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| Product | Description | |
|---|---|---|
| myeloperoxidase | Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene. Group: Enzymes. Synonyms: MPO; verdoperoxidase. Enzyme Commission Number: EC 1.11.2.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0513; myeloperoxidase; EC 1.11.2.2; MPO; verdoperoxidase. Cat No: EXWM-0513. |  |
| Myeloperoxidase, human white blood cells | Myeloperoxidase, human white blood cells (MPO) is a peroxidase. In Myeloperoxidase, human white blood cells mediate oxidative stress by promoting the production of reactive oxygen species (ROS) and active nitrogen (RNS), regulating the polarization and inflammation-related signaling pathways of microglia and neutrophils. Myeloperoxidase, human white blood cells has antibacterial activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MPO. CAS No. 9003-99-0. Pack Sizes: 5 U. Product ID: HY-125859A. |  |
| Myeloperoxidase Inhibitor-II (4-(5-Fluoro-1H-indol-3-yl)butanamide, MPO Inhibitor II) | A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT (Ki = 631nM). Kinetic studies reveal that the inhibitor acts as a good one-electron donor for the intermediate Compound I "Fe(IV)=O.Por +", facilitating the formation of Compound II (Fe(IV)-OH.Por) and thereby preventing the reduction of Compound I directly to the resting state "Fe(IV).Por" via the "halogenation cycle", while, on the other hand, behaves as a poor electron donor for Compound II, thereby preventing the completion of the "peroxidase cycle" by stalling the further reduction of Compound II to the resting state. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O, Primary Target: Myeloperoxidase. US Biological Life Sciences. |  Worldwide |
| Native Human Myeloperoxidase | Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. Group: Enzymes. Synonyms: MPO; myeloperoxidase; Peroxidase; myelo; EC 1.11.1.7; 9003-99-0. Enzyme Commission Number: EC 1.11.1.7. CAS No. 9003-99-0. Peroxidase. Activity: > 50 units/mg protein. Storage: -20°C. Form: Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride. Source: Human leuk ocytes. Species: Human. MPO; myeloperoxidase; Peroxidase; myelo; EC 1.11.1.7; 9003-99-0. Cat No: NATE-0457. | |
| Native Human Myeloperoxidase A+B | Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. Group: Enzymes. Synonyms: MPOAB; MPOA+B; Myeloperoxidase A+B. Purity: > 98% (SDS-PAGE). Peroxidase. Activity: Typically > 1,000 U/mL. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. MPOAB; MPOA+B; Myeloperoxidase A+B. Cat No: NATE-0459. | |
| Native Human Myeloperoxidase Isoform A | Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. Group: Enzymes. Synonyms: MPOA; Myeloperoxidase Isoform A; EC 1.11.1.7; 9003-99-0; MPO A. Enzyme Commission Number: EC 1.11.1.7. CAS No. 9003-99-0. Purity: > 98% (SDS-PAGE). Peroxidase. Mole weight: 151 kDa. Activity: Typically > 1 ,000 U/mL. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. MPOA; Myeloperoxidase Isoform A; EC 1.11.1.7; 9003-99-0; MPO A. Cat No: NATE-0458. | |
| Native Human Myeloperoxidase Isoform B | Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. Group: Enzymes. Synonyms: MPOB; MPO B; Myeloperoxidase Isoform B; EC 1.11.1.7; 9003-99-0. Enzyme Commission Number: EC 1.11.1.7. CAS No. 9003-99-0. Purity: > 96% (SDS-PAGE). Peroxidase. Mole weight: 149 kDa. Activity: > 500 U/mL. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. MPOB; MPO B; Myeloperoxidase Isoform B; EC 1.11.1.7; 9003-99-0. Cat No: NATE-0460. | |
| Native Human Myeloperoxidase Isoform C | Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. Applications: Protein cystalline research. Group: Enzymes. Synonyms: MPOC; MPO C; Myeloperoxidase Isoform C; EC 1.11.1.7; 9003-99-0. Enzyme Commission Number: EC 1.11.1.7. CAS No. 9003-99-0. Purity: > 96% (SDS-PAGE). Peroxidase. Mole weight: 146 kDa. Activity: Typically > 1 ,000 U/mg protein. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. MPOC; MPO C; Myeloperoxidase Isoform C; EC 1.11.1.7; 9003-99-0. Cat No: NATE-0461. | |
