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| Product | Description | |
|---|---|---|
| NMDA | NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors. Uses: Excitatory amino acid agonists. Synonyms: LC488A; LC 488A; LC-488A. Grades: >98%. CAS No. 6384-92-5. Molecular formula: C5H9NO4. Mole weight: 147.13. |  |
| NMDA | NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Uses: Scientific research. Group: Natural products. Alternative Names: N-Methyl-D-aspartic acid. CAS No. 6384-92-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-17551. |  |
| NMDA Antagonist XI, N1-dansyl-spermine (NMDA Channel Blocker, N1-dansyl-spermine, N1-DnsSpm) | An N-sulfonyl-polyamine that acts as a potent and more specific antagonist ofnMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13uM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58uM) and diminishes the induction of ornithine decarboxylase. At higher concentration (100uM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| NMDAR2C/2D Inhibitor, DQP-1105 | The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications. Group: Fluorescence/luminescence spectroscopy. |  |
| NMDAR2C/2D Inhibitor, DQP-1105 (DQP-1105, NMDA Antagonist IV) | A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4uM) and GluN1/GluN2D (2.2uM) over GluN1/GluN2B (206uM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NMDA Receptor NR2BCT(1292-1304)-TAT | A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function. Group: Fluorescence/luminescence spectroscopy. | |
| NMDA Receptor NR2BCT(1292-1304)-TAT (Tat-NR2BCT, H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH2) | A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of nMDAR function with no effect on either the catalytic activity of DAPK1 or the nMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic nMDA receptors (at 50uM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from nMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???N??O??, Molecular Weight: 3382. US Biological Life Sciences. | Worldwide |
| Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C1) antibody produced in rabbit | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert N1) antibody produced in rabbit | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Glutamate Receptor NMDAR2C (NR2C) antibody produced in rabbit | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-NMDAR2B/GRIN2B antibody produced in goat | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-NMDA Receptor 1/GRIN1 antibody produced in goat | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-NMDAR1 (pSer890) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-NMDAR1 (pSer896) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-NMDAR1 (pSer897) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-NMDAR2B (pTyr1336) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| CNS-1102 (N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine Hydrochloride, Cerestat, Aptiganel Hydrochloride, NMDA Antagonist V) | A non-competitive, subunit non-selective, potent antagonist fornMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14uM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches. Group: Biochemicals. Grades: Highly Purified. CAS No. 137159-92-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CP-101,606 (Traxoprodil, CP-101606, (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol, NMDA Antagonist VI) | A highly selective antagonist for NR2B subunit containing nMDA receptors (IC50 = 0.039uM for NR2B and >100uM for NR2A, NR2C, and NR2D). Widely used as neuroprotective, analgesic, antidepressant, and anti-Parkinsonian agent in research. Group: Biochemicals. Grades: Highly Purified. CAS No. 134234-12-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Eliprodil (alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX) | A negative allosteric modulator selective for NR2B containingnMDA receptors (IC50 = 1, >100, and >100uM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for alpha1 receptor (Ki = 0.013uM), one