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| Product | Description | |
|---|---|---|
| Natural protease-enzyme blend for hair care | An all-natural protease-enzyme blend that enhances natural hair color and restores shine by removing excess protein-build up. Applications: Hair conditioners. Group: Enzymes. Synonyms: Natural protease; Natural protease enzyme blend; hair care; hair conditioners; protease enzyme blend; enhances natural hair color; enzyme for hair; natural hair color; Natural protease-enzyme blend for hair care. Cosmetic enzymes. Appearance: powder or liquid. Lipase; Cosmetic; lipase-based enzyme blend; breaks down human sebum; breaks down residual oil; human sebum; breaks down human sebum and residual oil; residual oil; human sebum; Lipase-based enzyme blend for cosmetic. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: BODY-2816. |  |
| 3,4-Dichloroisocoumarin | 3,4-Dichloroisocoumarin is a potent serine-protease and SrLip inhibitor (K i for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 51050-59-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126034. |  |
| 3- (Benzyl oxycarbonyl amino) propionalde hyde | 3- (Benzyl oxycarbonyl amino) propionalde hyde is used as a reagent in the synthesis of Tuberactinomycin N, a peptide antibiotic that is used as an anti-tuberculotic drug. 3- (Benzyl oxycarbonyl amino) propionalde hyde is also used as a reagent to prepare L-epicapreomycidine, a guanidino amino acid that is naturally found in hydrolyzates of protease inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 65564-05-8. Pack Sizes: 1g, 5g. Molecular Formula: C11H13NO3, Molecular Weight: 207.23. US Biological Life Sciences. |  Worldwide |
| 4-Hydroxycoumarin | 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1076-38-6. Pack Sizes: 10 mM * 1 mL; 50 g. Product ID: HY-N6856. | |
| 4-Hydroxycoumarin (Standard) | 4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1076-38-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N6856R. | |
| 4-O-Benzyl-D-galactal | 4-O-Benzyl-D-galactal, a carbohydrate intermediate utilized in the synthesis of a diverse line of pharmaceuticals and natural products, should be handled with caution. Its significant potential for application stems from its use as a starting material for creating lactose derivatives. These derivatives offer various pharmaceutical uses, ranging from antibiotics to anticancer agents and protease inhibitors. CAS No. 157380-76-2. Molecular formula: C13H16O4. Mole weight: 236.26. |  |
| 6-(Dimethylamino)purine | 6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen , insulin-like gene 1 , and serine protease inhibitor 2 genes , and induce apoptosis in lymphoma cells ( apoptosis ) [1] [3] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Dimethylaminopurine; 6-DMAP. CAS No. 938-55-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-W010128. | |
| 6-Thioguanine | 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases ( PLpros ) and also potently inhibits USP2 activity, with IC 50 s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Thioguanine; 2-Amino-6-purinethiol. CAS No. 154-42-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-13765. | |
| 6-Thioguanine (Standard) | 6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases ( PLpros ) and also potently inhibits USP2 activity, with IC 50 s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. Uses: Scientific research. Group: Natural products. CAS No. 154-42-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13765R. | |
| acrosin | Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: acrosomal proteinase; acrozonase; α-acrosin; β-acrosin; upsilon-acrosin; acrosomal protease; acrosin amidase. Enzyme Commission Number: EC 3.4.21.10. CAS No. 9068-57-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4094; acrosin; EC 3.4.21.10; 9068-57-9; acrosomal proteinase; acrozonase; α-acrosin; β-acrosin; upsilon-acrosin; acrosomal protease; acrosin amidase. Cat No: EXWM-4094. | |
| (±)-Alliin | (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (M pro ) [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-L-Alliin. CAS No. 17795-26-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126085. | |
| Antibiotic L-696,474 (18-Dehydroxycytochalasin H) | Natural cytochalasin derivative. Antiviral. Inhibitor of HIV-1 protease. Antifungal activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 141994-72-1. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Atazanavir | Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor. Atazanavir is a substrate and inhibitor of CYP3A4 , and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: BMS-232632. CAS No. 198904-31-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17367. | |
