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| Product | Description | |
|---|---|---|
| NK1 receptor antagonist 2 | NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 579475-17-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145250. |  |
| 2-? (3, ?5-?Bis (trifluoromethyl) ?phenyl) ?-?2-?methylpropanoic Acid | 2-? (3, ?5-?Bis (trifluoromethyl) ?phenyl) ?-?2-?methylpropanoic Acid is a reagent used in the synthesis of NK1/NK3 receptor antagonists used in the treatment of depression. Group: Biochemicals. Grades: Highly Purified. CAS No. 289686-70-0. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H10F6O2, Molecular Weight: 300.2. US Biological Life Sciences. |  Worldwide |
| 2-Hydroxy-4-(phenylmethyl)-3-morpholinone | 2-Hydroxy-4-(phenylmethyl)-3-morpholinone, is an intermediate used for the synthesis of NK1 Receptor Antagonist Aprepitant (A729800), used as as antiemetic drugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 287930-73-8. Pack Sizes: 500mg, 5g. Molecular Formula: C11H13NO3, Molecular Weight: 207.23. US Biological Life Sciences. | Worldwide |
| (2R) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl]ethoxy]-4- (phenylmethyl) -3-morpholinone | (2R) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl]ethoxy]-4- (phenylmethyl) -3-morpholinone, is the key 3- (4-Fluorophenyl) morpholine moiety used in the synthesis of NK1 receptor antagonist Aprepitant (A729800). Group: Biochemicals. Grades: Highly Purified. CAS No. 287930-75-0. Pack Sizes: 25mg, 250mg. Molecular Formula: C21H19F6NO3, Molecular Weight: 447.37. US Biological Life Sciences. | Worldwide |
| (2R,3R)-2-benzhydryl-N-benzylquinuclidin-3-amine-(D)-10-camphorsulfonate | (2R,3R)-2-benzhydryl-N-benzylquinuclidin-3-amine-(D)-10-camphorsulfonate is an impurity of Maropitant. Maropitant is a neurokinin (NK1) receptor antagonist. Synonyms: Maropitant Impurity 1. Grade: 99% by HPLC. CAS No. 2243127-08-2. Molecular formula: C37H46N2O4S. Mole weight: 614.85. |  |
| (2R,4S)-Benzyl 5-oxo-2,4-diphenyloxazolidine-3-carboxylate | (2R,4S)-Benzyl 5-oxo-2,4-diphenyloxazolidine-3-carboxylate is an intermediate in the preparation of Rolapitant (R639800). Rolapitant is an NK1 receptor antagonist that is used in the treatment of chemotherapy-induced nausea and vomiting. Group: Biochemicals. Grades: Highly Purified. CAS No. 205654-80-4. Pack Sizes: 250mg, 1g. Molecular Formula: C23H19NO4, Molecular Weight: 373.4. US Biological Life Sciences. | Worldwide |
| (2S,3S)-2-benzhydryl-N-benzylquinuclidin-3-amine-(1R)-10-camphorsulfonate | (2S,3S)-2-benzhydryl-N-benzylquinuclidin-3-amine-(1R)-10-camphorsulfonate is an impurity of Maropitant. Maropitant is a neurokinin (NK1) receptor antagonist. Synonyms: Maropitant Impurity A; Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1R,4S)-, compd. with (2S,3S)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine (1:1). Grade: 99% by HPLC. CAS No. 862543-55-3. Molecular formula: C37H46N2O4S. Mole weight: 614.85. | |
| 2- (Trimethylstannyl) pyridine | 2- (Trimethylstannyl) pyridine is a useful synthetic intermediate. It is used to prepare L-mannonic acid derivatives as HIV-1 protease inhibitors. It is also used to synthesize aryl indole NK1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 13737-05-8. Pack Sizes: 1g, 10g. Molecular Formula: C8H13NSn, Molecular Weight: 241.91. US Biological Life Sciences. | Worldwide |
| Acetylaszonalenin | Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes. It acts as an antagonist of neurokinin-1 (NK1) receptor. Synonyms: 2-acetoxy-n,n,n-trimethylethanaminium iodide; (+)-Acetylaszonalenin; (5aS,13aR,14aS)-5-acetyl-14a-(1,1-dimethyl-2-propen-1-yl)-5a,13a,14,14a-tetrahydro-indolo[3',2':4,5]pyrrolo[2,1-c][1,4]benzodiazepine-7,13(5H,12H)-dione; LL-S490β; Antibiotic LL-S490β. Grade: ≥95%. CAS No. 42230-55-7. Molecular formula: C25H25N3O3. Mole weight: 415.48. | |
