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(S)-Duloxetine Hydrochloride (Potent 5-HT and NA Reuptake Inhibitor, Blocks Dopamine Reuptake, (+)-(S)-N-Methyl-3-(1-naphthyloxy)- 3-(2-thienyl)propanamine hydrochloride)
High affinity, competitive 5-HT and norepinephrine (NE) re-uptake inhibitor (Ki values are 8.5 and 45nm for 5-HT and NE reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46nm for 5-HT and NE reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki=300nm in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 136434-34-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
(3S)-N-Methyl-γ-(1-naphthalenyloxy)-3-thiophenepropanamine is an impurity of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: DLX-ISO 3; Duloxetine EP Impurity F; (γS)-N-Methyl-γ-(1-naphthalenyloxy)-3-thiophenepropanamine; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(3-thienyl)-1-propanamine; 3-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-; (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine. Grade: ≥95%. CAS No. 959392-22-4. Molecular formula: C18H19NOS. Mole weight: 297.41.
Duloxetine
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (Ki=4.6 nM), used for major depressive disorder, generalized anxiety disorder, fibromyalgia and neuropathic pain. Uses: Adrenergic uptake inhibitors; analgesics; antidepressive agents; dopamine uptake inhibitors; serotonin uptake inhibitors. Synonyms: (S)-Duloxetine; Cymbalta; Yentreve; (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine; LY 248686; Xeristar; LY248686; LY-248686; (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine; (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine. Grade: >98%. CAS No. 116539-59-4. Molecular formula: C18H19NOS. Mole weight: 297.41.
Duloxetine-d7 Maleate
Labeled Duloxetine, which is used as an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Group: Biochemicals. Alternative Names: (γS)-N-Methyl-γ-(1-naphthalenyloxy-d7)-2-thiophenepropanamine Maleate; (+)-(S)-N-Methyl-γ-(1-naphthyloxy-d7)-2-thiophenepropylamine Maleate; LY-248686 Maleate. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Duloxetine Maleate
Duloxetine Maleate is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine Maleate; (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine Maleate; LY-248686 Maleate; (S)-N-methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine (Z)-2-Butenedioate; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine (2Z)-2-butenedioate (1:1); 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, (2Z)-2-butenedioate (1:1). Grade: ≥95%. CAS No. 116817-86-8. Molecular formula: C22H23NO5S. Mole weight: 413.49.
Duloxetine Impurity. Group: Biochemicals. Alternative Names: (+)-(S)-N-Methyl-gamma-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride; LY-248686; Duloxetine hydrochloride. Grades: Highly Purified. CAS No. 136434-34-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences.
Worldwide
(±)-N-Methylduloxetine
(±)-N-Methylduloxetine is an impurity of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: 2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-; N,N-Dimethyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine; N,N-Dimethyl-3-((1-naphthalenyl)oxy)-3-(2-thienyl)propanamine; N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine. Grade: 95%. CAS No. 116817-11-9. Molecular formula: C19H21NOS. Mole weight: 311.44.
(R)-Duloxetine
(R)-Duloxetine is the R-configuration of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: (γR)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine; (R)-N-Methyl-3-(1-naphthoxy)-3-(2-thienyl)propylamine; (3R)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine; 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γR)-; Duloxetine EP Impurity A; Duloxetine USP Related Compound A. Grade: 95%. CAS No. 116539-60-7. Molecular formula: C18H19NOS. Mole weight: 297.41.
(S)-N-Desmethyl Duloxetine Hydrochloride
(S)-N-Desmethyl Duloxetine Hydrochloride is an impurity of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: (γS)-γ-(1-Naphthalenyloxy)-2-thiophenepropanamine Hydrochloride; (S)-γ-(1-Naphthalenyloxy)-2-thiophenepropanamine Hydrochloride; (3S)-3-(1-Naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1); 2-Thiophenepropanamine, γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride (1:1). CAS No. 1798887-69-0. Molecular formula: C17H18ClNOS. Mole weight: 319.85.
Duloxetine Hydrochloride
An antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence. Group: Biochemicals. Alternative Names: (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine Hydrochloride; (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine Hydrochloride; LY-248686. Grades: Highly Purified. CAS No. 136434-34-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
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