-Methylnicotinamide Quick inquiry Where to buy Suppliers range | A nicotinamide derivative that inhibits state 3 respiration in isolated rat liver mitochondria. It is toxic to rat B65 neuroblastoma cells and is used in studies associated with early symptoms of Parkinson's disease. Group: Biochemicals. Alternative Names: 6-Methyl-3-Pyridinecarboxamide; 6-Methylnicotinic Acid Amide; 6-Methylpyridine-3-carboxamide. Grades: Highly Purified. CAS No. 6960-22-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
7-Doxyl Stearic Acid Quick inquiry Where to buy Suppliers range | A spin-labeled fatty acid. The reduction of doxylstearates takes place at the level of the ubiquinone in the respiratory chain in mitochondria in these cells. Group: Biochemicals. Alternative Names: 2-(5-Carboxypentyl)-4,4-dimethyl-2-undecyl-. Grades: Highly Purified. CAS No. 40951-82-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
8-[(6-Amino)hexyl]-amino-ATP - ATTO-665 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-ATP - ATTO-665 is a fluorescent probe used in live cell imaging to monitor ATP-dependent biological processes. It is commonly used to track mitochondrial function and ATP synthesis in cells. ATTO-665 is also used to detect drug interactions with ATP-binding proteins, such as kinases, in drug discovery research. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-5'-triphosphate, labeled with ATTO 665, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O13P3- ATTO 665 (free acid). Mole weight: 1225.37 (free acid). | |
8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101, an essential fluorescent dye for investigating GTPase activity and binding in biological assays, is an exquisite addition to scientific experimentation. The dye is particularly valuable when coupled with Rho GTPases that yield intriguing insights into important cellular activities such as cytoskeletal rearrangement and cell migration. Moreover, the dye's versatility is a cause for praise as it can be employed to label and visualize subcellular structures, including but not limited to mitochondria. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho101, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C53H67N10O17P3 (free acid). Mole weight: 1208.39 (free acid). | |
Acetyl-L-carnitine-[13C2] hydrochloride Quick inquiry Where to buy Suppliers range | Acetyl-L-carnitine-[13C2] hydrochloride is the carbon-13 labelled edition of Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is an acetic acid ester of L-carnitine that transports fatty acids into the mitochondria. It was demonstrated that exhibits antidepressant and neuroprotective activity, and it can upregulate metabotropic glutamate receptor 2 (mGlu2). Synonyms: Acetyl-13C2-L-carnitine hydrochloride; (2R)-3-Carboxy-2-[(13C2)ethanoyloxy]-N,N,N-trimethylpropan-1-aminium chloride. Grades: 99% atom 13C. CAS No. 1219093-38-5. Molecular formula: C7[13C]2H18ClNO4. Mole weight: 241.68. | |
Acetyl-L-carnitine-[d3] hydrochloride Quick inquiry Where to buy Suppliers range | Acetyl-L-carnitine-[d3] hydrochloride is the deuterium labelled edition of Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is an acetic acid ester of L-carnitine that transports fatty acids into the mitochondria. It was demonstrated that exhibits antidepressant and neuroprotective activity, and it can upregulate metabotropic glutamate receptor 2 (mGlu2). Synonyms: Acetyl-L-carnitine-(N-methyl-d3) hydrochloride. Grades: 98% (CP); 99% atom D. CAS No. 1334532-17-0. Molecular formula: C9H15D3ClNO4. Mole weight: 242.72. | |
Alexidine dihydrochloride Quick inquiry Where to buy Suppliers range | Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus. Synonyms: 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2); 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride; Biguanide, 1,1'-hexamethylenebis[5-(2-ethylhexyl)-, dihydrochloride; 1,6-Bis(2-ethylhexylbiguanido)hexane dihydrochloride; Alexidine hydrochloride; Hexamethylenebis(2-ethylhexyl)biguanide dihydrochloride. Grades: >98%. CAS No. 1715-30-6. Molecular formula: C26H58N10Cl2. Mole weight: 581.71. | |
