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| Product | Description | |
|---|---|---|
| MT1 | MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060573-82-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111976. |  |
| MT1-MMP Inhibitor, NSC405020 | The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. |  |
| MT1-MMP Inhibitor, NSC405020 (3,4-Dichloro-N-(1-methylbutyl)benzamide, 3,4-Dichloro-N-(pentan-2-yl)benzamide) | A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-b3/MT tumor growth in xenografted mice (0.5mg/kg, intratumoral). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Temporin-MT1 antimicrobial peptide precursor | Temporin-MT1 antimicrobial peptide precursor is an antibacterial peptide isolated from Amolops mantzorum. Synonyms: Thr-Leu-Lys-Lys-Ser-Leu-Leu-Leu-Phe-Phe-Phe-Leu-Gly-Thr-Ile-Asn-Leu-Ser-Leu-Cys-Glu-Gln-NH2. Grade: >98%. Molecular formula: C120H195N27O30S. Mole weight: 2528.10. |  |
| (1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile | (1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Ramelteon. Synonyms: 2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile; Dihydro-1H-indeno[5,4-B]furan-8(2H)-ylidene)acetonitrile. Grade: >95%. CAS No. 221530-44-5. Molecular formula: C13H11NO. Mole weight: 197.23. | |
| 1-(2-aminoethyl)-6-methoxyindan | 1-(2-aminoethyl)-6-methoxyindan is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: 2,3-Dihydro-6-methoxy-1H-indene-1-ethanamine; rac-2,3-Dihydro-6-methoxy-1H-indene-1-ethanamine. Grade: 95%. CAS No. 108048-37-9. Molecular formula: C12H17NO. Mole weight: 191.27. | |
| 1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-acetamide | 1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-acetamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Grade: >90%. CAS No. 1053239-38-5. Molecular formula: C13H15NO2. Mole weight: 217.26. | |
| (2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile | (2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: (E)-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile; (E)-(6-methoxyindan-1-ylidene)acetonitrile. Grade: 95%. CAS No. 187871-98-3. Molecular formula: C12H11NO. Mole weight: 185.22. | |
| 2-Iodomelatonin | 2-Iodomelatonin is a potent agonist of the melatonin receptors 1 (MT1) with Ki value of 28 pM. It could be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues. It inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 30-fold more potently than melatonin. It has been used to characterize the role of MT1 in melatonin-mediated signaling. It is useful in receptor binding studies with radioactive iodomelatonin. Synonyms: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide; N-Acetyl-2-iodo-5-methoxytryptamine. Grade: ≥98% by HPLC. CAS No. 93515-00-5. Molecular formula: C13H15IN2O2. Mole weight: 358.18. | |
| 2-Iodomelatonin | Potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues. Group: Biochemicals. Grades: Highly Purified. CAS No. 93515-00-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| (2Z)-(6-Methoxy-2,3-dihydro-1H-inden-1-ylidene)acetonitrile | (2Z)-(6-Methoxy-2,3-dihydro-1H-inden-1-ylidene)acetonitrile is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: A byproduct formed during the production of ramelteon. Synonyms: (Z)-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile; (2Z)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile. CAS No. 468104-14-5. Molecular formula: C12H11NO. Mole weight: 185.22. | |
| 4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one | 4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep medication used to treat sleeplessness (insomnia). Synonyms: 4,5-Dibromo-6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one; Ramelteon Impurity I. CAS No. 196597-77-0. Molecular formula: C11H8Br2O2. Mole weight: 331.99. | |
| 4-Acetyl Ramelteon | 4-Acetyl Ramelteon is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: N-[2-(4-Acetyl-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl])ethyl]propanamide. Grade: >95%. CAS No. 1346598-94-4. Molecular formula: C18H23NO3. Mole weight: 301.38. | |
