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A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo. Group: Biochemicals. Alternative Names: NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-ß-D-ribofuranuronamide. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.
A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14nM, 20nM, 2.4uM and 6.2nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1uM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 35920-39-9. Pack Sizes: 10mg. US Biological Life Sciences.
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Dansyl-NECA
Dansyl-NECA. Group: Biochemicals. Grades: Purified. CAS No. 219982-12-4. Pack Sizes: 1mg. US Biological Life Sciences.
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Dansyl-NECA
Dansyl-NECA is a selective fluorescent adenosine A1 receptor agonist and shows effects in permitting visualization of A1 receptors in the rat cerebellar cortex. Synonyms: Dansyl-NECA; DansylNECA; Dansyl NECA; 1-Deoxy-1- [6- [ [6- [ [ [5-dimethylamino) -1-naphthalenyl] sulfonyl] amino] hexyl] amino] -9H-purin-9-yl] -N-ethyl-β -D-ribofuranuronamide. Grades: ≥99% by HPLC. CAS No. 219982-12-4. Molecular formula: C30H40N8O6S. Mole weight: 640.75.
A potent selective adenosine receptor agonist. Group: Biochemicals. Alternative Names: N6-Benzyl-NECA. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
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2-Hexynyl-5'-N-ethylcarboxamidoadenosine
2-Hexynyl-5'-N-ethylcarboxamidoadenosine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-HEXYNYL-5'-N-ETHYLCARBOXAMIDOADANOSINE;2-HEXYNYL-5-N-ETHYLCARBOXAMIDO-*ADENOSIN;2-(1-hexyn-1-yl)adenosine-5'-n-ethyluronamide;he-neca;2-hexynyladenosine-5'-N-ethylcarboxamide;2-(1-Hexyn-1-yl)adenosine-5μ-N-ethyluronamide, 2-Hexynyl-5μ-ethylcarboxamido. Product Category: Heterocyclic Organic Compound. Appearance: Yellow Solid. CAS No. 141018-30-6. Molecular formula: C18H24N6O4. Mole weight: 415.44. Purity: >99%. Product ID: ACM141018306. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2-Hexynyl-NECA.
2-Hexynyl-5'-N-ethylcarboxamidoadenosine
Possesses high affinity to adenosine (A1 & A2) receptors, inhibiting radioligands from binding to these sites. Synonyms: 2-Hexynyl-5'-N-ethylcarboxamidoadenosine; 2-Hexynyl-NECA; HENECA. CAS No. 141018-30-6. Molecular formula: C18H24N6O4. Mole weight: 388.42.
2-Iodo-5'-ethylcarboxamido Adenosine
2-Iodo-5'-ethylcarboxamido Adenosine is a potent and selective adenosine receptor agonist. 2-Iodo-5'-ethylcarboxamido Adenosine can be used to determine binding and structural properties between receptor subtypes. Uses: A potent selective adenosine receptor agonist. Synonyms: 1-(6-Amino-2-iodo-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide; 2-Iodo-NECA. Grades: 95%. CAS No. 141018-29-3. Molecular formula: C12H15IN6O4. Mole weight: 434.19.
A selective A2 adenosine receptor antagonist. Pharmacology: Ki vs [3H]NECA at A2 receptors in rat striatal membranes: 11± 3 uM; Ki vs [3H]CHA at A1 receptors in rat cerebral cortical membranes: 45 ± 4 uM. Group: Biochemicals. Alternative Names: DMPX, 3,7-Dimethyl-1-(2-propynyl)xanthine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
A useful template for the development of A2B adenosine receptor agonists. It was confirmed to be a full agonist in a functional assay based on the measurement of its capacity to modulate cAMP levels in CHO cells expressing the hA2B receptor. Synonyms: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide; 2',3'-O-isopropylidene-NECA. CAS No. 39491-53-7. Molecular formula: C15H20N6O4. Mole weight: 348.36.
5'-Ethylcarboxamido-2-iodo-2', 3'-O-isopropyl ideneadenosine. Group: Biochemicals. Alternative Names: 1-(6-Amino-2-iodo-9H-purin-9-yl)-1-deoxy-N-ethyl-2,3-O-(1-methylethylidene)-b-D-ribofuranuronamide; 2-Iodo-Isopropylidene-NECA. Grades: Highly Purified. CAS No. 162936-24-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
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5'-Ethylcarboxamido-2-iodoadenosine
5'-Ethylcarboxamido-2-iodoadenosine. Group: Biochemicals. Alternative Names: 2-Iodo-NECA. Grades: Highly Purified. CAS No. 141018-29-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg. Molecular Formula: C12H15IN6O4. US Biological Life Sciences.
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5'-Ethyl carboxamidoadenosine
5'-Ethyl carboxamidoadenosine. Group: Biochemicals. Alternative Names: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide; NECA. Grades: Highly Purified. CAS No. 35920-39-9. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C12H16N6O4. US Biological Life Sciences.
Worldwide
5'-Ethylcarboxamido-adenosine
5'-Ethylcarboxamido-adenosine, a remarkable biomedicine, exhibits its prowess in cancer therapeutics. This extraordinary compound operates as an adenosine receptor agonist, effectively restraining the proliferation of malignant cells while orchestrating apoptosis. Uses: Vasodilator agents. Synonyms: NECA; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide; 5'-Ethylcarboxamido-D-adenosine. Grades: ≥ 95% by HPLC. CAS No. 35920-39-9. Molecular formula: C12H16N6O4. Mole weight: 308.29.