(+/-)-alpha-Lipoamide Quick inquiry Where to buy Suppliers range | (+/-)-alpha-Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation process. It may be used in treatment of insulin resistance by stimulating mitochondrial biogenesis. It has shown to have a good therapeutic effect on early diabetic nephropathy when used in combination with Alprostadil. Uses: (+/-)-alpha-lipoamide may be used in treatment of insulin resistance by stimulating mitochondrial biogenesis. it has shown to have a good therapeutic effect on early diabetic nephropathy. Synonyms: Lipoamide; Lipoacin; NSC 90787; NSC-90787; NSC90787; Lipoamide;Thioctamide;Thioctic acid amide;Vitamin N;Alpha-Lipoic acid amide;5-(Dithiolan-3-yl)pentanamide;(±)-α-Lipoamide;DL-Lipoamide;DL-6,8-Thioctamide;1,2-Dithiolane-3-pentanamide. Grades: >98 %. CAS No. 940-69-2. Molecular formula: C8H15NOS2. Mole weight: 205.34. | |
Aminocardiolipin Quick inquiry Where to buy Suppliers range | Amino-CL can be modified with or attached to amine reactive probes/surfaces. Cardiolipin (CL) is an important component in prokaryotic and in eukaryotic inner mitochondrial membranes. Monolysocardiolipin is an intermediate in CL remodeling, and acetyl transferase tafazzin mutations impairing linoleic acid transfer to MCL are considered the main reason of Barth syndrome. Synonyms: Amino-CL. Molecular formula: C69H135NO17P2. Mole weight: 1312.78. | |
AMPK activator Quick inquiry Where to buy Suppliers range | AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. D942 is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels. AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, which shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 μM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Synonyms: D942; AMPK activator; 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]furan-2-carboxylic Acid. Grades: ≥95%. CAS No. 849727-81-7. Molecular formula: C22H21FO4. Mole weight: 368.4. | |
AMP - lyophilized Quick inquiry Where to buy Suppliers range | AMP - lyophilized is also known as adenosine monophosphate. With its role in multiple biochemical pathways, extensive research has been conducted to explore its potential in fortifying immune responses is augmenting mitochondrial functionality is as well as ameliorating neurological afflictions. Furthermore, this lyophilized iteration offering a convenient means of storage and reconstitution, facilitating further investigation and potential preclinical utilization. Synonyms: Adenosine-5'-monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H14N5O7P (free acid). Mole weight: 347.22 (free acid). | |
Anhydrofulvic acid Quick inquiry Where to buy Suppliers range | In acidic condition, Anhydrofulvic acid inhibits mitochondrial respiration of Candida utilis using both succinate and cytochrome C as respiratory substrates, but not using NADH. Anhydrofulvic acid has antifungal activity. Synonyms: 1H,10H-Pyrano[4,3-b][1]benzopyran-9-carboxylic acid, 7,8-dihydroxy-3-methyl-10-oxo-; 7,8-dihydroxy-3-methyl-10-oxo-1H-pyrano[4,3-b]chromene-9-carboxylic acid. CAS No. 95730-85-1. Molecular formula: C14H10O7. Mole weight: 290.23. | |
Ant-ATP Quick inquiry Where to buy Suppliers range | Ant-ATP is a key reagent in the biomedicine industry used for the detection and measurement of ATP levels. It is particularly effective in studying the mechanisms of diseases associated with mitochondrial dysfunction, such as Parkinson's disease. Ant-ATP can also be used to screen potential drugs that target ATP production, making it a valuable tool in drug discovery and development. Synonyms: 2'/3'-O-Anthraniloyl-adenosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 289633-56-3. Molecular formula: C17H21N6O14P3 (free acid). Mole weight: 626.30 (free acid). | |
ApCpp (Nic) Quick inquiry Where to buy Suppliers range | ApCpp (Nic) is a cutting-edge biomedical compound fostering a pivotal role in bolstering cellular energy compoundion. apCpp (Nic) is acutely augments mitochondrial function. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-ribofuranosyl-nicotinamide)] [(α,β)-methyleno]triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H30N7O16P3 (free acid). Mole weight: 741.43 (free acid). | |
