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(5S, 5'S) -5, 5'- (Azanediylbis (methylene) ) bis (3- (3-fluoro-4-morpholinophenyl) oxazolidin-2-one) is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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benzyl (4-morpholinophenyl)carbamate
Benzyl (4-morpholinophenyl)carbamate is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: N-carbobenzoxy-4-morpholinyl aniline; Linezolid Impurity 19. CAS No. 348626-43-7. Molecular formula: C18H20N2O3. Mole weight: 312.36.
An orally bioavailable fluoro-diaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of LRRK2 activity (IC50=4.76 and 6.87nM for hr-wt-LRRK2 and G2019S-LRRK2 mutant, respectively) with selectivity over PLK4, GAK, TNK1, CAMKK2, and PIP4K2C (IC50 <300nM) in a 185-kinase panel. Does neither exert cytotoxicity nor block neuronal development of human or rat cortical neurons at 1uM. Shown to prevent GS-LRRK2-induced neuronal injury (EC50 ~4nM) and G2019S- or R1441C-LRRK2-mediated neuronal death in both rat and human cortical neurons (EC50 ~100nM). Even though exhibits favorable pharmacokinetic profile and metabolic stability, and yet suffers from limited blood brain barrier penetration (~4%). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
N- (2- (2- (2-Methoxy-4-morpholinophenylamino) -5-fluoropyrimidin-4-ylamino) phenyl) methanesulfonamide. Group: Biochemicals. Alternative Names: CZC-25146. Grades: Highly Purified. CAS No. 1191911-26-8. Pack Sizes: 10mg. Molecular Formula: C22H25FN6O4S, Molecular Weight: 488.54. US Biological Life Sciences.
Worldwide
N- (3-Fluoro-4-morpholinophenyl) acetamide
N- (3-Fluoro-4-morpholinophenyl) acetamide is a degradation products of Linezolid (L466500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500). Group: Biochemicals. Alternative Names: (R) -5- (Hydroxymethyl) -3- (3-fluoro-4-morpholinophenyl) oxazolidin-2-one; (R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-2-oxazolidinone; (5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-2-oxazolidinone. Grades: Highly Purified. CAS No. 168828-82-8. Pack Sizes: 100mg. US Biological Life Sciences.
(R)-(3-(4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: 2-Oxazolidinone, 5-[[(methylsulfonyl)oxy]methyl]-3-[4-(4-morpholinyl)phenyl]-, (5R)-; Linezolid Impurity 26. CAS No. 556801-09-3. Molecular formula: C15H20N2O6S. Mole weight: 356.39.
(R)-5-(hydroxymethyl)-3-(4-morpholinophenyl)oxazolidin-2-one is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: 3-(4-(4-Morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one; Linezolid Impurity 22. CAS No. 264601-17-4. Molecular formula: C14H18N2O4. Mole weight: 278.30.
(S) -1-Azido-3- (N- (3-fluoro-4-morpholinophenyl) acetamido) propan-2-yl Acetate
(S) -1-Azido-3- (N- (3-fluoro-4-morpholinophenyl) acetamido) propan-2-yl Acetate is an degradation products of Linezolid (L466500). Linezolid impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
(S) -1-Chloro-3- ( (3-fluoro-4-morpholinophenyl) amino) propan-2-ol
(S) -1-Chloro-3- ( (3-fluoro-4-morpholinophenyl) amino) propan-2-ol is an intermediate in the synthesis of Linezolid (L466500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
(S)-2-((3-(4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: Linezolid Impurity 31. CAS No. 556801-12-8. Molecular formula: C22H21N3O5. Mole weight: 407.42.
(S)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: Linezolid Impurity 28. CAS No. 2180621-71-8. Molecular formula: C15H19FN2O6S. Mole weight: 374.38.
(S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: 2-Oxazolidinone, 3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-, (5S); Linezolid Impurity 24. CAS No. 2180529-06-8. Molecular formula: C14H17FN2O4. Mole weight: 296.29.
Used in the preparation of substituted oxazolidinones, useful in the treatment of disorders associated with blood coagulation. Group: Biochemicals. Alternative Names: (5S)-5-Aminomethyl-3-(4-morpholinophenyl)-1,3-oxazolidin-2-one. Grades: Highly Purified. CAS No. 952288-54-9. Pack Sizes: 25mg. US Biological Life Sciences.
(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: Linezolid Impurity 08. CAS No. 216869-17-9. Molecular formula: C17H22FN3O4. Mole weight: 351.37.
(S) -N- (3- ( (3-Fluoro-4-morpholinophenyl) amino) -2-hydroxypropyl) acetamide
(S) -N- (3- ( (3-Fluoro-4-morpholinophenyl) amino) -2-hydroxypropyl) acetamide is a degradation products of Linezolid (L466500). Linezolid impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
3-Aminoisonicotinic Acid Methyl Ester
3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenyl quinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 55279-30-6. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H8N2O2, Molecular Weight: 152.15. US Biological Life Sciences.
