Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Orexin 2 Receptor Agonist | Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC 50 of 23 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1796565-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19320. |  |
| Orexin 2 Receptor Agonist 2 | Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2114324-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138695. | |
| Orexin A (1-15) (free acid) | Orexin A (1-15) (free acid) is the N-terminal segment of orexin A and contains two disulfide bonds. Synonyms: Hypocretin-1 (1-15) (Human, Mouse, Rat); Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-OH (Disulfide bridge: Cys6-Cys12, Cys7-Cys14). Grade: ≥95%. CAS No. 2022956-49-4. Molecular formula: C67H109N23O22S4. Mole weight: 1717.01. |  |
| Orexin A (16-33) | Orexin A (16-33) lacks the disulfide bridge of orexin A, but retains part of the full-length OXA/OXB activity. It has been used in place of intact neuropeptides. Synonyms: Hypocretin-1 (16-33) (Human, Mouse Rat); H-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2; L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-histidyl-glycyl-L-alanyl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-leucinamide; OXA 16-33. Grade: ≥95%. CAS No. 1374694-00-4. Molecular formula: C85H136N24O23. Mole weight: 1862.16. | |
| Orexin A (human, rat, mouse) | An orexin receptors agonist. It can stimulate feeding following central administration. Grade: 95%. CAS No. 205640-90-0. Molecular formula: C152H243N47O44S4. Mole weight: 3561.12. | |
| Orexin A (human, rat, mouse) | Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor ( OX1R ) and the orexin-2 receptor ( OX2R ). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Hypocretin-1 (human, rat, mouse). CAS No. 205640-90-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-106224. | |
| Orexin A (human, rat, mouse) acetate | Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging[1][2][3][4]. Uses: Scientific research. Group: Peptides. Alternative Names: Hypocretin-1 (human, rat, mouse) acetate. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-106224B. | |
| Orexin b(human) | Orexin b(human). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-2;HYPOCRETIN-2, HUMAN;H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU. Product Category: Heterocyclic Organic Compound. CAS No. 205640-91-1. Molecular formula: C123H212N44O35S. Product ID: ACM205640911. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Orexin B human | An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Human orexin B. Grade: ≥95% by HPLC. CAS No. 205640-91-1. Molecular formula: C123H212N44O35S. Mole weight: 2899.36. | |
| Orexin B, human TFA | An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Human orexin B (TFA); Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2.TFA; L-arginyl-L-seryl-glycyl-L-prolyl-L-prolyl-glycyl-L-leucyl-L-glutaminyl-glycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-seryl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide trifluoroacetic acid. Grade: ≥98%. Molecular formula: C123H212N44O35S.C2HF3O2. Mole weight: 3013.36. | |
| Orexin B (rat, mouse) | An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Rat orexin B; Orexin B (mouse); H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2; L-arginyl-L-prolyl-glycyl-L-prolyl-L-prolyl-glycyl-L-leucyl-L-glutaminyl-glycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparagyl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide. Grade: ≥95% by HPLC. CAS No. 202801-92-1. Molecular formula: C126H215N45O34S. Mole weight: 2936.39. | |
| Orexin B, rat, mouse | Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K i s of 420 and 36 nM for OX1 and OX2, respectively. Uses: Scientific research. Group: Peptides. Alternative Names: Rat orexin B; Orexin B (mouse). CAS No. 202801-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1349. | |
| Orexin receptor antagonist 2 | Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pK i s of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1457940-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136922. | |
| Orexin receptor antagonist 3 | Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1293282-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-137093. | |
