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MAGL inhibitor 21 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL), an enzyme responsible for the inactivation of the endocannabinoid 2-arachidonoylglycerol (2-AG). It exhibits analgesic and tissue-protecting effects in animal models. Synonyms: MAGL Inhibitor 21; 1,3-Benzodioxol-5-ylmethyl 6-(4-phenylphenyl)hexanoate. Grades: ≥98%. CAS No. 1643657-35-5. Molecular formula: C26H26O4. Mole weight: 402.5.
1H-Pyrrolo[3,2-b]pyridine-6-carboxylic Acid Methyl Ester is the methyl ester derivative of 1H-Pyrrolo[3,2-b]pyridine-6-carboxylic Acid (P998590) and is used as a reagent in the synthesis of azetidinylpiperidine derivatives as monoacylglycerol lipase inhibitors useful in the treatment of inflammatory pain. Group: Biochemicals. Grades: Highly Purified. CAS No. 1015609-11-6. Pack Sizes: 50mg, 500mg. Molecular Formula: C9H8N2O2, Molecular Weight: 176.17. US Biological Life Sciences.
Worldwide
1-Monopalmitolein
1-Palmitoleoyl glycerol is a biologically active monoacylglycerol. It increases daunomycin accumulation, shown to inhibit P-glycoprotein in Caco-2 cells. 1-Palmitoleoyl glycerol induces thymocyte apoptosis. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Glyceryl palmitoleate. CAS No. 37515-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-133948.
2-acylglycerol O-acyltransferase
Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate. Group: Enzymes. Synonyms: acylglycerol palmitoyltransferase; monoglyceride acyltransferase; acyl coenzyme A-monoglyceride acyltransferase; monoacylglycerol acyltransferase. Enzyme Commission Number: EC 2.3.1.22. CAS No. 9055-17-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2166; 2-acylglycerol O-acyltransferase; EC 2.3.1.22; 9055-17-8; acylglycerol palmitoyltransferase; monoglyceride acyltransferase; acyl coenzyme A-monoglyceride acyltransferase; monoacylglycerol acyltransferase. Cat No: EXWM-2166.
2-Amino-1-(4-phenoxyphenyl)ethanol
2-Amino-1-(4-phenoxyphenyl)ethanol is used as a reagent in the synthesis of (4-phenoxyphenyl) tetrazolecarboxamides and its related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Group: Biochemicals. Grades: Highly Purified. CAS No. 153285-74-6. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15NO2, Molecular Weight: 229.27. US Biological Life Sciences.
Worldwide
(2E,?4E)?-2,?4-?Tetradecadienoic acid
(2E,?4E)?-2,?4-?Tetradecadienoic acid is used as a reactant in polymerization reactions such as the syntheses of monoacylglycerol and 1,?2-?diacyl-?sn-?glycerol. Group: Biochemicals. Grades: Highly Purified. CAS No. 24738-49-6. Pack Sizes: 5mg, 25mg. Molecular Formula: C14H24O2, Molecular Weight: 224.34. US Biological Life Sciences.
Worldwide
2-Linoleoyl glycerol
2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Monolinolein; 2-Monolinoleoylglycerol. CAS No. 3443-82-1. Pack Sizes: 500 μg (14.10 mM * 100 μL in Methyl acetate); 1 mg (14.10 mM * 200 μL in Methyl acetate). Product ID: HY-130311.
2-Oleoyl glycerol
2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol, is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. Synonyms: 2-Monoolein; 2-OG; 2-Monooleoylglycerol; 2-Glyceryl monooleate; Glyceryl 2-oleate; 2-(9Z-octadecenoyl)-sn-glycerol. Grades: >99%. CAS No. 3443-84-3. Molecular formula: C21H40O4. Mole weight: 356.54.
