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| Product | Description | |
|---|---|---|
| Nuclease-free Water | Nuclease-free Water. Ddh2o is purified by reverse osmosis method. it is suitable for most molecular and cell biology applications. Group: Cloning Enzymes. Purity: 25ml. Storage: Store at Room Temperature. Cat No: CE-3009. |  |
| Nuclease P1 | Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries [1]. Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc. Uses: Scientific research. Group: Signaling pathways. CAS No. 54576-84-0. Pack Sizes: 250 U. Product ID: HY-P2963. |  |
| Nuclease, restrictionendodeoxyribo-, SpeI | Nuclease, restrictionendodeoxyribo-, SpeI. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RESTRICTION ENDONUCLEASES SPE I;SPE I;SPE I RESTRICTION ENZYME;RESTRICTION ENDONUCLEASE SPE I FROM*SPHA EROTILUS SP;spei5'.actagt.3'isolatedfromsphaerotilusspecies;spe i from sphaerotilus sp.;RESTRICTION ENDONUCLEASE SPE I. Product Category: Heterocyclic Organic Compound. CAS No. 115926-60-8. Molecular formula: ClH. Mole weight: 36.46094;g/mol. Purity: 0.96. IUPACName: chlorane. Canonical SMILES: Cl. ECNumber: 231-595-7. Product ID: ACM115926608. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Nuclease, restrictionendodeoxyribo-, StyI | Nuclease, restrictionendodeoxyribo-, StyI. Uses: Designed for use in research and industrial production. Additional or Alternative Names: STY I;STY I RESTRICTION ENZYME;RESTRICTION ENDONUCLEASES STY I;RESTRICTION ENDONUCLEASE STY I FROM ESCH;sty i from escherichia coli strain carrying pst27;RESTRICTION ENDONUCLEASE STY I. Product Category: Heterocyclic Organic Compound. CAS No. 96880-98-7. Purity: 0.96. Product ID: ACM96880987. Alfa Chemistry ISO 9001:2015 Certified. | |
| Nuclease S1, Aspergillus oryzae | Nuclease S1, Aspergillus oryzae is a specific endonuclease that degrades single stranded DNA (ssDNA) and RNA. Nuclease S1 can also remove protruding single-strand ends from double-stranded DNA [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37288-25-8. Pack Sizes: 10 KU. Product ID: HY-P2773. | |
| Nuclease, Serratia marcescens | Serratia marcescens nuclease (EC 3.1.30.2) is a nonspecific nuclease. Serratia marcescens nuclease has broad utility due to its potent digestive activity toward both DNA and RNA [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Serratia marcescens nuclease. CAS No. 9025-65-4. Pack Sizes: 5 KU; 10 KU; 25 KU. Product ID: HY-131160. | |
| Aspergillus nuclease S1 | Aspergillus nuclease S1 is an endonuclease enzyme derived from Aspergillus oryzae that splits single-stranded DNA (ssDNA) and RNA into oligo- or mononucleotides. Group: Enzymes. Synonyms: endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease. Enzyme Commission Number: EC 3.1.30.1. CAS No. 37288-25-8. Nuclease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3707; Aspergillus nuclease S1; EC 3.1.30.1; 37288-25-8; endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease. Cat No: EXWM-3707. | |
| Cas9-C-NLS Nuclease | Cas9-C-NLS Nuclease. Cas9-c-nls nuclease is the recombinant streptococcus pyogenes cas9 (wt) protein with a c-terminal nucleic localization signal (nls). it can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researchers requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4 at 25°C. Cat No: CE-3502. | |
| Cas9-N-NLS Nuclease | Cas9-N-NLS Nuclease. Cas9-n-nls nuclease is the recombinant streptococcus pyogenes cas9 (wt) protein with a n-terminal nucleic localization signal (nls) that can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researcher´s requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store all components at -20 ?. Source: E.coli. Cat No: CE-3503. | |
| Cas9 Nuclease | Cas9 Nuclease. Recombinant streptococcus pyogenes cas9 (wt) nuclease is purified from e. coli.it can be used for genome editing by inducing site-specific double stranded breaks in double stranded dna. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system. the rnp complex recognizes the target site by matching grna with the genomic dna sequence and leads to dna breaks within 3 bases from the ngg pam (protospacer adjacent motif). with gencrispr cas9 nuclease, customers can screen highly efficient grna using in vitro dna cleavage assays. it could be a powerful tool for gene editing. Group: Cloning Enzymes. Purity: 10μg; 50μg. Storage: Store at -20 ?. Source: E.coli. Cat No: CE-3501. | |
| Deoxyribonuclease B, Recombinant | Deoxyribonuclease B (DNAse B) is one of several extracellular enzymes produced by group A beta-hemolytic streptococci. Since DNAse B is produced extensively by group A serotypes and is not produced in significant amounts by other serological groups (C and G), anti-DNAse B is a reliable streptococcal antibody test for both skin and throat infections. Applications: Used in the formulation of anti-dnase b assays which are used in the diagnosis of group a streptococcal based illnesses. Group: Enzymes. Synonyms: DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNas. Enzyme Commission Number: EC 3.1.21.1. Purity: > 97%. Mole weight: 21 - 31kD. Form: Frozen liquid. Source: Escherichia coli. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: NATE-1153. | |
| deoxyribonuclease I | Preference for double-stranded DNA. Group: Enzymes. Synonyms: pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Enzyme Commission Number: EC 3.1.21.1. CAS No. 9003-98-9. DNASE1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3571; deoxyribonuclease I; EC 3.1.21.1; 9003-98-9; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: EXWM-3571. | |
| Deoxyribonuclease I from Bovine pastoris, Recombinant | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Recombinant bovine pancreatic deoxyribonuclease 1 produced in pichia pastoris. chromatogr....1.21.1. CAS No. 9003-98-9. Purity: Chromatographically purified. DNASE1. Activity: > 5000 units per mg protein. Storage: Store at 2-8°C. Form: lyophilized powder. Source: Pichia pastoris. Species: Bovine pancreatic. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nucle | |