| 4-Hydroxy Ramelteon | 4-Hydroxy Ramelteon is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: A metabolite of ramelteon (r110051). Synonyms: (S)-N-(2-(4-hydroxy-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl)propionamide. Grade: >95%. CAS No. 1204581-50-9. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
| 4-Hydroxy Ramelteon β-D-Glucuronide | 4-Hydroxy Ramelteon β-D-Glucuronide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Molecular formula: C22H29NO9. Mole weight: 451.47. | |
| 4-Hydroxy Ramelteon beta-D-Glucuronide | 4-Hydroxy Ramelteon beta-D-Glucuronide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: 4-Hydroxy Ramelteon ?-D-Glucuronide; 4-Hydroxy Ramelteon beta-D-Glucuronide. Molecular formula: C22H29NO9. Mole weight: 451.47. | |
| 4-P-PDOT | 4-P-PDOT is an antagonist of the melatonin 2 (MT2) receptor (pKi = 8.37) that displays 60-fold selectivity for MT2 over MT1. Synonyms: AH 024; cis-4-phenyl-2-Propionamidotetralin; N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide. Grade: ≥98%. CAS No. 134865-74-0. Molecular formula: C19H21NO. Mole weight: 279.4. | |
| 4-P-PDOT | 4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity)[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 134865-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100609. | |
| 8-M-PDOT | 8-M-PDOT is a melatonin receptor agonist, with 20-fold selective for the MT2 (vs MT1) subtype (pKi = 8.23 and 8.95 at human recombinant MT1 and MT2 receptors respectively). Synonyms: 8-Methoxy-2-propionamidotetralin. Grade: ≥99% by HPLC. CAS No. 134865-70-6. Molecular formula: C14H19NO2. Mole weight: 233.31. | |
| Afobazole | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Synonyms: CM346; Afobazol; Fabomotizole; CM 346; CM-346. Grade: >98%. CAS No. 173352-21-1. Molecular formula: C15H21N3O2S. Mole weight: 307.41. | |
| Afobazole hydrochloride | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Synonyms: CM346 hydrochloride; Afobazol hydrochloride; Fabomotizole hydrochloride; CM 346 hydrochloride; CM-346 hydrochloride. Grade: >98%. CAS No. 173352-39-1. Molecular formula: C15H22ClN3O2S. Mole weight: 343.87. | |
| Agomelatine | Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K i s of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively [1]. Agomelatine is a selective 5-HT2C receptor antagonist with pK i s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: S-20098. CAS No. 138112-76-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17038. | |
| Agomelatine hydrochloride | Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with K i s of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively [1]. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pK i s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: S-20098 hydrochloride. CAS No. 1176316-99-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17038A. | |
| Amiselimod HCl | Amiselimod, formerly known as MT-1303, is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases. And it also is a potent and selective immunosuppressant and sphingosine 1 phosphate receptor modulator, as an investigational therapy for people with relapsing-remitting muscular sclerosis (RRMS), inflammatory bowel disease (IBD), and other autoimmune diseases. Synonyms: 2-amino-2-{2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl}propane-1,3-diol hydrochloride; MT-1303; MT1303; MT 1303; Amiselimod HCl. CAS No. 942398-84-7. Molecular formula: C19H31ClF3NO3. Mole weight: 413.91. | |
| DH 97 | DH 97 is a potent MT2 melatonin receptor antagonist (pKi = 8.03) with 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively. Synonyms: DH-97; DH 97; DH97; N-Pentanoyl-2-benzyltryptamine; N-[2-(2-benzyl-1H-indol-3-yl)ethyl]pentanamide. CAS No. 220339-00-4. Molecular formula: C22H26N2O. Mole weight: 334.46. | |
| (E)-1-(2-Aminoethylidene)-6-methoxyindan | (E)-1-(2-Aminoethylidene)-6-methoxyindan is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: (E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethanamine; (2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethanamine. CAS No. 178676-73-8. Molecular formula: C12H15NO. Mole weight: 189.25. | |