ApoE4 Modulator, PH002 (Apolipoprotein E4 Structure Corrector, ApoE4 Structure Corrector, 4-{4-[2-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-acetylamido]-benzyl}-piperazine-1-carboxylic Acid Tert-butyl Ester) Quick inquiry Where to buy Suppliers range | A phthalazinone derived compound that directly binds to the 22kD amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells (IC50 = 116nM) thereby reversing the detrimental effects of ApoE4. Established to be more potent than GIND25. Restores mitochondrial functions and elevates the levels of complex IV subunit 1. Shown to increase in COX1 levels in primary neurons from NSE-ApoE4 transgenic mouse cortex and hippocampus. Shown to rescue impairments of mitochondrial motility in primary neurons from NSE-ApoE4 transgenic mice (~200nM). Also restores endoplasmic reticulum and Golgi apparatus transit of ApoE4 in cultured neurons and brings it to levels normally found in ApoE3 and ApoE4-R61T. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 491.6. US Biological Life Sciences. | Worldwide |
ATP-γ-AmNS Quick inquiry Where to buy Suppliers range | ATP-γ-AmNS, the biochemical component that elevates ATP potency in the human body, presents a groundbreaking solution to energy supply deficits, manifesting in various metabolic disorders and mitochondrial malfunctions. Its exceptional efficacy in combating these ailments, by increasing energy availability and function, yields a profound impact on overall health. Thus, ATP-γ-AmNS has become an inexorable asset in biomedicine, revolutionizing the therapeutic landscape. Synonyms: Adenosine-5'-triphosphate-γ-(sulfo-1-naphthyl)amide, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H23N6O15P3S (free acid). Mole weight: 712.41 (free acid). | |
Atractyloside, Calcium Salt Quick inquiry Where to buy Suppliers range | Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity. Group: Biochemicals. Alternative Names: (2 β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo- β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt. Grades: Highly Purified. CAS No. 772298-35-8 free acid. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
Atractyloside potassium salt Quick inquiry Where to buy Suppliers range | Atractyloside potassium salt is the potassium salt of atractyloside, which inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane. Uses: Inhibitor of the adenine nucleotide translocator (ant). Synonyms: (2b,4a,15a)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-b-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic acid dipotassium salt Atractylic acid dipotassium salt Atractylin (C30 glucoside). Grades: >98%. CAS No. 102130-43-8. Molecular formula: C30H44K2O16S2. Mole weight: 802.99. | |
Bax inhibitor peptide V5 acetate Quick inquiry Where to buy Suppliers range | Bax inhibitor peptide V5 acetate, a Bax-mediated apoptosis inhibitor, is a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. It is used in cancer treatment. Synonyms: BIP-V5 acetate; H-Val-Pro-Met-Leu-Lys-OH.CH3CO2H; VPMLK acetate; L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine acetic acid. Grades: ≥95%. CAS No. 2760881-58-9. Molecular formula: C29H54N6O8S. Mole weight: 646.85. | |
β-NADH, Reduced Disodium Salt (Nicotinamide Adenine Dinucleotide) Quick inquiry Where to buy Suppliers range | Beta-nicotinamide adenine dinucleotide hydrate. Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH. Grades: Highly Purified. CAS No. 606-68-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H27N7O14P2Na2, Molecular Weight: 709.41. US Biological Life Sciences. | Worldwide |