| eSpCas9-N-NLS Nuclease | eSpCas9-N-NLS Nuclease. Espcas9 nuclease is a mutant form of cas9 nuclease. compared with the wild type cas9 nuclease, espcas9 reduces off-target effects by over 10-fold, while maintaining robust on-target genome editing efficiency. genscript has developed a espcas9-n-nls nuclease which contains a nuclear localization sequence (nls) on the n-terminus of the protein to meet all the researchers requirements (e.g. in vitro cleavage assay, rnp complex transfection, and micro injection). Group: Cloning Enzymes. Purity: 100μg; 500μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4, at 25°C. Cat No: CE-3507. | |
| Micrococcal nuclease | Micrococcal nuclease is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Signaling pathways. CAS No. 9013-53-0. Pack Sizes: 5 KU. Product ID: HY-P2754. | |
| Micrococcal Nuclease | Micrococcal Nuclease. Micrococcal nuclease is obtained by expression of a recombinant micrococcal nuclease gene in escherichia coli, molecular weight is 16.8 kda. it is a non-specific exo or endonuclease that consumes double-stranded, single-stranded, circularized, and linear nucleic acids, and has a better digestion of single strands, and it tend to digest ats or the aus region of the dna or rna, producing a single nucleotide and a dinucleotide with 3' phosphoric acid.; high activity.; high protein purity, sds-page purity >95%.; good stability. Group: DNA Modifying Enzymes. Purity: 100KU; 200KU. Storage: Store at -20°C. Cat No: ME-4002. | |
| Mung Bean Nuclease, Reaction Buffer (10x) | Mung Bean Nuclease, Reaction Buffer (10x). Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1ml. US Biological Life Sciences. |  Worldwide |
| Native Aspergillus oryzae Nuclease S1 | Nuclease S1 isolated from Aspergillus oryzae exhibits endo-and exolytic hydrolytic activity for the phosphodiester bonds of single-stranded DNA and RNA yielding 5-phosphomononucleotide and 5-phosphooligonucleotide end-products. It is used to digest non-annealed polynucleotide tails and hairpin loops in RNA and DNA duplexes and can be used to convert superhelical DNA to the linear form. The nuclease s1 enzyme from aspergillus oryzae has the ability to degrade single-stranded oligonucleotides composed of either deoxynucleotides or ribonucleotides. Applications: Nuclease s1 from aspergillus oryzae has been used in a study to assess a bi ochemical method for mapping mutational...e S1 nuclease; EC 3.1.30.1; 37288-25-8. Enzyme Commission Number: EC 3.1.30.1. CAS No. 37288-25-8. Nuclease. Storage: -20°C. Form: Solution containing 30 mM sodium acetate, 50 mM NaCl, 1 mM ZnCl2, 50% glycerol, 2 mg/ml protein. Source: Aspergillus oryzae. endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease; EC 3.1.30.1; 37288-25-8. Cat No: NATE-0492. | |
| Native Bovine Deoxyribonuclease I | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Protein determined by biuret. Applications: Used for the removal of dna from protein samples. dnase...rom bovine pancreas has also been used in a study to investigate the effects of minor and major groove-binding drugs and intercalators on the dna association of minor groove-binding proteins reca and deoxyribonuclease i. Group: Enzymes. Synonyms: DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA end | |
| Native Bovine Deoxyribonuclease I RNase-free solution | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Applications: Used in molecular biology applications for removing dna during rna purifica...zyme Commission Number: EC 3.1.21.1. CAS No. 9003-98-9. DNASE1. Mole weight: mol wt 29.1 kDa. Storage: -20°C. Form: buffered aqueous glycerol solution. Source: Bovine pancreas. Species: Bovine. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: NATE-0199. | |
| Native Penicillium citrinum Nuclease P1 | Nuclease P1 from Penicillium citrinum is a zinc-dependent endonuclease that exhibits increased activity in the presence of low concentrations of urea. Applications: Nuclease p1 from penicillium citrinum has been used in a study to assess crystal structures using ammonium sulphate or polyethylene glycol 4000 as a precipitating agent. it has also been used in a study to investigate a method for the direct sequence analysis 20-25 nucleotides from the terinini of 5? or 3? end group labeled rna. nuclease p1 is used to improve the sensitivity of a 32p-labeling method for the detection of dna adducts. the enzyme has an optimal temperature of approximately 70 oc, but for a long incubation, a temperature below 60 oc is more suitable. it is stable in the ph range of 5-8. Group: Enzymes. Synonyms: Endonuclease P1; EC 3.1.30.1; 54576-84-0; Nuclease P1; P1 nuclease. Enzyme Commission Number: EC 3.1.30.1. CAS No. 54576-84-0. Nuclease. Mole weight: 42-50 kDa. Activity: > 200 units/mg protein (E1%/280, 3?-5?-Phosphodiesterase). Storage: 2-8°C. Form: lyophilized powder. Source: Penicillium citrinum. Endonuclease P1; EC 3.1.30.1; 54576-84-0; Nuclease P1; P1 nuclease. Pack: vial of > 250 units (using RNA substrate). Cat No: NATE-0491. | |
| Native Staphylococcus aureus Nuclease micrococcal | Micrococcal Nuclease is an endo-exonuclease that preferentially digests single-stranded nucleic acids. The rate of cleavage is 30 times greater at the 5' side of A or T than at G or C and results in the production of mononucleotides and oligonucleotides with terminal 3'-phosphates. The enzyme is also active against double-stranded DNA and RNA and all sequences will be ultimately cleaved. Applications: Nuclease from staphyl oc occus aureus has been used in a study to assess coagulase and heat-resistant strains found in animals. it has also been used in a study to investigate the expression characteristic of two genes in s. aureus that encode two thermostable nucleases. Group: Enzymes. Synonyms: Micrococcal Nuclease; EC 3.1.31.1; spleen endonuclease; thermonuclease; nuclease T; micrococcal endonuclease; nuclease T'; staphylococcal nucle. Enzyme Commission Number: EC 3.1.31.1. CAS No. 9013-53-0. MNase. Activity: 100-300 units/mg protein. Storage: -20°C. Source: Staphylococcus aureus. Micrococcal Nuclease; EC 3.1.31.1; spleen endonuclease; thermonuclease; nuclease T; micrococcal endonuclease; nuclease T'; staphylococcal nuclease; spleen phosphodiesterase; Staphylococcus aureus nuclease; Staphylococcus aureus nuclease B; ribonucleate (deoxynucleate) 3'-nucleotidohydrolase; 9013-53-0; Endonuclease micrococcal; MNase. Cat No: NATE-0452. | |