| Atazanavir sulfate | Atazanavir (BMS-232632) sulfate is a highly selective and orally active HIV-1 protease inhibitor. Atazanavir sulfate is a substrate and inhibitor of CYP3A4 , and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: BMS-232632 sulfate. CAS No. 229975-97-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17367A. | |
| Camostat mesylate | Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2 , shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Camostat mesilate; FOY305; FOY-S980. CAS No. 59721-29-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13512. | |
| Cholesteryl sulfate sodium | Cholesteryl sulfate sodium is an orally available, NPC2 -targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis ( EC 50 =50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 2864-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111355B. | |
| Chymotrypsin | Chymotrypsin is a proteolytic enzyme. It can priority hydrolyze tyrosine containing l-isomer, phenylalanine and the peptide bond of tryptophan, the best effective condition is pH 8.0. Its activity can be restrained by heavy metal or natural trypsin inhibitor in some degrees. Applications: Practically used to heal cicatrisation caused by injuries, inflammation and it is also used for avoiding part dropsy, blood-gathering, haematoma caused by wrick, breast dropsy after operation, tympanitis and rhinitis brief introduction of production: the high purity chymotrypsin is extracted from bovine or porcine pancreas and purified by affinity chromatography in order to avoid being polluted by other protease. Group: Enzymes. Synonyms: Chymotrypsin; Alpha-chymotrypsin; Chymotrypsin A; Chymotrypsin B. CAS No. 9004-7-3. Chymotrypsin. Appearance: inquire. Chymotrypsin; Alpha-chymotrypsin; Chymotrypsin A; Chymotrypsin B. Pack: inquire. Cat No: BIO-1012. | |
| Cyclotheonamide A | Cyclotheonamide A is a serine protease inhibitor (cyclic polypeptide), which can be obtained from marine sponges of the genus Theonella. Group: Marine natural products. Alternative Names: Cyclo[(2S)-2-(formylamino)-β-alanyl-L-prolyl-(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexanoyl-D-phenylalanyl-(2E,4S)-4-amino-5-(4-hydroxyphenyl)-2-pentenoyl]. CAS No. 129033-04-1. Mole weight: 731.8. Purity: 95%+. IUPACName: N-[ (3S, 7E, 9S, 12R, 16S, 19S)-12-Benzyl-16-[3- (diaminomethylideneamino)propyl]-9-[ (4-hydroxyphenyl)methyl]-2, 6, 11, 14, 15, 18-hexaoxo-1, 5, 10, 13, 17-pentazabicyclo[17. 3. 0]docos-7-en-3-yl]formamide. Canonical SMILES: C1CC2C (=O)NC (C (=O)C (=O)NC (C (=O)NC (C=CC (=O)NCC (C (=O)N2C1)NC=O)CC3=CC=C (C=C3)O)CC4=CC=CC=C4)CCCN=C (N)N. Catalog: ACM129033041. |  |
| Cytochalasin A | Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease ( IC 50 =3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 14110-64-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6773. | |
| DNA-PK Substrate | DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11 - 24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.). Uses: Scientific research. Group: Peptides. CAS No. 146064-85-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5429. | |
| Fosamprenavir | Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility [1]. Anti- HIV infection [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Amprenavir phosphate; GW 433908. CAS No. 226700-79-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-78726. | |
| Granzyme A from Human, Recombinant (carrier-free) | Granzyme A is a serine protease belonging to the granzyme family and is expressed exclusively by cytotoxic T cells (CTL) and NK cells. Most circulating CD56+CD8- NK cells, and approximately half of circulating CD8+ T cells, coexpress both granzymes A and B. Group: Enzymes. Synonyms: Hanukah factor serine protease (HFSP); Cytolytic T cell-and natural killer cell-specific trypsin-like serine protease; Cytotoxic T-lymphocyte-associated serine esterase 3; CTLA3; Granzyme A; Granzyme. Enzyme Commission Number: EC 3.4.21.78. CAS No. 143180-73-8. Purity: >90%, as determined by Coomassie stained SDS-PAGE. Granzyme A. Mole weight: 55 kD in non-reducing conditions by SDS-PAGE. Activity: >5,000 pmol/min/ug. Storage: Unopened vial can be stored at -70°C for six months. For maximum results, quick spin vial prior to opening. Avoid repeated freeze/thaw cycles. Form: 0.22 um filtered protein solution is in 20 mM Tris, 150 mM NaCl, pH 7.5. Source: 293E cell line. Species: Human. Hanukah factor serine protease (HFSP); Cytolytic T cell-and natural killer cell-specific trypsin-like serine protease; Cytotoxic T-lymphocyte-associated serine esterase 3; CTLA3; Granzyme A; Granzyme. Cat No: NATE-1934. | |