β-Nicotinamide Adenine Dinucleotide Phosphate, Sodium Salt Hydrate ( β-NADP-Na, TPN-Na) Quick inquiry Where to buy Suppliers range | NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: b-NADP sodium salt hydrate; β-NADP-Na, β-NADP-sodium salt, Coenzyme II sodium salt, NADP, TPN-Na, TPN, Triphosphopyridine nucleotide sodium salt; 2'-(Dihydrogen Phosphate) Adenosine 5'-(Trihydrogen Diphosphate) P'?5'-Ester with 3-(Aminocarbonyl)-1- β -D-ribofuranosyl pyridinium , Inner Salt Sodium Salt; 2'-(Dihydrogen phosphate) Adenosine 5'-(Trihydrogen Diphosphate) P'?5'-Ester with 3-(Aminocarbonyl)-1- β -D-ribofuranosyl pyridinium Inner Salt Sodium Salt; Adenosine 5'-(Trihydrogen Diphosphate), P'?5'-Ester with 3-(Aminocarbonyl)-1- β -D-ribofuranosyl pyridinium Inner Salt, 2'-(Dihydrogen Phosphate) Monosodium Salt; NSC 20273; Sodium NADP. Grades: Highly Purified. CAS No. 698999-85-8,1184-16-3. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C21H27N7O17P3 Na xH2O, Molecular Weight: 765.42 (anhydrous). US Biological Life Sciences. | Worldwide |
Betulinic Acid Quick inquiry Where to buy Suppliers range | Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. Group: Biochemicals. Alternative Names: Mairin; (+)-Betulinic acid; 3 β-Hydroxylup-20(29)-en-28-oic Acid; Betulic Acid; Lupatic Acid; NSC 113090; β-Betulinic Acid; (3 β)-3-HydroxyLup-20(29)-en-28-oic Acid. Grades: Highly Purified. CAS No. 472-15-1. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C??H??O?, Molecular Weight: 456.7. US Biological Life Sciences. | Worldwide |
CAY10485 Quick inquiry Where to buy Suppliers range | Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT (Acetyl-Coenzyme A acetyltransferase) gene. Both ACAT-1 and ACAT-2 are acetyl-CoA C-acetyltransferase enzyme. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins. Synonyms: 3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide. Grades: ≥98%. CAS No. 615264-62-5. Molecular formula: C27H27NO7. Mole weight: 477.5. | |
CAY10486 Quick inquiry Where to buy Suppliers range | Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT (Acetyl-Coenzyme A acetyltransferase) gene. Both ACAT-1 and ACAT-2 are acetyl-CoA C-acetyltransferase enzyme. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins. Synonyms: 4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide. Grades: ≥98%. CAS No. 615264-52-3. Molecular formula: C19H19NO4. Mole weight: 325.4. | |
CB-839 Quick inquiry Where to buy Suppliers range | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Synonyms: CB-839; CB839; CB 839. Grades: 98%. CAS No. 1439399-58-2. Molecular formula: C26H24F3N7O3S. Mole weight: 571.57. | |
Cinnabarinic acid Quick inquiry Where to buy Suppliers range | Cinnabarinic acid is a kynurenine pathway metabolite of tryptophan and is produced by the oxidation of 3-Hydroxyanthranilic acid. It is a metabotropic glutamate receptor (mGlu4R-specific) agonist. It activates mGlu4 receptors in transiently transfected HEK293 cells and is selective over all other mGlu subtypes. It decreases cAMP levels in native cultured cerebellar granule cells. It may be used in studies of the functions of components of the kynurenine metabolic pathway. It leads to loss of apoptosis and mitochondrial respiration. It induces apoptosis in thymocytes by the generation of reactive oxygen species. It also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. It has neuroprotective activity. Synonyms: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 606-59-7. Molecular formula: C14H8N2O6. Mole weight: 300.22. | |
CTPI-2 Quick inquiry Where to buy Suppliers range | CTPI-2 is the third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. Synonyms: SLC25A1 Inhibitor CTPI-2; Benzoic Acid, 2-[[(4-Chloro-3-Nitrophenyl)Sulfonyl]Amino]-; 2-[(4-Chloro-3-Nitrophenyl)Sulphonyl]Anthranilic Acid. Grades: 98%. CAS No. 68003-38-3. Molecular formula: C13H9ClN2O6S. Mole weight: 356.74. | |
DCA Quick inquiry Where to buy Suppliers range | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
D-Carnitine Quick inquiry Where to buy Suppliers range | Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Group: Biochemicals. Alternative Names: (2S)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Inner Salt; D- (3-Carboxy-2-hydroxypropyl) trimethyl Ammonium Hydroxide Inner Salt; (+)-Carnitine; (+)-D-Carnitine; D-(+)-Carnitine; d-Carnitine. Grades: Highly Purified. CAS No. 541-14-0. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2-fluoro-1,1-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785) Quick inquiry Where to buy Suppliers range | A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 96201-88-6. Pack Sizes: 10mg. Molecular Formula: C??H??F?NNaO?, Primary Target: DHODH. US Biological Life Sciences. | Worldwide |