| NLS-Cas9-EGFP Nuclease | NLS-Cas9-EGFP Nuclease. Nls-cas9-egfp is a fusion protein contains a nuclear localization sequence (nls) on its n terminal and egfp on the c terminal. the egfp can be used as a reporter for tracking or sorting transfected cells, which enables the possibility of enriching cell populations for desired genome edits via fluorescence activated cell sorting (facs). it significantly reduces the labor and cost associated with single cell cloning and genotyping in genome editing applications. Group: Cloning Enzymes. Purity: 100μg; 500μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA,1 mM DTT, 50% Glycerol PH7.4, at 25°C. Cat No: CE-3506. | |
| NLS-Cas9-NLS Nuclease | NLS-Cas9-NLS Nuclease. Nls-cas9-nls is produced by expression in an e. coli strain carrying a plasmid encoding the cas9 gene from streptococcus pyogenes with a double-ends nuclear localization signal (nls). it can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researcher´s requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4 at 25?. Cat No: CE-3504. | |
| ribonuclease H | Acts on RNA-DNA hybrids. Group: Enzymes. Synonyms: endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H. Enzyme Commission Number: EC 3.1.26.4. CAS No. 9050-76-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3592; ribonuclease H; EC 3.1.26.4; 9050-76-4; endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H. Cat No: EXWM-3592. | |
| ribonuclease M5 | Converts the 5S-rRNA precursor from Bacillus subtilis into 5S-rRNA, with 5'-phosphate and 3'-hydroxy groups. Group: Enzymes. Synonyms: RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease. Enzyme Commission Number: EC 3.1.26.8. CAS No. 62253-00-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3596; ribonuclease M5; EC 3.1.26.8; 62253-00-3; RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease. Cat No: EXWM-3596. | |
| Serratia marcescens nuclease | Hydrolyses double- or single-stranded substrate. Group: Enzymes. Synonyms: endonuclease (Serratia marcescens); barley nuclease; plant nuclease I; nucleate endonuclease. Enzyme Commission Number: EC 3.1.30.2. CAS No. 9025-65-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3708; Serratia marcescens nuclease; EC 3.1.30.2; 9025-65-4; endonuclease (Serratia marcescens); barley nuclease; plant nuclease I; nucleate endonuclease. Cat No: EXWM-3708. | |
| Water, Sterile, Nuclease & Endotoxin Free | United States Biological produces ultrapure water suitable in all molecular biology procedures and available at very reasonable pricing. Produced under cGMP. Group: Biochemicals. Grades: Molecular Biology Grade. CAS No. 7732-18-5. Pack Sizes: 50ml, 100ml, 250ml, 500ml, 1L. US Biological Life Sciences. | Worldwide |
| Water, Sterile, Nuclease Free | United States Biological produces ultrapure water suitable in all molecular biology procedures and available at very reasonable pricing. Produced under cGMP. Group: Biochemicals. Grades: Molecular Biology Grade. CAS No. 7732-18-5. Pack Sizes: 500ml, 1L, 3L. US Biological Life Sciences. | Worldwide |
| 1,10-Phenanthroline monohydrate, 99% | 1,10-Phenanthroline monohydrate, 99%. Uses: When complexed with copper, it possesses nuclease activity that has been used to study dna-protein interactions. Group: Ligands for functional metal complexes. Alternative Names: ZX-AT006983; SCHEMBL3790396; KSC269G7H; UNII-KSX215X00E; 1,10-phenanthroline-hydrate; TL8003406; 1,10-Phenanthroline hydrate; AX8021147; 1,10-Phenanthroline monohydrate, ACS reagent, 99%; TR-018323. CAS No. 5144-89-8. Product ID: 1,10-phenanthroline; hydrate. Molecular formula: 198.225g/mol. Mole weight: C12H10N2O. C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1.O. InChI=1S/C12H8N2. H2O/c1-3-9-5-6-10-4-2-8-14-12 (10)11 (9)13-7-1; /h1-8H; 1H2. PPQJCISYYXZCAE-UHFFFAOYSA-N. |  |
| 1,2,3,4,6-Penta-O-acetyl-5-thio-b-D-galactopyranoside | Penta-O-acetyl-5-thio-b-D-galactopyranoside, a chemical compound, may be employed as a substance to gauge enzyme function, with a particular preference for esterases, nucleases, and glycosidases. Additionally, the compound's effectiveness extends to protein purification. Molecular formula: C16H22O10S. Mole weight: 406.40. |  |
| 2',5'-Anhydroarabinocytidine | 2',5'-Anhydroarabinocytidine is a modified nucleoside where the typical 3'-5' phosphodiester linkage between the sugar units is replaced by a 2',5'-anhydro linkage, connecting the sugar's 2' and 5' carbon atoms. The base is arabinocytidine, where the sugar is an arabinose derivative. This modification creates a unique structure that could affect the stability and interaction of the nucleoside with enzymes, such as nucleases, and may make it resistant to typical DNA or RNA degradation pathways. 2',5'-Anhydroarabinocytidine could have potential applications in nucleic acid-based therapies, where enhanced stability or altered enzymatic interactions are desired, and might be used for the development of antiviral drugs or in the synthesis of modified oligonucleotides for research purposes. Synonyms: Cytarabine Impurity F; 4-Amino-1-(2,5-anhydro-β-D-arabinofuranosyl)pyrimidin-2(1H)-one; Cytarabine EP impurity F; Cytarabine impurity 10 (or 1, 4, 17); 2',5'-Anhydro-1-(beta-D-arabinofuranosyl)cytosine; 4-Amino-1-(2,5-anhydro-β-D-arabinofuranosyl)-2(1H)-pyrimidinone; (2',5'-Anhydroarabinosyl)cytosine; NSC 340843; 4-Amino-1-((1R,3R,4S,7R)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidin-2(1H)-one. Grade: ≥95%. CAS No. 32830-01-6. Molecular formula: C9H11N3O4. Mole weight: 225.20. | |
