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| Product | Description | |
|---|---|---|
| Motilin | Motilin (human, porcine) is an endogenous motilin receptor ligand (Ki = 2.3 nM, and EC50=0.3 nM in a Chinese hamster ovary cell line) that regulates gastrointestinal motor function. Uses: Gastrointestinal agents. Synonyms: Human motilin; Motilin (human, porcine); Motilin (porcine); MOTILIN; Motilin (human); 9072-41-7; Motilin [MI]; Human motilin [MI]; 52906-92-0; h-Motilin; UNII-D85V250YSI; CHEMBL525634; D85V250YSI; Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln; GTPL1458; CCA90692; Motilin porcine, >=97% (HPLC); BDBM50599720; AKOS024457017. Grade: ≥95%. CAS No. 52906-92-0. Molecular formula: C120H188N34O35S. Mole weight: 2699.1. |  |
| Motilin | Motilin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 52906-92-0. Product Category: Heterocyclic Organic Compound. CAS No. 52906-92-0. Molecular formula: C120H188N34O35S. Mole weight: 2699.05. Purity: 0.96. IUPACName: Motilin porcine. Canonical SMILES: CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)N. Product ID: ACM52906920. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Motilin, canine | Motilin, canine is a 22-amino acid peptide. Motilin is an effective agonist for gastrointestinal smooth muscle contraction. Synonyms: Motilin (canine); H-Phe-Val-Pro-Ile-Phe-Thr-His-Ser-Glu-Leu-Gln-Lys-Ile-Arg-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln-OH; L-phenylalanyl-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-histidyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-glutaminyl-L-lysyl-L-isoleucyl-L-arginyl-L-alpha-glutamyl-L-lysyl-L-alpha-glutamyl-L-arginyl-L-asparagyl-L-lysyl-glycyl-L-glutamine. Grade: ≥95% by HPLC. CAS No. 85490-53-5. Molecular formula: C120H194N36O34. Mole weight: 2685.05. | |
| (Leu13)-Motilin (human, porcine) | (Leu13)-Motilin (human, porcine) produces an excitatory reaction in the gastrointestinal tract of chickens, with varying sensitivity in different regions. The mechanisms of action are different between the proventriculus and the intestinal segments. Motilin analogues contract intestinal segments by acting directly on smooth muscle cells whereas in the proventriculus it causes contraction and enhancement of electric field stimulation-induced responses by acting on the intramural cholinergic neurons. Synonyms: H-Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln-OH; L-phenylalanyl-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosyl-glycyl-L-alpha-glutamyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-alpha-glutamyl-D-arginyl-D-asparagyl-L-lysyl-glycyl-D-glutamine; Motilin (swine), 13-L-leucine-. Grade: 95%. CAS No. 59530-69-7. Molecular formula: C121H190N34O35. Mole weight: 2681.01. | |
| ANQ 11125 | ANQ 11125 has been found to be a motilin receptor antagonist. Synonyms: ANQ 11125; ANQ-11125; ANQ11125. Grade: ≥95% by HPLC. CAS No. 153966-48-4. Molecular formula: C86H125N19O21. Mole weight: 1761.05. | |
| ANQ-11125 TFA | ANQ-11125 TFA is a potent and selective antagonist of motilin (pKd : 8.24). ANQ-11125 TFA blocks motilide-induced contractions in vitro in the rabbit. Molecular formula: C88H126F3N19O23. Mole weight: 1875.05. | |
| EM574 | EM574 is an agonist of motilin receptor with an IC50 value of 6.17 nM which binds to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay. Synonyms: Idremcinal; 8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin. Grade: ≥98%. CAS No. 110480-13-2. Molecular formula: C39H69NO12. Mole weight: 743.96. | |
| EM574 | Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor). Group: Biochemicals. Grades: Highly Purified. CAS No. 110480-13-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C39H69NO12. US Biological Life Sciences. |  Worldwide |
| GSK 962040 | GSK 962040 is a selective motilin receptor agonist with pEC50 value of 7.9. It is effective as a stimulant of human and rabbit gastrointestinal motility. lt represents a new opportunity as a treatment in diabetic gastroparesis. It is discovered as a therapeutic agent for conditions associated with delayed gastric emptying. It is highly selective against motilin receptor over the human ghrelin receptor and hERG. It also has no significant activity against other receptors including 5-HT, adrenergic, dopamine, histamine and adenosine receptors. It is found to enhance the EFS-induced cholinergic contraction and cause a small muscle contraction at high concentration in rabbit isolated gastric antrum. It also induces the contraction of human-isolated stomach preparations at 10μM. It had no significant activity at a range of other receptors (including ghrelin), ion channels and enzymes in vitro. It was preferred because its initial IC50 values at CYP3A4 were significantly higher than our preferred threshold of 10 μM. It induced phasic contractions, the duration of which was dose-related. It strongly facilitated cholinergic activity in the antrum, with lower activity in fundus and small intestine only. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 may be used as a treatment in diabetic gastroparesis. Synonyms: GSK-962040; GSK 962040; GSK962040; Camicinal; 1-[4-(3-fluoroanilino)piperidin-1- | |
| GSK 962040 hydrochloride | GSK 962040 hydrochloride is the hydrochloride form of GSK 962040, which is a selective motilin receptor agonist with pEC50 value of 7.9. It may be used as a treatment in diabetic gastroparesis. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 hydrochloride was developed by glaxosmithkline and has been in cilinic phase 2. Synonyms: Camicinal hydrochloride; GSK-962040 hydrochloride; GSK 962040 hydrochloride; GSK962040 hydrochloride; 2-[4-(3-Fluoroanilino)piperidin-1-yl]-1-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]ethanone hydrochloride. Grade: >98%. CAS No. 923565-22-4. Molecular formula: C25H34ClFN4O. Mole weight: 461.02. | |
| H-D-Trp(Boc)-OH | A reagent used in the synthesis of novel marocyclic compounds as motilin receptor antagonists. Synonyms: 1-(t-Butoxycarbonyl)-D-tryptophan; (R)-2-Amino-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid; Nin-Boc-D-tryptophan. Grade: ≥ 98% (TLC). CAS No. 201290-11-1. Molecular formula: C16H20N2O4. Mole weight: 304.35. | |
| YIL 781, Hydrochloride Salt | Ghrelin receptor antagonist (GHS-R1a) (Ki = 17nM). Displays no significant affinity for the motilin receptor (Ki = 6uM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo. Group: Biochemicals. Alternative Names: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 875258-85-8. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?.HCl, Molecular Weight: 445.96. US Biological Life Sciences. | Worldwide |
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