| Aprepitant | Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3nM; IC50 = 0.09nM for the human receptor).It is selective for NK1 over NK3 receptors (Ki = 454.1nM for human NK3). In vivo, aprepitant (1mg/Kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P. It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting. Group: Biochemicals. Alternative Names: 5-[[ (2R, 3S) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl]ethoxy]-3- (4-fluorophenyl) -4-morpholinyl]methyl]-1, 2-dihydro-3H-1, 2, 4-triazol-3-one; Emend; L 754030; MK-869; ONO-7436. Grades: Highly Purified. CAS No. 170729-80-3. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.43. US Biological Life Sciences. | Worldwide |
| Befetupitant | Befetupitant is a potent and selective NK1 receptor antagonist. Befetupitant is potentially useful in controlling chemotherapy-induced nausea and vomiting. Synonyms: Ro 67-5930; Ro67-5930; Ro675930; Ro-675930; 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-morpholino-4-(o-tolyl)pyridin-3-yl)propanamide. Grade: >98%. CAS No. 290296-68-3. Molecular formula: C14H24Cl2N4O2. Mole weight: 565.56. | |
| Benzomalvin A | It is produced by the strain of Penicillum sp. Benzomalvin A was isolated as an active inhibitor of substance P binding to mammalian neurokinin NK1 receptors. Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast α-glucosidase in vitro with IC50 of 383.2 μM. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively). Synonyms: (-)-Benzomalvin A; Enzomalvin-A. Grade: ≥95%. CAS No. 157047-96-6. Molecular formula: C24H19N3O2. Mole weight: 381.43. | |
| Benzomalvin B | It is produced by the strain of Penicillum sp. Benzomalvin B was isolated as an active inhibitor of substance P binding to mammalian neurokinin NK1 receptors. Benzomalvin B is a fungal metabolite produced by Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml. Synonyms: (-)-Benzomalvin B; Enzomalvin-B. Grade: ≥95%. CAS No. 157047-97-7. Molecular formula: C24H17N3O2. Mole weight: 379.41. | |
| Benzomalvin C | Benzomalvin C is produced by the strain of Penicillum sp. It is a neurokinin NK1 receptor antagonist and IDO inhibitor. Synonyms: 6'-methyl-3-phenyl-13'h-spiro[oxirane-2,7'-quinazolino[3,2-a][1,4]benzodiazepine]-5',13'(6'h)-dione; GK3542; GK 3542; GK-3542; benzomalvin C. Grade: >98%. CAS No. 157047-98-8. Molecular formula: C24H17N3O3. Mole weight: 395.41. | |
| Boc-3,4-dichloro-D-phenylalanine | Boc-3,4-dichloro-D-phenylalanine is used to prepare fluorinated β-aminoacyl 1,2,4-triazolo[4,3-a]piperazine amides as dipeptidyl peptidase IV inhibitors and antidiabetic agents. It is also used in the synthesis of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3-(2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide as a potent and orally active dual neurokinin NK1/NK2 receptor antagonist. Synonyms: Boc-D-Phe(3,4-DiCl)-OH; Boc-D-Phe(3,4-Cl2)-OH; (R)-Boc-2-amino-3-(3,4-dichlorophenyl)propionic acid; Boc-D-Phe(3,4-Cl2)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(3,4-dichlorophenyl)propanoic acid; D-Phenylalanine, 3,4-dichloro-N-[(1,1-dimethylethoxy)carbonyl]-; Boc-D-3,4-Dichlorophenylalanine; AK162594; N-BOC-3,4-DICHLORO-D-PHENYLALANINE. Grade: ≥ 98% (HPLC). CAS No. 114873-13-1. Molecular formula: C14H17Cl2NO4. Mole weight: 334.20. | |
| Burapitant | Burapitant is a drug developed by Sanofi-Aventis which was one of the first compounds developed that acts as a potent and selective antagonist for the NK1 receptor. Synonyms: SSR240600; SSR-240600; SSR 240600; 1-[2-[(2R)-4-[2-[3,5-Bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-alpha,alpha-dimethyl-4-piperidineacetamide. Grade: >98%. CAS No. 537034-22-3. Molecular formula: C32H47N7O4. Mole weight: 682.53. | |