| Granzyme H from Human, Recombinant (carrier-free) | Granzyme H is a member of the granzyme family of serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme Hs functions are largely unknown. The more abundant expression of Granzyme H than Granzyme B in NK cells suggests that Granzyme H may complement the pro-apoptotic function of Granzyme B in this cell type. Group: Enzymes. Synonyms: Granzyme H; GZMH; Granzyme. Enzyme Commission Number: EC 3.4.21.-. Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Alkalophilic proteinase. Mole weight: Multiple bands between 38-40 kDa, reducing conditions by SDS-PAGE. Activity: >5,000 pmol/min/ug. Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 °C as supplied.3 months, -70 °C under sterile conditions after opening. Form: Supplied as a 0.2 μm filtered solution in HEPES, NaCl and Brij-35. Source: Mouse myeloma cell line. Species: Human. Granzyme H; GZMH; Granzyme. Cat No: NATE-1935. | |
| Granzyme K from Human, Recombinant | Granzyme K is a protein that in humans is encoded by the GZMK gene. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Group: Enzymes. Synonyms: Granzyme K; GZMK; GZMK. Enzyme Commission Number: EC 3.4.21.-. Purity: >98% (SDS-PAGE). Alkalophilic proteinase. Activity: ~29 U/ug protein. Stability: Stable for at least 6 months when stored at -80°C. Dilute solutions (e. g. 1-1000ng/ml) should be used within 24 hours. Storage: at -80°C. Form: Liquid. In PBS containing 10% sucrose and ~0.5M sodium chloride. Contains no preservatives. Source: E. coli. Species: Human. Granzyme K; GZMK; GZMK. Cat No: NATE-1936. | |
| Hinokinin | Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Hinokinin. CAS No. 26543-89-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N10420. | |
| N-Ethylmaleimide | N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC 50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: NEM. CAS No. 128-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0843. | |
| Nitro-grela | Nitro-grela. Uses: This catalyst is used for an efficient synthesis of hcv protease inhibitor, biln 2061. the nitro-grela catalyst is a stable olefin metathesis initiator active in various ring-closing, cross, and enyne metathesis reactions. its efficiency has been proven in numerous total syntheses of natural and biologically active compounds, and in material science. Group: Polymerization catalystspolymerization reagents. Alternative Names: [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro[(2-isopropoxy-5-nitrobenzylidene)]ruthenium(II). CAS No. 502964-52-5. Product ID: [1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichloro-[(5-nitro-2-propan-2-yloxyphenyl)methylidene]ruthenium. Molecular formula: 671.63. Mole weight: C31H37Cl2N3O3Ru. CC1=CC (=C (C (=C1)C)N2CCN (C2=[Ru] (=CC3=C (C=CC (=C3)[N+] (=O)[O-])OC (C)C) (Cl)Cl)C4=C (C=C (C=C4C)C)C)C. InChI=1S/C21H26N2. C10H11NO3. 2ClH. Ru/c1-14-9-16 (3)20 (17 (4)10-14)22-7-8-23 (13-22)21-18 (5)11-15 (2)12-19 (21)6; 1-7 (2)14-10-5-4-9 (11 (12)13)6-8 (10)3; /h9-12H, 7-8H2, 1-6H3; 3-7H, 1-2H3; 2*1H; /q; +2/p-2. RQQSRSPQJIAORC-UHFFFAOYSA-L. 97%+. |  |
| Nitro-grela | This catalyst is used for an efficient synthesis of HCV Protease Inhibitor, BILN 2061. The nitro-Grela catalyst is a stable olefin metathesis initiator active in various ring-closing, cross, and enyne metathesis reactions. Its efficiency has been proven in numerous total syntheses of natural and biologically active compounds, and in material science. Group: Olefin metathesisruthenium catalysts. Alternative Names: [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro[(2-isopropoxy-5-nitrobenzylidene)]ruthenium(II). CAS No. 502964-52-5. Molecular formula: C31H37Cl2N3O3Ru. Mole weight: 671.63. Appearance: Green to dark green powder to crystal. Purity: 97%+. IUPACName: [1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichloro-[(5-nitro-2-propan-2-yloxyphenyl)methylidene]ruthenium. Canonical SMILES: CC1=CC (=C (C (=C1)C)N2CCN (C2=[Ru] (=CC3=C (C=CC (=C3)[N+] (=O)[O-])OC (C)C) (Cl)Cl)C4=C (C=C (C=C4C)C)C)C. Catalog: ACM502964525-1. | |
| Palmatine chloride | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC 50 s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC 50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 10605-02-4. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g. Product ID: HY-N0110. | |
| Palmatine hydroxide | Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC 50 s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC 50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 131-04-4. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g. Product ID: HY-N0110B. | |
| Papain | Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries. Uses: Scientific research. Group: Natural products. CAS No. 9001-73-4. Pack Sizes: 100 mg. Product ID: HY-P1645. | |