| (E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine | (E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the preparation of ramelteon. Synonyms: 2-[(8E)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-ylidene]ethan-1-amine; 2-[(E)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene]ethylamine. Grade: >95%. CAS No. 196597-61-2. Molecular formula: C13H15NO. Mole weight: 201.26. | |
| (E)-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethyl]propanamide | (E)-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the preparation of ramelteon. Synonyms: N-[(2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethyl]propanamide. Grade: >95%. CAS No. 196597-82-7. Molecular formula: C15H19NO2. Mole weight: 245.32. | |
| GR 135531 | GR 135531 is a high affinity agonist of MT3 melatonin receptors, with low affinity for MT1 and MT2 melatonin receptors. GR 135531 can be used to discriminate between the melatonin receptor subtypes. Synonyms: GR 135531; GR135531; GR-1355315-Methoxycarbonylamino-N-acetyltryptamine; 5-MCA-NAT; methyl N-[3-(2-acetamidoethyl)-1H-indol-5-yl]carbamate. Grade: ≥97% by HPLC. CAS No. 190277-13-5. Molecular formula: C14H17N3O3. Mole weight: 275.31. | |
| Luzindole | Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel 1b ) over MT1 (Mel 1a ) with K i values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-0774. CAS No. 117946-91-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101254. | |
| Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1[1]. (Ex/Em=325 nm/400 nm). Uses: Scientific research. Group: Peptides. Alternative Names: Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2. CAS No. 720710-69-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4931. | |
| MMP-9 Inhibitor II (MMP-9 PEX Inhibitor) | This compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a =2.1uM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100uM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100M, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20mg/kg, 6 days/week, i.v. and i.t.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| rac Ramelteon-d3 (rac N-[-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide-d3, rac TAK-375-d3, rac Rozerem-d3) | Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic. Group: Biochemicals. Alternative Names: rac N-[-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide-d3; rac TAK-375-d3; rac Rozerem-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ramelteon | Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic. Group: Biochemicals. Alternative Names: N-[-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide; TAK-375; Rozerem. Grades: Highly Purified. CAS No. 196597-26-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ramelteon | Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-375. CAS No. 196597-26-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0014. | |
| Ramelteon-[d5] | One of the isotope labelled form of Ramelteon, which is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus. Synonyms: N-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}(D5)propanamide; (S)-N-(2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl)propanamide. Grade: >98%. CAS No. 1134159-63-9. Molecular formula: C16H16D5NO2. Mole weight: 264.37. | |
| Ramelteon Metabolite M-II (2-Hydroxy-N- [2- [ (8S) -1, 6, 7, 8-tetrahydro-2H-cyclopenta [e]benzofuran-8-yl]ethyl]-) | Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic. Group: Biochemicals. Alternative Names: 2-Hydroxy-N- [2- [ (8S) -1, 6, 7, 8-tetrahydro-2H-cyclopenta [e]benzofuran-8-yl]ethyl]-. Grades: Highly Purified. CAS No. 896736-21-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (R)-Ramelteon | (R)-Ramelteon is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: N-[2-[(8R)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide; (R)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propanamide. CAS No. 196597-27-0. Molecular formula: C16H21NO2. Mole weight: 259.34. | |
| S26131 | S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 296280-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-122136. | |