| [Ala11,D-Leu15]-Orexin B | [Ala11,D-Leu15]-Orexin B. Group: Biochemicals. Grades: Purified. CAS No. 532932-99-3. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| [Ala11,D-Leu15]-Orexin B | [Ala11,D-Leu15]-Orexin B is a selective OX2 receptor agonist with EC50 values are 0.13nM for human OX2. Grade: ≥95% by HPLC. CAS No. 532932-99-3. Molecular formula: C120H206N44O35S. Mole weight: 2857.28. | |
| [Ala11,D-Leu15]-Orexin B(human) | [Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 ( EC 50 =0.13 nM) over OX1 (52 nM) [1]. Uses: Scientific research. Group: Peptides. CAS No. 532932-99-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1340. | |
| Biotinyl-(Gln1)-Orexin A (human, mouse, rat) | Biotinyl-(Gln1)-Orexin A (human, mouse, rat). Synonyms: (Biotinyl-Gln1)-Hypocretin-1 (Human, Rat, Mouse); Biotinyl-Gln-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14). Grade: ≥95%. CAS No. 2022973-13-1. Molecular formula: C162H260N50O46S5. Mole weight: 3804.49. | |
| Biotinyl-(Glu1)-Orexin A (human, mouse, rat) | Biotinyl-(Glu1)-Orexin A (human, mouse, rat) is the N-terminally biotin-labeled OXA. Synonyms: Biotinyl-(Glu1)-Hypocretin-1 (human, mouse, rat); Biotinyl-Glu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14). Grade: ≥95%. CAS No. 1678416-50-6. Molecular formula: C162H259N49O47S5. Mole weight: 3805.47. | |
| (Cys(Acm)6.12)-Orexin A (human, mouse, rat) | (Cys(Acm)6.12)-Orexin A (human, mouse, rat). Synonyms: [Cys(Acm)6,12]-Hypocretin-1 (Human, Mouse, Rat); Pyr-Pro-Leu-Pro-Asp-Cys(Acm)-Cys-Arg-Gln-Lys-Thr-Cys(Acm)-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bond). Grade: ≥95%. CAS No. 2022974-96-3. Molecular formula: C158H255N49O46S4. Mole weight: 3705.33. | |
| 1-(tert-Butyloxycarbonyl)-3,3-difluoro-4-aminopiperidine | 1-(tert-Butyloxycarbonyl)-3,3-difluoro-4-aminopiperidine is synthetic building block for pharmaceuticals. It can be obtained from N-Benzyl- β-alanine Ethyl Ester (B232975) which is used as a reagent in organic synthesis including that of dipivaloyloxyphenyl aminopropionate β-agonist prodrugs which are used in the treatment of psoriasis. N-Benzyl- β-alanine Ethyl Ester (B232975) is also used in the synthesis of N,N'-dithiobis(N-benzyl- β-alanine) dethyl ester, which is an important intermediate of insecticide OK-135, and in synthesis of spiropiperidine-based orexin-2 receptor (OX2R) antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1255666-48-8. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H18F2N2O2, Molecular Weight: 236.26. US Biological Life Sciences. | Worldwide |
| 2-Acetyl-4- (trifluoromethyl) phenol | 2-Acetyl-4- (trifluoromethyl) phenol was used to study benzoxazepine-?based Orexin-?2 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 67589-15-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H7F3O2, Molecular Weight: 204.15. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-fluoronicotinic acid | 2-Amino-5-fluoronicotinic Acid acts as a reagent used in the synthesis of fluoropiperidine derivatives as orexin receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1196154-03-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C6H5FN2O2, Molecular Weight: 156.12. US Biological Life Sciences. | Worldwide |
| 2-Bromo-4-methyl-benzoic Acid | 2-Bromo-4-methyl-benzoic Acid can be used to synthesize difluoropyrrolidines (an orexin receptor modulator) and isoquinolinones and azepinones. Group: Biochemicals. Grades: Highly Purified. CAS No. 7697-27-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H7BrO2, Molecular Weight: 215.04. US Biological Life Sciences. | Worldwide |
| 2-Methyl-1,3-benzoxazole-6-carboxylic Acid | 2-Methyl-1,3-benzoxazole-6-carboxylic Acid is used in the synthesis of orexin 1 receptor antagonists, used in the treatment of obesity. Also used in the synthesis of novel benzoxazole amides as novel enhancers of HIV-1 protease inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 13452-14-7. Pack Sizes: 100mg, 500 mg. Molecular Formula: C9H7NO3. US Biological Life Sciences. | Worldwide |
| (2R,5R)-Benzyl 5-amino-2-methylpiperidine-1-carboxylate | (2R,5R)-Benzyl 5-amino-2-methylpiperidine-1-carboxylate is a reactant used in the preparation of pyridylamino-nitrile-piperidinyl Orexin receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1207853-72-2. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C14H20N2O2, Molecular Weight: 248.32. US Biological Life Sciences. | Worldwide |
