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| Product | Description | |
|---|---|---|
| 2-Benzyl-1,3-propanediol Diacetate | 2-Benzyl-1,3-propanediol Diacetate is an intermediate in the synthesis of Sinorphan (S490950), an inhibitor of angiotensin-converting enzyme and neutral endopeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 110230-64-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H18O4. US Biological Life Sciences. |  Worldwide |
| 3-Aminocyclohexane carboxylic Acid | 3-Aminocyclohexane carboxylic Acid is an intermediate used to prepare PF-04449913 as potent and orally bioavailable Smoothened inhibitor and potential antitumor. It is also used in the synthesis of functionalized glutaramides as selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Group: Biochemicals. Grades: Highly Purified. CAS No. 25912-50-9. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H13NO2, Molecular Weight: 143.18. US Biological Life Sciences. | Worldwide |
| 3-? (Boc-?amino) ?cyclohexane carboxyli?c Acid | 3-? (Boc-?amino) ?cyclohexane carboxyli?c Acid is used to prepare functionalized glutaramides as selective inhibitors of neutral endopeptidase. It is also used to synthesize Rho-kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 334932-13-7. Pack Sizes: 500mg, 1g. Molecular Formula: C12H21NO4, Molecular Weight: 243.3. US Biological Life Sciences. | Worldwide |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. |  |
| Boc-2-aminoindane-2-carboxylic acid | Boc-2-aminoindane-2-carboxylic acid is used to prepare thiol dipeptides as dual inhibitors of angiotensin-I-converting enzyme and neutral endopeptidase. It is also used in the synthesis of bombesin analogs. Synonyms: Boc-Aic-OH; 2-((tert-Butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid; N-BOC-2-AMINOINDANE-2-CARBOXYLIC ACID; 2-(BOC-AMINO)INDANE-2-CARBOXYLIC ACID; 2-[(tert-butoxy)carbonylamino]indane-2-carboxylic acid; BOC AIC OH. Grades: ≥ 98% (HPLC). CAS No. 71066-00-7. Molecular formula: C15H19NO4. Mole weight: 277.32. | |
| cathepsin F | Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3. Group: Enzymes. Enzyme Commission Number: EC 3.4.22.41. CAS No. 65997-74-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4216; cathepsin F; EC 3.4.22.41; 65997-74-2. Cat No: EXWM-4216. |  |
| cathepsin S | A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family). Group: Enzymes. Enzyme Commission Number: EC 3.4.22.27. CAS No. 71965-46-3. CTSS. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4201; cathepsin S; EC 3.4.22.27; 71965-46-3. Cat No: EXWM-4201. | |
| cathepsin V | Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2. Group: Enzymes. Synonyms: Cathepsin L2; cathepsin U. Enzyme Commission Number: EC 3.4.22.43. CAS No. 223670-00-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4218; cathepsin V; EC 3.4.22.43; 223670-00-6; Cathepsin L2; cathepsin U. Cat No: EXWM-4218. | |
| CGS 35066 | CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor with > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 = 22 and 2300 nM, respectively). It blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH). Synonyms: CGS 35066; CGS35066; CGS-35066; α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid; (2S)-3-dibenzofuran-3-yl-2-(phosphonomethylamino)propanoic acid. Grades: ≥99% by HPLC. CAS No. 261619-50-5. Molecular formula: C16H16NO6P. Mole weight: 349.28. | |
| deuterolysin | Proteolytic activity found in Penicillium roqueforti, P. caseicolum, Aspergillus sojae and A. oryzae. Optimum pH of 5 for digesting various proteins. Strong action on protamine and histones. Insensitive to phosphoramidon. About 20 kDa. A distinct Aspergillus sojae endopeptidase is larger and has a neutral pH optimum. Type example of peptidase family M35. Formerly included in EC 3.4.24.4. Group: Enzymes. Synonyms: Penicillium roqueforti protease II; microbial neutral proteinase II; acid metalloproteinase; neutral proteinase II; Penicillium roqueforti metalloproteinase. Enzyme Commission Number: EC 3.4.24.39. CAS No. 247028-11-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4321; deuterolysin; EC 3.4.24.39; 247028-11-1; Penicillium roqueforti protease II; microbial neutral proteinase II; acid metalloproteinase; neutral proteinase II; Penicillium roqueforti metalloproteinase. Cat No: EXWM-4321. | |
| Ecadotril | Ecadotril is a neutral endopeptidase(NEP) inhibitor and determined by the presence of peptidase family M13 as a neutral endopeptidase inhibited by phosphoramidon. lt is the (S)-enantiomer of racecadotril. It acts as an antihypertensive. Uses: Ecadotril acts as an antihypertensive. Synonyms: Ecadotril; BAY y 7432; BAY-y 7432; BP 1.02; S049; S.049; Sinorphan; N-[(S)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine benzyl ester;S-Acetorphan;Sinorphan;Benzyl 2-[[(2S)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate; Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (S)-. Grades: 95%. CAS No. 112573-73-6. Molecular formula: C21H23NO4S. Mole weight: 385.48. | |