| 2'-Deoxy-2'-fluoroguanosine-5'-triphosphate | 2'-Deoxy-2'-fluoroguanosine-5'-triphosphate is an important reagent widely used in nucleic acid research and diagnosis in biomedical industry. Its significance lies in the fact that it is an essential component of synthetic modified DNA strands, and its role is enhanced by the excellent stability conferred by its unique fluorine substitution and nuclease resistance. Multiple applications of the compound include drug discovery, genetic engineering, and research related to antiviral drugs. Synonyms: 2'-Deoxy-2'-fluoro-D-guanosine-5'-triphosphate; 2'-F-dGTP; 2'-Deoxy-2'-fluoroguanosine 5'-(tetrahydrogen triphosphate); 2'-Fluoro GTP; 2'-Fluoro-2'-deoxy-GTP; 2'-Fluoro-2'-deoxyguanosine-5'-triphosphate; 2'-FdGTP; 2'-deoxy-2'-fluoroguanosine triphosphate; 2'-Fluoro-2'-deoxyguanosine 5'-triphosphoric acid; Guanosine, 2'-deoxy-2'-fluoro-, 5'-(tetrahydrogen triphosphate); 2'F-dGTP; 2'-Fluoro-dGTP. Grade: 95%. CAS No. 202186-97-8. Molecular formula: C10H15FN5O13P3. Mole weight: 525.17. | |
| 2'-F-Ac-C-ANA-CE Phosphoramidite | 2'-F-Ac-C-ANA-CE Phosphoramidite is a remarkably efficacious phosphoramidite reagent, extensively employed in intricate oligonucleotide synthesis endeavors. This paramount constituent functions as a fundamental unit in fabricating nucleic acids bearing ameliorated characteristics, specifically in the realm of antiviral functionality. The integration of 2'-F-Ac-C modification augments deftness against nuclease degradation and guarantees heightened stability, rendering it exceptionally congruous for the purpose of combatting viral afflictions. Synonyms: 5'-Dimethoxytrityl-N4-acetyl-2'-deoxy-2'-fluoroarabinocytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C41H49FN5O8P. Mole weight: 789.83. | |
| 2'-F-dTTP | 2'-F-dTTP is a modified nucleoside triphosphate that increases the stability of nucleases. Synonyms: 2'-Fluoro-thymidine-5'-Triphosphate. Grade: ≥95% by AX-HPLC. Molecular formula: C10H16N2O14P3F. Mole weight: 500.16. | |
| 2'-O-Methyl-3'-deoxyuridine | 2'-O-Methyl-3'-deoxyuridine is a modified nucleoside that features a 2'-O-methyl group and a 3'-deoxy structure. The 2'-O-methyl modification at the ribose sugar enhances the stability of the nucleoside by protecting it from nuclease degradation. The 3'-deoxy group prevents further elongation of the nucleotide chain, making it useful as a chain terminator. This modification is primarily applied in DNA synthesis, particularly in the design of oligonucleotides for gene editing, diagnostic applications, and therapeutic uses, where increased stability and controlled chain termination are required. Synonyms: 3'-Deoxy-2'-O-methyluridine; 1-((2R,3R,5S)-5-(Hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Grade: ≥95%. Molecular formula: C10H14N2O5. Mole weight: 242.23. | |
| 2'-O-Methyl-5-methyl-UTP | 2'-O-Methyl-5-methyl-UTP is a sugar-modified nucleoside triphosphate that increases target affinity and nuclease stability, while reducing immune response. Synonyms: 2'-O-Methyl-5-methyluridine-5'-Triphosphate. Grade: ≥90% by AX-HPLC. Molecular formula: C11H19N2O15P3. Mole weight: 512.19. | |
| 2-O-MOE-Spacer Phosphoramidite | 2-O-MOE-Spacer Phosphoramidite is a modified phosphoramidite used in the synthesis of oligonucleotides, incorporating a 2'-O-methoxyethyl (MOE) modification on the ribose sugar. The MOE modification enhances the stability, nuclease resistance, and hybridization properties of the oligonucleotide, improving its performance in biological applications. The spacer refers to a chemical linker that separates the modified nucleoside from the rest of the oligonucleotide chain, often used to introduce flexibility or to provide a region for further functionalization, such as conjugation to other molecules like drugs, probes, or proteins. The phosphoramidite group at the 5'-position allows for the incorporation of this modified nucleotide into the growing oligonucleotide chain during synthesis. This phosphoramidite is useful for creating oligonucleotides with enhanced properties, such as improved cellular uptake, stability, and functionality, in applications like antisense therapy, RNA-based therapeutics, or gene editing. Synonyms: (2R,3S,4S)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5-O-DMT-2-O-MOE-D-Ribose 3-CE phosphoramidite; DMT-2'-O-MOE-D-Ribitol phosphoramidite; 5'-O-DMTr-2'-O-MOE-3'-Phosphoramidite; Abasic 2'-O-MOE amidite; DMT-2'-O-MOE-D-Ribitol 3-CE phosphoramidite. Grade: ≥95%. CAS No. 2934665-30-0. Molecular formula: | |
| 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N-dibutylformamide-isocytidine 3'-CE phosphoramidite | 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N-dibutylformamide-isocytidine 3'-CE phosphoramidite is a highly specialized and indispensable building block utilized in the intricate synthesis of RNA and DNA strands, careening through the impermeable terrain of nucleic acid research and development. It propels researchers towards the ultimate goal of introducing a phosphorothioate linkage at the prestigious 3'-end of oligonucleotide synthesis, effectively impeding nuclease degradation with magnificent fortitude. Behold, as this product facilitates the development of novel anti-cancer drugs, gene therapy, and RNA interference (RNAi) technologies with unparalleled excellence. Molecular formula: C54H79N6O8PSi. Mole weight: 999.30. | |
| 3'-BHQ-3 CPG | 3'-BHQ-3 CPG, a modified nucleotide, is a vital component of oligonucleotide synthesis for scientific research. The merging of black hole quencher (BHQ) and 3' cytosine (C) modification endows it with magnified quenching capacity for fluorescent probes and enhanced nuclease stability that is imperative in the domain of diagnostics and therapeutics for addressing viral, cancerous, and immune disorders. Synonyms: 3'-QD-3 CPG; 3-Diethylamino-5-phenylphenazium-7-diazobenzene-4''-(N-ethyl-2-O-(4,4'-dimethoxytrityl))-N-ethyl-2-O-glycolate-CPG. | |
| 3'-Deoxy-2'-C-methyluridine | 3'-Deoxy-2'-C-methyluridine is a modified nucleoside used in DNA synthesis. It features a 3'-deoxy structure, meaning the 3'-hydroxyl group is removed, which prevents further chain elongation, and a 2'-C-methyl modification, where a methyl group is attached to the 2'-carbon of the ribose sugar. This modification is used primarily in DNA, as it can improve the stability of the nucleic acid and protect it from nuclease degradation. Additionally, the 3'-deoxy group acts as a chain terminator, making it useful in the design of oligonucleotides for gene editing, diagnostics, and therapeutic applications. Synonyms: 2'-C-Methyl-3'-deoxyuridine; 1-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Grade: ≥95%. CAS No. 934014-19-4. Molecular formula: C10H14N2O5. Mole weight: 242.23. | |