| 3-Chloro-1-methyl-1h-pyrazol-5-amine Hydrochloride | 3-Chloro-1-methyl-1h-pyrazol-5-amine Hydrochloride is a reagent used in the preparation of heteroaryl-fused pyridines as orexin receptor inhibitors useful in the treatment of orexin receptor-mediated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1312949-22-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C4H6ClN3; (HCl), Molecular Weight: 131.563646. US Biological Life Sciences. | Worldwide |
| ACT 335827 | ACT 335827 has been found to be an orexin OX1 receptor antagonist and could probably exhibit anxiolytic effects in vivo. Synonyms: ACT-335827; ACT 335827; ACT335827; (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide. Grade: ≥98% by HPLC. CAS No. 1354039-86-3. Molecular formula: C31H38N2O5. Mole weight: 518.64. | |
| ACT 462206 | ACT 462206 has been found to be a potent and selective dual orexin receptor antagonist and could exhibit anxiolytic-like activities. Synonyms: ACT-462206; ACT 462206; ACT462206; (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide. Grade: ≥99% by HPLC. CAS No. 1361321-96-1. Molecular formula: C20H24N2O4S. Mole weight: 388.48. | |
| ACT-462206 | ACT-462206 is an orally active and potent dual Orexin 1 / Orexin 2 receptor antagonist with IC 50 s of 60 nM ( Orexin 1 ) and 11 nM ( Orexin 2 ), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1361321-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101834. | |
| Almorexant | Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with K d values of 1.3 nM ( OX1 ) and 0.17 nM ( OX2 ), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca 2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT 078573. CAS No. 871224-64-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10805. | |
| Almorexant | Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. Uses: For research used only. Synonyms: ACT-078573. Grade: 0.99. CAS No. 871224-64-5. Molecular formula: C29H31F3N2O3. Mole weight: 512.573. | |
| Almorexant-13C, d3 | Almorexant-13C, d3 is a labelled Almorexant. Almorexant is an antagonist of OX1 and OX2 orexin receptors developed for the treatment of insomnia. Synonyms: (αR,1S)-3,4-Dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-Isoquinolineacetamide-13C, D3. Grade: > 95%. Molecular formula: C29H28F3N2O3D3. Mole weight: 516.58. | |
| Almorexant HCl | Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. Synonyms: ACT078573; ACT 078573; ACT-078573. Grade: >98%. CAS No. 913358-93-7. Molecular formula: C29H32ClF3N2O3. Mole weight: 549.02. | |
| Almorexant hydrochloride | Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with K d values of 1.3 nM ( OX1 ) and 0.17 nM ( OX2 ), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca 2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT 078573 hydrochloride. CAS No. 913358-93-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10805A. | |
| Danavorexton | Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-925. CAS No. 2114324-48-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133898. | |
| DORA-22 | DORA-22 is a dual orexin receptor antagonist. It can improve mild stress-induced insomnia with minimal effect on memory. Synonyms: DORA22; DORA 22; (5-Fluoro-2-(pyrimidin-2-yl)phenyl)((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)methanone. CAS No. 1088991-95-0. Molecular formula: C23H22F2N4O2. Mole weight: 424.44. | |
| EMPA | EMPA is a high-affinity, reversible and selective orexin OX 2 receptor antagonist. [ 3 H]EMPA binds to human and rat OX 2 -HEK293 membranes with K D values of 1.1 and 1.4 nM respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 680590-49-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108682. | |
| EMPA | EMPA is a potent and selective OX2 receptor antagonist (IC50 = 2.3 nM and 1900 nM for OX2 and OX1, respectively) with no activity at a panel of 80 receptors. EMPA blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 = 7.9 nM and 8.8 nM, respectively) and reverses orexin-B-induced hyperlocomotion in mice. Synonyms: N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide. Grade: ≥98% by HPLC. CAS No. 680590-49-2. Molecular formula: C23H26N4O4S. Mole weight: 454.54. | |
| Firazorexton | Firazorexton is a potent orexin type 2 receptor (OX2R) agonist extracted from patent WO2019027058A1, example 395. CAS No. 2274802-95-6. Molecular formula: C22H25F3N2O4S. Mole weight: 470.51. | |