| Immobilized Pepsin (Agarose Resin) | Immobilized Pepsin allows efficient generation of F(ab?)2 from IgG. Pepsin is a nonspecific endopeptidase that is active only at acid pH and irreversibly denatured at neutral or alkaline pH. Immobilized Pepsin is advantageous because the digestion can be immediately stopped by simply removing the gel from the IgG. Digestion by pepsin normally produces a F(ab?)2 fragment and numerous small peptides of the Fc portion. The resulting F(ab?)2 fragment is composed of two disulfide-connected Fab units. The Fc fragment is extensively degraded, and its small fragments can be separated from F(ab?)2 by dialysis, gel filtration or ion exchange chromatography. Group: Enzymes. Synonyms: Immobilized Pepsin. Enzyme Commission Number: EC 3.4.23.1. Pepsin. Storage: Upon receipt store product at 4-8°C. Product is shipped at ambient temperature. Form: 50% slurry containing 50% glycerol in 0.1M sodium acetate; pH 4.5, and 0.05% sodium azide as a preservative. Immobilized Pepsin (Agarose Resin); Protein Fragmentation Enzymes Kits; Fab fragment; Immobilized Pepsin; Pepsin. Pack: 5mL settled gel, contains sufficient material to generate F(ab?)2 fragments from up to 20 samples containing up to 10mg of IgG. Cat No: NATE-1866. | |
| LHW090-A7 sodium | LHW090-A7 is an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. It has been shown to induce the increase of plasma levels of endogenous atrial natriuretic peptides (NPs). Synonyms: (S)-3-(3'-Chloro-[1,1'-biphenyl]-4-yl)-2-(((S)-1-ethoxy-1-oxopropan-2-yl)amino)propanoic sodium salt. Grades: ≥98%. Molecular formula: C20H21ClNO4·Na. Mole weight: 397.8. | |
| neprilysin | A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13. Group: Enzymes. Synonyms: neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metallo. Enzyme Commission Number: EC 3.4.24.11. CAS No. 82707-54-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4292; neprilysin; EC 3.4.24.11; 82707-54-8; neutral endopeptidase; endopeptidase 24.11; kidney-brush-border neutral peptidase; enkephalinase (misleading); endopeptidase-2; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; endopeptidase; membrane metalloendopeptidase; kidney-brush-border neutral endopeptidase; kidney-brush-border neutral proteinase; endopeptidase-2; CALLA glycoprotein; CALLA; common acute lymphoblastic leukemia antigen; CALLA glycoproteins; common acute lymphoblastic leukemia-associated antigens; neutral metallendopeptidase; membrane metalloendopeptidase; NEP; neutral endopeptidase 24.11; CD10; neutral endopeptidase; acute lymphoblastic leukemia antigen. Cat No: EXWM-4292. | |
| Opiorphin | Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC 50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 864084-88-8. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-W345510. |  |
| Phosphoramidon disodium | Phosphoramidon disodium, a microbial metabolite , is a specific metalloprotease thermolysin inhibitor with an IC 50 of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme ( ECE ), neutral endopeptidase ( NEP ), and angiotensin-converting enzyme ( ACE ) with IC 50 values of 3.5, 0.034, and 78 μM, respectively [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 164204-38-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2021A. | |
| Racecadotril | Racecadotril (Acetorphan) is a neutral endopeptidase ( NEP ) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with K i s of 4500 and 6.1 nM, , respectively. Antidiarrheal agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetorphan. CAS No. 81110-73-8. Pack Sizes: 10 mM * 1 mL; 200 mg; 1 g. Product ID: HY-17399. | |
| Sar-[D-Phe8]-des-Arg9-Bradykinin | Sar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. It shows hypotensive and angiogenic activity in vivo. Uses: Hypotensive agent. Synonyms: Sar[DPhe8][des-Arg9]BK; [N-methylglycine,D-Phe8,des-Arg9]bradykinin. CAS No. 126959-88-4. Molecular formula: C47H66N12O11. Mole weight: 975.11. | |
| SQ28603 | SQ28603 is a selective neutral endopeptidase (NEP 3.4.24.11) inhibitor. Synonyms: 3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid; SQ 28,603; SQ 28603; SQ-28603. CAS No. 100845-83-8. Molecular formula: C13H17NO3S. Mole weight: 267.34. | |
| stromelysin 1 | An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4298; stromelysin 1; EC 3.4.24.17; 79955-99-0; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: EXWM-4298. | |
| WS75624 A | WS75624 A is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 A; WS 75624 A; WS-75624A. Molecular formula: C18H24N2O5S. Mole weight: 380.5. | |
| WS75624 B | WS75624 B is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 B; WS 75624 B; WS-75624B. Molecular formula: C18H24N2O5S. Mole weight: 380.5. | |
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