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Orphenadrine Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H] MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and cytochrome P450 (CYP) 2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Orphenadrine. CAS No. 83-98-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-157959. MedChemExpress MCE
Orphenadrine citrate Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K i of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4682-36-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0369A. MedChemExpress MCE
Orphenadrine citrate salt analytical standard. Group: Antihistamines standards. Alfa Chemistry Analytical Products 4
Orphenadrine citrate salt United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. Alfa Chemistry Analytical Products 2
Orphenadrine Citrate Salt Muscle relaxant (skeletal); antihistaminic. Group: Biochemicals. Alternative Names: N, N-Dimethyl-2- [ (2-methylphenyl) phenylmethoxy] ethanamine Citrate Salt; Banflex; Norflex; X-Otag. Grades: Highly Purified. CAS No. 4682-36-4. Pack Sizes: 5g. US Biological Life Sciences. USBiological 2
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Orphenadrine-[d3] Orphenadrine-[d3] is the labelled analogue of Orphenadrine, which is a skeletal muscle relaxant. It acts in the central nervous system to produce its muscle relaxant effects. Synonyms: Orphenadrine D3; Disipal-d3; Orphenadine-d3; o-Methyldiphenhydramine-d3; 2-Methyldiphenhydramine-d3; Biorphen-d3; Brocadisipal-d3; Invagesic-d3; 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine-d3; Norgesic-d3. Grade: >95%. CAS No. 1185011-75-9. Molecular formula: C18H20D3NO. Mole weight: 272.41. BOC Sciences 2
Orphenadrine-d3 Citrate Salt Muscle relaxant (skeletal); antihistaminic. Group: Biochemicals. Alternative Names: N, N-Dimethyl-2- [ (2-methylphenyl) phenylmethoxy] ethanamine-d3 Citrate Salt; O-Mono methyl diphenhydramine-d3-Citrate Salt; BS-5930-d3; Biorphen-d3; Birocasipal-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
Orphenadrine hydrochloride ?98.0% (AT). Group: Fluorescence/luminescence spectroscopyapi standardseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: Disipal,Orphenadrine Hydrochloride, o-Monomethyldiphenhydramine hydrochloride, Mephenamin, Phenyl-o-tolylmethyl dimethylaminoethyl ether hydrochloride, N,N-Dimethyl-2-[(2-methylphenyl)phenylmethoxy]ethanamine hydrochloride, beta-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride, 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine hydrochloride, N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylamine hydrochloride, o-Methyldiphenhydramine hydrochloride. Alfa Chemistry Analytical Products 2
Orphenadrine hydrochloride Orphenadrine hydrochloride. Uses: Designed for use in research and industrial production. Product Category: Amine Salts. CAS No. 341-69-5. Molecular formula: C18H23NO.HCl. Mole weight: 305.84. Product ID: ACM341695. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
Orphenadrine N-Oxide A metabolite of Orphenadrine. Group: Biochemicals. Alternative Names: N, N-Dimethyl-2- [ (2-methylphenyl) phenylmethoxy] ethanamine N-Oxide; N, N-Dimethyl-2-[ (o-methyl-α -phenylbenzyl) oxy]ethylamine N-Oxide. Grades: Highly Purified. CAS No. 29215-00-7. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 2
Worldwide
Orphenadrine Related Compound A United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. Alfa Chemistry Analytical Products
Orphenadrine Related Compound B United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. Alfa Chemistry Analytical Products
Orphenadrine Related Compound C United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. Alfa Chemistry Analytical Products 2
Orphenadrine Related Compound E United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. Alfa Chemistry Analytical Products 2
Orphenadrine Related Compound F United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. Alfa Chemistry Analytical Products 2
Didesmethyl orphenadrine An impurity of Orphenadrine. Orphenadrine is a skeletal muscle relaxant used primarily to treat muscle pain and spasms, often in combination with rest and physical therapy. It is also used to alleviate motor control symptoms in Parkinson's disease. Synonyms: 2-[(2-Methylphenyl)phenylmethoxy]ethanamine; 2-[(O-Methyl-α-phenylbenzyl)oxy]ethylamine; 2-(Phenyl(o-tolyl)methoxy)ethanamine; N,N-Didemethylorphenadrine; Orphenadrine EP impurity C; Orphenadrine impurity C; (+/-)-N,N-Didemethylorphenadrine; N,N-Didemethyl orphenadrine. Grade: ≥95%. CAS No. 17349-96-1. Molecular formula: C16H19NO. Mole weight: 241.33. BOC Sciences 7
O-Demethyl-m-methyl Orphenadrine Citrate Salt O-Demethyl-m-methyl Orphenadrine Citrate Salt. Group: Biochemicals. Alternative Names: N, N-Dimethyl-2- [ (3-methylphenyl) phenylmethoxy] ethanamine Citrate Salt. Grades: Highly Purified. Pack Sizes: 50mg. Molecular Formula: C24H31NO8, Molecular Weight: 461.5. US Biological Life Sciences. USBiological 3