of the two types of unique non-opioid, non-phencyclidine brain alpha receptors. Blocks neuronal voltage-gated Ca2+. Group: Biochemicals. Grades: Highly Purified. CAS No. 119431-25-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MNI-caged-NMDA | MNI-caged-NMDA, NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group, is used as a ligand for glutamate receptor subtypes in the isolation of post-synaptic receptor activation. Synonyms: (R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid. Grades: ≥99% by HPLC. CAS No. 1227675-52-6. Molecular formula: C14H17N3O6. Mole weight: 323.3. | |
| N-Methyl-D-aspartic acid (NMDA) | NMDA?N-Methyl-D-aspartic acid?is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Group: Biochemicals. Alternative Names: (R)-2-(Methylamino)succinic acid; NMDA; N-Methyl-D-aspartate. Grades: Highly Purified. CAS No. 6384-92-5. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C?H?NO?, Molecular Weight: 147.13. US Biological Life Sciences. | Worldwide |
| NVP-AAM077 Tetrasodium Hydrate (NVP-AAM077, [[[ (1S) -1- (4-Bromophenyl) ethyl]amino] (1, 2, 3, 4-tetrahydro-2, 3-dioxo-5-quinoxalinyl) methyl] Phosphonic Acid Tetrasodium Hydrate, PEAQX Tetrasodium Hydrate, NMDA Antagonist VII) | A potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078uM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy. Group: Biochemicals. Grades: Highly Purified. CAS No. 459836-30-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PMPA (NMDA antagonist) | PMPA (NMDA antagonist). Group: Biochemicals. Grades: Purified. CAS No. 113919-36-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PMPA (NMDA antagonist) | PMPA (NMDA antagonist) is a selective competitive antagonist at the NMDA receptor, with Ki= 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Synonyms: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid. CAS No. 113919-36-1. Molecular formula: C6H13N2O5P. Mole weight: 224.15. | |
| TCN-201 (3-Chloro-4-fluoro-N- [ (4-{ [2- (phenylcarbonyl) hydrazino] carbonyl}phenyl) methyl] benzenesulfonamide, NMDA Antagonist X) | A negative allosteric modulator selective for NR2A containingnMDA receptors (pIC50 = 6.8 and <4.3uM for NR2A and NR2B, respectively). No effect on NR2B-containingnMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containingnMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent. Group: Biochemicals. Grades: Highly Purified. CAS No. 852918-02-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 10Panx | Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1 β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by >70%. Group: Biochemicals. Grades: Highly Purified. CAS No. 955091-53-9. Pack Sizes: 1mg. Molecular Formula: C58H79N15O16, Sequence: WRQAAFVDSY. US Biological Life Sciences. | Worldwide |
| (+/-) -1- (1, 2-Diphenylethyl) piperidine maleate | (+/-) -1- (1, 2-Diphenylethyl) piperidine maleate is a blocker of the NMDA ion channel. Group: Biochemicals. Grades: Highly Purified. CAS No. 207461-99-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H27NO4, Molecular Weight: 381.46. US Biological Life Sciences. | Worldwide |
| (±) -1- (1, 2-Diphenylethyl) piperidine maleate | High affinity antagonist at the ion channel on the NMDA receptor. Group: Biochemicals. Grades: Purified. CAS No. 207461-99-2. Pack Sizes: 10mg, 50mg. Molecular Formula: , Melting Point: US Biological Life Sciences. | Worldwide |
| (±)-1-(1,2-Diphenylethyl)piperidine maleate | The meleate salt form of (±)-1-(1,2-Diphenylethyl)piperidine, which has been found to be a high affinity antagonist at the ion channel on the NMDA receptor. Synonyms: (+/-)-1-(1,2-Diphenylethyl)piperidine maleate. Grades: ≥98% by HPLC. CAS No. 207461-99-2. Molecular formula: C19H23N.C4H4O4. Mole weight: 381.47. | |