| peptidase Do | This serine endopeptidase is essential for the clearance of denatured or aggregated proteins from the inner-membrane and periplasmic space in Escherichia coli. Natural substrates of the enzyme include colicin A lysis protein, pilin subunits and MalS from E. coli. The enzyme has weak peptidase activity with casein and other non-native substrates. The peptidase acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Molecular chaperones and peptidases control the folded state of proteins by recognizing hydrophobic stretches of polypeptide that become exposed by misfolding or unfolding. They then bind these hydrophobic substrates to prevent aggregation or assist in protein refolding. If attempts at refolding fail, then irreversibly damaged proteins are degraded by peptidases such as this enzyme. Belongs in peptidase family S1C. Group: Enzymes. Synonyms: DegP; DegP protease; HtrA; high temperature requirement protease A; HrtA heat shock p. Enzyme Commission Number: EC 3.4.21.107. CAS No. 161108-11-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4102; peptidase Do; EC 3.4.21.107; 161108-11-8; DegP; DegP protease; HtrA; high temperature requirement protease A; HrtA heat shock protein; protease Do; Do protease. Cat No: EXWM-4102. | |
| Pine Pollen Powder | Pine pollen powder comes from pinaceae plant pinus massoniana and pinus tabulaeformis. Pine pollen powder contain a variety of nutrients, including 22 kinds of amino acids, 14 vitamins and 30 kinds of trace elements and a large number of active protease, flavonoids and other active substances. Pine pollen powder is known as the king of natural vitamin. Yesherb pine pollen powder have processed wall breaking by advanced technology with broken rate up to 99%, make the untrients more easily to absorb. Group: Others. Pine Pollen Powder; Pinus Massoniana. Cat No: EXTC-119. | |
| Silymarin | Silymarin is an extract of the milk thistle ( Silybum marianum ). Silymarin is an effective SARS-CoV-2 main protease (M pro ) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research [1] [2] [4]. Uses: Scientific research. Group: Natural products. CAS No. 65666-07-1. Pack Sizes: 250 mg; 500 mg. Product ID: HY-N7073. | |
| Tamarixetin | Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p ( ClpP ) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC 50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis , and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 4'-O-Methyl Quercetin. CAS No. 603-61-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1181. | |
| Theaflavin 3,3'-digallate | Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC 50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro ( K d =8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 [1]. Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent [2]. Uses: Scientific research. Group: Natural products. Alternative Names: TF-3; ZP10. CAS No. 30462-35-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1992. | |
| Ucf-101 | Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2 , with an IC 50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC 50 >200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313649-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125959. | |
| UCF 101 | UCF 101 is an Omi/HtrA2 protease inhibitor with IC50 value of 9.5 μM. Omi/HtrA2 is a mitochondria serine protease released in response to apoptotic stimuli. UCF 101 is naturally fluorescent enabling the visualization of its entry into cells. Synonyms: RT-014861; 5-({5-[2-(Dihydroxyamino)phenyl]furan-2-yl}methylidene)-1,3-diphenyl-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione. Grades: ≥98%. CAS No. 313649-08-0. Molecular formula: C27H17N3O5S. Mole weight: 495.5. | |
| Vorapaxar Sulfate | Vorapaxar, also known as SCH 530348, is a thrombin receptor (protease-activated receptor, PAR-1) antagonist based on the natural product himbacine. Synonyms: SCH530348; SCH 530348, SCH-530348; Vorapaxar sulfate. Grades: 98%. CAS No. 705260-08-8. Molecular formula: C29H35FN2O8S. Mole weight: 590.66. | |
| 1,2,3-Tri-O-benzoyl-4,6-O-benzylidene-b-D-galactopyranose | 1,2,3-Tri-O-benzoyl-4,6-O-benzylidene-b-D-galactopyranose is a carbohydrate derivative of high complexity and versatility. Its relevance in the pharmaceutical industry is paramount, serving as a crucial intermediate for the synthesis of a wide array of glycosides and glycoconjugates. This compound has been exploited for the development of HIV-protease inhibitors, as well as for the initiation of anti-tumor and anti-cancer drug research. Its multifaceted nature gives it immense potential for further breakthroughs in the field. Molecular formula: C34H28O9. Mole weight: 580.58. | |
| AZ 3451 | AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling. Synonyms: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide; AZ-3451; AZ3451. Grades: ≥98%. CAS No. 2100284-59-9. Molecular formula: C30H27BrN4O3. Mole weight: 571.46. | |
