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| Product | Description | |
|---|---|---|
| neprilysin | A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13. Group: Enzymes. Synonyms: neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metallo. Enzyme Commission Number: EC 3.4.24.11. CAS No. 82707-54-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4292; neprilysin; EC 3.4.24.11; 82707-54-8; neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metalloendopeptidase; kidney-brush-border neutral endopeptidase; kidney-brush-border neutral proteinase; endopeptidase-2; CALLA glycoprotein; CALLA; common acute lymphoblastic leukemia antigen; CALLA glycoproteins; common acute lymphoblastic leukemia-associated antigens; neutral metallendopeptidase; membrane metalloendopeptidase; NEP; neutral endopeptidase 24.11; CD10; neutral endopeptidase; acute lymphoblastic leukemia antigen. Cat No: EXWM-4292. |  |
| Neprilysin/CD10 human | recombinant, expressed in HEK 293 cells, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| 2,3-Dihydro-3-oxo-5-isothiazolecarboxylic Acid | 2,3-Dihydro-3-oxo-5-isothiazolecarboxylic Acid is an intermediate used to prepare substituted β-aminopropionic acid derivatives as neprilysin inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1257444-26-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C4H3NO3S, Molecular Weight: 145.139999999999. US Biological Life Sciences. |  Worldwide |
| 2R,4R-Sacubitril | An isomer of Sacubitril. Sacubitril is a neprilysin inhibitor that is commonly used in combination with valsartan (an angiotensin II receptor blocker) to form a dual-acting medication known as sacubitril/valsartan. Synonyms: (2R,4R)-Sacubitril; LCZ 696 Impurity B; 4-((rel-(2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; Sacubitril-(2R,4R) Isomer. Grade: 90%. CAS No. 766480-48-2. Molecular formula: C24H29NO5. Mole weight: 411.49. |  |
| (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride | (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 149690-12-0. Pack Sizes: 50mg, 250mg. Molecular Formula: C20H26ClNO2. US Biological Life Sciences. | Worldwide |
| (2R,4S)-4-Amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride | An impurity of Sacubitril, a neprilysin inhibitor that is used in combination with valsartan to treat high blood pressure. Synonyms: 1038924-71-8; (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride(2R,4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoic acid; hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride; SCHEMBL597864. CAS No. 1038924-71-8. Molecular formula: C18H22ClNO2. Mole weight: 319.8. | |
| 6-Chloro 3-Methyl Uracil | 6-Chloro 3-Methyl Uracil is an impurity of Sacubitril. Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Synonyms: 6-Chloro-3-methyluracil; 6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione; 3-Methyl-6-chlorouracil; 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione; 6-Chloro-3-methylpyrimidine-2,4-dione; 6-Chloro-2-hydroxy-3-methylpyrimidin-4(3H)-one. CAS No. 4318-56-3. Molecular formula: C5H5ClN2O2. Mole weight: 160.56. | |
| Angiotensin Fragment 1-7 acetate | Angiotensin Fragment 1-7 is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity with IC50 of 0.65 μM. This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I. It has been studied in the context of ameliorating the symptoms of metabolic syndrome. Synonyms: 5-L-isoleucine-1-7-angiotensin II; Ang-(1-7). Grade: ≥95%. Molecular formula: C41H62N12O11·xC2H4O2. Mole weight: 899. | |
| Bexarotene (4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic Acid) | A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce AB40 and AB42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6h and 50% reduction in 72h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of AB proteases, insulin degrading enzyme, and neprilysin. Group: Biochemicals. Grades: Highly Purified. CAS No. 153559-49-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| dactylysin | An endopeptidase of 100 kDa secreted from the skin of the amphibian, Xenopus laevis (Dactylêtre du Cap). Resembles neprilysin in insensitivity to 1 μM captopril, but differs from it in being insensitive to thiorphan (1 μM) and unable to digest [Met5]enkephalin, [Leu5]enkephalin, oxytocin, and substance P-(7-11)-peptide. A similar endopeptidase is found in human neuroblastoma cells. Group: Enzymes. Synonyms: peptide hormone inactivating endopeptidase; PHIE. Enzyme Commission Number: EC 3.4.24.60. CAS No. 139466-40-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4343; dactylysin; EC 3.4.24.60; 139466-40-3; peptide hormone inactivating endopeptidase; PHIE. Cat No: EXWM-4343. | |