| 1-[ (2-Chlorophenyl) (methylimino) methyl]cyclopentanol-d8 Hydrochloride | 1-[ (2-Chlorophenyl) (methylimino) methyl]cyclopentanol-d8 Hydrochloride is an intermediate used in the synthesis of (S)-Ketamine-d6 Hydrochloride (K165312), which is labeled (S)-Ketamine (K165310, HCl salt), which is the more active enantiomer of the NMDA receptor antagonist and anesthetic agent Ketamine (K165300). Also, it is the deuterized form of 1-[ (2-Chlorophenyl) (methylimino) methyl]cyclopentanol Hydrochloride (C379760), which has potential use as a component of household cleaning solution products. IT is also an intermediate in the production of the cyclohexanone analogue. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C13H8D8ClNO; HCl, Molecular Weight: 245.773646. US Biological Life Sciences. | Worldwide |
| 1,2-Difluorobenzene | 1,2-Difluorobenzene is used in electrochemical analysis of transition metal complexes. 1,2-difluorobenzene is also a potent inhibitor of NMDA receptor. Group: Biochemicals. Alternative Names: NSC 10275; o-Difluorobenzene. Grades: Highly Purified. CAS No. 367-11-3. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 1,3,5-Tribromo-adamantane | 1,3,5-Tribromo-adamantane is one of memantine impurities. Memantine, also called Namenda, a N-methyl D-aspartate (NMDA) antagonist prescribed to treat symptoms of moderate to severe Alzheimer's, blocks the toxic effects associated with excess glutamate and regulates glutamate activation. Synonyms: 1,3,5-Tribromotricyclo[3.3.1.13,7]decane. Grades: ≥ 95%. CAS No. 707-34-6. Molecular formula: C10H13Br3. Mole weight: 372.92. | |
| 1,4-Diaminobutane dihydrochloride | It is an NMDA receptor agonist produced by the breakdown of amino acids after the death of an organism. It is a polyamine plant growth regulator affecting the synthesis of macromolecules and the development of root systems in plants. Uses: Used in biochemical research. Synonyms: 1,4-Butanediamine Dihydrochloride; Putrescine Dihydrochloride; Putrescine Hydrochloride; Tetramethylenediamine Dihydrochloride. Grades: ≥ 98 %. CAS No. 333-93-7. Molecular formula: C4H12N2.2HCl. Mole weight: 161.07. | |
| 18-Methoxycoronaridine | 18-Methoxycoronaridine is a derivative of ibogaine. It is a α3β4 nicotinic antagonist and, in contrast to ibogaine, has no affinity at the α4β2 subtype nor at NMDA-channels nor at the serotonin transporter, and has significantly reduced affinity for sodium channels and for the σ receptor, but retains modest affinity for μ-opioid receptors where it acts as an antagonist, and κ-opioid receptors. Synonyms: (-)-18-methoxycoronaridine. Grades: > 95%. CAS No. 308123-60-6. Molecular formula: C22H28N2O3. Mole weight: 368.47. | |
| 1-Adamantan-d15-amine | 1-Adamantan-d15-amine is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian. Group: Biochemicals. Grades: Highly Purified. CAS No. 33830-10-3. Pack Sizes: 1mg, 10mg. Molecular Formula: C10H2D15N. US Biological Life Sciences. | Worldwide |
| 1-Amino-1-cyclopropanecarboxylic acid | 1-Aminocyclopropane-1-carboxylic Acid is a plant growth regulator and an NMDA agonist acting at the glycine site (1). It is also a useful compound to develop DNA-encoded small molecule libraries for screening enzyme inhibitors (2). Group: Biochemicals. Alternative Names: 1-Aminocyclopropane carboxylic Acid; 1-Amino-1-carboxycyclopropane; 1-Aminocyclopropane-1-carboxylate; 1-Aminocyclopropane carboxylic Acid; ACC; ACPC; NSC 98430; α -Aminocyclopropane carboxylic Acid. Grades: Highly Purified. CAS No. 22059-21-8. Pack Sizes: 5g, 10g, 25g, 50g. Molecular Formula: C?H?NO?, Molecular Weight: 101.1. US Biological Life Sciences. | Worldwide |
| 1-Aminocyclobutanecarboxylic acid | 1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist acting at the glycine site, NR1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22264-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-30006. | |
| 1-Aminocyclopropane-1-carboxylic acid | 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 22059-21-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-30004. | |
| 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 | An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Group: Fluorescence/luminescence spectroscopy. | |