| Casopitant | Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. Uses: Antiemetics. Synonyms: GW679769; GW 679769; GW-679769; Zunrisa; Rezonic; 4-(4-Acetylpiperazin-1-yl)-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide. CAS No. 414910-27-3. Molecular formula: C30H35F7N4O2. Mole weight: 616.62. | |
| Casopitant mesylate | Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of Substance P (HY-P0201). Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW679769B. CAS No. 414910-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14405A. | |
| Casopitant Mesylate | Casopitant Mesylate is a potent, selective and orally active neurokinin 1 (NK1) receptor antagonist binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. Uses: Active tachykinin nk1 receptor antagonist. Synonyms: (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide; methanesulfonic acid. Grade: ≥98%. CAS No. 414910-30-8. Molecular formula: C31H39F7N4O5S. Mole weight: 712.72. | |
| Copper (II) Bromide | Copper (II) Bromide is used as a catalyst in chemical reactions. Used in the coupling of o-Iodophenols and aryl acetylenes avoiding the use of palladium. Copper (II) Bromide is also used in the preparation of NK1/NK2 receptor antagonists used in the regulation of tachykinin. Group: Biochemicals. Grades: Highly Purified. CAS No. 7789-45-9. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: Br?Cu, Molecular Weight: 223.35. US Biological Life Sciences. | Worldwide |
| CP-122721 | CP-122721, a phenylpiperidin derivative, has been found to be a NK1 receptor antagonist that could probably be effective as antidepressant and antiemetic agent. The result of Phase II clinical trial for depression of it has not been reported yet since 2003. Synonyms: CP122721; CP 122721; 3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-piperidine. Grade: 98%. CAS No. 145742-28-5. Molecular formula: C20H23F3N2O2. Mole weight: 380.40. | |
| CP 141938 | CP 141938 is a potent and selective neurokinin-1 (NK1) receptor antagonist with very different brain tendencies and potency in centrally mediated activity models. Synonyms: Methanesulfonamide, N-[4-methoxy-3-[[[(2R,3R)-2-phenyl-3-piperidinyl]amino]methyl]phenyl]-N-methyl-, rel-; Methanesulfonamide, N-[4-methoxy-3-[[(2-phenyl-3-piperidinyl)amino]methyl]phenyl]-N-methyl-, cis-; rel-N-[4-Methoxy-3-[[[(2R,3R)-2-phenyl-3-piperidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide; CP141938; CP-141938. Grade: ≥95%. CAS No. 182822-62-4. Molecular formula: C21H29N3O3S. Mole weight: 403.54. | |
| CP 96345 | CP 96345 is an effective and selective non-peptide NK1 receptor antagonist and has been found to show activities in restraining neurogenic inflammation in vivo. Uses: Hypnotics and sedatives. Synonyms: CP-96345; CP 96345; CP96345; (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine. Grade: ≥98% by HPLC. CAS No. 132746-60-2. Molecular formula: C28H32N2O. Mole weight: 412.57. | |
| CS-003 Free base | CS-003 is a triple tachykinin receptor antagonist, showing high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 has therapeutic efficacy on respiratory diseases associated with neurokinins. CAS No. 191672-52-3. Molecular formula: C34H38Cl2N2O6S. Mole weight: 673.65. | |
| Dapitant | Dapitant, also known as RPR100893, is a potent and selective NK1 receptor antagonist both in vitro and in vivo, and exhibits high affinity for guinea pig and human NK1 receptor.Dapitant was developed as a potential drug for the acute treatment of migraine. However, in clinical trials, it was not effective. Synonyms: RPR100893; RPR 100893; RPR-100893; Erispant; (S)-1-((3aS,4S,7aS)-4-hydroxy-4-(2-methoxyphenyl)-7,7-diphenylhexahydro-1H-isoindol-2(3H)-yl)-2-(2-methoxyphenyl)propan-1-one. CAS No. 153438-49-4. Molecular formula: C37H39NO4. Mole weight: 561.72. | |