Linezolid Impurity. Group: Biochemicals. Alternative Names: Deacetyl linezolid; (5S)-5-(Aminomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone; (-) - (S) -5- (Aminomethyl) -3- (3-fluoro-4-morpholinophenyl) oxazolidin-2-one. Grades: Highly Purified. CAS No. 168828-90-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
Worldwide
Atopaxar
Atopaxar is a Protease-activated receptor-1 (PAR-1) inhibitor. It can inhibit the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with IC50 value of 0.019μM. Atopaxar exhibits potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 0.064 and 0.031μM. It may become a therapeutic option for atherothrombotic disease. In May 2012, Phase-II for Acute coronary syndromes in European Union was discontinued. Uses: Acute coronary syndromes. Synonyms: E5555; E-5555; E 5555; ER-172594-00; ER172594-00; ER 172594-00; Atopaxar;1-(3-(tert-butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethan-1-one;474550-69-1(hydrobromide). Grades: 98%. CAS No. 751475-53-3. Molecular formula: C29H38FN3O5. Mole weight: 527.64.
CYC116
CYC116 is an orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine protein kinases that are only expressed in actively dividing cells and are critical in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account for most of the mitogenic and chemotactic effects of vascular endothelial growth factor (VEGF) on adult endothelial cells. Group: Inhibitors. Alternative Names: CYC116; CYC 116; CYC-116. CAS No. 693228-63-6. Molecular formula: C18H20N6OS. Mole weight: 368.46. Appearance: Solid powder. Purity: >98%. IUPACName: 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine. Canonical SMILES: NC1=NC (C)=C (C2=NC (NC3=CC=C (N4CCOCC4)C=C3)=NC=C2)S1. Catalog: ACM693228636.
Cyt387 (CYT11387)
Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 values of 11nM and 18nM, respectively. Inhibits JAK3 at much higher concentrations (IC50 = 155nM). Group: Biochemicals. Alternative Names: N- (cyanomethyl) -4- (2- (4-morpholinophenylamino) pyrimidin-4-l) -benzamide. Grades: Highly Purified. CAS No. 1056634-68-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
CZC-54252 HCl
CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Group: Inhibitors. Alternative Names: CZC-54252 HCl; CZC-54252 hydrochloride; CZC-54252; CZC 54252; CZC54252. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. Appearance: Solid powder. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride. Canonical SMILES: CS (=O) (NC1=CC=CC=C1NC2=NC (NC3=CC=C (N4CCOCC4)C=C3OC)=NC=C2Cl)=O. [H]Cl. Catalog: ACM1784253059.
Deacetyl Linezolid
An impurity of Linezolid , as antimycobacterial agent. Group: Biochemicals. Alternative Names: (5S)-5-(Aminomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone; (-) - (S) -5- (Aminomethyl) -3- (3-fluoro-4-morpholinophenyl) oxazolidin-2-one. Grades: Highly Purified. CAS No. 168828-90-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Defluoro Linezolid
Defluoro Linezolid is an impurity of Linezolid, which is an antibiotic used for the treatment of infections caused by Gram-positive bacteria. Synonyms: (S)-N-{[3-(4-Morpholinophenyl)-2-oxooxazolidin-5-yl]methyl}acetamide; Desfluoro linezolid; N-[[(5S)-3-[4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide; Acetamide, N-[[(5S)-3-[4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-; Desfluorolinezolid; 1-({[(5S)-3-(p-Morpholinophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-1-ethanone. Grades: ≥95%. CAS No. 556801-15-1. Molecular formula: C16H21N3O4. Mole weight: 319.36.
Demethyl linezolid
Demethyl linezolid is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: (S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)formamide; Linezolid Impurity 10. CAS No. 168828-65-7. Molecular formula: C15H18FN3O4. Mole weight: 323.32.
IC86621
IC86621, also known as DNA-PK Inhibitor III, is potent DNA-Pk inhibitor with potential anticancer activity. Group: Inhibitors. Alternative Names: IC86621; IC 86621; IC-86621; DNA-PK Inhibitor III. CAS No. 404009-40-1. Molecular formula: C12H15NO3. Mole weight: 221.25. Appearance: White solid powder. Purity: >98%. IUPACName: 1-(2-hydroxy-4-morpholinophenyl)ethanone. Canonical SMILES: CC(C1=CC=C(N2CCOCC2)C=C1O)=O. Catalog: ACM404009401.
Lazertinib
Lazertinib, also known as YH-25448 and GNS-1480, is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible 3rd generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer. Lazertinib is expected to beneficial for the NSCLC patients with brain metastasis due to good blood brain barrier (BBB) penetration property as well as for the treatment of primary lung lesion and extracranial lesions. Uses: Protein kinase inhibitors. Synonyms: 2-Propenamide, N-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-2-pyrimidinyl)amino)-4-methoxy-2-(4-morpholinyl)phenyl)-; N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide; Lazertinib; YH-25448; YH 25448; YH25448; GNS-1480; GNS 1480; GNS1480. CAS No. 1903008-80-9. Molecular formula: C30H34N8O3. Mole weight: 554.64.