DL-Carnitine Quick inquiry Where to buy Suppliers range | Carnitine regulates fatty acid transport in mitochondria, elevates serum carnitine fractions. Uses: Regulates fatty acid transport in mitochondria, elevates serum carnitine fractions. Synonyms: (3-carboxy-2-hydroxypropyl)trimethyl-,hydroxide,innersalt,dl-ammoniu;1-propanaminium,3-carboxy-2-hydroxy-n,n,n-trimethyl-,hydroxide,innersalt,;DL-CARNITINE;CARNITIN;(±)-(3-carboxy-2-hydroxypropyl)trimethylammonium hydroxide;1-Propanaminium, 3-carboxy-2-h. Grades: ≥95%. CAS No. 406-76-8. Molecular formula: C7H15NO3. Mole weight: 161.20. | |
DS16570511 Quick inquiry Where to buy Suppliers range | DS16570511 is an inhibitor of the mitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+ influx. It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). Synonyms: 4-(3-(3-(((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methyl)amino)benzoyl)-1H-indol-1-yl)butanoic acid. Grades: ≥95%. Molecular formula: C30H25Cl2N3O4. Mole weight: 562.44. | |
EDA-ADP - ATTO-Rho6G Quick inquiry Where to buy Suppliers range | EDA-ADP - ATTO-Rho6G is a fluorescent probe widely used in biomedical research. It is crucial for studying calcium signals and mitochondrial activity due to its ability to selectively bind to ATP in live cells, enabling real-time monitoring of ATP levels. With its high sensitivity and photostability, it has facilitated investigations on ATP-related diseases such as cancer, neurodegenerative disorders and cardiovascular conditions. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with ATTO Rho6G, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C44H54N10O14P2(free acid). Mole weight: 1008.33 (free acid). | |
Elamipretide triacetate Quick inquiry Where to buy Suppliers range | Elamipretide triacetate is an aromatic-cationic tetrapeptide that targets the mitochondrial intima and is an inhibitor of cardiolipin peroxidase. It easily penetrates cell membranes and has been used in therapeutic trials investigating Leber's Hereditary Optic Neuropathy. Synonyms: L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, acetate (1:3); SS-31 triacetate; H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2.3CH3CO2H; D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide acetic acid; D-Arg-2',6'-Dmt-Lys-Phe-NH2 triacetate. Grades: ≥95%. CAS No. 1849610-71-4. Molecular formula: C32H49N9O5.3C2H4O2. Mole weight: 819.95. | |
Ethyl Hydrogen Malonate Quick inquiry Where to buy Suppliers range | Ethyl Hydrogen Malonate has been shown to impair brain mitochondrial succinate and malate transport. It is also found in the extract of Hericum erinaceus mushroom which shows antitumor effects in tumor-bearing mice. Group: Biochemicals. Alternative Names: 1-Ethyl Ester Propanedioic Acid; Ethyl Ester Malonic Acid; Monoethyl Ester Malonic Acid; (Ethoxycarbonyl)acetic Acid; 3-Ethoxy-3-oxopropanoic Acid;Ethyl Malonate; Monoethyl Hydrogen Malonate; Monoethyl Malonate. Grades: Highly Purified. CAS No. 1071-46-1. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
Etiroxate Carboxylic Acid Quick inquiry Where to buy Suppliers range | Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state. Group: Biochemicals. Alternative Names: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-α-methyl-tyrosine; α-Methyl-DL-thyroxine. Grades: Highly Purified. CAS No. 3414-34-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Etomoxir (2- [6- (4-Chlorophenoxy) hexyl] oxiranecarboxylic Acid, Ethyl Ester) Quick inquiry Where to buy Suppliers range | An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug. Group: Biochemicals. Alternative Names: 2- [6- (4-Chlorophenoxy) hexyl] oxiranecarboxylic Acid, Ethyl Ester. Grades: Highly Purified. CAS No. 82258-36-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Fmoc-β-alanine pentafluorophenyl ester Quick inquiry Where to buy Suppliers range | Fmoc-β-alanine pentafluorophenyl ester is a Fmoc protected alanine derivative. Also, it is a reagent used in the synthesis of benzophenone-peptide nucleic acid derivative for mitochondrial targeting. Synonyms: Fmoc-β-Ala-OPfp; FMOC-BETA-ALA-OPFP; AK170195; Fmoc-b-Ala-OPfp; Fmoc-I(2)-Ala-OPfp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine-pentafluorophenylester; (2,3,4,5,6-pentafluorophenyl) 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate; FMOC BETA ALA OPFP. Grades: ≥ 99% (HPLC). CAS No. 149303-38-8. Molecular formula: C24H16F5NO4. Mole weight: 477.40. | |