| 2,3-Dihydropyran | 2,3-Dihydropyran is used in the synthesis of potent and selective myeloperoxidase inhibitors useful as antimicrobial oxidants. Also is used to synthesize novel and selective ?1 receptor ligands. Group: Biochemicals. Alternative Names: 3,4-Dihydro-2H-pyran; 3,4-Dihydro-1,2-pyran; Dihydro-pyran; 2,3-Dihydro-4H-pyran; 2,3-Dihydro-γ-pyran; 2H-3,4-Dihydropyran; 3,4-Dihydro-2H-pyran; 5,6-Dihydro-4H-pyran; Dihydro-2H-pyran; Dihydropyran; NSC 57860; NSC 73472; Δ2-Dihydropyran. Grades: Highly Purified. CAS No. 110-87-2. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 3-Chloro-L-tyrosine | 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Chlorotyrosine. CAS No. 7423-93-0. Pack Sizes: 10 mM * 1 mL; 250 mg; 500 mg; 1 g. Product ID: HY-W041171. | |
| 5-Methoxy-2-methylindole | An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis. Group: Biochemicals. Alternative Names: 5-Methoxy-2-methyl-1H-indole; 2-Methyl-5-methoxyindole; NSC 63817. Grades: Highly Purified. CAS No. 1076-74-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| ARN726 | ARN726 is a systemically active and orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 value of 27 nM for human and 63 nM for rat NAAA. The selectivity for NAAA is better than fatty acid amide hydrolase (FAAH) with IC50s of 100 uM. It is also selective over acid cermidase with IC5Os of 12.5 uM. ARN726 can decrease lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. Synonyms: ARN-0726; ARN 0726. Grades: ≥95%. CAS No. 1628343-77-0. Molecular formula: C14H24N2O3. Mole weight: 268.35. |  |
| Evodenoson | Evodenoson is a selective agonist of the A 2A adenosine receptor. Evodenosons primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenosons protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATL 313; DE 112. CAS No. 844873-47-8. Pack Sizes: 1 mg. Product ID: HY-105017. | |
| Kaempferitrin | Cytotoxic and anti-inflammatory compound (weak). Antioxidant and lipid peroxidation inhibitor. Free radical scavenger. Inhibitor of myeloperoxidase activity. Hypoglycemic, decreases blood glucose levels in diabetic and normal rats. Insulinomimetic. Modulates glucose homeostasis. Decreaes blood glucose levels and stimulates glucose uptake in muscle. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells. Improves insulin resistance by the activation of the classical insulin transduction pathway. Increases adiponectin secretion in 3T3-L1 adipocytes. Antinoniceptive. May have antidyslipidemic activity. Source:Isolated from Calendula officinalis. Group: Biochemicals. Grades: Highly Purified. CAS No. 482-38-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H30O14, Method for Determining. US Biological Life Sciences. | Worldwide |
| Lubiprostone | Lubiprostone (SPI-0211; RU0211) increases intestinal fluid secretion through generation of CIC-2 / CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RU-0211; SPI-0211. CAS No. 136790-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0679. | |
| Mitiperstat | Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD4831. CAS No. 1933460-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145581. | |
| MPO-IN-28 | MPO-IN-28 is a myeloperoxidase (MPO) inhibitor with IC50 of 44 nM. Synonyms: GNF-Pf-3346; 1-(7-methoxy-4-methylquinazolin-2-yl)guanidine; (7-methoxy-4-methyl-quinazolin-2-yl)-guanidine. CAS No. 37836-90-1. Molecular formula: C11H13N5O. Mole weight: 231.25. | |
