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Nebivolol Impurity 1 An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.19 nM. Synonyms: (R,R,S,S)-Nebivolol; (αR,α'S,2R,2'S)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol; (R)-1-((R)-6-Fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol. Grades: > 95%. CAS No. 1360598-84-0. Molecular formula: C22H25F2NO4. HCl. Mole weight: 405.45. BOC Sciences 7
Nebivolol Impurity 10 HCl (RS,SR) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.31 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'S,?2R,?2'R)?-. Grades: > 95%. CAS No. 920275-23-6. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Impurity 11 (SR,SR) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.32 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'R,?2S,?2'R)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. Mole weight: 405.45. BOC Sciences 7
Nebivolol Impurity 12 HCl (RR,RR) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.33 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'R,?2R,?2'R)?-. Grades: > 95%. CAS No. 920275-25-8. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Impurity 13 HCl (SS,SS) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.34 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'S,?2S,?2'S)?-. Grades: > 95%. CAS No. 920275-27-0. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Impurity 14 (D-Nebivolol) (SR,RR) HCl An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.35 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'R,?2R,?2'S)?-. Grades: > 95%. CAS No. 213132-06-0. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Impurity 15 Nebivolol Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-93-0. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508930. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 16 Nebivolol Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-96-3. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508963. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 17 Nebivolol Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-95-2. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508952. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 18 Nebivolol Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315508-94-1. Molecular formula: C11H12ClFO2. Mole weight: 230.66. Catalog: APB1315508941. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 2 HCl (SR,RS) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.20 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'R,?2S,?2'S)?-. Grades: > 95%. CAS No. 920275-19-0. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Impurity 3 An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.24 nM. Synonyms: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,?4-dihydro-α-[[(phenylmethyl)?amino]?methyl]?-, (αR,?2R)?-. Grades: > 95%. CAS No. 1029684-20-5. Molecular formula: C17H18FNO2. Mole weight: 287.34. BOC Sciences 7
Nebivolol Impurity 36 Nebivolol Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 6-fluorochroman-2-carboxylate. CAS No. 1219915-01-1. Molecular formula: C11H11FO3. Mole weight: 210.20. Catalog: APB1219915011. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 37 Nebivolol Impurity 37. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-ethyl 6-fluorochroman-2-carboxylate. CAS No. 1335103-88-2. Molecular formula: C12H13FO3. Mole weight: 224.23. Catalog: APB1335103882. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 38 Nebivolol Impurity 38. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 6-fluorochroman-2-carboxylate. CAS No. 1335103-90-6. Molecular formula: C12H13FO3. Mole weight: 224.23. Catalog: APB1335103906. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 39 Nebivolol Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-chloro-1-(6-fluorochroman-2-yl)ethanone. CAS No. 1219914-99-4. Molecular formula: C11H10ClFO2. Mole weight: 228.65. Catalog: APB1219914994. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 4 An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.25 nM. Synonyms: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,?4-dihydro-α-[[(phenylmethyl)?amino]?methyl]?-, (αS,?2S)?-. Grades: > 95%. CAS No. 129050-29-9. Molecular formula: C17H18FNO2. Mole weight: 287.34. BOC Sciences 7
Nebivolol Impurity 40 Nebivolol Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2-chloro-1-(6-fluorochroman-2-yl)ethanone. CAS No. 1219915-00-0. Molecular formula: C11H10ClFO2. Mole weight: 228.65. Catalog: APB1219915000. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 47 Nebivolol Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-(benzylamino)-1-((S)-6-fluorochroman-2-yl)ethanol. CAS No. 1030385-16-0. Molecular formula: C18H20FNO2. Mole weight: 301.36. Catalog: APB1030385160. Alfa Chemistry Analytical Products 4
Nebivolol Impurity 5 An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.26 nM. Synonyms: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,?4-dihydro-α-[[(phenylmethyl)?amino]?methyl]?-. Grades: > 95%. CAS No. 99199-91-4. Molecular formula: C17H18FNO2. Mole weight: 287.34. BOC Sciences 7
Nebivolol Impurity 6 (SS) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.27 nM. Synonyms: (S)-(benzylamino)((S)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.26. BOC Sciences 7
Nebivolol Impurity 7 (RR) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.28 nM. Synonyms: (R)-(benzylamino)((R)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. BOC Sciences 7
Nebivolol Impurity 8 (SR) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.29 nM. Synonyms: (S)-(benzylamino)((R)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. BOC Sciences 7