ABX-1431
ABX-1431 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 14 and 27 nM for human and rat enzyme, respectively). Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4- (trifluoromethyl) phenyl]methyl]piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1446817-84-0. Molecular formula: C20H22F9N3O2. Mole weight: 507.3.
acylglycerol kinase
Acts on both 1- and 2-acylglycerols. Group: Enzymes. Synonyms: monoacylglycerol kinase; monoacylglycerol kinase (phosphorylating); sn-2-monoacylglycerol kinase; MGK; monoglyceride kinase; monoglyceride phosphokinase. Enzyme Commission Number: EC 2.7.1.94. CAS No. 62213-37-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3124; acylglycerol kinase; EC 2.7.1.94; 62213-37-0; monoacylglycerol kinase; monoacylglycerol kinase (phosphorylating); sn-2-monoacylglycerol kinase; MGK; monoglyceride kinase; monoglyceride phosphokinase. Cat No: EXWM-3124.
acylglycerol lipase
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. This enzyme participates in glycerolipid metabolism. Group: Enzymes. Synonyms: monoacylglycerol lipase; monoacylglycerolipase; monoglyceride lipase; monoglyceride hydrolase; fatty acyl monoester lipase; monoacylglycerol hydrolase; monoglyceridyllipase; monoglyceridase. Enzyme Commission Number: EC 3.1.1.23. CAS No. 9040-75-9. Monoglyceride lipase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3448; acylglycerol lipase; EC 3.1.1.23; 9040-75-9; monoacylglycerol lipase; monoacylglycerolipase; monoglyceride lipase; monoglyceride hydrolase; fatty acyl monoester lipase; monoacylglycerol hydrolase; monoglyceridyllipase; monoglyceridase. Cat No: EXWM-3448.
Arachidonoyl Serinol
Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [ 3 H]2-oleoylglycerol and [ 3 H]anandamide with IC 50 s of ~70 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183718-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121476.
FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3-carbamoyl-6-hydroxybiphenyl-3-yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoyl hydroxybiphenyl-3-yl) ester)
A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
glycerol-3-phosphate 2-O-acyltransferase
A membrane-associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with ω-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols. Group: Enzymes. Synonyms: sn-2-glycerol-3-phosphate O-acyltransferase; glycerol-3-phosphate O-acyltransferase (ambiguous). Enzyme Commission Number: EC 2.3.1.198. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2141; glycerol-3-phosphate 2-O-acyltransferase; EC 2.3.1.198; sn-2-glycerol-3-phosphate O-acyltransferase; glycerol-3-phosphate O-acyltransferase (ambiguous). Cat No: EXWM-2141.
Glyceryl Monostearate
While the names glyceryl monostearate and mono- and diglycerides are used for a variety of esters of long-chain fatty acids, the esters fall into two distinct grades: 40-55 percent monoglycerides The PhEur describes glyceryl monostearate 40-55 as a mixture of monoacylglycerols, mostly monostearoylglycerol, together with quantities of di- and triacylglycerols. It contains 40-55% of monoacylglycerols, 30-45% of diacylglycerols, and 5-15% of triacylglycerols. Synonyms: Capmul GMS-50; Cutina GMS; 2, 3-dihydroxypropyl octadecanoate; Geleol; glycerine monostearate; glycerin monostearate; glycerol monostearate; glyceroli monostearas; glycerol stearate; glyceryl stearate; GMS; HallStar GMS; Imwitor 191; Imwitor 900; Kessco GMS; Lipo GMS; monoester with 1, 2, 3-propanetriol; monostearin; Myvaplex 600P; Myvatex; 1, 2, 3-propanetriol octadecanoate; Protachem GMS-450; Ri. CAS No. 31566-31-1. Product ID: PE-0518. Molecular formula: C21H42O4. Mole weight: 358.6. Category: Emollient; Emulsifying Agents; Solubilizing Agents; Stabilizing Agents; Sustained-release Agents; Tablet and Capsule Lubricant. Product Keywords: Emulsifier Excipients; Solubilizer Excipients; PE-0518; Glyceryl Monostearate; Emollient; Emulsifying Agents; Solubilizing Agents; Stabilizing Agents; Sustained-release Agents; Tablet and Capsule Lubricant; C21H42O4; 31566-31-1. UNII: NA. Chemical Name: Octadecanoic acid, monoester with 1, 2, 3-propanetriol. Gra
Glycidyl Docosahexaenoate-d5
A labeled monoacylglycerol used in the preparation of triacylglycerols acylated with n-3 polyunsaturated fatty acids for nutritional applications. Group: Biochemicals. Alternative Names: (all-Z)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Glycidyl Eicosapentaenoate-d5