| Native Human Eosinophil Peroxidase | Eosinophil peroxidase is an enzyme found within the eosinophil granulocytes, innate immune cells of humans and mammals. This oxidoreductase protein is encoded by the gene EPX, expressed within these myeloid cells. EPO shares many similarities with its orthologous peroxidases, myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO). The protein is concentrated in secretory granules within eosinophils. Eosinophil peroxidase is a heme peroxidase, its activities including the oxidation of halide ions to bacteriocidal reactive oxygen species, the cationic disruption of bacterial cell walls, and the post-translational modification of protein amino acid residues....8% (SDS-PAGE). Peroxidase. Mole weight: 77 kda (~53 kDa mw heavy chain, ~13 kDa mw light chain). Activity: > 1,000 U/mL (Enzymatic). Appearance: Clear, green to brown liquid. Storage: 2-8°C. Form: Liquid. Source: Human Eosinophils. Species: Human. EPX; eosinophil peroxidase; EPO; EPP; EPX PEN; EPX-PEN; EC 1.11.1.7; 9003-99-0; peroxidase; lactoperoxidase; guaiacol peroxidase; plant peroxidase; Japanese radish peroxidase; horseradish peroxidase (HRP); soybean peroxidase (SBP); extensin peroxidase; heme peroxidase; oxyperoxidase; protoheme peroxidase; pyrocatechol peroxidase; scopoletin peroxidase; Coprinus cinereus peroxidase; Arthromyces ramosus peroxidase. Cat No: NATE-0228. | |
| NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD) | A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFa-stimulated NF-kB activity (IC50~50uM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents lkBa phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2, 4, 6-trinitro Benzene sulfonic acid (TNBS)-induced colitis in rodent models (4.5mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| O-1602 | O-1602 is an atypical analog of cannabinoid which acts as a potent and selective agonist of the cannabinoid (CB) receptor G protein-coupled 55(GPR55). Its EC50 values are 13, >30,000, and >30,000 nM for GPR55, CB1, and CB2, respectively. It reduces movement-induced firing of nociceptive C fibers in a rat model of inflammatory joint pain. It also decreases IL-6 and TNF-α levels and myeloperoxidase activities in the plasma, lungs, and pancreas in a mouse model of acute pancreatitis. It reduces growth of Mz-ChA-1, HuCCT-1, CCLP-1, and SG231 cholangiocarcinoma cells at a concentration of 50 μM in vitro. It increases calcium mobilization and lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner and increases food intake and fat mass in rats. It induces activation of RhoA, cdc42 and rac1. Synonyms: O-1602; O 1602; O1602; 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol. Grades: ≥98% by HPLC. CAS No. 317321-41-8. Molecular formula: C17H22O2. Mole weight: 258.36. | |
| Octylamine | Octylamine is used as a reactant in the synthesis of 2H-indazoles and 1H-indazolones which are used as myeloperoxidase(MPO) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 111-86-4. Pack Sizes: 50g, 100g. Molecular Formula: C8H19N, Molecular Weight: 129.24. US Biological Life Sciences. | Worldwide |
| o-Dianisidine (Fast Blue B) | o-Dianisidine has been used for neutrophil myeloperoxidase activity (MPO) assay; used for staining erythrocytes; constituent in neutral benzidine staining of dried blood smears. Group: Biochemicals. Alternative Names: 3,3'-Dimethoxybenzidine; Fast Blue B; 4,4'-Diamino-3,3'-dimethoxybiphenyl. Grades: Highly Purified. CAS No. 119-90-4. Pack Sizes: 25g, 100g. Molecular Formula: C14H16N2O2, Molecular Weight: 244.3. US Biological Life Sciences. | Worldwide |
| Peroxidase | Peroxidase. Synonyms: Peroxidase froM horseradish(EIA Grade,Purified);84 kDa myeloperoxidase;89 kDa myeloperoxidase;ANTI-MYELOPEROXIDASE(N-TERMINAL) antibody produced in rabbit;Myeloperoxidase light chain;Apoperoxidase;Peroxidase isoenzymes Type XI: Apoenzyme from horseradish;ANTI-MYELOPEROXIDASE (CENTER) antibody produced in rabbit. CAS No. 9003-99-0. Product ID: CDF4-0034. Category: Enzyme Preparations. Product Keywords: Food Ingredients; Enzyme Preparations; Peroxidase; CDF4-0034; 9003-99-0; 232-668-6; 9003-99-0. Purity: 0.99. Color: Red-Brown. EC Number: 232-668-6. Physical State: Powder. Solubility: H2O: soluble. |  |
