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| Product | Description | |
|---|---|---|
| Myriocin | Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids. Group: Biochemicals. Alternative Names: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Myriocin | Myriocin is an unsaturated hydrocarbon and fatty acid derivative produced by Myriococcum albomyces NRRL 3858. It has antifungal activity. Synonyms: thermozymocidin. Grades: >97% by HPLC. CAS No. 35891-70-4. Molecular formula: C21H39NO6. Mole weight: 401.54. |  |
| Myriocin | Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces , Isaria sinclairi and Mycelia sterilia , is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC 50 of 3.5 μg/mL for inhibiting HCV infection [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Thermozymocidin; ISP-I. CAS No. 35891-70-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6798. |  |
| Myriocin | Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid. Product Category: Inhibitors. Appearance: Off-white solid. CAS No. 35891-70-4. Molecular formula: C21H39NO6. Mole weight: 401.54. Purity: >98%. IUPACName: (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid. Canonical SMILES: CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O. Density: 1.123±0.06 g/cm3(Predicted). Product ID: ACM35891704. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Myriocin from Mycelia sterilia | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Myriocin, Mycelia sterilia - CAS 35891-70-4 | A potent immunosuppressant. Group: Fluorescence/luminescence spectroscopy. | |
| Myriocin (Thermozymocidin, ISP) | Myriocin is an a-amino fatty acid derived from species of several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| (+)-Myriocin (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl- | (+)-Myriocin (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-. Group: Biochemicals. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C21H39NO6. US Biological Life Sciences. | Worldwide |
| 1-(1-iodoethyl)-4-octylbenzene | 1-(1-iodoethyl)-4-octylbenzene is an impurity of Fingloimod, also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 15mg, 30mg. Molecular Formula: C16H25I, Molecular Weight: 344.27. US Biological Life Sciences. | Worldwide |
| 1-?(2-?Iodoethyl)?-?2-?octylbenzene | 1-?(2-?Iodoethyl)?-?2-?octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 162358-96-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H25I, Molecular Weight: 344.27. US Biological Life Sciences. | Worldwide |
| 2-(4-Octylphenyl)ethyl 1-Methanesulfonate | An intermediate in the preparation of FTY720-d4 (F805002), a labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Group: Biochemicals. Alternative Names: 4-Octylbenzeneethanol 1-Methanesulfonate. Grades: Highly Purified. CAS No. 162358-06-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| FTY720 Hydrochloride | FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Alternative Names: 2-Amino-2- (2- (4-octylphenyl) ethyl) propane-1, 3-diol Hydrochloride; Fingolimod Hydrochloride. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| FTY720 Phosphate | FTY720 is a derivative of ISP-1 (myriocin). FTY720 phosphate is a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5, IC50 values = 0.2-6 nM). Synonyms: FTY720P; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, 1-(dihydrogen phosphate). Grades: ≥98%. CAS No. 402615-91-2. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
| N-[1, 1-Bis[ (acetyloxy) methyl]-3- (4-octylphenyl) propyl]acetamide-d4 | Protected FTY720-d4 (F805002), a labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Group: Biochemicals. Alternative Names: 2-Acetoxymethyl-2-acetylamino-4-(4-octylphenyl)acetic-d4 Acid Butyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N- (1, 1-Bis (hydroxymethyl) -3- (4-octylphenyl) propyl) acetamide | An intermediate in the preparation of FTY720-d4 (F805002), a labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Group: Biochemicals. Grades: Highly Purified. CAS No. 249289-10-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
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