Formyl-L-methionine Quick inquiry Where to buy Suppliers range | Formyl-L-methionine is a protein amino acid present in the organelles of bacteria and related eukaryotes. It is a derivative of the amino acid methionine, in which a formate is added to the amino group of the methionine. It plays a crucial role in protein biosynthesis in bacteria, Mitochondria and chloroplasts. But it is not used for protein biosynthesis in Eukaryotic Cytosol, in which only the nuclear genes are translated. It's also not used in ARCHAEA. In humans, it is recognized by the immune system as a foreign substance and stimulates the body to fight potential infections. Synonyms: For-L-Met-OH; N-Formyl-L-methionine; 2-formamido-4-methylsulfanylbutanoic acid; N-Formyl-L -Methionine; L-Methionine, N-formyl-;(S)-2-Formamido-4-(methylthio)butanoic acid. Grades: ≥ 98% (HPLC). CAS No. 4289-98-9. Molecular formula: C6H11NO3S. Mole weight: 177.22. | |
γ-(6-Aminohexyl)-ATP - ATTO-655 Quick inquiry Where to buy Suppliers range | γ-(6-Aminohexyl)-ATP - ATTO-655, a fluorescent-labeled nucleotide that has garnered favor amongst researchers in the biomedical arena, enables high resolution imaging of living cells and tissues, with exceptional sensitivity providing access to intracellular signaling pathways and protein binding activities. But ATTO-655 isn't just for examining healthy cells; it is frequently employed in cancer studies, where it yields crucial insights on how mitochondrial activity and dynamics vary. Synonyms: γ-(6-Aminohexyl)-adenosine-5'-triphosphate, labeled with ATTO 655, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H29N6O13P3- ATTO 655 (free acid). Mole weight: 1115.35 (free acid). | |
GDC-0152 Quick inquiry Where to buy Suppliers range | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Synonyms: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Molecular formula: C25H34N6O3S. Mole weight: 498.646. | |
Glutaryl-L-Carnitine, Lithium Salt Quick inquiry Where to buy Suppliers range | A metabolite of L-Carnitine. Increased formation and excretion of glutarylcarnitin results from a glutaryl-CoA dehydrogenase deficiency, an inborn error of lysine and tryptophan metabolism. Secondary carnitine depletion due to increased formation and urinary excretion of glutarylcarnitine is suggested to play an important role in the neuropathogenesis of glutaryl-CoA dehydrogenase deficiency, inducing excitotoxic neuronal damage and mitochondrial dysfunction. Group: Biochemicals. Alternative Names: (2R)-3-Carboxy-2-(4-carboxy-1-oxobutoxy)-N,N,N-trimethyl-1-propanaminium inner salt; Glutarylcarnitine; L-Carnitine lithium glutarate. Grades: Highly Purified. CAS No. 102636-82-8 (free acid). Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
GT1b-Ganglioside (triammonium salt) Quick inquiry Where to buy Suppliers range | GT1b-Ganglioside is demonstrated to protect mouse brain cells against L-cysteine-induced damage of mitochondrial DNA and increased lipid peroxidation, suggested to operate through scavenging of OH radicals promoted by L-cysteine. GT1b-Ganglioside is also demonstrated to suppress seizures, damage to mitochondrial DNA and lipid peroxidation induced by kainic acid. Synonyms: Trisialoganglioside-GT1b (porcine brain, triammonium salt). Grades: >99%. CAS No. 59247-13-1. Molecular formula: C95H174N8O47. Mole weight: 2180.42. | |
GW 7647 Quick inquiry Where to buy Suppliers range | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPAR&delta. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPAR&alpha. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[ (Cyclohexylamino) carbonyl] (4-cyclohexylbutyl) amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grades: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