| Ezlopitant | Ezlopitant, also known as CJ-11,974, is a NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Synonyms: CJ 11,974; CJ-11974; CJ11974; (7S,8S)-7-[di(phenyl)methyl]-N-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine. CAS No. 147116-64-1. Molecular formula: C31H38N2O. Mole weight: 454.66. | |
| FK 888 | FK 888 is a potent and selective tachykinin NK1 receptor antagonist (Ki = 0.69 nM) with 320-fold selectivity for human over rat NK1 receptors. It inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. Synonyms: FK-888; FK 888; FK888. (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide; (2S,4R)-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidine-2-carboxamide. Grade: ≥98% by HPLC. CAS No. 138449-07-7. Molecular formula: C36H36N4O4. Mole weight: 588.69. | |
| Fosnetupitant | Fosnetupitant, a piperazine derivative, has been found to be a NK1 receptor antagonist that could be used in nausea and vomiting caused by chemotherapy. It was just reported a Phase II trail in Japan. Synonyms: Fosnetupitant; T672P80L2S; Fosnetupitant; Piperazinium, 4-(5-((2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl-1-oxopropyl)methylamino)-4-(2-methylphenyl)-2-pyridinyl)-1-methyl-1-((phosphonooxy)methyl)-, inner salt. Grade: 98%. CAS No. 1703748-89-3. Molecular formula: C31H35F6N4O5P. Mole weight: 688.61. | |
| FR 113680 | FR 113680 is a novel tripeptide substance P antagonist with NK1 receptor selectivity originated by Fujisawa for the treatment of Asthma. But no development are reported yet. Uses: Asthma. Synonyms: FR 113680; FR113680; FR-113680; Ac-Thr-trp(cho)-phe-N-mebzl. Ac-Thr-trp(cho)-phe-N-mebzl; N-acetyl-L-threonyl-1-formyl-D-tryptophyl-N-methyl-N-(phenylmethyl)-L-Phenylalaninamide. Grade: 98%. CAS No. 126088-92-4. Molecular formula: C35H39N5O6. Mole weight: 625.72. | |
| GR 203040 | GR 203040 is a selective NK1 receptor antagonist with high affinity. GR 203040 potently inhibits substance P binding to NK1 receptors (pKi = 10.1 to 10.5). Synonyms: (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride. Grade: ≥98% by HPLC. CAS No. 168398-02-5. Molecular formula: C20H24N6O·2HCl. Mole weight: 437.37. | |
| GR 82334 | GR 82334 is a tachykinin NK1 receptor antagonist. Synonyms: GR-82334; GR 82334; GR82334; Physalaemin(1-11), D-pro(9)(spiro-gamma-lactam)leu(10)-trp(11)-; Physalemin, 9-deglycine-10-((5S)-6-oxo-L-alpha-(2-methylpropyl)-1,7-diazaspiro(4.4)nonane-7-acetic acid)-11-L-tryptophanamide-. Grade: >98%. CAS No. 129623-01-4. Molecular formula: C69H91N15O16. Mole weight: 1386.57. | |
| GR 94800 | GR 94800 is a potent and selective tachykinin NK2 receptor antagonist (pKB = 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively). Synonyms: N-Benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-L-norleucinamide. Grade: >98%. CAS No. 141636-65-9. Molecular formula: C49H61N9O8. Mole weight: 904.08. | |
| GR 94800 TFA | GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively. Molecular formula: C51H62F3N9O10. Mole weight: 1018.08. | |
| Maropitant | Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147116-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10053. | |