Worldwide
O-Demethyl-m-methyl Orphenadrine-d5 Citrate Salt O-Demethyl-m-methyl Orphenadrine-d5 Citrate Salt. Group: Biochemicals. Alternative Names: N, N-Dimethyl-2- [ (3-methylphenyl) phenylmethoxy] ethanamine-d5 Citrate Salt. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C24H26D5NO8, Molecular Weight: 466.54. US Biological Life Sciences. USBiological 3
Worldwide
1-[ (2-Bromoethoxy) phenylmethyl]-2-methylbenzene-d4 1-[ (2-Bromoethoxy) phenylmethyl]-2-methylbenzene-d4 is an labelled metabolite of Orphenadrine (O695300). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H13D4BrO, Molecular Weight: 309.23. US Biological Life Sciences. USBiological 9
Worldwide
2- ( (3-Hydroxy (phenyl)methyl)benzyl) (methyl)amino)ethanol (3- ( ( (2-Hydroxyethyl) (methyl) amino) methyl) phenyl) (phenyl) methanone-d3 is an intermediate in the synthesis of Nefopam-d3 (N389402), a cyclized labelled analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C17H18D3NO2. US Biological Life Sciences. USBiological 9
Worldwide
2-Methylbenzhydrol 2-Methylbenzhydrol is a metabolite of the antihistaminic Orphenadrine, which is a muscarinic antagonist with muscle relaxant activity. Synonyms: Benzenemethanol, 2-methyl-α-phenyl-; 2-Methyl-α-phenylbenzenemethanol; Benzhydrol, 2-methyl-; NSC 27910; o-Methylbenzhydrol; Phenyl(2-tolyl)methanol; Phenyl(o-tolyl)methanol; α-(2-Methylphenyl)benzenemethanol; α-(2-Methylphenyl)benzyl alcohol. Grade: ≥95%. CAS No. 5472-13-9. Molecular formula: C14H14O. Mole weight: 198.26. BOC Sciences 4
2-Methylbenzophenone An impurity of Orphenadrine, which is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects. Synonyms: Methanone, (2-methylphenyl)phenyl-; Benzophenone, 2-methyl-; (Phenyl)(o-tolyl)methanone; 2-Methylphenyl phenyl ketone; NSC 67362; o-Benzoyltoluene; o-Methylbenzophenone; o-Tolyl phenyl ketone; Phenyl 2-methylphenyl ketone; Phenyl 2-tolyl ketone; Phenyl o-tolyl ketone; Phenyl(2-tolyl)methanone. Grade: ≥95%. CAS No. 131-58-8. Molecular formula: C14H12O. Mole weight: 196.24. BOC Sciences 4
Bis(phenyl-o-tolylmethyl) ether An impurity of Orphenadrine, which is a skeletal muscle relaxant, and acts in the central nervous system to produce its muscle relaxant effects. Synonyms: Des(N,N-dimethylethanamine) Orphenadrine Dimer; Bis(o-methyl-α-phenylbenzyl) ether; Orphenadrine Impurity 2. CAS No. 40673-52-7. Molecular formula: C28H26O. Mole weight: 378.52. BOC Sciences 6
Diphenhydramine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material. Group: Pharmacopeia & metrological institutes standardspharma & vet compounds & metabolitespharma & vet compounds & metabolitesapi standardsbritish pharmacopoeiaeuropean pharmacopoeia (ph. eur.)impurity standardspharmaceutical toxicologypharmacopoeial standards. Alternative Names: Histacyl, Difenhydramine hydrochloride, Sedopretten, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1), Allergival, Benzhydramine hydrochloride, Denydryl, Bena, Bena-Fedrin, Benylin, Diphantine, 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, Benzantin, Fenylhist, Resmin, Vena, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (9CI), Bagodryl, Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (8CI), Asdrin, Bax, Benadryl,Orphenadrine Hydrochloride Imp. D (EP), Syntedril, Diphenhydramine Hydrochloride, b-Dimethylaminoethyl benzhydryl ether hydrochloride, Allergina, Benadril hydrochloride, S 8, Benzhydrol b-dimethylaminoethyl ether hydrochloride, Halbmond, Wehydryl, Orphenadrine Hydrochloride Imp. D (EP) as Hydrochloride, 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride, Dimedrol hydrochloride, Allergan, Sekundal D, Benodine, Dimedrol, Noctomin, Alledryl, Amidryl, Dibondrin, Restamin, Orphenadrine Imp. D (EP), Benocten. Alfa Chemistry Analytical Products 2
Nefopam Hydrochloride A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant. Group: Biochemicals. Alternative Names: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine Hydrochloride; (+/-)-Nefopam Hydrochloride; Acupan; Ajan; Fenazoxine; Fenazoxine hydrochloride; R 738. Grades: Highly Purified. CAS No. 23327-57-3. Pack Sizes: 50mg. US Biological Life Sciences. USBiological 2
Worldwide
Tofenacin A metabolite of Orphenadrine. An antidepressant prodrug. Group: Biochemicals. Alternative Names: N-Methyl-2- [ (2-methylphenyl) phenylmethoxy] ethanamine; N-Methyl-2- [ (o-methyl-α -phenylbenzyl) oxy] ethylamine; Demethylorphenadrine; N-Demethylorphenadrine; N-Desmethylorphenadrine; Tofenacine. Grades: Highly Purified. CAS No. 15301-93-6. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 3
Worldwide
Tofenacin Hydrochloride Tofenacin Hydrochloride. Group: Biochemicals. Alternative Names: ORPHENADRINE RELATED COMPOUND C. Grades: Highly Purified. CAS No. 10488-36-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C17H21NOClH. US Biological Life Sciences. USBiological 8
Worldwide

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