HCV371 Quick inquiry Where to buy Suppliers range | HCV371 is a potent and selective HCV NS5B polymerase inhibitor. It binds the NS5B with an apparent dissociation constant of 150 nM, which leads to high selectivity and lack of cytotoxicity in the antiviral assays. It displayed broad inhibitory activities against the NS5B RdRp enzyme. It showed no inhibitory activity against a panel of human polymerases, including mitochondrial DNA polymerase gamma and other unrelated viral polymerases. Synonyms: HCV-371; HCV 371; HCV371. (R)-2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid. Grades: 98%. CAS No. 675184-27-7. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. | Worldwide |
Homoveratric Acid Quick inquiry Where to buy Suppliers range | Homoveratric Acid is a dopamine metabolite that inhibits brain mitochondrial respiration via monoamine oxidase/H2O2-dependent or non-dependent pathway. Group: Biochemicals. Alternative Names: 3,4-Dimethoxyphenylacetic Acid; 2- (3, 4-Dimethoxyphenyl) acetate; 2-(3,4-Dimethoxyphenyl)acetic Acid; 3,4-Dimethoxybenzeneacetic Acid; NSC 2753; NSC 27897. Grades: Highly Purified. CAS No. 93-40-3. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
Kainic acid Quick inquiry Where to buy Suppliers range | Kainic acid is a naturally occurring neuroexcitatory amino acid. It is a selective agonist for a subtype of ainate-class ionotropic glutamate receptor found in seaweed. It increases production of mitochondrial dysfunction, reactive oxygen species and apoptosis in neurons in many regions of the brain. It increases glutamate release and stimulates Na channels, inducing epileptic seizures and neurocytosis (apoptosis). It has been used to study mechanisms of apoptosis and epilepsy. Uses: Excitatory amino acid agonists. Synonyms: (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; (-)-α-Kainic Acid; Digenic Acid; Digenin; Helminal; L-α-Kainic Acid; α-Kainic Acid. Grades: ≥98% by HPLC. CAS No. 487-79-6. Molecular formula: C10H15NO4. Mole weight: 213.23. | |
L-Carnitine Quick inquiry Where to buy Suppliers range | L-carnitine is a constituent striated muscle and liver, and also a cofactor involved in fatty acid metabolism for transporting fatty acids through the inner mitochondrial membrane. It also acts as an inhibitor of HDAC. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Levocarnitine; Vitamin BT; (R)-Carnitine; Carnitor; ST-198; ST 198; ST198; (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate. Grades: 98%. CAS No. 541-15-1. Molecular formula: C7H15NO3. Mole weight: 161.201. | |
L-Carnitine 97+% Quick inquiry Where to buy Suppliers range | Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Group: Biochemicals. Alternative Names: (2R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Inner Salt; L- (3-Carboxy-2-hydroxypropyl) trimethyl Ammonium Hydroxide Inner Salt; (-)-Carnitine; (-)-L-Carnitine; (R)-Carnitine; Levocarnitine; Natrulon RC; ST 198; Vitamin BT. Grades: Highly Purified. CAS No. 541-15-1. Pack Sizes: 100g, 250g, 500g, 1Kg. Molecular Formula: C?H??NO?, Molecular Weight: 161.2. US Biological Life Sciences. | Worldwide |
Mant-ADP Quick inquiry Where to buy Suppliers range | Mant-ADP is an extensively employed biochemical compound within the biomedical industry, serving as a pivotal substrate for an array of enzymes implicated in nucleotide metabolism. Its significance lies in its profound contribution to the exploration of enzyme kinetics and regulation associated with energy metabolism, encompassing afflictions like mitochondrial disorders and metabolic syndromes. Synonyms: 2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-diphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 151481-85-5. Molecular formula: C18H22N6O11P2(free acid). Mole weight: 560.35 (free acid). | |
Mitochondrial Pyruvate Carrier Inhibitor, UK5099 ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023) Quick inquiry Where to buy Suppliers range | A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Group: Biochemicals. Grades: Highly Purified. CAS No. 56396-35-1. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |