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Canagliflozin Ring Opening Impurity Canagliflozin Ring Opening Impurity is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: (2S,3R,4R,5R)-1-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)hexane-1,2,3,4,5,6-hexaol; D-Glucitol, 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-; 1-C-[3-[[5-(4-Fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol. Molecular formula: C24H27FO6S. Mole weight: 462.53. BOC Sciences 6
Citalopram Ring-opening Impurity Oxalate Citalopram Ring-opening Impurity Oxalate is an impurity of Citalopram, which is a serotonin (5-HT) uptake inhibitor used as an antidepressant. Synonyms: Citalopram Alkene Impurity Oxalate (Mixture Of Z And E Isomers); 4-(4-(Dimethylamino)-1-(4-fluorophenyl)but-1-en-1-yl)-3-(hydroxymethyl)benzonitrile oxalate; Citalopram Olefinic Impurity Oxalate. Molecular formula: C20H21FN2O.C2H2O4. Mole weight: 414.43. BOC Sciences 6
Everolimus Ring-Opening Impurity An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Retroaldol Degradation Product. Grade: 90% (Mixture of isomers). CAS No. 1708118-13-1. Molecular formula: C53H83NO14. Mole weight: 958.25. BOC Sciences 8
Ezetimibe ring-opening dehydrate impurity An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L31) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (αR,βS)-β-[(4-Fluorophenyl)amino]-α-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanoic Acid. Grade: > 95%. CAS No. 1292292-63-7. Molecular formula: C24H21F2NO3. Mole weight: 409.44. BOC Sciences 8
Ava23-Calcitonin (salmon) An impurity of Calcitonin (salmon). Calcitonin (salmon) is a synthetic form of the hormone calcitonin, derived from salmon. It is a potent 32-amino acid peptide used primarily to manage bone health and calcium regulation. Calcitonin (salmon) is used to treat conditions such as postmenopausal osteoporosis, Paget's disease, and hypercalcemia. Synonyms: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Ava-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Cys1&Cys7 bridge); Ava Calcitonin; [Ava23]-Calcitonin (salmon); CSNLSTCVLGKLSQELHKLQTY-Ava-RTNTGSGTP-NH2(Cys1&Cys7 bridge); L-Cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-5-aminopentanoate-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide; Proline ring opening calcitonin (salmon); Calcitonin (salmon) (Proline ring opening); [5-Aminovaleric acid]23-calcitonin (salmon). Grade: ≥95%. Molecular formula: C145H242N44O48S2. Mole weight: 3433.91. BOC Sciences 6
Benzyl Penicilloic Acid HCl (Mixture of Diastereomers) An impurity of Penicilloic Acid which is a thiazolidinedicarboxylic acid obtained from the penicillins by the hydrolytic opening of the lactam ring. Grade: > 95%. Molecular formula: C16H20N2O5S.HCl. Mole weight: 388.87. BOC Sciences 6
Benzyl Penicilloic Acid Mono-Sodium Salt (Mixture of Diastereomers) An impurity of Penicilloic Acid which is a thiazolidinedicarboxylic acid obtained from the penicillins by the hydrolytic opening of the lactam ring. Grade: > 95%. Molecular formula: C16H19N2O5S.Na. Mole weight: 374.39. BOC Sciences 6
Dapagliflozin Open Sugar Impurity Dapagliflozin Open Sugar Impurity is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin open sugar impurity; 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3R,4R,5R)-1-(4-Chloro-3-(4-ethoxybenzyl)phenyl)hexane-1,2,3,4,5,6-hexaol; Dapagliflozin ring opening impurity; (1R,2S,3R,4R)-1-(4-Chloro-3-(4-ethoxybenzyl)phenyl)hexane-1,2,3,4,5,6-hexaol. Molecular formula: C21H27ClO7. Mole weight: 426.89. BOC Sciences 7
Everolimus Related Compound 3 Everolimus Ring-Opening Impurity. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid. Grade: 95%. CAS No. 147438-30-0. Molecular formula: C32H49NO9. Mole weight: 591.75. BOC Sciences 8
2-? [ [ (1R, ?2R) ?-?2-? [ [4-? (1, ?2-?Benzisothiazol-?3-?yl) ?-?1-?piperazinyl] ?methyl] ?cyclohexyl] ?methyl] ?-1H-?isoindole-?1, ?3 (2H) ?-?dione 2-? [ [ (1R, ?2R) ?-?2-? [ [4-? (1, ?2-?Benzisothiazol-?3-?yl) ?-?1-?piperazinyl] ?methyl] ?cyclohexyl] ?methyl] ?-1H-?isoindole-?1, ?3 (2H) ?-?dione is an intermediate in synthesizing Lurasidone Opened Imide (L474935), an impurity in the synthesis of Lurasidone (L474920) which is antipsychotic used for treatment of schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 1260025-92-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C27H30N4O2S. US Biological Life Sciences. USBiological 9
Worldwide
2-(3-methoxypropyl)-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide An impurity of Brinzolamide, a potent carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Synonyms: 2-(3-METHOXYPROPYL)-2H-THIENO[3,2-E][1,2]THIAZINE-6-SULFONAMIDE 1,1-DIOXIDE; 2-(3-methoxypropyl)-1,1-dioxothieno[3,2-e]thiazine-6-sulfonamide; B0464-284943; 2-(3-METHOXYPROPYL)-2H-THIENO[3,2-E][1,2]THIAZINE-6-SULFONAMIDE1,1-DIOXIDE. CAS No. 171273-35-1. Molecular formula: C10H14N2O5S3. Mole weight: 338.42. BOC Sciences 3
2-(3-Methoxypropyl)-4-oxo-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide An impurity of Brinzolamide, a potent carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Synonyms: 2-(3-Methoxypropyl)-4-oxo-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; 3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide. Grade: 98.0%. CAS No. 154127-41-0. Molecular formula: C10H14N2O6S3. Mole weight: 354.41. BOC Sciences 2
(2R,4S)-2-[(2S,5S)-5-(4-Hydroxyphenyl)-3,6-dioxo-2-piperazinyl]-5,5-dimethyl-4-thiazolidinecarboxylic Acid (2R,4S)-2-[(2S,5S)-5-(4-Hydroxyphenyl)-3,6-dioxo-2-piperazinyl]-5,5-dimethyl-4-thiazolidinecarboxylic Acid is an impurity in the synthesis of N-(Penicillan-6-yl) Open Ring Amoxicillinamide Disodium Salt , whch is an impurity of Amoxicillin (A634235); a semi-synthetic antibiotic related to Penicillin (P233500). Antibacterial. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H19N3O5S. US Biological Life Sciences. USBiological 10
Worldwide
[2S-[2α,5α,6 β (S*) ] ] -6- [ [ (4-Hydroxyphenyl) [ [ [ (4-nitrophenyl) methoxy] carbonyl] amino] acetyl] amino] -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo [3. 2. 0] heptane-2-carboxylic Acid [2S-[2α,5α,6 β (S*) ] ] -6- [ [ (4-Hydroxyphenyl) [ [ [ (4-nitrophenyl) methoxy] carbonyl] amino] acetyl] amino] -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo [3. 2. 0] heptane-2-carboxylic Acid is an impurity in the synthesis of N-(Penicillan-6-yl) Open Ring Amoxicillinamide Disodium Salt, which is an impurity of Amoxicillin (A634235); a semi-synthetic antibiotic related to Penicillin (P233500). Antibacterial. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H23N4NaO9S. US Biological Life Sciences. USBiological 10
Worldwide
3 β,5 β-Dihydroxy Drospirenone-d4 Ring-opened (Alcohol Impurity) Intermediate in the preparation of labeled Drospirenone. Group: Biochemicals. Alternative Names: (3S, 5R, 6R, 7R, 8R, 9S, 10R, 13S, 14S, 15S, 16S, 17S) -Octadecahydro-17- (3-hydroxypropyl) -10, 13-dimethyl-5H-dicyclopropa [6, 7: 15, 16]cyclopenta [a]phenanthrene-3, 5, 17-triol-d4; [3S-(3α,5α,6 β,7 β,8α,9 β, 10α, 13α, 14 β,15 β,16 β , 17α ) ]-Octadecahydro-17- (3-hydroxypropyl) -10, 13-dimethyl-5H-dicyclopropa [6, 7: 15, 16]cyclopenta [a]phenanthrene-3, 5, 17-triol-d4; 17-(3-Hydroxypropyl)-6 β,7 β:15 β,16 β-dimethyleneandrostane-3 β,5 β,17 β-triol-d4. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 2
Worldwide
3 β,5 β-Dihydroxy Drospirenone Ring-opened (Alcohol Impurity) Intermediate in the preparation of Drospirenone. Group: Biochemicals. Alternative Names: (3S, 5R, 6R, 7R, 8R, 9S, 10R, 13S, 14S, 15S, 16S, 17S) -Octadecahydro-17- (3-hydroxypropyl) -10, 13-dimethyl-5H-dicyclopropa [6, 7: 15, 16]cyclopenta [a]phenanthrene-3, 5, 17-triol; [3S-(3α,5α,6 β,7 β,8α,9 β, 10α, 13α, 14 β,15 β,16 β , 17α ) ]-Octadecahydro-17- (3-hydroxypropyl) -10, 13-dimethyl-5H-dicyclopropa [6, 7: 15, 16]cyclopenta [a]phenanthrene-3, 5, 17-triol; 17-(3-Hydroxypropyl)-6 β,7 β:15 β,16 β-dimethyleneandrostane-3 β,5 β,17 β-triol. Grades: Highly Purified. CAS No. 82543-18-8. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
Worldwide
5-Beta-Hydroxy-Drospirenone-17-Propanol 5-Hydroxy Drospirenone Ring-opened Alcohol Impurity is an impurity of Drospirenone. Synonyms: (5R,6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-Octadecahydro-5,17-dihydroxy-17-(3-hydroxypropyl)-10,13-dimethyl-3H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-3-one; 17α-[3-Hydroxypropyl]-6β,7β:15β,16β-dimethylen-5β-androstan-5,17β-ol-3-one. Grade: > 95%. CAS No. 1357252-81-3. Molecular formula: C24H36O4. Mole weight: 388.54. BOC Sciences 5
Acetylated penicilloic acid of piperacillin An impurity of Piperacillin, which is a broad-spectrum antibiotic used to treat serious, hospital-acquired infections in combination with the beta lactamase inhibitor tazobactam. Synonyms: (2R,4S)-3-Acetyl-2-{(1R)-carboxy[(2R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetamido]methyl}-5,5-dimethylthiazolidine-4-carboxylic acid; (2R,4S)-3-Acetyl-2-[(R)-carboxy-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid; Glycine, (2R)-N-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]-2-phenylglycyl-2-[(2R,4S)-3-acetyl-4-carboxy-5,5-dimethyl-2-thiazolidinyl]-, (2R)-; (2R)-N-((4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl)-2-((2R)-phenylglycyl)-2-((2R,4S)-3-acetyl-4-carboxy-5,5-dimethyl-2-thiazolidinyl)glycine; Piperacillin Impurity 19; Piperacillin (Open Ring); N-Acetyl Piperacillin Penicilloic Acid Isomer 1. Grade: ≥95%. CAS No. 1706671-50-2. Molecular formula: C25H31N5O9S. Mole weight: 577.61. BOC Sciences 5
Acetyl brimonidine An impurity of Brimonidine. Brimonidine is an α2-Adrenoceptor agonist used as eye drops to treat open-angle glaucoma or ocular hypertension. Synonyms: Acetyl Brimonidine Impurity; 1-(2-((5-Bromo-6-quinoxalinyl)amino)-4,5-dihydro-1H-imidazol-1-yl)ethanone; 5-Bromo-N-(1-acetylimidazolidin-2-ylidene)quinoxalin-6-amine; 1-(2-((5-Bromoquinoxalin-6-yl)amino)-4,5-dihydro-1H-imidazol-1-yl)ethan-1-one. Grade: ≥95%. CAS No. 1158184-23-6. Molecular formula: C13H12BrN5O. Mole weight: 334.17. BOC Sciences 5
Ampicillin open ring dimer An impurity of Ampicillin, an antibiotic used for the treatment of various bacterial infections. Synonyms: (4S)-2-{1-[(R)-2-amino-2-phenylacetamido]-2-[(1R)-2-{[(4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl]methylamino}-2-oxo-1-phenylethylamino]-2-oxoethyl}-5,5-dimethylthiazolidine-4-carboxylic acid. Molecular formula: C31H40N6O7S2. Mole weight: 672.82. BOC Sciences 6
Anidulafungin Impurity A Anidulafungin Impurity A is a degradation impurity of Anidulafungin, a semisynthetic echinocandin used as an antifungal drug. Anidulafungin has been used in the treatment of invasive fungal infections including candidiasis, candidemia and esophageal candidiasis. Synonyms: Anidulafungin Open-chain Degradant. Molecular formula: C58H73N7O17. Mole weight: 1140.25. BOC Sciences 6
Apixaban Amino Acid Impurity It is an open ring impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: Apixaban open ring acid; Apixaban Open Chain Acid; 5-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic acid. CAS No. 2206825-87-6. Molecular formula: C25H27N5O5. Mole weight: 477.51. BOC Sciences 6
Apixaban Impurity 31 An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: Apixaban methyl ester and cyclic amide open chain methyl ester. CAS No. 2458079-10-0. Molecular formula: C27H30N4O6. Mole weight: 506.56. BOC Sciences 6
Aprepitant open ring methyl ester Aprepitant open ring methyl ester is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: N-(Destriazolonomethyl) N-(Methylcarboxyacetamidohydrazono) Aprepitant; Hydrazinecarboxylic acid, 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]-, methyl ester; Methyl 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylate; Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)-1-iminoethyl)hydrazine-1-carboxylate; Aprepitant Open-Ring Methyl Ester Impurity. Grade: ≥95%. CAS No. 219821-37-1. Molecular formula: C24H25F7N4O4. Mole weight: 566.48. BOC Sciences 6
Arginine Ring-opened Aztreonam Arginine Ring-opened Aztreonam is an Aztreonam (A965200) Impurity I. Aztreonam is the first totally synthetic monocyclic β-lactam antibiotic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C19H31N9O10S2, Molecular Weight: 609.63. US Biological Life Sciences. USBiological 3
Worldwide
Aztreonam Impurity A Aztreonam Impurity A is an metabolite of Aztreonam, a synthetic monocyclic β-lactam antibiotic. Synonyms: SQ 26992; Open Ring Aztreonam; [S-[R*,R*-(Z)]]-2-[[(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-3-(sulfoamino)-butanoic acid. Grade: > 95%. CAS No. 87500-74-1. Molecular formula: C13H19N5O9S2. Mole weight: 453.45. BOC Sciences 6
Brimonidine-[d4] D-Tartrate Brimonidine-[d4] D-Tartrate is the labelled impurity of Brimonidine. Brimonidine is a medication used for the treatment of eye disorders including open-angle glaucoma and high fluid pressure. Synonyms: Brimonidine-d4 D-Tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-d4-2-yl)-6-quinoxalinamine D-Tartrate. Grade: 95% by HPLC; 98% atom D. CAS No. 1316758-27-6. Molecular formula: C11H6D4BrN5.C4H6O6. Mole weight: 446.25. BOC Sciences 2
Cefaclor EP Impurity E An impurity of Cefaclor, a second-generation cephalosporin antibiotic used for the treatment of a wide variety of bacterial infections. Synonyms: Cefaclor Open-Ring Impurity; 2-((R)-2-Amino-2-phenylacetamido)-2-(5-chloro-4-oxo-3,4-dihydro-2H-1,3-thiazin-2-yl)acetic Acid. Grade: 95%. CAS No. 188915-50-6. Molecular formula: C14H14ClN3O4S. Mole weight: 355.80. BOC Sciences 6
Cefdinir Impurity 4 Cefdinir impurity formed by hydrolytic degradation pathway β-lactam ring opened lactones. Synonyms: [2RS-[2α[RS*(Z)],5β]]-α-[[(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-1,2,5,7-tetrahydro-5-methyl-7-oxo-4H-furo[3,4-d][1,3]thiazine-2-acetic Acid. Grade: > 95%. CAS No. 178422-45-2. Molecular formula: C14H15N5O6S2. Mole weight: 413.43. BOC Sciences 6
Cefdinir Impurity H Cefdinir Impurity H is one of Cefdinir impurities. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Synonyms: Cefdinir impurity H; 178949-04-7; Cefdinir decarboxy open ring lactone; 2O1193FN39; (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyimino-N-[(5-methyl-7-oxo-1,2,4,5-tetrahydrofuro[3,4-d][1,3]thiazin-2-yl)methyl]acetamide; (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)-N -(((2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H -furo(3,4-d)(1,3)thiazin-2-yl)methyl(acetamide; 2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)-N -(((2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H -furo(3,4-d)(1,3)thiazin-2-yl)methyl(acetamide, (Z)-; UNII-2O1193FN39; SCHEMBL23871786; (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)-N-{[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H-furo[3,4-d][1,3]thiazin-2-yl]methyl}acetamide; 4-Thiazoleacetamide, 2-amino-alpha-(hydroxyimino)-N-((1,2,5,7-tetrahydro-5-methyl-7-oxo-4H-furo(3,4-d)(1,3)thiazin-2-yl)methyl)-; 4-THIAZOLEACETAMIDE, 2-AMINO-.ALPHA.-(HYDROXYIMINO)-N-((1,2,5,7-TETRAHYDRO-5-METHYL-7-OXO-4H-FURO(3,4-D)(1,3)THIAZIN-2-YL)METHYL)-. Molecular formula: C14H15N5O6S2. Mole weight: 413.43. BOC Sciences 6
Cefprozil Monohydrate EP Impurity G An impurity of Cefprozil, a cephalosporin antibiotic used to treat a variety of bacterial infections. Synonyms: Z-Cefprozil open ring (USP); (Z)-open ring cefprozil; (R)-2-{(R)-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido](carboxy)methyl}-5-[(Z)-prop-1-enyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid. Grade: 90%. Molecular formula: C18H21N3O6S. Mole weight: 407.44. BOC Sciences 6
Cefprozil Monohydrate EP Impurity I An impurity of Cefprozil, a cephalosporin antibiotic used to treat a variety of bacterial infections. Synonyms: E-Cefprozil open ring; (R)-2-{(R)-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido](carboxy)methyl}-5-[(E)-prop-1-enyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid. Grade: 90%. Molecular formula: C18H21N3O6S. Mole weight: 407.44. BOC Sciences 6
Cyclosporin A-Derivative 1 Free base Cyclosporin A-Derivative 1 Free base is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Cyclosporin A open ring; N-Methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester; Cyclosporin A-Derivative 1 (Free base); Cyclosporin A seco(MeGly-MeLeu) Methyl Ester; Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}; LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}. Grade: ≥95%. CAS No. 286852-20-8. Molecular formula: C65H117N11O14. Mole weight: 1276.69. BOC Sciences
Dapagliflozin Open Ring Dapagliflozin Open Ring is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; Dapagliflozin Impurity 5 (Mixture of Diastereomers). Grade: >90%. CAS No. 2100872-88-4. Molecular formula: C21H27ClO7. Mole weight: 426.89. BOC Sciences 7
Dolutegravir Impurity B An impurity of Dolutegravir. Dolutegravir is an antiretroviral drug belonging to the integrase strand transfer inhibitor (INSTI) class. Synonyms: N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-(3-hydroxy-1-methylpropyl)-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide; Dolutegravir ring open impurity; N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide. Grade: ≥95%. CAS No. 2374716-73-9. Molecular formula: C20H19F2N3O5. Mole weight: 419.38. BOC Sciences 7
Donepezil Open-Ring Keto Acid Donepezil Open-Ring Keto Acid is an impurity of Donepezil, a medication for the treatment of Alzheimer's disease. Synonyms: 2-[3-(1-Benzylpiperidin-4-yl)-2-oxopropyl]-4,5-dimethoxybenzoic acid. CAS No. 197010-25-6. Molecular formula: C24H29NO5. Mole weight: 411.498. BOC Sciences 7
Dorzolamide Impurity A Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension. Uses: Carbonic anhydrase inhibitors. Synonyms: L671152; MK507; L 671152; MK 507; L-671152; MK-507; Trusopt. Grade: >98%. CAS No. 120279-96-1. Molecular formula: C10H16N2O4S3. Mole weight: 324.44. BOC Sciences 7
Ertapenem Ring Open Impurity An impurity of Ertapenem. Ertapenem is a carbapenem antibiotic. Synonyms: 1H-Pyrrole-2-acetic acid, 5-carboxy-4-[[(3S,?5S)?-5-[[(3-carboxyphenyl)?amino]?carbonyl]?-3-pyrrolidinyl]?thio]?-2,?3-dihydro-α-[(1R)?-1-hydroxyethyl]?-3-methyl-, (αS,?2S,?3R)?-. Grade: > 95%. CAS No. 357154-27-9. Molecular formula: C22H27N3O8S. Mole weight: 493.54. BOC Sciences 7
Everolimus EP Impurity B An impurity of Everolimus, an mTOR blocker that inhibits the growth of certain cancer. Synonyms: Everolimus 19-Ene Open-Ring Impurity; Everolimus Related Compound 2; seco Everolimus; (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin. CAS No. 1062122-63-7. Molecular formula: C53H83NO14. Mole weight: 958.22. BOC Sciences 8
Ezetimibe Azetidinone (Ring-opened Impurity) A degradation product of the antihyperlipoproteinem ic Ezetimibe. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
Worldwide
Ezetimibe Azetidinone Ring-opened Impurity An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L8) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe Azetidinone Ring-opened Sodium Salt Impurity (Technical Grade, >75%). Grade: > 95%. CAS No. 1391053-63-6. Molecular formula: C24H23F2NO4. Mole weight: 427.45. BOC Sciences 8
Ezetimibe (Diacid Impurity) An open-ringed diacid impurity of Ezetimibe. Group: Biochemicals. Alternative Names: (2R) -2- [ (S) - [ (4-Fluorophenyl) amino] [4- (phenylmethoxy) phenyl] methyl] pentanedioic Acid. Grades: Highly Purified. CAS No. 1013025-04-1. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 2
Worldwide
Ezetimibe Ring-Open Impurity An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L15) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide. Grade: > 95%. CAS No. 1197811-72-5. Molecular formula: C24H23FNO3. Mole weight: 411.45. BOC Sciences 8
Fenoterol Degradation Impurity A An impurity of Fenoterol. Fenoterol is a β2 adrenoreceptor agonist designed to open up the airways to the lungs. It is classed as sympathomimetic β2 agonist and asthma medication. Synonyms: ,?2,?3,?4-tetrahydro-2-[2-(4-hydroxyphenyl)?-1-methylethyl]?-4,?6,?8-Isoquinolinetriol. Grade: > 95%. CAS No. 161040-25-1. Molecular formula: C18H21NO4. Mole weight: 315.37 80.91. BOC Sciences 8
Flupirtine Dimer Flupirtine Dimer is an impurity of Flupirtine. Flupirtine is a selective neuronal potassium channel opener that acts as an Analgesic, having substituted pyridine with central analgesic properties. Synonyms: diethyl (6,6'-diamino-2,2'-bis((4-fluorobenzyl)amino)-[3,3'-bipyridine]-5,5'-diyl)dicarbamate. Grade: 98%. CAS No. 1417916-52-9. Molecular formula: C30H32F2N8O4. Mole weight: 606.62. BOC Sciences 8
Flupirtine Impurity 04 hydrochloride It is an impurity of Flupirtine. Flupirtine is a selective neuronal potassium channel opener act as an Analgesic, having substituted pyridine with central analgesic properties. Uses: The major active metabolite of flupirtine in human plasma. Synonyms: N-[2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]acetamide Hydrochloride. CAS No. 95777-69-8. Molecular formula: C14H16ClFN4O. Mole weight: 310.75. BOC Sciences 8
Fosfomycin Trometamol EP Impurity A Fosfomycin Trometamol EP Impurity A is an impurity of Fosfomycin, which is an antibiotic with broad spectrum antibacterial activity. Synonyms: (1,2-Dihydroxypropyl)phosphonic acid; P-(1,2-Dihydroxypropyl)phosphonic Acid; Fosfomycin trometamol Impurity-A; Fosfomycin open ring impurity; propyleneglycolphosphonate; Phosphonic acid, (1,2-dihydroxypropyl)-; Fosfomycin open ring; Fosfomycin Tromethamine EP impurity A. Grade: >90%. CAS No. 84954-80-3. Molecular formula: C3H9O5P. Mole weight: 156.07. BOC Sciences 8
Gabapentin Related Compound A Gabapentin Lactam (Gabapentin EP Impurity A; Gabapentin USP Related Compound A) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels. Group: Biochemicals. Alternative Names: 3-Azaspiro-[4,5]decan-3-one; Gabapentin lactam; USP Gabapentin Related Compound A; Gabapentin EP Impurity A; Gabapentin USP Related Compound A. Grades: Highly Purified. CAS No. 64744-50-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C?H??NO, Molecular Weight: 153.22. US Biological Life Sciences. USBiological 7
Worldwide
Oxacyclohexane open ring tacrolimus Oxacyclohexane open ring tacrolimus is an impurity of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: Tacrolimus Open Ring Impurity; Tacrolimus related compound, tacrolimus open ring; 3H-Pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,12H,23H)-tetrone, 5,6,11,13,14,15,16,17,18,20,24,25,26,26a-tetradecahydro-5,15,20,20-tetrahydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,26aS)-; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,26aS)-5,6,11,13,14,15,16,17,18,20,24,25,26,26a-Tetradecahydro-5,15,20,20-tetrahydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,12H,23H)-tetrone; 3H-Pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,20H,23H)-tetrone, 5,6,11,12,13,14,15,16,17,18,24,25,26,26a-tetradecahydro-5,15,20,20-tetrahydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,26aR*]]-. Grade: ≥90% by HPLC. CAS No. 144432-23-5. Molecular formula: C44H71NO13. Mole weight: 822.03. BOC Sciences
(R)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide An impurity of Brinzolamide, a potent carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Synonyms: (R)-4-HYDROXY-2-(3-METHOXYPROPYL)-3,4-DIHYDRO-2H-THIENO[3,2-E][1,2]THIAZINE-6-SULFONAMIDE 1,1-DIOXIDE; (4R)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; SCHEMBL3576264; (R)-4-HYDROXY-2-(3-METHOXYPROPYL)-3,4-DIHYDRO-2H-THIENO[3,2-E][1,2]THIAZINE-6-SULFONAMIDE1,1-DIOXIDE. CAS No. 165117-54-4. Molecular formula: C10H16N2O6S3. Mole weight: 356.44. BOC Sciences 3
(S)-4-amino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide An impurity of Brinzolamide, a potent carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. CAS No. 2183841-60-1. Molecular formula: C10H17N3O5S3. Mole weight: 355.45. BOC Sciences 3
Tigecycline (open C-ring D-ring) Quinone Trifluoroacetic Acid Salt Tigecycline (open C-ring D-ring) quinone Trifluoroacetic Acid Salt is a salt of Tigecycline (open C-ring D-ring) quinone, an impurity of Tigecycline (T440015). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C26H32N4O8 · x(C2HF3O2). US Biological Life Sciences. USBiological 3
Worldwide
(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)-N-{[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H-furo[3,4-d][1,3]thiazin-2-yl]methyl}acetamide (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)-N-{[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H-furo[3,4-d][1,3]thiazin-2-yl]methyl}acetamide is one of Cefdinir impurities. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Synonyms: [2RS-[2α(Z),5α]]-2-Amino-α-(hydroxyimino)-N-[(1,2,5,7-tetrahydro-5-methyl-7-oxo-4H-furo[3,4-d][1,3]thiazin-2-yl)methyl]-4-thiazoleacetamide; N-[(5-Methyl-7-oxo-1,2,5,7-tetrahydro-4H-furo[3,4-d][1,3]thiazin)-2-ylmethyl]-2-(2-amino-4-thiazolyl)-2-[(Z)-hydroxyimino]acetamide; Cefdinir impurity H; Cefdinir decarboxy open ring lactone; Cefdinir Impurity 3 (Mixture of Diastereomers). Grade: 95%. CAS No. 178949-04-7. Molecular formula: C13H15N5O4S2. Mole weight: 369.42. BOC Sciences 3

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