| 3'-O-Acetyl-N2-isobutyryl-4'-thio-2'-deoxy-beta-D-guanosine | 3'-O-Acetyl-N2-isobutyryl-4'-thio-2'-deoxy-β-D-guanosine is a chemically modified nucleoside with multiple functional group modifications. The 3'-hydroxyl group of the deoxyribose sugar is acetylated, and the N2 position of the guanine base is protected with an isobutyryl group. Additionally, the 4'-oxygen atom of the sugar is replaced by sulfur, forming a 4'-thio sugar derivative. The acetyl and isobutyryl groups act as protecting groups during oligonucleotide synthesis, ensuring selective reactions at other sites. This compound is primarily used in nucleic acid chemistry for synthesizing modified oligonucleotides, offering enhanced stability, nuclease resistance, and unique structural or biochemical properties for research or therapeutic applications. Synonyms: N-(2-Methyl-1-oxopropyl)-3'-O-acetyl-2'-deoxy-4'-thioguanosine; N2-Isobutyryl-3'-O-acetyl-4'-thio-2'-deoxyguanosine. Molecular formula: C16H21N5O5S. Mole weight: 395.43. | |
| 3'-O-Acetyl-N4-benzoyl-4'-thio-2'-deoxy-beta-D-cytidine | 3'-O-Acetyl-N4-benzoyl-4'-thio-2'-deoxy-beta-D-cytidine is a modified nucleoside with several structural modifications. The 3'-O-acetyl group is attached to the 3' hydroxyl of the sugar, providing steric protection and increasing the stability of the nucleoside. The N4-benzoyl modification is attached to the nitrogen at the N4 position of the cytosine base, which can affect its interactions with other nucleic acids or enzymes, potentially enhancing binding affinity or altering recognition. The 4'-thio modification replaces the oxygen atom at the 4' position of the ribose sugar with a sulfur atom, which can increase the stability and binding affinity of the nucleoside. The 2'-deoxy structure indicates the absence of the 2'-hydroxyl group, making it a deoxyribonucleotide, suitable for DNA synthesis. This modified nucleoside can be used in DNA research, gene editing, or therapeutic applications where increased stability, nuclease resistance, and specific interactions with biological targets are important. Synonyms: Cytidine, N-benzoyl-2'-deoxy-4'-thio-, 3'-acetate; N-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thio-cytidine; N4-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thio-cytidine. Grade: ≥95%. CAS No. 667882-71-5. Molecular formula: C18H19N3O5S. Mole weight: 389.43. | |
| 3'-O-Acetyl-N6-benzoyl-4'-thio-2'-deoxy-beta-D-adenosine | 3'-O-Acetyl-N6-benzoyl-4'-thio-2'-deoxy-beta-D-adenosine is a modified nucleoside with several structural changes. The 3'-O-acetyl group is attached to the 3' position of the sugar, providing steric protection and increasing the stability of the nucleoside. The N6-benzoyl modification is attached to the adenine base at the N6 position, which can alter the interactions of the nucleoside with enzymes or other nucleic acids. The 4'-thio modification involves replacing the oxygen at the 4' position of the sugar with a sulfur atom, which can enhance the stability and binding properties of the nucleoside. Finally, the 2'-deoxy structure indicates the absence of the hydroxyl group at the 2' position, making it a deoxyribonucleotide. This modified nucleoside can be used in DNA synthesis, particularly for research applications involving stability enhancement, resistance to nucleases, and altered interactions with biological systems. Synonyms: Adenosine, N-benzoyl-2'-deoxy-4'-thio-, 3'-acetate; N-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thioadenosine; N6-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thioadenosine. Grade: ≥95%. CAS No. 667882-73-7. Molecular formula: C19H19N5O4S. Mole weight: 413.45. | |
| 3'-O-allyl-2'-deoxythymidine-5'-triphosphate trisodium salt | 3'-O-allyl-2'-deoxythymidine-5'-triphosphate trisodium salt: a substrate utilized in enzymatic reactions, PCR and sequencing, is ideal for improving nuclease resistance and duplex stability when synthesizing modified DNA oligos. Its multifaceted potential is truly remarkable. Synonyms: 3'-O-allyl-2'-dTTP·Na3. Grade: ≥97% by HPLC. Molecular formula: C13H18N2Na3O14P3. Mole weight: 588.18. | |
| 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite | 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite is a modified nucleotide used in the synthesis of Threose Nucleic Acid (TNA) molecules for biomedical research. TNA is a promising alternative to DNA and RNA for gene and drug delivery due to its chemical stability and resistance to nuclease degradation. This specific phosphoramidite derivative incorporates a benzoyl-adenosine moiety, making it ideal for designing TNA-based drugs for the treatment of viral infections, inflammatory diseases, and cancer. Synonyms: DMTr-TNA A(Bz)-amidite; TNA-A(Bz)-CE-Phosphoramidite; DMTr-TNA A(Bz)-Phosphoramidite; N-Benzoyl-9-[(2R)-3alpha-[(diisopropylamino)(2-cyanoethoxy)phosphinooxy]-4beta-(4,4'-dimethoxytrityloxy)tetrahydrofuran-2beta-yl]-9H-purine-6-amine; 1-{2'-O-[(2-Cyanoethoxy)(diisopropyl amino)phosphino]-3'-O-[(4,4'-dimethoxytriphenyl)methyl]-a-L-threofuranosyl}-N6-benzoyladenine; (2R,3R,4S)-2-[6-(Benzoylamino)-9H. Grade: 98%. CAS No. 325683-93-0. Molecular formula: C46H50N7O7P. Mole weight: 843.92. | |
| 4'-Thio-2'-deoxycytidine | 4'-Thio-2'-deoxycytidine is a modified nucleoside where the oxygen atom at the 4' position of the ribose sugar is replaced with a sulfur atom, creating a thio group. The 2'-deoxy structure means the nucleoside lacks the hydroxyl group at the 2' position, making it a deoxyribonucleotide, which is commonly used in DNA synthesis. The 4'-thio modification increases the stability of the nucleoside and can improve its resistance to nucleases. This modification can also affect the binding affinity and specificity of the nucleoside in interactions with other nucleic acids or proteins. 4'-Thio-2'-deoxycytidine is often used in DNA-based research, including gene editing, oligonucleotide design, and therapeutic applications, where stability and nuclease resistance are important. Synonyms: 2'-Deoxy-4'-thiocytidine; NSC 764276; 1-(2-Deoxy-4-thio-beta-D-ribofuranosyl)cytosine; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)pyrimidin-2(1H)-one. Grade: ≥95%. CAS No. 134111-30-1. Molecular formula: C9H13N3O3S. Mole weight: 243.28. | |