| Bacterial Protease, Liquid, 100 mL | Liquid. Converts protein to amino acid. 100 mL per bottle. Commercial grade enzyme. May be stored at 5° C for up to 1 year without appreciable loss of activity. Comes with safety data sheet (SDS) and Nature's Catalyst Booklet. Product ID: 202390. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Celastrol | Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC 50 of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Tripterine; Tripterin. CAS No. 34157-83-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13067. | |
| clasto-Lactacystin β-lactone | Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces , acts as an irreversible 20S proteasome inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: Omuralide; β-Clastolactacystin. CAS No. 154226-60-5. Pack Sizes: 50 μg (2.34 mM * 100 μL in Methyl acetate). Product ID: HY-108549. | |
| Dihydroeponemycin | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells. Grades: ≥98%. CAS No. 126463-64-7. Molecular formula: C20H36N2O6. Mole weight: 400.5. | |
| Epoxomicin | Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: BU-4061T. CAS No. 134381-21-8. Pack Sizes: 10 mM * 1 mL; 100 μg; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-13821. | |
| Epoxomicin | Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. Uses: Proteasome inhibitors. Synonyms: BU-4061T. Grades: >98%. CAS No. 134381-21-8. Molecular formula: C28H50N4O7. Mole weight: 554.72. | |
| Marizomib | Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC 50 =3.5, 28, and 430 nM, respectively) [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Salinosporamide A; NPI-0052. CAS No. 437742-34-2. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-10985. | |
| Radicicol | Radicicol is an inhibitor of Hsp90 with an IC 50 value < 1 μM, and leads to proteasomal degradation [1]. Radicicol exhibits inhibition on PDK with IC 50 s of 230 μM ( PDK1 ) and 400 μM ( PDK3 ). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB [2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein ( FTO ), with an IC 50 value of 16.04 μM [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Monorden. CAS No. 12772-57-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6769. | |
| Tomatine | Tomatine is a glycoalkaloid, found in the tomato plant ( Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: α-Tomatine; Lycopersicin; Tomatin. CAS No. 17406-45-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N2166. | |
| Trigonelline | Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti- HSV-1 , antibacterial, and antifungal activity and induces ferroptosis. Uses: Scientific research. Group: Natural products. Alternative Names: Trigenolline. CAS No. 535-83-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0414. | |
| Trigonelline chloride | Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti- HSV-1 , antibacterial, and antifungal activity, and induces ferroptosis. Uses: Scientific research. Group: Natural products. Alternative Names: Trigonelline hydrochloride. CAS No. 6138-41-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0415. | |
| Trigonelline (Standard) | Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis. Uses: Scientific research. Group: Natural products. CAS No. 535-83-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0414R. | |
| Trypsin | [Source]: porcine pancreas (or bovine pancreas) [Molecular weight] :~23.3KDa [Structure features]: folding single-chain (alkalescence) [Nature]: As a protein enzyme, a type of serine proteases, specialized hydrolysis carboxyl terminal is peptide linkage of alkaline amino acid. Applications: (1) used to research, with polypeptide and protein to survey and evaluate sequence. (2) bio-products tools enzyme, such as activation of the recombinant human insulin original, and so on. (3) biochemical medicine bulk drug. Group: Enzymes. Synonyms: Trypsin; EGF. CAS No. 9002-7-7. Trypsin. Appearance: inquire. Trypsin; EGF. Pack: inquire. Cat No: BIO-1011. | |
| Valproic acid | Valproic acid (VPA) is an orally active HDAC inhibitor, with IC 50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 ( IC 50 , 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: Dipropylacetic Acid. CAS No. 99-66-1. Pack Sizes: 500 mg; 1 g; 5 g; 25 g. Product ID: HY-10585. | |
| Valproic acid sodium | Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC 50 in the range of 0.5 and 2 mM, also inhibits HDAC1 ( IC 50 , 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: Sodium Valproate sodium. CAS No. 1069-66-5. Pack Sizes: 500 mg; 1 g; 5 g; 25 g. Product ID: HY-10585A. | |
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