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| Product | Description | |
|---|---|---|
| MT-4 | MT-4 is a derivative of a tissue transglutaminase ( TG2 ) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel. Uses: Scientific research. Group: Signaling pathways. CAS No. 2327925-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128595. |  |
| 1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester | 1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate used in the synthesis of Defluoro Dolutegravir (D228715), which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Grades: Highly Purified. CAS No. 1246616-75-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H21NO7, Molecular Weight: 327.33. US Biological Life Sciences. |  Worldwide |
| 3-Bromo-1-(2,2-dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester | 3-Bromo-1-(2,2-dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate in the synthesis of Defluoro Dolutegravir (D228715). Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Grades: Highly Purified. CAS No. 1246616-76-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C15H20BrNO7, Molecular Weight: 406.23. US Biological Life Sciences. | Worldwide |
| 3-Bromo-1,4-dihydro-4-oxo-1-(2-oxoethyl)-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester | 3-Bromo-1,4-dihydro-4-oxo-1-(2-oxoethyl)-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate in the synthesis of Defluoro Dolutegravir (D228715). Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Grades: Highly Purified. CAS No. 1246616-77-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H14BrNO6, Molecular Weight: 360.16. US Biological Life Sciences. | Worldwide |
| 4'-Ethynyl-2'-deoxyadenosine | 4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. Synonyms: (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol. Grades: ≥95%. CAS No. 306305-07-7. Molecular formula: C12H13N5O3. Mole weight: 275.26. |  |
| 4'-Methylthymidine | It shows inhibitory activity against HIV in MT-4 cells. Synonyms: 4'-c-methylthymidine; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione; 1-(2-Deoxy-4-C-methyl-β-D-erythro-pentofuranosyl)thymine. Grades: ≥95%. CAS No. 139925-84-1. Molecular formula: C11H16N2O5. Mole weight: 256.26. | |
| Bictegravir | Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. Synonyms: GS-9883; GS 9883; GS9883. Grades: ≥98%. CAS No. 1611493-60-7. Molecular formula: C21H18F3N3O5. Mole weight: 449.39. | |
| Collinone | It is produced by the strain of Streptomuces coelicolor CH999. It has anti-gram-positive bacterial activity including methicillin-resistant staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE). MIC is 16-32 μg/mL. It has no effect on gram-negative bacteria, fungi and viruses. It is toxic to HeLa, Vero, MT-4 and other tumor cells. CAS No. 343315-22-0. Molecular formula: C27H18O12. Mole weight: 534.42. | |
| CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV) | A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1alpha/CXCL12 for CXCR4 binding (IC50 = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC50 = 56uM; 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???FN??O??S?. xH?O, Sequence: N alpha-4-fluorobenzoyl-Arg-Arg-Nal-Cys4-Tyr-Cit-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys¹3-Arg-NH2 (Disulfide bond: 4 ? 13; Nal = L-3-(2-naphthyl)alanine; Cit = L-citrulline). US Biological Life Sciences. | Worldwide |
| Dolutegravir | Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Alternative Names: (4R, 12aS)-N-[(2, 4-Difluorophenyl)methyl]-3, 4, 6, 8, 12, 12a-hexahydro-7-hydroxy-4-methyl-6, 8-dioxo-2H-pyrido[1', 2':4, 5]pyrazino[2, 1-b][1, 3]oxazine-9-carboxamide; GSK 1349572; S/GSK1349572. Grades: Highly Purified. CAS No. 1051375-16-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H19F2N3O5, Molecular Weight: 419.38. US Biological Life Sciences. | Worldwide |
| Encenicline, HCl salt | EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor. In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drugs. Synonyms: EVP-6124; EVP 6124; EVP6124; MT-4666; MT 4666; MT4666; Encenicline. IUPAC/Chemical name:(R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride. Grades: 0.98. CAS No. 550999-74-1. Molecular formula: C16H18Cl2N2OS. Mole weight: 357.293. | |
| Evocalcet | Evocalcet is a calcium-sensing receptor agonist under the development of Kyowa Hakko Kirin. Phase III clinical trials for Secondary hyperparathyroidism are on-going in Japan. Uses: Secondary hyperparathyroidism. Synonyms: MT-4580; MT 4580; MT4580; KHK-7580; KHK7580; KHK 7580; Evocalcet;2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic acid. Grades: 98%. CAS No. 870964-67-3. Molecular formula: C24H26N2O2. Mole weight: 374.48. | |
| EVP-6124 | EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). It shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs and improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Synonyms: EVP-6124; EVP6124; EVP 6124; MT-4666; MT4666; MT 4666; Encenicline. Grades: >98%. CAS No. 550999-75-2. Molecular formula: C16H17ClN2OS. Mole weight: 320.84. | |
| KRH1636 | KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. It efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXCR4 coreceptor. It also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. It prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. It seems to be a promising agent for the treatment of HIV-1 infection. Uses: Krh1636 seems to be a promising agent for the treatment of hiv-1 infection. Synonyms: KRH-1636; KRH 1636; KRH1636. N-[(2S)-5-(diaminomethylideneamino)-1-[[(1S)-1-naphthalen-1-ylethyl]amino]-1-oxopentan-2-yl]-4-[[methyl(pyridin-2-yl)amino]methyl]benzamide;KRH-1636;N-((S)-5-guanidino-1-(((S)-1-(naphthalen-1-yl)ethyl)amino)-1-oxopentan-2-yl)-4-(((pyridin-2-ylmethyl)amino. Grades: 98%. CAS No. 568526-77-2. Molecular formula: C32H37N7O2. Mole weight: 551.70. | |