| PF-06282999 | PF-06282999 is a selective myeloperoxidase Inhibitor originate by Pfizer. It showed good oral pharmacokinetics in preclinical species and robust irreversible inhibition of plasma MPO activity. In Mar 2015, Pfizer terminated phase I trial for the treatment of Acute coronary syndromes in Healthy volunteers in USA. Uses: Acute coronary syndromes. Synonyms: PF-06282999; PF06282999; PF06282999. 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide. Grades: 98%. CAS No. 1435467-37-0. Molecular formula: C13H12ClN3O3S. Mole weight: 325.77. | |
| PF-1355 | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Synonyms: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Molecular formula: C14H15N3O4S. Mole weight: 321.35. | |
| PMX 53 acetate | PMX 53 is a potent and orally active C5aR(CD88) antagonist and Mas-related gene 2 (MrgX2) agonist. It stimulates MrgX2-mediated mast cell degranulation, inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis, inhibits lung metastasis in a mouse breast cancer model, and reduces atherosclerotic lesions in a mouse model of atherosclerosis. Synonyms: L-Arginine, N-acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-, (6?2)-lactam, monoacetate; Ac-Phe-Orn(1)-Pro-D-Cha-Trp-Arg-(1).CH3CO2H; C 5aRA acetate salt. Grades: ≥95%. CAS No. 852629-88-0. Molecular formula: C47H65N11O7.C2H4O2. Mole weight: 956.14. | |
| Reparixin L-lysine salt | The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 uM for CXCR1 weight and CXCR1 Ile43Val, respectively). Treatment with reparixin significantly counteracts secondary degeneration by reducing oligodendrocyte apoptosis, migration to the injury site of neutrophils and ED-1-positive cells. The best beneficial outcome of reparixin treatment required 7-day administration either by i.p. route (15 mg/kg) or subcutaneous infusion via osmotic pumps (10 mg/kg), reaching a steady blood level of 8 microg/ml. Reparixin effectively decreased systolic blood pressure and increased the blood flow. The thoracic aorta wall thickness was significantly decreased in SHR-R compared to SHR-N. Pre-treatment with reparixin reduced the motor deficits observed in this model of ischemia and reperfusion. Myeloperoxidase activity and IL-iβ were reduced in the reparixin-treated group. Histological analysis revealed that ischemic injury was also attenuated by reparixin pre-treatment. Synonyms: Repertaxin L-lysine salt. Grades: >98%. CAS No. 266359-93-7. Molecular formula: C20H35N3O5S. Mole weight: 429.57. | |
| Taurohyodeoxycholic acid sodium | Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 38411-85-7. Pack Sizes: 50 mg; 100 mg. Product ID: HY-114360A. | |
| Verdiperstat | Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC 50 of 630 nM, and can be used in the research of neurodegenerative brain disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD3241. CAS No. 890655-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17646. | |
| Zegocractin | Zegocractin, also known as CM4620, is a selective Orai1 inhibitor, prevents Ca2+ entry in acinar cells. The intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species. SOCE via STIM1/Orai complexes promotes activation and fibroinflammatory gene expression within pancreatic stellate cells. CM4620 also decreased myeloperoxidase activity and inflammatory cytokine expression in pancreas and lung tissues, fMLF peptide-induced oxidative burst in human neutrophils, and cytokine production in human peripheral blood mononuclear cells (PBMCs) and rodent PaSCs, indicating that Orai1/STIM1 channels participate in the inflammatory responses of these cell types during acute pancreatitis. Group: Inhibitors. Alternative Names: CM-4620; CM 4620; CM4620; Zegocractin. CAS No. 1713240-67-5. Molecular formula: C19H11ClF3N3O3. Mole weight: 421.76. Appearance: Solid powder. Purity: >98%. IUPACName: N-(5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide. Canonical SMILES: O=C (NC1=NC=C (C2=C (Cl)C=C (OC (F) (F)O3)C3=C2)N=C1)C4=C (C)C=CC=C4F. Catalog: ACM1713240675. |  |
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