| 4-Thio-2'-F-dU Phosphoramidite | 4-Thio-2'-F-dU Phosphoramidite is a chemically modified phosphoramidite in which the oxygen atom at the 4-position of the uracil base is replaced with a sulfur atom, and the ribose sugar is substituted with a fluorine atom at the 2'-position. The 3'-cyanoethyl (CE) phosphoramidite group facilitates its incorporation into oligonucleotides during automated synthesis. This modification enhances the stability and nuclease resistance of the resulting DNA strands and introduces unique structural and chemical properties, such as thiol-reactive functionality. It is widely used in therapeutic oligonucleotide development, molecular biology research, and the study of nucleic acid-protein interactions. Synonyms: 4-Thio-2'-F-dU CEP; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-deoxy-2'-fluoro-4-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-deoxy-2'-fluoro-4-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 4-S-(2-cyanoethyl)-2'-F-dU 3'-CE-phosphoramidite. Grade: ≥95%. Molecular formula: C42H49FN5O7PS. Mole weight: 817.91. | |
| 5-Br-CTP | 5-Br-CTP is a base modified ribonucleoside triphosphate used in SELEX technology to provide thermal stability and nuclease resistance to aptamers. Synonyms: 5-Bromocytidine-5'-Triphosphate. Grade: ≥90% by AX-HPLC. Molecular formula: C9H15N3O14P3Br. Mole weight: 562.05. | |
| 5-Br-dU-CE Phosphoramidite | 5-Br-dU-CE Phosphoramidite, a chemical compound used in oligonucleotide synthesis, boasts a 5-bromo-2'-deoxyuridine (Br-dU) group that is linked to a cytosine base, thereby elevating base-pairing specificity and amplifying nuclease resistance. Its potential applications in the realm of biomedical research, encompassing cancer treatment, antiviral agents, and gene therapy, warrant close scrutiny. Synonyms: 5'-Dimethoxytrityl-5-bromo-2'-deoxyUridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C39H46BrN4O8P. Mole weight: 809.69. | |
| 5-Br-UTP | 5-Br-UTP is a base modified ribonucleoside triphosphate used in SELEX technology to provide thermal stability and nuclease resistance to aptamers. Synonyms: 5-Bromouridine-5'-Triphosphate. Grade: ≥90% by AX-HPLC. Molecular formula: C9H14N2O15P3Br. Mole weight: 563.0. | |
| 5'-O-DMT-N6-Acetyl-2'-deoxyadenosine 3'-CE phosphoramidite | 5'-O-DMT-N6-Acetyl-2'-deoxyadenosine 3'-CE phosphoramidite is a key component for the synthesis of modified oligonucleotides, which have applications in gene therapy and antiviral drug development. This phosphoramidite can be used to introduce an N6-acetyldeoxyadenosine modification to oligonucleotide strands, which has been shown to enhance their cellular uptake and improve their stability towards nucleases. It is also useful for generating oligonucleotides with 3'-CE modifications, which can improve their binding and selectivity towards complementary RNA targets. Synonyms: Adenosine N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N-Acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxyadenosine. Grade: ≥98% by HPLC. CAS No. 1027734-01-5. Molecular formula: C42H50N7O7P. Mole weight: 795.86. | |
| 5'-O-DMTr-2',3'-dideoxy-3'-fluoro-D-altritol-5-methyluridine | 5'-O-DMTr-2',3'-dideoxy-3'-fluoro-D-altritol-5-methyluridine is a modified nucleoside featuring a 5-methyluridine base attached to a D-altritol sugar backbone, which lacks the 2' and 3' hydroxyl groups (dideoxy) and has a fluorine atom at the 3' position. The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group, enabling its use in solid-phase oligonucleotide synthesis. This compound combines the enhanced chemical stability and nuclease resistance of the altritol backbone with the methylation at the 5-position of uridine, which can improve duplex stability and modulate biological activity, making it suitable for therapeutic and diagnostic oligonucleotide development. Synonyms: 1,5-Anhydro-6-O-[bis(4-methoxyphenyl)phenylmethyl]-2,3-dideoxy-2-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-fluoro-D-altritol; 1-((3R,4S,5R,6R)-6-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-hydroxytetrahydro-2H-pyran-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione. Grade: ≥95%. CAS No. 1117903-20-4. Molecular formula: C32H33FN2O7. Mole weight: 576.61. | |
| 5'-O-DMTr-2',3'-dideoxy-3'-fluoro-D-altritol uridine | 5'-O-DMTr-2',3'-dideoxy-3'-fluoro-D-altritol uridine is a modified nucleoside analog where the uridine base is attached to a D-altritol sugar backbone, lacking the 2' and 3' hydroxyl groups (dideoxy) and containing a fluorine substitution at the 3' position. The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group to facilitate its use in solid-phase oligonucleotide synthesis. This analog is valuable in designing chemically modified nucleic acids, offering enhanced stability against nuclease degradation and improved biophysical properties, making it useful for therapeutic, diagnostic, or biochemical applications. Synonyms: 1,5-Anhydro-6-O-[bis(4-methoxyphenyl)phenylmethyl]-2,3-dideoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-fluoro-D-altritol. Grade: ≥95%. CAS No. 1117903-09-9. Molecular formula: C31H31FN2O7. Mole weight: 562.59. | |
| 5'-O-DMTr-N2-isobutyroyl-2',3'-dideoxy-3'-fluoro-D-allitol guanidine | 5'-O-DMTr-N²-isobutyroyl-2',3'-dideoxy-3'-fluoro-D-allitol guanidine is a modified nucleoside analog featuring a guanine-like base with an N²-isobutyroyl protecting group attached to a D-allitol sugar backbone. The sugar is modified with a 3'-fluoro substitution and lacks the 2' and 3' hydroxyl groups (dideoxy). The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group, enabling its application in solid-phase oligonucleotide synthesis. This structure is designed for improved nuclease resistance, enhanced thermal stability of oligonucleotide duplexes, and optimized interactions in therapeutic or diagnostic nucleic acid applications. Synonyms: 1,5-Anhydro-6-O-[bis(4-methoxyphenyl)phenylmethyl]-2,3-dideoxy-2-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]-3-fluoro-D-allitol. Grade: ≥95%. CAS No. 1197033-32-1. Molecular formula: C36H38FN5O7. Mole weight: 671.72. | |