| Lenacapavir | Lenacapavir (GS-6207) is a HIV-1 capsid inhibitor. Lenacapavir shows anti-HIV activity with an EC 50 of 100 pM in MT-4 cells. Lenacapavir displays a mean EC 50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs) [1]. Lenacapavir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-6207. CAS No. 2189684-44-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-111964. | |
| Lorundrostat | Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MT-4129. CAS No. 1820940-17-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147277. | |
| Loviride | Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor ( NNRTI ), with an IC 50 of 0.3 μM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 89439. CAS No. 147362-57-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15355. | |
| Loviride | Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 μM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Loveride; Loviride (USAN/INN); loviride. Product Category: Inhibitors. Appearance: Solid. CAS No. 147362-57-0. Molecular formula: C17H16Cl2N2O2. Mole weight: 351.227 g/mol. Purity: 0.96. IUPACName: 2-(2-acetyl-5-methylanilino)-2-(2,6-dichlorophenyl)acetamide. Canonical SMILES: CC1=CC(=C(C=C1)C(=O)C)NC(C2=C(C=CC=C2Cl)Cl)C(=O)N. Density: 1.354g/cm³. Product ID: ACM147362570. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Mavorixafor hydrochloride | Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC 50 value of 13 nM against CXCR4 125 I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC 50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD-070 hydrochloride; AMD-11070 hydrochloride. CAS No. 880549-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50101C. | |
| Mavorixafor trihydrochloride | Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively.Mavorixafor trihydrochloride can be used for the study of WHIM syndrome[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD-070 trihydrochloride; AMD-11070 trihydrochloride. CAS No. 2309699-17-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50101A. | |
| MT477 | MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays. Synonyms: MT 477; MT-477; tetramethyl 6'-[(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate. CAS No. 328069-91-6. Molecular formula: C31H30N2O12S3. Mole weight: 718.77. | |
| SARS-CoV-IN-2 | SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC 50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC 50 s of 21.5 and 30 nM; and IC 90 s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1 -induced cytopathic effect with an EC 50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 888958-26-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-135856. | |
| SARS-CoV-IN-3 | SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC 50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC 50 s of 11.7 and 20.4 nM; and IC 90 s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1 -induced cytopathic effect with an EC 50 of 10 μM in MT-4 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 888958-27-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-135858. | |
| Tenofovir maleate | Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT. Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. Synonyms: Viread maleate; GS 1278 maleate; GS1278 maleate; GS-1278 maleate; PMPA maleate; TDF maleate. Grades: >98%. CAS No. 1236287-04-9. Molecular formula: C13H18N5O8P. Mole weight: 403.28. | |
| 1,4-Butanediyl bismethane thiosulfonate | 1,4-Butanediyl bismethane thiosulfonate. Group: Biochemicals. Alternative Names: MTS-4-MTS. Grades: Highly Purified. CAS No. 55-99-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C6H14O4S4. US Biological Life Sciences. | Worldwide |
| 1,4-Butanediyl Bismethane thiosulfonate (MTS-4-MTS) | A sulfhydryl cross-linking reagent. Group: Biochemicals. Alternative Names: MTS-4-MTS. Grades: Highly Purified. CAS No. 55-99-2. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C?H??O?S?, Molecular Weight: 278.41. US Biological Life Sciences. | Worldwide |
| (1-Oxyl-2,2,5,5-tetramethylpyrroline-3-yl)carbamidoethyl methanethiosulfonate | (1-Oxyl-2,2,5,5-tetramethylpyrroline-3-yl)carbamidoethyl methanethiosulfonate. Group: Biochemicals. Alternative Names: 2, 5-Dihydro-2, 2, 5, 5-tetramethyl-4- [ [ [2- [ (methylsulfonyl) thio] ethyl] amino] carbonyl] -1H-pyrrol-1-yloxy; MTS-4-oxyl. Grades: Highly Purified. CAS No. 384342-59-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C12H21N2O4S2. US Biological Life Sciences. | Worldwide |
| (1-Oxyl-2,2,5,5-tetramethylpyrroline-3-yl)carbamidoethyl Methanethiosulfonate (MTS-4-Oxyl) | A highly reactive thiol-specific spin-label. A specific conformational probe of thiol site structure by virtue of its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study. Group: Biochemicals. Alternative Names: MTS-4-Oxyl. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-[ (5-Fluoresceinyl) aminocarbonyl]ethyl methanethiosulfonate | 2-[ (5-Fluoresceinyl) aminocarbonyl]ethyl methanethiosulfonate. Group: Biochemicals. Alternative Names: Methanesulfonothioic acid S-[3-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-3-oxopropyl] ester; MTS-4-fluorescein. Grades: Highly Purified. CAS No. 351330-42-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C24H19NO8S2. US Biological Life Sciences. | Worldwide |
| Dinotefuran | Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MTI-446. CAS No. 165252-70-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 1 g. Product ID: HY-B0827. | |
| N-Succinimidyl oxycarbonyl propyl methanethiosulfonate | N-Succinimidyl oxycarbonyl propyl methanethiosulfonate. Group: Biochemicals. Alternative Names: Methanesulfonothioic acid S-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl] ester; MTS-4-NHS. Grades: Highly Purified. CAS No. 690632-55-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C9H13NO6S2. US Biological Life Sciences. | Worldwide |
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