| N-Acetyl-L-tryptophan | N-Acetyl-L-Tryptophan, is a derivative of L-Tryptophan, that can be used as a competitive inhibitor to identify and characterize tryptophanases. It can also be used as an NK1 tachykinin receptor antagonist, that may help to develop a novel therapeutic intervention for the treatment of reperfusion injury in acute ischemic stroke. Synonyms: Ac-L-Trp-OH; L-Tryptophan, N-acetyl-; N-Acetyl-Trp-OH; N-Acetyltryptophan; N-Acetyl-L-tryptophan; (2S)-2-acetamido-3-(1H-indol-3-yl)propanoic acid. Grade: ≥ 99.5% (HPLC). CAS No. 1218-34-4. Molecular formula: C13H14N2O3. Mole weight: 246.30. | |
| (R)-1-(1-(Bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene | An intermediate of Rolapitant, a selective NK1 receptor antagonist. Synonyms: (R)-1-(1-(Bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene; Benzene, 1-[(1R)-1-(bromomethoxy)ethyl]-3,5-bis(trifluoromethyl)-; 1-[(1R)-1-(bromomethoxy)ethyl]-3,5-bis(trifluoromethyl)benzene; 1,3-Bis(trifluoromethyl)-5-[(R)-1-(bromomethoxy)ethyl]benzene. Grade: >98%. CAS No. 530441-95-3. Molecular formula: C11H9BrF6O. Mole weight: 351.08. | |
| RC 160 | RC 160 is a cyclic octapeptide somatostatin analog (Ki= 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). RC 160 is a peptide neurokinin-1 receptor (NK1) antagonist and inhibits increases in vascular permeability stimulated by substance P in a concentration-dependent manner in isolated guinea pig trachea and main bronchi. It is used in the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and AIDS-related diarrhea. Uses: Antineoplastic agents. Synonyms: D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-tryptophanamide, cyclic (2→7)-disulfide; BMY-41606; BMY 41606; BMY41606; RC160; RC-160; DP-05-094; Octastatin; L-Tryptophanamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2→7)-disulfide; RC 160 (protein); Vapreotide; D-Phe-Cys-Trp-D-Trp-Lys-Val-Cys-Trp-CONH2 (Disulfide bridge: Cys2-Cys7). Grade: 98%. CAS No. 103222-11-3. Molecular formula: C57H70N12O9S2. Mole weight: 1131.37. | |
| Rolapitant | Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH619734. CAS No. 552292-08-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14751. | |
| Rolapitant hydrochloride hydrate | Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH619734 hydrochloride hydrate. CAS No. 914462-92-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16436. | |
| Rolapitant hydrochlorideRolapitant HCl | Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting, and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM, which does not interact with CYP3A4 and demonstrates potent centrally-mediated anti-emetic activity in both acute and delayed ferret emesis models. CAS No. 858102-79-1. Product ID: API858102791. Molecular formula: C25H27ClF6N2O2. Mole weight: 536.94. SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4.Cl. |  |
| Spantide I | Spantide I is a selective NK1 receptor antagonist (Ki = 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors, respectively). Uses: Analgesics. Synonyms: [D-Arg1, D-Trp7,9, Leu11]-Substance P. CAS No. 91224-37-2. Molecular formula: C75H108N20O13. Mole weight: 1497.79. | |
| Vapreotide | Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC 50 of 330 nM. Uses: Scientific research. Group: Peptides. Alternative Names: RC160; BMY 41606. CAS No. 103222-11-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0061. | |
| Vapreotide acetate | Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC 50 of 330 nM. Uses: Scientific research. Group: Peptides. Alternative Names: RC-160 acetate; BMY-41606 acetate. CAS No. 849479-74-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0061A. | |
| Vofopitant dihydrochloride | Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ 3 H]SP binding to the NK1 receptor with pK i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GR 205171A. CAS No. 168266-51-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12143. | |
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