Nebivolol Impurity 9 (RS) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.30 nM. Synonyms: (R)-(benzylamino)((S)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. BOC Sciences 7
Nebivolol Impurity A This active molecular is a β-adrenergic receptor antagonist. Levonebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and left ventricular failure in Europe. It is highly cardioselective under certain circumstances. In Apr 2015, US FDA approved an ANDA for nebivolol submitted by Amerigen. In Jan 2016, Forest Laboratories and the University of Chicago withdrew a phase II/III trial for Hypertension in patients with chronic obstructive pulmonary disease in USA. Uses: Treatment of hypertension and left ventricular failure. Synonyms: R67145; R-67145; R 67145; Levonebivolol. (αS,α'S,2R,2'S)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; [2S-[2R*[R*[R*(S*)]]]]-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-methanol; Levonebivolol; R 67145; l-Nebivolol. Grades: 98%. CAS No. 118457-16-2. Molecular formula: C22H25F2NO4. Mole weight: 405.44. BOC Sciences 7
Nebivolol Impurity B (SR,SS) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.17 nM. Synonyms: [2S-[2R*[R*[S*(R*)]]]]-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol. Grades: > 95%. CAS No. 119365-25-2. Molecular formula: C22H25F2NO4. Mole weight: 405.45. BOC Sciences 7
Nebivolol Impurity I HCl (RR,SR) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.21 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'S,?2R,?2'R)?-. Grades: > 95%. CAS No. 920275-20-3. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Impurity II HCl (SS,RS) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.22 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'S,?2S,?2'S)?-. Grades: > 95%. CAS No. 920299-27-0. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
(2S*,2'S*)-Nebivolol Impurity C An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.15 nM. Grades: > 95%. CAS No. 876514-31-7. Molecular formula: C11H11FO2. Mole weight: 194.21. BOC Sciences 7
Nebivolol EP Impurity A Nebivolol EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1696472-15-7. Molecular formula: C22H26FNO4. Mole weight: 387.45. Catalog: APB1696472157. Alfa Chemistry Analytical Products 4
Nebivolol EP Impurity C Nebivolol EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1224567-85-4. Molecular formula: C29H32ClF2NO4. Mole weight: 532.02. Catalog: APB1224567854. Alfa Chemistry Analytical Products 4
1-(3,4-dihydro-2H-chromen-2-yl)-2-(methylamino)ethanol An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.12 nM. Synonyms: 1-(3,4-dihydro-2H-chromen-2-yl)-2-(methylamino)ethanol. Grades: > 95%. Molecular formula: C12H17NO2. Mole weight: 207.27. BOC Sciences 7
2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone] HCl An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.13 nM. Synonyms: 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone] HCl. Grades: > 95%. Molecular formula: C22H21F2NO4. HCl. Mole weight: 401.41 36.46. BOC Sciences 7
4-Hydroxy Nebivolol An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.11 nM. Synonyms: 4-Hydroxy nebivolol hydrochloride; 6-fluoro-2-[2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]-1-hydroxyethyl]-3,4-dihydro-2H-chromen-4-ol;hydrate;hydrochloride. Grades: > 95%. CAS No. 178383-76-1. Molecular formula: C22H25F2NO5. Mole weight: 421.45. BOC Sciences 7
Desfluoro Nebivolol An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.18 nM. Synonyms: Defluoro Nebivolol; α-[[[2-(3,4-Dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]methyl]-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol; 1-(Chroman-2-yl)-2-[2-(6-fluorochroman-2-yl)]- 2-hydroxyethylamino)ethanol. Grades: > 95%. CAS No. 129101-34-4. Molecular formula: C22H26FNO4. Mole weight: 387.46. BOC Sciences 7
Nebivolol O-Beta-D-Glucuronide An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.10 nM. Synonyms: Nebivolol O-β-D-Glucuronide; 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-[2-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino]ethyl β-D-Glucopyranosiduronic Acid. Grades: > 95%. Molecular formula: C28H33F2NO10. Mole weight: 581.57. BOC Sciences 7
Nebivolol Related Compound 1 HCl (Mixture of (RR,SR) and (SS,RS) Isomer) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.36 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'R,?2S,?2'R)?-; + 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'S,?2R,?2'S)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Related Compound 2(Mixture of Diastereomers) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.37 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, (αR,?α'R,?2R,?2'S)?-; + 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, (αS,?α'S,?2R,?2'S)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. Mole weight: 405.45. BOC Sciences 7
Nebivolol Related Compound 3 HCl (Mixture of (RS,SR), (SR,SR) and (SR,RS) Isomers) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.38 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'S,?2S,?2'R)?-; + 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'R,?2S,?2'R)?-; 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'R,?2S,?2'R)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. BOC Sciences 7
Nebivolol Related Compound 4 (Mixture of (R,R) and (S,S) Isomers) An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.39 nM. Synonyms: (S)-(benzylamino)((S)-chroman-2-yl)methanol;& (R)-(benzylamino)((R)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. BOC Sciences 7

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