| 1-Aminocyclopropanecarboxylic acid | 1-Aminocyclopropanecarboxylic acid is a small molecule agonist at the glycine modulatory site of the NMDA receptor. Described to mimic the effects of glycine at the NMDAR, 1-Aminocyclopropanecarboxylic acid competitively inhibits binding of [3H]glycine and enhances the binding of [3H]MK-801 to NMDAR-coupled cation channels similarly to glycine (though with less efficacy). Uses: Neuroprotective agents. Synonyms: ACC; ACPC; NSC 98430; 1-Aminocyclopropane-1-carboxylic acid. Grades: ≥98%. CAS No. 22059-21-8. Molecular formula: C4H7NO2. Mole weight: 101.1. | |
| (1-Bromocyclopentyl-2,2,3,3,4,4,5,5-d8)(2-chlorophenyl)-methanone | (1-Bromocyclopentyl-2,2,3,3,4,4,5,5-d8)(2-chlorophenyl)-methanone is used in the preparation of NMDA receptor modulator in the treatment of NMDA-mediated diseases. Also, it is an intermediate used in the synthesis of (S)-Ketamine-d6 Hydrochloride (K165312), which is labeled (S)-Ketamine (K165310, HCl salt) which is the more active enantiomer of the NMDA receptor antagonist and anesthetic agent Ketamine (K165300). Group: Biochemicals. Grades: Highly Purified. CAS No. 1073255-38-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C12H4D8BrClO, Molecular Weight: 295.63. US Biological Life Sciences. | Worldwide |
| 1-Nitro-7-hydroxy-3,5-dimethyladamantane | 1-Nitro-7-hydroxy-3,5-dimethyladamantane is one of memantine impurities. Memantine, also called Namenda, a N-methyl D-aspartate (NMDA) antagonist prescribed to treat symptoms of moderate to severe Alzheimer's, blocks the toxic effects associated with excess glutamate and regulates glutamate activation. Synonyms: 3,5-dimethyl-7-nitroadamantan-1-ol; SCHEMBL1075031; 1-Nitro-7-hydroxy-3,5-dimethyladamantane; 2460757-92-8. Molecular formula: C12H19NO3. Mole weight: 225.28. | |
| (1R,2S)-(-)-2-Amino-1,2-diphenylethanol | (1R,2S)-(-)-2-Amino-1,2-diphenylethanol is a hydroxylated 1,2-diphenethylamine derivative with affinity for the NMDA receptor. Group: Biochemicals. Alternative Names: (1R,2S)-erythro-(-)-2-Amino-1,2-diphenylethanol; (1R,2S)-Diphenyl-2-aminoethanol; (1R,2S)-1,2-Diphenyl-2-aminoethanol; (1R,2S)-2-Amino-1,2-diphenylethanol; (αR, βS)- β-Amino-α-phenylbenzeneethanol. Grades: Highly Purified. CAS No. 23190-16-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| (-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid | (-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid is a reagent used in the synthesis of 3-substituted aminocyclopentanes as potent NR2B subtype-sellective NMDA antagonists in the treatment of neuropathic pain and Parkinsons. Group: Biochemicals. Grades: Highly Purified. CAS No. 261165-05-3. Pack Sizes: 50mg, 100mg. Molecular Formula: C11H19NO4, Molecular Weight: 229.27. US Biological Life Sciences. | Worldwide |
| (1S,2R)-cis-4-Cyclohexene-1,2-dicarboxylic Acid 1-Monomethyl Ester | (1S,2R)-cis-4-Cyclohexene-1,2-dicarboxylic Acid 1-Monomethyl Ester acts as a reagent in the asymmetric synthesis of unnatural β-amino acids, and also in the selective preparation of N-methyl-D-aspartic acid (NMDA) antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 88335-93-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H12O4, Molecular Weight: 184.19. US Biological Life Sciences. | Worldwide |
| 2-(3,3-Diphenylpropylamino)-N,N-Diphenylacetamide Hydrochloride | N 20C hydrochloride is a non-competitive NMDA glutamate receptor antagonist. Synonyms: 2-(3,3-Diphenylpropylamino)-N,N-diphenylacetamide hydrochloride. Grades: 98%. CAS No. 928313-94-4. Molecular formula: C29H29ClN2O. Mole weight: 457.01. | |
| 2,3 cis-Piperidine Dicarboxylic Acid (Ionotropic Glutamate Receptor Antagonist, PDA, cis PDA, cis-Piperidine-2,3-dicarboxylic Acid) | A non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Used in blocking general excitatory synaptic transmissions. Group: Biochemicals. Grades: Highly Purified. CAS No. 46026-75-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2,3-Pyridinedicarboxylic acid | Quinolinic acid is an endogenous NMDA agonist and transmitter candidate. It may distinguish between NMDA receptor subtypes. By overactivating NMDA receptors, quinolinic acid produces neurotoxicity, which has been implicated in certain neurodegenerative disorders. Uses: A metabolite of tryptophan; used to make assert (herbicide) and nicotinic acid. Synonyms: pyridine-2,3-dicarboxylic acid. Grades: 99 %. CAS No. 89-00-9. Molecular formula: C7H5NO4. Mole weight: 167.12. | |