A labeled monoacylglycerol used in the preparation of triacylglycerols acylated with n-3 polyunsaturated fatty acids for nutritional applications. Group: Biochemicals. Alternative Names: (all-Z)-5,8,11,14,17-Eicosapentaenoic Acid Glycidyl-d5 Ester; EPA Glycidyl-d5 Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Glycidyl Linoleate-d5
Potential inhibitor of Monoacylglycerol Lipase. Group: Biochemicals. Alternative Names: (9Z,12Z)-9,12-Octadecadienoic Acid 2-Oxiranylmethyl Ester-d5; Linoleic Acid 2,3-Epoxypropyl Ester-d5; 2,3-Epoxypropyl Linoleate-d5; Linoleic Acid Glycidyl Ester-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Glycidyl Myristate-d5
Labeled Glycidyl Myristate. A potential inhibitor of monoacylglycerol lipase. Group: Biochemicals. Alternative Names: Tetradecanoic Acid 2-Oxiranylmethyl-d5 Ester; Glycidyl-d5 Tetradecanoate; Myristic Acid Glycidyl-d5 Ester; NSC 404224-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
hormone-sensitive lipase
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) as well as cholesteryl esters, steroid fatty acid esters, retinyl esters and p-nitrophenyl esters. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP. Group: Enzymes. Synonyms: HSL. Enzyme Commission Number: EC 3.1.1.79. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3507; hormone-sensitive lipase; EC 3.1.1.79; HSL. Cat No: EXWM-3507.
Immobilized Lipase from Candida antarctica
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Applications: Lipases are used industrially for the resolution of chiral compounds and the transesterification production of biodiesel. Group: Enzymes. Synonyms: EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase. Lipase. Activity: >2 U/mg. Appearance: Slightly brown. Storage: 2-8°C. Form: Beads. Source: Candida antarctica. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Immobilized Lipase; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1260.
Immobilized Lipase from Thermomyces lanuginosus
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Group: Enzymes. Synonyms: EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; cap. Lipase. Activity: 250 IUN/g. Storage: 0-25 °C. Form: Light yellow to yellowish brown granule. Source: Thermomyces lanuginosus. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1591.
JJKK 048
JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC 50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1515855-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108613.
JW 618
JW 618 is an inhibitor of monoacylglycerol lipase (MAGL), displaying IC50 values of 123, 385, and 6.9 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. MAGL is a 33 kDa serine hydrolase that catalyses the hydrolysis of monoacylglycerols to their corresponding fatty acids. Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate. Grades: ≥98%. CAS No. 1416133-88-4. Molecular formula: C17H14F6N2O2. Mole weight: 392.3.
JW 642
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively). Synonyms: JW642; JW-642; JW 642. Grades: >98%. CAS No. 1416133-89-5. Molecular formula: C21H20F6N2O3. Mole weight: 462.39.
JZL184
JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. Synonyms: JZL184; JZL 184; JZL-184. Grades: >98%. CAS No. 1101854-58-3. Molecular formula: C27H24N2O9. Mole weight: 520.49.
JZL195
JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46.
JZL195
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC 50 s of 2 and 4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210004-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15250.
KML-29
KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. Group: Biochemicals. Alternative Names: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic Acid 2,2,2-Trifluoro-1-(trifluoromethyl)ethyl Ester; 1,1,1,3,3,3-Hexafluoropropan-2-yl 4- (Bis (benzo[d][1, 3]dioxol-5-yl) (hydroxy) methyl) piperidine-1-carboxylate; KML29. Grades: Highly Purified. CAS No. 1380424-42-9. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
LEI-106
LEI-106 is a potent inhibitor of sn-1 DAGLα (IC50 = 18 nM). It inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in mouse brain membrane homogenates and in HEK293T cell membrane preparations. Synonyms: 2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid. Grades: ≥98%. CAS No. 1620582-23-1. Molecular formula: C26H27NO6S. Mole weight: 481.6.
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Group: Enzymes. Synonyms: PS Lipase; Triacylglycerol acylhydrolase; Triacylglycerol lipase. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Activity: >30 U/mg. Appearance: Light beige powder. Storage: at -20°C. Source: Pseudomonas cepacia. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1611.