| 5'-O-DMTr-N2-isobutyroyl-2',3'-dideoxy-3'-fluoro-D-altritol guanidine | 5'-O-DMTr-N²-isobutyroyl-2',3'-dideoxy-3'-fluoro-D-altritol guanidine is a modified nucleoside analog where a guanine-like base is attached to a D-altritol sugar backbone. This structure features a 3'-fluoro substitution and lacks the 2' and 3' hydroxyl groups (dideoxy). The base's N²-position is protected with an isobutyroyl group, and the 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group for use in solid-phase synthesis. This compound is engineered for enhanced nuclease resistance and improved thermal stability of oligonucleotides, making it valuable in therapeutic, diagnostic, or biochemical research involving modified nucleic acids. Synonyms: 1,5-Anhydro-6-O-[bis(4-methoxyphenyl)phenylmethyl]-2,3-dideoxy-2-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]-3-fluoro-D-altritol. Grade: ≥95%. CAS No. 1117903-82-8. Molecular formula: C36H38FN5O7. Mole weight: 671.72. | |
| 5'-O-DMT-thymidine 3'-thiophosphoramidite | 5'-O-DMT-thymidine 3'-thiophosphoramidite, a highly indispensable reagent employed in numerous biomedical applications, has the capability to confer augmented stability and safeguard the resultant sequences against degradation by nucleases. Its employment facilitates the precise introduction of 5'-O-DMT-thymidine into the oligonucleotide chain, thereby enabling focused therapeutic interventions for drug administration, gene suppression, and pathological condition detection. Synonyms: 5'-Dimethoxytrityl-2'-deoxythymidine 3'-[(B-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite; dT-Thiophosphoramidite. Grade: 90%. Molecular formula: C44H48N3O8PS2. Mole weight: 841.97. | |
| 6-OMe-dG(dmf)-CE Phosphoramidite | 6-OMe-dG(dmf)-CE Phosphoramidite is a modified phosphoramidite used in the synthesis of oligonucleotides, particularly for applications requiring increased stability or functionality. It features a 6-O-methyl (OMe) group on the guanine (dG) base, which can enhance the stability of the oligonucleotide and influence its hybridization properties by protecting the base from certain enzymatic activities. The (dmf) modification likely refers to a dimethylformamide-based protecting group or solvent component, providing stability during the synthesis process. This phosphoramidite is particularly useful in creating oligonucleotides for applications like gene silencing, antisense therapy, and RNA-based drug development, where nuclease resistance, stability, and targeted interactions are critical. The 6-O-methylation of guanine helps improve the resistance to degradation and enhances the overall performance of the synthesized oligonucleotides in biological systems. Synonyms: 5'-O-DMT-6-OMe-dG(dmf)-CE Phosphoramidite; 5'-O-DMT-6-OMe-dG(dmf)-3'-CE Phosphoramidite; 5'-O-DMT-N2-DMF-6-OMe-2'-deoxyguanosine 3'-CE Phosphoramidite. Grade: ≥95%. Molecular formula: C44H55N8O7P. Mole weight: 838.95. | |
| 7-Propargylamino-7-deaza-dGTP - ATTO-580Q | 7-Propargylamino-7-deaza-dGTP - ATTO-580Q is a fluorescent nucleotide analog used for labeling DNA during polymerase chain reaction (PCR) or sequencing. It can specifically label adenine bases and is useful for detecting mutations or identifying DNA-protein interactions. Its unique structure also makes it resistant to nucleases and exonucleases. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyguanosine-5'-triphosphate, labeled with ATTO 580Q, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C14H20N5O13P3- ATTO 580Q (free acid). Mole weight: 1235.25 (free acid). | |
| A(Ac)-TOM-CE Phosphoramidite | 2'-O-TOM-A(Ac) Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-O-TOM (2'-O-tomc) modification attached to an adenosine (A) nucleotide, along with an acetyl (Ac) group. This modification enhances stability and protects against nuclease degradation. It is often employed in applications such as RNA interference, gene expression modulation, and therapeutic RNA-based treatments. The synthesis of RNA using monomers containing the 2'-O-Triisopropylsilyloxymethyl (TOM) group (TOM-Protecting-Group) has very high coupling efficiency along with fast, simple deprotection. Synonyms: 5'-Dimethoxytrityl-N-acetyl-Adenosine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N-Acetyl-2'-O-[(triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)adenosine; Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methyleth. Grade: ≥95%. CAS No. 253586-13-9. Molecular formula: C52H72N7O9PSi. Mole weight: 998.23. | |
| Aluminon | Aluminon (ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium) is a complexometric titration indicator and can also be used as a nuclease inhibitor affecting transfection. Aluminon is a kind of biological materials or organic compounds that are widely used in life science research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium. CAS No. 569-58-4. Pack Sizes: 5 g. Product ID: HY-124493. | |
| BAMH I | BAMH I. Uses: Designed for use in research and industrial production. Additional or Alternative Names: e.c.3.1.23.6;endodeoxyribonucleasebamfi;endodeoxyribonucleasebamhi;endodeoxyribonucleasebamki;endodeoxyribonucleasebamni;endodeoxyribonucleasebsti;endonucleasebamhi;restrictionendodeoxyribo-nucleasbamhi. Product Category: Heterocyclic Organic Compound. CAS No. 81295-09-2. Purity: 0.96. Product ID: ACM81295092. Alfa Chemistry ISO 9001:2015 Certified. | |
| Brivudine | Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro. Synonyms: (E)-5-(2-Bromovinyl)-2'-deoxyuridine; (E)-5-(2-Bromovinyl)deoxyuridine; (E)-5-O-(2-bromoethenyl)-2'-deoxyuridine; 5-[(1E)-2-Bromoethenyl]-2'-deoxyuridine; 5-[(E)-2-Bromoethenyl]-2'-deoxyuridine; BVDU; Brivudin; Bromovinyldeoxyuridine; Helpin. Grade: ≥98% by HPLC. CAS No. 69304-47-8. Molecular formula: C11H13BrN2O5. Mole weight: 333.14. | |