| 24-Hydroxycholesterol | 24-Hydroxycholesterol, also known as 24-OH-Chol, a natural sterol, is the main cholesterol elimination product of the brain. 24-Hydroxycholesterol is a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol acts as a neurotoxin to SH-SY5Y human neuroblastoma cells which showed corresponding morphological changes: the cells became round, lost adhesion to the petri-dish, and neurite outgrowth degenerated. Synonyms: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 24-hydroxycholesterol; 24S-hydroxycholesterol; cerebrosterol; cholest-5-ene-3,24-diol. CAS No. 30271-38-6. Molecular formula: C27H46O2. Mole weight: 402.65. | |
| 24-Hydroxycholesterol | 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR , and a potent activator of the transcription factors LXR. Uses: Scientific research. Group: Natural products. CAS No. 30271-38-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg. Product ID: HY-N2370. | |
| 24(S)-Hydroxycholesterol | 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 24S-OHC; 24S-HC; Cerebrosterol. CAS No. 474-73-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-16940. | |
| 2-Amino-5-chloro-3-nitro-6-picoline | 2-Amino-5-chloro-3-nitro-6-picoline is a reagent used in the synthesis of 1,4-dihydroquinoxaline-2,3-diones as antagonists to the NMDA receptor. 2-Amino-5-chloro-3-nitro-6-picoline is prepared through the use of sulfuric acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 56960-82-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H6ClN3O2, Molecular Weight: 187.58. US Biological Life Sciences. | Worldwide |
| 2-Chlorophenyl Cyclopentyl-d9 Ketone | 2-Chlorophenyl Cyclopentyl-d9 Ketone is an intermediate in synthesizing (S)-Ketamine-d6 Hydrochloride (K165312), a labelled (S)-Ketamine (K165310, HCl salt) which is the more active enantiomer of the NMDA receptor antagonist and anesthetic agent Ketamine (K165300). 2-Chlorophenyl Cyclopentyl-d9 Ketone is also a labelled analogue of 2-Chlorophenyl Cyclopentyl Ketone (C377820), which is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons. Group: Biochemicals. Grades: Highly Purified. CAS No. 1073255-46-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H4D9ClO. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy Felbamate | An impurity of Felbamate. Felbamate is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site. Synonyms: 2-Phenyl-1,2,3-propanetriol 1,3-Dicarbamate; 2-Hydroxy-2-phenyl-1,3-propanediyl dicarbamate. Grades: > 95%. CAS No. 109482-32-8. Molecular formula: C11H14N2O5. Mole weight: 254.24. | |
| 2-Methoxy Benzene acetonitrile | 2-Methoxyphenyl acetonitri le was used in the synthesis of 2- (1-cyano-1- (2-methoxy) phenyl) methylidene-3-phenylthiazolidine-4, 5-dione as possible antibiotic agent. It can also be used to synthesize 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex. Group: Biochemicals. Grades: Highly Purified. CAS No. 7035-3-2. Pack Sizes: 5g, 25g. Molecular Formula: C9H9NO, Molecular Weight: 147.169999999999. US Biological Life Sciences. | Worldwide |
| 2-Methoxy Ketamine Hydrochloride | 2-methoxy Ketamine is an analog of ketamine (K165300, HCl salt) which is a dissociative anesthetic that acts as an NMDA receptor channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 6728-62-7. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C14H20ClNO2, Molecular Weight: 269.77. US Biological Life Sciences. | Worldwide |
| 2-Methyl-3-trifluoromethylaniline | 2-Methyl-3-trifluoromethylaniline is a reactant in the synthesis of methylguanidine derivatives as prospective PET radioligands for the open channel of the NMDA receptor, linked to Alzheimers, epilepsy and other neurodegenerative disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 54396-44-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H8F3N. US Biological Life Sciences. | Worldwide |