MGAT2-IN-1
An orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) (IC50= 7.8 for human, and 2.4 nM for mouse MGAT2). Synonyms: N-(4-chloro-2,6-difluorophenyl)-1-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]pyrimidin-2-yl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydroindole-5-sulfonamide. CAS No. 1800025-30-2. Molecular formula: C27H21ClF5N7O3S. Mole weight: 654.01.
MJN110
MJN110 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor that modulates the synaptic processes. MJN110 has the potential for the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain. Uses: Antihyperalgesic agent. Synonyms: MJN-110; MJN 110; MJN110;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate. Grades: 98%. CAS No. 1438416-21-7. Molecular formula: C22H21Cl2N3O4. Mole weight: 462.33.
Monoglyceride lipase from Human, Recombinant
In enzymology, an acylglycerol lipase (EC 3.1.1.23) is an enzyme that catalyzes a chemical reaction that uses water molecules to break the glycerol monoesters of long-chain fatty acids. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. This enzyme participates in glycerolipid metabolism. Group: Enzymes. Synonyms: MLL; HU-K5; HUK5; MAGL; MGL; Lysophospholipase homolog; Lysophospholipase-like. Enzyme Commission Number: EC 3.1.1.23. Purity: > 85% by SDS-PAGE. Monoglyceride lipase. Mole weight: 36.4 kDa. Activity: > 170 units/mg. Storage: Store at +4°C for short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freeze/thaw cycles. Form: Liquid. Source: E. coli and fused to His-tag at N-terminus. Species: Human. acylglycerol lipase; glycerol-ester acylhydrolase; monoacylglycerol lipase; monoacylglycerolipase; monoglyceride lipase; monoglyceride hydrolase; fatty acyl monoester lipase; monoacylglycerol hydrolase; monoglyceridyllipase; monoglyceridase; MLL; HU-K5; HUK5; MAGL; MGL; Lysophospholipase homolog; Lysophospholipase-like. Cat No: NATE-1638.
N-Arachidonyl maleimide
N-Arachidonyl maleimide (NAM) is a potent and irreversible inhibitor of monoacylglycerol lipase (MAGL), an enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Synonyms: NAM; 1-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl]pyrrole-2,5-dione. Grades: ≥98%. CAS No. 876305-42-9. Molecular formula: C24H35NO2. Mole weight: 369.5.
Native Aspergillus niger Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Group: Enzymes. Synonyms: Lipase AP6. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Mole weight: ~ 45,000. Activity: ~200 U/g. Storage: 2-8°C. Form: Powder (fine). Source: Aspergillus niger. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1607.
Native Aspergillus oryzae Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Group: Enzymes. Synonyms: Triacylglycerol acylhydrolase; Triacylglycerol lipase. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Activity: ~50 U/mg. Appearance: White lyophilized powder. Storage: 2-8°C. Source: Aspergillus oryzae. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1608.
Native Aspergillus oryzae Lipase (Solution)
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Group: Enzymes. Synonyms: Lipolase 100L. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Activity: >100 U/mg. Storage: 2-8°C. Form: Solution. Source: Aspergillus oryzae. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1610.
Native Bacillus sp. Monoglyceride Lipase
In enzymology, an acylglycerol lipase (EC 3.1.1.23) is an enzyme that catalyzes a chemical reaction that uses water molecules to break the glycerol monoesters of long-chain fatty acids. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. This enzyme participates in glycerolipid metabolism. Is an enzyme produced by microorganisms. this product shall be used for a diagnostics reagent. Applications: Useful for enzymatic determiantion of triglyceride. Group: Enzymes. Synonyms: EC 3.1.1.23; acylglycerol lipase; glycerol-ester acylhydrolase; monoacylglycerol lipase; monoacylglycerolipase; monoglyceride lipase; monoglyceride hydrolase; fatty acyl monoester lipase; monoacylglycerol hydrolase; monoglyceridyllipase; monoglyceridase. Enzyme Commission Number: EC 3.1.1.23. CAS No. 9040-75-9. Monoglyceride lipase. Mole weight: 20 kDa (gel filtration). Activity: > 20 U/mg. Appearance: White powder. Storage: Storage at-20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Bacillus sp. EC 3.1.1.23; acylglycerol lipase; glycerol-ester acylhydrolase; monoacylglycerol lipase; monoacylglycerolipase; monoglyceride lipase; monoglyceride hydrolase; fatty acyl monoester lipase; monoacylglycerol hydrolase; monoglyceridyllipase; monoglyceridase. Cat No: NATE-0455.