| Clofarabine Phosphoramidite | Clofarabine Phosphoramidite is a modified phosphoramidite derived from the chemotherapeutic agent clofarabine, a purine nucleoside analog. In this compound, the ribose sugar is substituted with a 2'-fluoro and 2-chloro group, and the base is a chlorinated adenine analog. The sugar moiety features a 3'-cyanoethyl (CE) phosphoramidite group, enabling its incorporation into oligonucleotides during automated synthesis. This modification is used to synthesize oligonucleotides with enhanced stability, resistance to nuclease degradation, and potential therapeutic properties. Clofarabine phosphoramidite is particularly valuable in creating DNA or RNA analogs for research into cancer therapeutics and nucleic acid-based drug development. Synonyms: 2-Chloro-2'-deoxy-2'-fluoro-rA(dmf) Phosphoramidite; 2-Chloro-2'-deoxy-2'-fluoro-rA(dmf) 3'-CED phosphoramidite. Grade: ≥97%. Molecular formula: C43H51ClFN8O6P. Mole weight: 861.35. | |
| dA(Bz)-3'-PS Phosphoramidite | dA(Bz)-3'-PS Phosphoramidite is a deoxyadenosine-derived phosphoramidite designed for oligonucleotide synthesis with a 3'-phosphorothioate (PS) linkage. In this modification, a non-bridging oxygen atom in the phosphate backbone is replaced by a sulfur atom, significantly improving nuclease resistance and biological stability of the oligonucleotides. The adenine base is protected with a benzoyl (Bz) group at the N6 position to prevent side reactions during synthesis while maintaining proper base-pairing properties. This phosphoramidite is particularly valuable in therapeutic oligonucleotide development, such as antisense oligonucleotides and siRNA, where enhanced stability, enzymatic resistance, and prolonged biological activity are critical for efficacy. Synonyms: 5'-DMT-dA(Bz)-3'-PS-Phosphoramidite; dA(Bz) ThioPhosphamidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[S-[2-(benzoylthio)ethyl] 1-pyrrolidinylphosphonothioite]; S-(2-(((((2R,3S,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate. Grade: ≥90%. CAS No. 178272-29-2. Molecular formula: C51H51N6O7PS2. Mole weight: 955.09. | |
| dC(Ac)-3'-PS Phosphoramidite | dC(Ac)-3'-PS Phosphoramidite is a cytidine-derived phosphoramidite designed for the synthesis of oligonucleotides containing a 3'-phosphorothioate (PS) linkage. The 3'-PS modification replaces a non-bridging oxygen atom in the phosphate group with a sulfur atom, providing enhanced nuclease resistance and improved biological stability to the resulting oligonucleotides. The cytosine base is protected with an acetyl (Ac) group at the N4 position to prevent unwanted side reactions during synthesis. This phosphoramidite is widely used in therapeutic applications, such as antisense oligonucleotides and siRNA, where increased stability, resistance to enzymatic degradation, and prolonged activity are critical for performance. Synonyms: 5'-DMT-dC(Ac)-3'-PS-Phosphoramidite; Cytidine, N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; Cytidine, N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[S-[2-(benzoylthio)ethyl] 1-pyrrolidinylphosphonothioite]; dC(Ac) ThioPhosphamidite. Grade: ≥90%. Molecular formula: C45H49N4O8PS2. Mole weight: 869.00. | |
| dC(Bz)-3'-PS Phosphoramidite | dC(Bz)-3'-PS Phosphoramidite is a cytidine-derived phosphoramidite used for synthesizing oligonucleotides containing a 3'-phosphorothioate (PS) linkage. The 3'-PS modification replaces a non-bridging oxygen atom in the phosphate group with a sulfur atom, enhancing the nuclease resistance and biological stability of the resulting oligonucleotides. The cytosine base is protected with a benzoyl (Bz) group at the N4 position to prevent side reactions during synthesis. This phosphoramidite is particularly useful in therapeutic oligonucleotides, such as antisense and siRNA applications, where improved stability, enzymatic resistance, and prolonged biological activity are essential. Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[S-[2-(benzoylthio)ethyl] 1-pyrrolidinylphosphonothioite]; dC(Bz) ThioPhosphamidite; 5'-DMT-dC(Bz)-3'-PS-Phosphoramidite. Grade: ≥90%. CAS No. 178272-25-8. Molecular formula: C50H51N4O8PS2. Mole weight: 931.07. | |
| DEPC-Treated Water | DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity[1]. Uses: Scientific research. Group: Biochemical assay reagents. Pack Sizes: 500 mL. Product ID: HY-156262. | |
| dG(iBu)-3'-PS Phosphoramidite | dG(iBu)-3'-PS Phosphoramidite is a deoxyguanosine-derived phosphoramidite designed for oligonucleotide synthesis incorporating a 3'-phosphorothioate (PS) linkage. The 3'-PS modification replaces a non-bridging oxygen atom in the phosphate group with a sulfur atom, providing enhanced nuclease resistance and improved biological stability for the resulting oligonucleotides. The guanine base is protected with an isobutyryl (iBu) group at the N2 position to prevent side reactions during synthesis while maintaining proper base-pairing properties. This phosphoramidite is widely used in therapeutic applications, such as antisense oligonucleotides and siRNA, where increased enzymatic resistance, stability, and prolonged activity are essential for performance. Synonyms: 5'-DMT-dG(iBu)-3'-PS-Phosphoramidite; dG(iBu) ThioPhosphamidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-[S-[2-(benzoylthio)ethyl] 1-pyrrolidinylphosphonothioite]; S-(2-(((((2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate. Grade: ≥90%. CAS No. 178272-31-6. Molecular formula: C48H53N6O8PS2. Mole weight: 937.08. | |
| dG-Thiophosphoramidite | dG-Thiophosphoramidite, a premium reagent, is widely utilized in biomedical research. Its application lies in the synthesis of DNA oligonucleotides equipped with thiophosphate links, rendering them incredibly potent agents for combating diseases such as cancer and viral infections, courtesy of enhanced nuclease resistance. Researchers entrust this reagent for its dependable performance as it is easily accessible and has a sound reputation. Synonyms: 5'-Dimethoxytrityl-N-isobutyryl-2'-deoxyGuanosine, 3'-[(ß-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite. Molecular formula: C48H53N6O8PS2. Mole weight: 937.07. | |
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