Linezolid D3
2H Labeled Compounds. Alternative Names: (S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide-2,2,2-d3. CAS No. 1127120-38-0. Mole weight: 340.37. Purity: >98%. Catalog: ACM1127120380.
Linezolid Diphthalimide
Linezolid Diphthalimide. Group: Biochemicals. Alternative Names: 2, 2- (3, 3- (3-Fluoro-4-morpholinophenylazane diyl) bis (2-hydroxypropane -3, 1-diyl) ) diidoindoline-1, 3-dione. Grades: Highly Purified. Pack Sizes: 250mg. Molecular Formula: C32H31FN4O7, Molecular Weight: 602.61. US Biological Life Sciences.
Worldwide
Linezolid Impurity 12
N-t-Butyl Linezolid is a derivative of Linezolid, prototype of the oxazolidinone antimicrobials. Synonyms: N-t-Butyl Linezolid; (S)-N-(tert-Butyl)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide. Grades: > 95%. CAS No. 1215006-11-3. Molecular formula: C20H28FN3O4. Mole weight: 393.45.
Linezolid Impurity 16
Linezolid Dipthalimide is an impurity in the synthesis of Linezolid, a prototype of the oxazolidinone antimicrobials. It inhibits bacterial mRNA translation. Synonyms: Linezolid Diphthalimide; 2,2'-(3,3'-(3-Fluoro-4-morpholinophenylazanediyl)bis(2-hydroxypropane-3,1-diyl))diidoindoline-1,3-dione. Grades: > 95%. CAS No. 1798014-14-8. Molecular formula: C32H31FN4O7. Mole weight: 602.61.
Linezolid Impurity 19
Linezolid Impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one. CAS No. 168828-90-8. Molecular Formula: C14H18FN3O3. Mole Weight: 295.31. Catalog: APB168828908.
[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol is an intermediate in the synthesis of Linezolid Dimer, an impurity of the antibacterial agent Linezolid. Synonyms: [(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol; (R)-5-(Hydroxymethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one; (R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-2-oxazolidinone. Grades: > 95%. CAS No. 168828-82-8. Molecular formula: C14H17FN2O4. Mole weight: 296.30.
MorDalphos
P-N-ligand for use in the Pd-catalyzed cross-coupling of ammonia and hydrazine. Ref. (2) with a diverse range of sterically hindered, unbiased aryl chlorides. Low catalyst loading and mild conditions. Ref (5) with diamines in a chemoselective arylation process. Ref (6) with solvent-free or aqueous conditions. P-N-ligand for the gold-catalyzed stereoselective hydroamination of internal alkynes with dialkylamines to afford E-amines. P-N-ligand for use in the Pd-catalyzed for mono-α-arylation of ketones employing aryl chlorides, bromides, iodides, mesylates (Ref. 7) and tosylates. Group: Organic phosphine compounds. Alternative Names: 2-Morpholinophenyldi(1-adamantyl)phosphine; SC11165; bis(1-adamantyl)-(2-morpholin-4-ylphenyl)phosphane; Mor-DalPhos; 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine; Di(1-adamantyl)-2-morpholinophenylphosphine; ZINC71773616; AK307802. CAS No. 1237588-12-3. Molecular formula: C30H42NOP. Mole weight: 463.646g/mol. IUPACName: bis(1-adamantyl)-(2-morpholin-4-ylphenyl)phosphane. Canonical SMILES: C1COCCN1C2=CC=CC=C2P (C34CC5CC (C3)CC (C5)C4)C67CC8CC (C6)CC (C8)C7. Catalog: ACM1237588123.
Reversine
Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Synonyms: Reversine; 656820-32-5; 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine; CHEMBL188343; CHEBI:70723; C21H27N7O; N6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine; N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine; Z499CLJ023; MFCD07784513; N~6~-Cyclohexyl-N~2~-(4-Morpholin-4-Ylphenyl)-9h-Purine-2,6-Diamine; N(6)-cyclohexyl-N(2)-[4-(morpholin-4-yl)phenyl]-9H-purine-2,6-diamine; 2vgo. CAS No. 656820-32-5. Molecular formula: C21H27N7O. Mole weight: 393.49.
(R)-Linezolid
(R)-Linezolid is an enatiomeric impurity of Linezolid, an antibiotic used for the treatment of infections caused by Gram-positive bacteria. Synonyms: N-{[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl}acetamide; Linezolid R-Isomer; N-[[(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide; Acetamide, N-[[(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-; Linezolid R-isomer [USP-RS]; Linezolid Impurity R-isomer. Grades: ≥95%. CAS No. 872992-20-6. Molecular formula: C16H20FN3O4. Mole weight: 337.35.
XL019
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, displaying 100-fold selectivity over JAK1. XL019 inhibits proliferation and induce apoptosis in cells carrying the JAK2V617F mutation. Synonyms: (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide; XL-019. Grades: >98%. CAS No. 945755-56-6. Molecular formula: C25H28N6O2. Mole weight: 444.539.
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