Neutral Endope Suppliers USA
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Product | Description | |
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2-Benzyl-1,3-propanediol Diacetate Quick inquiry Where to buy Suppliers range | 2-Benzyl-1,3-propanediol Diacetate is an intermediate in the synthesis of Sinorphan (S490950), an inhibitor of angiotensin-converting enzyme and neutral endopeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 110230-64-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H18O4. US Biological Life Sciences. | Worldwide |
3-Aminocyclohexane carboxylic Acid Quick inquiry Where to buy Suppliers range | 3-Aminocyclohexane carboxylic Acid is an intermediate used to prepare PF-04449913 as potent and orally bioavailable Smoothened inhibitor and potential antitumor. It is also used in the synthesis of functionalized glutaramides as selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Group: Biochemicals. Grades: Highly Purified. CAS No. 25912-50-9. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H13NO2, Molecular Weight: 143.18. US Biological Life Sciences. | Worldwide |
3-? (Boc-?amino) ?cyclohexane carboxyli?c Acid Quick inquiry Where to buy Suppliers range | 3-? (Boc-?amino) ?cyclohexane carboxyli?c Acid is used to prepare functionalized glutaramides as selective inhibitors of neutral endopeptidase. It is also used to synthesize Rho-kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 334932-13-7. Pack Sizes: 500mg, 1g. Molecular Formula: C12H21NO4, Molecular Weight: 243.3. US Biological Life Sciences. | Worldwide |
Aminopeptidase N Inhibitor Quick inquiry Where to buy Suppliers range | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
Boc-2-aminoindane-2-carboxylic acid Quick inquiry Where to buy Suppliers range | Boc-2-aminoindane-2-carboxylic acid is used to prepare thiol dipeptides as dual inhibitors of angiotensin-I-converting enzyme and neutral endopeptidase. It is also used in the synthesis of bombesin analogs. Synonyms: Boc-Aic-OH; 2-((tert-Butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid; N-BOC-2-AMINOINDANE-2-CARBOXYLIC ACID; 2-(BOC-AMINO)INDANE-2-CARBOXYLIC ACID; 2-[(tert-butoxy)carbonylamino]indane-2-carboxylic acid; BOC AIC OH. Grades: ≥ 98% (HPLC). CAS No. 71066-00-7. Molecular formula: C15H19NO4. Mole weight: 277.32. | |
CGS 35066 Quick inquiry Where to buy Suppliers range | CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor with > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 = 22 and 2300 nM, respectively). It blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH). Synonyms: CGS 35066; CGS35066; CGS-35066; α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid; (2S)-3-dibenzofuran-3-yl-2-(phosphonomethylamino)propanoic acid. Grades: ≥99% by HPLC. CAS No. 261619-50-5. Molecular formula: C16H16NO6P. Mole weight: 349.28. | |
Ecadotril Quick inquiry Where to buy Suppliers range | Ecadotril is a neutral endopeptidase(NEP) inhibitor and determined by the presence of peptidase family M13 as a neutral endopeptidase inhibited by phosphoramidon. lt is the (S)-enantiomer of racecadotril. It acts as an antihypertensive. Uses: Ecadotril acts as an antihypertensive. Synonyms: Ecadotril; BAY y 7432; BAY-y 7432; BP 1.02; S049; S.049; Sinorphan; N-[(S)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine benzyl ester;S-Acetorphan;Sinorphan;Benzyl 2-[[(2S)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate; Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (S)-. Grades: 95%. CAS No. 112573-73-6. Molecular formula: C21H23NO4S. Mole weight: 385.48. | |
LHW090-A7 sodium Quick inquiry Where to buy Suppliers range | LHW090-A7 is an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. It has been shown to induce the increase of plasma levels of endogenous atrial natriuretic peptides (NPs). Synonyms: (S)-3-(3'-Chloro-[1,1'-biphenyl]-4-yl)-2-(((S)-1-ethoxy-1-oxopropan-2-yl)amino)propanoic sodium salt. Grades: ≥98%. Molecular formula: C20H21ClNO4·Na. Mole weight: 397.8. | |
Phosphoramidon Quick inquiry Where to buy Suppliers range | Phosphoramidon is a neutral endopeptidase 24.11 (NEP, neprilysin; EC 3.4.24.11) (Ki=2nM) inhibitor, which cleaves bioactive peptides such as bradykinin, neurotensin, and enkephalin. It also inhibits neprilysin 2 (Ki~2nM) and endothelin-converting enzyme (ECE) (IC50=0.68 μM). Uses: Peptide Inhibitors. CAS No. 119942-99-3. Product ID: R0805. | |
Sar-[D-Phe8]-des-Arg9-Bradykinin Quick inquiry Where to buy Suppliers range | Sar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. It shows hypotensive and angiogenic activity in vivo. Uses: Hypotensive agent. Synonyms: Sar[DPhe8][des-Arg9]BK; [N-methylglycine,D-Phe8,des-Arg9]bradykinin. CAS No. 126959-88-4. Molecular formula: C47H66N12O11. Mole weight: 975.11. | |
SQ28603 Quick inquiry Where to buy Suppliers range | SQ28603 is a selective neutral endopeptidase (NEP 3.4.24.11) inhibitor. Synonyms: 3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid; SQ 28,603; SQ 28603; SQ-28603. CAS No. 100845-83-8. Molecular formula: C13H17NO3S. Mole weight: 267.34. | |
WS75624 A Quick inquiry Where to buy Suppliers range | WS75624 A is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 A; WS 75624 A; WS-75624A. Molecular formula: C18H24N2O5S. Mole weight: 380.5. | |
WS75624 B Quick inquiry Where to buy Suppliers range | WS75624 B is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 B; WS 75624 B; WS-75624B. Molecular formula: C18H24N2O5S. Mole weight: 380.5. |