Native Bovine Lipoprotein Lipase
Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. LPL is attached to the luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) and by heparin sulfated proteoglycans. It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands. Group: Enzymes. Synony. Enzyme Commission Number: EC 3.1.1.34. CAS No. 9004-2-8. LPL. Activity: > 2,000 units/mg protein (BCA). Storage: 2-8°C. Form: ammonium sulfate suspension; Suspension in 3.8 M ammonium sulfate, 0.02 M Tris HCl, pH 8.0. Source: Bovine milk. Species: Bovine. lipoprotein lipase; clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; EC 3.1.1.34; 9004-02-8; LPL. Cat No: NATE-0416.
Native Burkholderia sp. Lipoprotein Lipase
Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. LPL is attached to the luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPI...rin in rats. Group: Enzymes. Synonyms: lipoprotein lipase; clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; EC 3.1.1.34; 9004-02-8; LPL. Enzyme Commission Number: EC 3.1.1.34. CAS No. 9004-2-8. LPL. Activity: > 50,000 units/mg solid. Storage: -20°C. Form: lyophilized powder. Source: Burkholderia sp. lipoprotein lipase; clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; EC 3.1.1.34; 9004-02-8; LPL. Cat No: NATE-0417.
Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. Applications: This enzyme is useful for enzymatic determination of triglyceride in serum when coupled with l-α-glycerophosphate oxidase and glycerol kinase. usually, the reaction can be completed in 5 minutes at 37°c by using 2.5~3.0 units of the enzyme per test (3.0ml) at ph around 7.0. Group: Enzymes. Synonyms: Lipoprotein lipase; LPL; EC 3.1.1.34; Clearing factor lipase; Diacylglycerol lipase; Diglyceride lipase. Enzyme Commission Number: EC 3.1.1.34. CAS No. 9004-2-8. LPL. Activity: Grade??1.0U/mg-solid or more. Stability: Store at -20°C. Appearance: Light brown amorphous powder, lyophilized. Source: Microorganism. Lipoprotein lipase; LPL; EC 3.1.1.34; Clearing factor lipase; Diacylglycerol lipase; Diglyceride lipase. Cat No: DIA-211.
Native Mucor miehei Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Applications: Lipase from mucor miehei can be used to drive the synthesis of flavor esters. lipase from mucor miehei has been used in a study to assess the nonthermal effect of microwave irradiation in nonaqueous enzymatic esterification. it has also been used in a study to investigate the hydrolysis of virgin coconut oil using immobilized lipase in a batch reactor. Group: Enzymes. Synonyms: Triacylglycerol acylhydrolase; Triacylglycerol lipase. Enzyme Commission Number: EC 3.1.1.3. CAS ...rol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1609.
Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. Applications: This enzyme is useful for enzymatic determination of triglyceride in serum when coupled with l-α-glycerophosphate oxidase and glycerol kinase. usually, the reaction can be completed in 5 minutes at 37°c by using 2.5~3.0 units of the enzyme per test (3.0ml) at ph around 7.0. Group: Enzymes. Synonyms: Lipoprotein lipase; LPL; EC 3.1.1.34; Clearing factor lipase; Diacylglycerol lipas. Enzyme Commission Number: EC 3.1.1.34. CAS No. 9004-2-8. LPL. Mole weight: approx. 134 kDa. Activity: Grade??20U/mg-solid or more (containing approx. 80% of stabilizers). Stability: Stable at-20°C for at least one year. Appearance: Light brown amorphous powder, lyophilized. Source: Pseudomonas sp. Lipoprotein lipase; LPL; EC 3.1.1.34; Clearing factor lipase; Diacylglycerol lipase; Diglyceride lipase. Cat No: DIA-210.
Native Rhizopus niveus Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Group: Enzymes. Synonyms: Triacylglycerol acylhydrolase; Triacylglycerol lipase. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Mole weight: ~83,000. Activity: >1.5 U/mg. Storage: 2-8°C. Form: Powder (fine). Source: Rhizopus niveus. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1612.