5'-N-Ethylcarboxamido-adenosine
5'-N-Ethylcarboxamido-adenosine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NECA, ST092443, SMR000104521, 5-N-Ethylcarboxamidoadenosine, ZINC00053379, (2S,3S,4R)-5-(6-aminopurin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide, 35920-39-9, 78647-50-4, ChemDiv2_002128, AC1MF9Y7, AGN-PC-00IQS6, MLS000108567, MLS001077284, E2387_SIGMA, CTK8F6931, 5-(N-Ethylcarboxamido)adenosine, MolPort-001-935-391, HMS1375A16, HMS2187P21, HMS3268O07. Product Category: Heterocyclic Organic Compound. Appearance: White to off-white powder. CAS No. 78647-50-4. Molecular formula: C12H16N6O4. Mole weight: 308.3. Purity: 0.96. IUPACName: 5-(6-aminopurin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide. Canonical SMILES: CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O. Product ID: ACM78647504. Alfa Chemistry ISO 9001:2015 Certified. Categories: 5-(N-Ethylcarboxamido)adenosine.
A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9nM for human A3R, and 113nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6uM and 2.05uM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA-induced bronchoconstriction in an allergic murine model. Group: Biochemicals. Grades: Highly Purified. CAS No. 212329-37-8. Pack Sizes: 5mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences.
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BODIPY 630/650X
BODIPY 630/650X is a fluorescent conjugate of the adenosine receptor ligand N-ethylcarboxamido-adenosine (NECA). BODIPY 630/650X displays excitation/emission maxima of 630/650 nm, respectively [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 380367-48-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-110213.
Cytochalasin E
It is produced by the strain of Rosellina necatrix. It has many biological activities, such as inhibiting cytokinesis reversibly, inhibiting megasophil endocytosis and exocytosis. Synonyms: (7S,13E,16S,18R,19E)-6,7-Epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22-trione; NSC 175151; [4S-(1E, 4R*, 6S*, 7E, 11aR*, 14R*, 14aR*, 15R*, 15aS*, 16aR*, 16bR*)]-3, 13, 14, 14a, 15, 15a, 16a, 16b-Octahydro-6-hydroxy-4, 6, 15, 15a-tetramethyl-14-(phenylmethyl)-[1, 3]Dioxacyclotridecino[4, 5-d]oxireno[f]isoindole-5, 10, 12(4H, 6H)-trione. Grades: >99% by HPLC. CAS No. 36011-19-5. Molecular formula: C28H33NO7. Mole weight: 495.56.
Dinitolmide
Dinitolmide (Zoalene), a fodder additive for poultry, has anti-coccidial effect. Dinitolmide can be used to prevent infections induced by Eimeria , such as Eimeria tenella , Eimeria necatrix , Eimeria brunette , and so on [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Zoalene. CAS No. 148-01-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1004.
KI-7
KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC 50 =445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC 50 s of 2390 nM and 2550 nM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1489263-00-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-131032.
LUF 6000
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). It was found to be an allosteric enhancer of Emax. It exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher. It was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. It converted a nucleoside A3 AR antagonist MRS542. It has anti-inflammatory effect. Uses: Luf6000 has anti-inflammatory effect. Synonyms: LUF6000; LUF 6000; LUF-6000. N-(3,4-Dichlorophenyl)-2-cyclohexyl-1H-imidazo[4,5-c]quinolin-4-amine;2-Cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo[4,5-c]quinolin-4-amine. Grades: >98 %. CAS No. 890087-21-5. Molecular formula: C22H20Cl2N4. Mole weight: 411.33.
Meptyldinocap
Meptyldinocap (2,4-DNOPC) is a novel powdery mildew (Erysiphe necator) fungicide which shows protectant and post-infective activities. Synonyms: 2,4-DNOPC. Grades: >98%. CAS No. 131-72-6. Molecular formula: C18H24N2O6. Mole weight: 364.39.
MRE 3008F20
MRE 3008F20 is a potent adenosine A3 receptor competitive antagonist, which is selective for human A3 receptors over human A1 and A2A receptors (Ki= 0.29, 141 and 1197 nM respectively). MRE 3008F20 has also been studied extensively in recent advances in adenosine receptor ligand in pulmonary diseases. Synonyms: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea; MRE 3008-F20; MRE 3008F20; MRE 3008 F20; MRE-3008-F20; MRE3008F20; MRE3008F20; MCP-NECA; MCP NECA; MCPNECA. Grades: ≥98% by HPLC. CAS No. 252979-43-4. Molecular formula: C21H20N8O3. Mole weight: 432.44.
N6-Benzyl -5'-ethyl carboxamidoadenosine
N6-Benzyl -5'-ethyl carboxamidoadenosine. Group: Biochemicals. Alternative Names: N6-Benzyl-NECA; 1-Deoxy-N-ethyl-1-[6-[(phenylmethyl)amino]-9H-purin-9-yl]-b-D-ribofuranuronamide. Grades: Highly Purified. CAS No. 152918-32-6. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C19H22N6O4. US Biological Life Sciences.
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N6-Benzyl-5'-ethylcarboxamido Adenosine
A potent selective adenosine receptor agonist. Uses: A potent selective adenosine receptor agonist. Synonyms: 1-Deoxy-N-ethyl-1-[6-[(phenylmethyl)amino]-9H-purin-9-yl]-β-D-ribofuranuronamide; N6-Benzyl-NECA. Grades: 97%. CAS No. 152918-32-6. Molecular formula: C19H22N6O4. Mole weight: 398.42.