| (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide | (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: N-[2-[(1S)-2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide; (S)-N-[2-(6-Hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-iden-1-yl)ethyl]propionamide. Grade: >95%. CAS No. 196597-88-3. Molecular formula: C16H23NO3. Mole weight: 277.36. | |
| (S)-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide | (S)-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: N-[2-[(1S)-2,3-Dihydro-6-methoxy-1H-inden-1-yl]ethyl]propanamide. CAS No. 178678-16-5. Molecular formula: C15H21NO2. Mole weight: 247.33. | |
| (S)-N-[2-(5-Bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl)ethyl]propanamide | (S)-N-[2-(5-Bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl)ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: (S)-N-[2-(5-bromo-6-hydroxyindan-1-yl)ethyl]propionamide. CAS No. 196597-84-9. Molecular formula: C14H18BrNO2. Mole weight: 312.2. | |
| (S)-N-[2-(5-Bromo-2,3-dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide | (S)-N-[2-(5-Bromo-2,3-dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: (S)-N-[2-(5-bromo-6-methoxyindan-1-yl)ethyl]propionamide; N-[2-[(1S)-5-Bromo-2,3-dihydro-6-methoxy-1H-inden-1-yl]ethyl]propanamide; Propanamide, N-[2-[(1S)-5-bromo-2,3-dihydro-6-methoxy-1H-inden-1-yl]ethyl]-; Propanamide, N-[2-(5-bromo-2,3-dihydro-6-methoxy-1H-inden-1-yl)ethyl]-, (S)-. Grade: ≥95%. CAS No. 196597-83-8. Molecular formula: C15H20BrNO2. Mole weight: 326.23. | |
| (S)-N-[2-[6-Allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl]ethyl]propanamide | (S)-N-[2-[6-Allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl]ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: N-[2-[(1S)-5-Bromo-6-(ethenyloxy)-2,3-dihydro-1H-inden-1-yl]ethyl]propanamide. CAS No. 1246820-28-9. Molecular formula: C16H20BrNO2. Mole weight: 338.24. | |
| (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide | (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: (S)-N-[2-[5-Bromo-2,3-dihydro-6-hydroxy-7-(2-propenyl)-1H-inden-1-yl]ethyl]propanamide; (S)-N-[2-(7-allyl-5-bromo-6-hydroxyindan-1-yl)ethyl] propionamide. CAS No. 196597-86-1. Molecular formula: C17H22BrNO2. Mole weight: 352.27. | |
| (S)-N-[2-[7-Allyl-5-bromo-6-benzyloxy-2,3-dihydro-1H-inden-1-yl]ethyl]propanamide | (S)-N-[2-[7-Allyl-5-bromo-6-benzyloxy-2,3-dihydro-1H-inden-1-yl]ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: (S)-N-(2-(7-allyl-6-(benzyloxy)-5-bromo-2,3-dihydro-1H-inden-1-yl)ethyl)propionamide. CAS No. 1246820-29-0. Molecular formula: C24H28BrNO2. Mole weight: 442.39. | |
| (S)-N-[6-Benzyloxy-5-bromo-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-ylidene)ethyl]propanamide | (S)-N-[6-Benzyloxy-5-bromo-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-ylidene)ethyl]propanamide is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Synonyms: N-[2-[(1S)-5-Bromo-2,3-dihydro-7-(2-hydroxyethyl)-6-(phenylmethoxy)-1H-inden-1-yl]ethyl]propanamide. Grade: >95%. CAS No. 1246820-32-5. Molecular formula: C23H28BrNO3. Mole weight: 446.38. | |
| Solitomab | Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 110; MT110. CAS No. 1005198-65-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99592. | |
| (S)-(-)-Pindolol | (S)-(-)-Pindolol, the more active enantiomer of pindolol, is 5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. Synonyms: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; AGI-001; MT-102; AGI001; MT102; AGI 001; MT 102; Espindolol; (S)-(-)-Pindolol. Grade: ≥99% by HPLC. CAS No. 26328-11-0. Molecular formula: C14H20N2O2. Mole weight: 248.32. | |
| Tasimelteon | Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-214778; VEC-162. CAS No. 609799-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14803. | |
| (-)-WIN 55,212-3 mesylate | (-)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor and presumably express the CB1 receptor. It also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors. Synonyms: [(11S)-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-1-ylmethanone mesylate. Grade: ≥98%. CAS No. 131543-25-4. Molecular formula: C27H26N2O3·CH3SO3H. Mole weight: 522.6. | |
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