| JNJ-10397049 | JNJ-10397049 is a potent and selective orexin 2 receptor (OX 2 R) antagonist, with a pK i of 8.3. JNJ-10397049 is 600-fold selective for the OX 2 R over the OX 1 R [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 708275-58-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10896. | |
| N-Acetyl-D-mannosamine | N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG , making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin ( HCRT ) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: N-Acetylmannosamine; ManNAc. CAS No. 3615-17-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-128850. | |
| Nalfurafine (TRK-820) | Nalfurafine is a κ-opioid receptor (KOR) agonist (EC50 = 0.05nM for human receptors expressed in CHO cell membranes).1 It is selective for κ-opioid over μ- and δ-opioid receptors (EC50s = 0.72 and 74.1nM, respectively). Nalfurafine (≥30ug/kg) reduces scratching behavior induced by chloroquine in mice, as well as locomotor activity when administered at a dose of 100ug/kg.2 In rats, nalfurafine (≥0.01mg/kg) reduces intracranial self-stimulation, lactic acid-induced stretching behavior, and scratching behavior induced by intradermal administration of serotonin.3 Nalfurafine is also an orexin 1 receptor (OX1R) antagonist (Ki = 250nM).4. Group: Biochemicals. Alternative Names: (2E)-N-[(5α,6 β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide; TRK-820. Grades: Highly Purified. CAS No. 152657-84-6. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C28H32N2O5, Molecular Weight: 476.56. US Biological Life Sciences. | Worldwide |
| Nivasorexant | Nivasorexant is a potent orexin receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-539313. CAS No. 1435480-40-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147294. | |
| OXA (17-33) | OXA (17-33) is a peptide orexin OX1 receptor agonist with EC50 value of 8.29 nM. It is a drug candidate for the treatment of heart failure and hypertension. Synonyms: Orexin A (17-33) trifluoroacetate salt H-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 trifluoroacetate salt; BDBM50445183. Grade: >97%. CAS No. 343268-91-7. Molecular formula: C79H125N23O22. Mole weight: 1749. | |
| OXA(17-33) | OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ?23-fold selectivity for the OX1 ( EC 50 =8.29 nM) over OX2 (187 nM) [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Orexin A (17-33) (human, mouse, rat, bovine). CAS No. 343268-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1341. | |
| SB-334867 | SB-334867 (SB 334867A) is an excellent,selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 334867A. CAS No. 249889-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10895. | |
| SB-334867 free base | SB-334867 free base (SB334867A free base) is an excellent, selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB334867A free base. CAS No. 792173-99-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10895A. | |
| SB-408124 Hydrochloride | SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-90-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-76612. | |
| SB-649868 | SB-649868 is a potent and selective orally active orexin ( OX ) 1 and OX 2 receptor antagonist ( pK i =9.4 and 9.5 at the OX 1 and OX 2 receptor, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK649868. CAS No. 380899-24-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10806. | |
| SB-674042 | SB-674042 is a potent and selective non-peptide orexin OX 1 receptor antagonist (K d =5.03 nM), exhibits 100-fold selectivity for OX 1 over OX 2 receptors with IC 50 values of 3.76 nM and 531 nM, respectively [1] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 483313-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10898. | |
| Seltorexant | Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist ( pK i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ-42847922. CAS No. 1293281-49-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109012. | |
| TCS 1102 | TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 916141-36-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10900. | |
| TCS-OX2-29 | TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX 2 R) antagonist with an IC 50 value of 40 nM and a pK I value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX 2 over OX 1 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 372523-75-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100452. | |
Our database is helping our users find suppliers everyday.