Native Rhizopus oryzae Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. Applications: Lipases are used industrially for the resolution of chiral compounds and the transesterification production of biodiesel. Group: Enzymes. Synonyms: EC 3.1.1.3; 9001-62-1; Lipase; Triacylglycerol acylhydrolase; Triacylglycerol lipase; butyrinase; tributyrinase; Tween hy. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Activity: > 30 U/mg. Form: powder, light brown. Source: Rhizopus oryzae. EC 3.1.1.3; 9001-62-1; Lipase; Triacylglycerol acylhydrolase; Triacylglycerol lipase; butyrinase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase. Cat No: NATE-0404.
Native Thermus flavus Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. The product is a crude preparation containing a mixture of intracellular lipases and is supplied as a lyophilized powder. Group: Enzymes. Synonyms: Triacylglycerol acylhydrolase; Triacylglycerol lipase. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Activity: >3.0 units/g. Stability: 2 years. Storage: 2-8°C. Form: Lyophilized powder. Source: Thermus flavus. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1614.
Native Thermus thermophilus Lipase
Triacylglycerol lipase is an enzyme with system name triacylglycerol acylhydrolase. This enzyme catalyses the following chemical reaction:triacylglycerol + H2O<-> diacylglycerol + a carboxylate. The product is a crude preparation containing a mixture of intracellular lipases and is supplied as a lyophilized powder. Group: Enzymes. Synonyms: Triacylglycerol acylhydrolase; Triacylglycerol lipase. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Activity: >3.0 units/g. Stability: 2 years. Storage: 2-8°C. Form: Lyophilized powder. Source: Thermus thermophilus. EC 3.1.1.3; lipase; triglyceride lipase; tributyrase; butyrinase; glycerol ester hydrolase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase; 9001-62-1. Cat No: NATE-1613.
NF 1819 is a selective irreversible β-lactam-based monoacylglycerol lipase inhibitor with IC50 values of 0.25 and 7.4 nM at rMAGL and hMAGL. Synonyms: NF-1819; NF 1819; NF1819; (3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone. Grades: ≥98% by HPLC. CAS No. 1881244-28-5. Molecular formula: C24H22FN5O4. Mole weight: 463.46.
Pristimerin
Pristimerin is a potent and reversible monoacylglycerol lipase ( MGL ) inhibitor with an IC 50 of 93 nM. Uses: Scientific research. Group: Natural products. Alternative Names: Celastrol methyl ester. CAS No. 1258-84-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1937.
TP-020
TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC 50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MGAT2-IN-1. CAS No. 1800025-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101857.
triacylglycerol lipase
The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolysed. Group: Enzymes. Synonyms: lipase (ambiguous); butyrinase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceri. Enzyme Commission Number: EC 3.1.1.3. CAS No. 9001-62-1. Lipase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3455; triacylglycerol lipase; EC 3.1.1.3; 9001-62-1; lipase (ambiguous); butyrinase; tributyrinase; Tween hydrolase; steapsin; triacetinase; tributyrin esterase; Tweenase; amno N-AP; Takedo 1969-4-9; Meito MY 30; Tweenesterase; GA 56; capalase L; triglyceride hydrolase; triolein hydrolase; tween-hydrolyzing esterase; amano CE; cacordase; triglyceridase; triacylglycerol ester hydrolase; amano P; amano AP; PPL; glycerol-ester hydrolase; GEH; meito Sangyo OF lipase; hepatic lipase; lipazin; post-heparin plasma protamine-resistant lipase; salt-resistant post-heparin lipase; heparin releasable hepatic lipase; amano CES; amano B; tributyrase; triglyceride lipase; liver lipase; hepatic monoacylglycerol acyltransferase. Cat No: EXWM-3455.
URB754
URB754 is a potent and non-competitive inhibitor of monoacylglycerol lipase (MAGL) with IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. The MAGL inhibitory activity of URB754 was reported to be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial samples. Synonyms: URB-754; URB 754; 6-methyl-2-(4-methylanilino)-3,1-benzoxazin-4-one. Grades: >98%. CAS No. 86672-58-4. Molecular formula: C16H14N2O2. Mole weight: 266.3.
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