| 2-MPPA | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM), which is selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. 2-MPPA can be used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties. Synonyms: 2-(3-Mercaptopropyl)pentanedioic acid; 2-MPPA; 2 MPPA; 2MPPA. CAS No. 254737-29-6. Molecular formula: C8H14O4S. Mole weight: 206.26. | |
| 2-Naphthalenecarboxylic Acid | 2-Naphthalenecarboxylic Acid has been studied for its structure-activity relationship for allosteric NMDA receptor inhibitors for potential development of NMDA receptor modulator agents for a variety of neuropsychiatric and neurological conditions. Group: Biochemicals. Alternative Names: β-Naphthoic Acid; 2-Naphthoic Acid (8CI); 2-Carboxynaphthalene; 2-Maythic Acid; 2-Naphthylcarboxylic Acid; Isonaphthoic Acid; NSC 59901. Grades: Highly Purified. CAS No. 93-09-4. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| (2R,3S)-Chlorpheg | (2R,3S)-Chlorpheg is a weakly active NMDA receptor antagonist. Synonyms: (2R,3S)-β-p-Chlorophenylglutamic acid. CAS No. 140924-23-8. Molecular formula: C11H12ClNO4. Mole weight: 257.67. | |
| (+)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphoric Acid | (+)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphoric Acid is a compound with NMDA antagonistic activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 100828-16-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C8H17N2O5P, Molecular Weight: 252.2. US Biological Life Sciences. | Worldwide |
| 3,5-Dihydroxynapthalene-2-carboxylic Acid | 3,5-Dihydroxynapthalene-2-carboxylic Acid is used as a negative or positive NMDA receptor inhibitor, via allosteric control. NMDA receptors regulate CHN (central nervous system) functions. Also used as a protein tyrosine phosphatase inhibitor due to the benzofuran-like moiety in the substructure. Group: Biochemicals. Alternative Names: UBP551. Grades: Highly Purified. CAS No. 89-35-0. Pack Sizes: 1g, 10g, 50g. Molecular Formula: C11H8O4, Molecular Weight: 204.18. US Biological Life Sciences. | Worldwide |
| 3-Amino-N-acetyl Memantine | 3-Amino-N-acetyl Memantine is one of memantine impurities. Memantine, also called Namenda, a N-methyl D-aspartate (NMDA) antagonist prescribed to treat symptoms of moderate to severe Alzheimer's, blocks the toxic effects associated with excess glutamate and regulates glutamate activation. Molecular formula: C14H24N2O. Mole weight: 236.35. | |
| 3-Chloro-4-nitrotoluene | 3-Chloro-4-nitrotoluene is used in the synthesis of quinoxaline derivatives in the development of a positron emission tomography radiotracer for the imaging of N-Methyl-D-aspartate receptor (NMDAR). Group: Biochemicals. Grades: Highly Purified. CAS No. 38939-88-7. Pack Sizes: 250mg, 1g. Molecular Formula: C7H6ClNO2, Molecular Weight: 171.58. US Biological Life Sciences. | Worldwide |
| 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic Acid | 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic Acid. Group: Biochemicals. Alternative Names: QZN-46; QNZ46; 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic Acid; NMDA Antagonist VIII. Grades: Highly Purified. CAS No. 1237744-13-6. Pack Sizes: 25mg. Molecular Formula: C24H17N3O6, Molecular Weight: 443.41. US Biological Life Sciences. | Worldwide |
| 4-Chlorokynurenine | 4-Chlorokynurenine is a prodrug of a NMDA receptor antagonist. 4-Chlorokynurenine has orally active and blood-brain permeability that can be used for the research of depression [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Cl-KYN; AV-101. CAS No. 153152-32-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108920. | |
| 4-Chloro Kynurenine-13C2,15N | 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application. Group: Biochemicals. Alternative Names: α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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