| (Des-Glu22)-Amyloid β-Protein (1-40) | Osaka mutation is the first deletion type mutation found in APP and Aβ. Aβ E22delta mutant is more resistant to degradation of two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme. The synthetic mutant Aβ has unusual aggregation properties, with enhanced oligomerization but no fibrillization. It inhibits long-term hippocampal enhancement more effectively than wild-type Aβ. Synonyms: Amyloid β-Protein (1-40) Osaka or Japanese Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH. Grade: ≥95%. CAS No. 1678416-36-8. Molecular formula: C189H288N52O55S. Mole weight: 4200.75. | |
| endothelin-converting enzyme 1 | A phosphoramidon-sensitive metalloendopeptidase in peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor. Group: Enzymes. Synonyms: endothelin-converting enzyme; ECE-1. Enzyme Commission Number: EC 3.4.24.71. CAS No. 138238-81-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4355; endothelin-converting enzyme 1; EC 3.4.24.71; 138238-81-0; endothelin-converting enzyme; ECE-1. Cat No: EXWM-4355. | |
| (Gly21)-Amyloid β-Protein (1-42) | The Flemish mutation (A21G) displays a decreased tendency to aggregate and a reduced neurotoxicity. A21G is pathogenic because it is degraded by Neprilysin significantly more slowly than WT Abeta42. Synonyms: Amyloid β-Protein (1-42) A21G; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Gly-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine. Grade: ≥95% by HPLC. CAS No. 383200-53-1. Molecular formula: C202H309N55O60S. Mole weight: 4500.08. | |
| (Lys22)-Amyloid β-Protein (1-40) | (Lys22)-Amyloid β-Protein (1-40) is an Italian mutation of β-amyloid 1-40 (E22K), which aggregates faster than wild-type sequence 1-40. It exhibits higher neurotoxicity, probably due to the salt bridge formed between Lys22 and Asp23 in the minor conformer. Like the Arctic, Flemish and Dutch mutants, it is degraded by neprilysin much more slowly than the wild-type Aβ. Synonyms: Amyloid β-Protein (1-40) Italian Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-Valine, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-lysyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-. Grade: ≥95%. CAS No. 302905-01-7. Molecular formula: C195H300N54O56S. Mole weight: 4328.92. | |
| Mca-(Ala7,Lys(Dnp)9)-Bradykinin | Mca-(Ala7,Lys(Dnp)9)-Bradykinin is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase related to neprilysin in amino acid sequence. It is used as a substrate for insulin-degrading enzymes (IDE) and ACE2. Synonyms: Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH; N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine; (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl); N2-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine. Grade: 95%. CAS No. 323577-36-2. Molecular formula: C66H81N15O19. Mole weight: 1388.44. | |
| MeOSuc-Gly-Leu-Phe-AMC | MeOSuc-Gly-Leu-Phe-AMC is a fluorogenic substrate for neprilysin 2. Synonyms: MeOSuc-GLF-AMC; L-Phenylalaninamide, N-(4-methoxy-1,4-dioxobutyl)glycyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; N-(4-Methoxy-4-oxobutanoyl)glycyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-phenylalaninamide; methyl 4-((2-(((S)-4-methyl-1-(((S)-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-4-oxobutanoate. Grade: ≥95%. CAS No. 201854-05-9. Molecular formula: C32H38N4O8. Mole weight: 606.68. | |
| meprin A | A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC 3.4.24.11 (astacin family). Formerly included in EC 3.4.24.11. Group: Enzymes. Synonyms: endopeptidase-2; meprin-a; meprin; N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase; PABA-peptide hydrolase; PPH. Enzyme Commission Number: EC 3.4.24.18. CAS No. 148938-24-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4299; meprin A; EC 3.4.24.18; 148938-24-3; endopeptidase-2; meprin-a; meprin; N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase; PABA-peptide hydrolase; PPH. Cat No: EXWM-4299. | |
| N-[(RS)-1-Carboxy-3-phenyl-propyl]-Ala-Ala-Phe-4-Abz-OH | N-[(RS)-1-Carboxy-3-phenyl-propyl]-Ala-Ala-Phe-4-Abz-OH is a specific inhibitor of thimet oligopeptidase (soluble metalloendopeptidase, EC 3.4.24.15) with a Ki of 0.027±0.003 μM. Neprilysin (Endopeptidase-2, EC 3.4.24.11) converts it into a potent inhibitor of angiotensin-converting enzyme (ACE). Synonyms: Cpp-AAF-pAb; Cfp-aaf-pab; N-(1-Carboxy-3-phenylpropyl)-ala-ala-phe-p-aminobenzoate; N-(1-Carboxy-3-phenylpropyl)-alanyl-alanyl-phenylalanine-4-aminobenzoate; L-Phenylalaninamide, N-(1-carboxy-3-phenylpropyl)-L-alanyl-L-alanyl-N-(4-carboxyphenyl)-; N-(1-Carboxy-3-phenylpropyl)-L-alanyl-N-{(2S)-2-[(4-carboxyphenyl)amino]-3-phenylpropanoyl}-L-alaninamide. Grade: ≥95%. CAS No. 116560-97-5. Molecular formula: C32H36N4O7. Mole weight: 588.66. | |
| PACAP-38 (human, mouse, ovine, porcine, rat) | PACAP-38 (human, mouse, ovine, porcine, rat) is a multifunctional neuropeptide that interacts with PACAP receptors and vasoactive intestinal peptide receptors to enhance intracellular cyclic AMP levels and exert systemic effects. It is a PAC1 agonist that strongly increases α-secretase activity. Upregulation of the APP-degrading enzyme promotes non-amyloidogenic processing of APP by reducing Aβ40/42 production, and thus may contribute to the prevention of Alzheimer's disease. Intranasal application of PACAP-38 in APP[V717I]-transgenic mice promotes the production of Aβ-degrading enzyme neprilysin by inducing somatostatin. Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat); H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-glycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-arginyl-L-tyrosyl-L-lysyl-L-glutaminyl-L-arginyl-L-valyl-L-lysyl-L-asparagyl-L-lysinamide. Grade: 95%. CAS No. 124123-15-5. Molecular formula: C203H331N63O53S. Mole weight: 4534.32. | |
| Sacubitril | Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC 50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHU-377. CAS No. 149709-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407. |  |
| Sacubitrilat | Sacubitrilat (Desethyl Sacubitril) is an active neprilysin ( NEP ) inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Desethyl Sacubitril; LBQ-657. CAS No. 149709-44-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17620. | |
| Sacubitril-[d4] | An isotope labelled AHU377, a methyl ester prodrug form of the neprilysin inhibitor LBQ657. Synonyms: AHU377-d4; (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoicacid,alpha-ethylester. Grade: ≥99% atom D. CAS No. 1884269-07-1. Molecular formula: C24H25D4NO5. Mole weight: 415.5. | |
| Sacubitril sodium | Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC 50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHU-377 sodium. CAS No. 149690-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407B. | |
| Sacubitril/Valsartan | Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure [1] [2] [3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LCZ696. CAS No. 936623-90-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18204A. | |
| Spinorphin | Spinorphin is an endogenous neuropeptide that inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Spinorphin exhibits antinociceptive effects in mice. Synonyms: L-Threonine, N-(N-(1-(N-(N-(N-L-leucyl-L-valyl)-L-valyl)-L-tyrosyl)-L-prolyl)-L-tryptophyl)-. CAS No. 137201-62-8. Molecular formula: C45H64N8O10. Mole weight: 877.03. | |
| Thiorphan | Thiorphan is a selective NEP (neprilysin) inhibitor with an IC 50 of 6.9 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 76721-89-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-W013375. | |
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