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2-Phenylbenzoxazole. Group: Ligands for functional metal complexes. Alternative Names: 2-Phenylbenzo[d]oxazole; Benzoxazole, 2-phenyl-. CAS No. 833-50-1. Product ID: 2-phenyl-1,3-benzoxazole. Molecular formula: 195.22. Mole weight: C13H9NO. C1=CC=C(C=C1)C2=NC3=CC=CC=C3O2. FIISKTXZUZBTRC-UHFFFAOYSA-N. InChI=1S/C13H9NO/c1-2-6-10 (7-3-1)13-14-11-8-4-5-9-12 (11)15-13/h1-9H.
1,2-Epoxybutane
1,2-Epoxybutane is a reagent used for potency of tricyclic oxazolo[2,3-f]purinediones as adenosine receptor ligands and anticonvulsants. Group: Biochemicals. Grades: Highly Purified. CAS No. 106-88-7. Pack Sizes: 1g, 10g. Molecular Formula: C4H8O. US Biological Life Sciences.
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2-Chloro-6-methoxy-pyridine
2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 17228-64-7. Pack Sizes: 5g, 25 g. Molecular Formula: C6H6ClNO, Molecular Weight: 143.57. US Biological Life Sciences.
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(2R,3R)-(-)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate, min. 97% (R,R)-NORPHOS-Rh
(2R,3R)-(-)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate, min. 97% (R,R)-NORPHOS-Rh. Uses: Ligand used in the enantioselective rhodium catalyzed hydrogenation of α-dehydroaminoesters and enamides. ligand used in the enantioselective rhodium catalyzed hydroboration of cyclopropenes. ligand used in the asymmetric rhodium catalyzed cleavage of racemic 1,3-oxazolidines. Additional or Alternative Names: (R,R)-NORPHOS-Rh;MFCD09839137;(2R,3R)-(-)-2,3-bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;(2R,3R)-(-)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene(1,5-cyclooctadiene)rhodium(I)tetrafluoroborate;521272-85-5. Product Category: Heterocyclic Organic Compound. CAS No. 521272-85-5. Molecular formula: C39H40BF4P2Rh-. Mole weight: 760.406g/mol. IUPACName: (1Z,5Z)-cycloocta-1,5-diene;[(1S,2R,3R,4R)-3-diphenylphosphanyl-2-bicyclo[2.2.1]hept-5-enyl]-diphenylphosphane;rhodium;tetrafluoroborate. Canonical SMILES: [B-](F)(F)(F)F.C1CC=CCCC=C1.C1C2C=CC1C(C2P(C3=CC=CC=C3)C4=CC=CC=C4)P(C5=CC=CC=C5)C6=CC=CC=C6.[Rh]. Product ID: ACM521272855. Alfa Chemistry ISO 9001:2015 Certified.
Butyldi-1-adamantylphosphine
Butyldi-1-adamantylphosphine. Uses: Ligand for the pd-catalyzed suzuki coupling reaction. ligand for the pd-catalyzed formation of α-aryl ketones. ligand for the pd-catalyzed aminations ligand for the pd-catalyzed heck reaction. ligand used for arylation of benzoic acids. ligand for the formylation of aryl bromides. ni-catalyzed denitrogenative alkyne insertion reactions of triazoles. ligand for palladium-catalyzed aminocarbonylation of aryl halides palladium-catalyzed direct arylation of oxazole at c-5 with aryl bromides, chlorides, and triflates palladium-catalyzed carbonylative sonogashira coupling of aryl bromides. Additional or Alternative Names: Butyldi-1-adamantylphosphine. Appearance: White solid. CAS No. 321921-71-5. Molecular formula: C24H39P. Mole weight: 358.54. Purity: 0.98. Product ID: ACM321921715. Alfa Chemistry ISO 9001:2015 Certified. Categories: BIS(ADAMANTAN-1-YL)(BUTYL)PHOSPHANE.
CPI-268456
CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 and inhibits LPS-induced IL-6 secretion in THP-1 cells. Synonyms: 2-[(4S)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide. Grades: ≥98%. CAS No. 1380087-86-4. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.3.
Fmoc-Ile-Ser[Psi(Me,Me)Pro]-OH
Fmoc-Ile-Ser[Psi(Me,Me)Pro]-OH is used as a reactant in the synthesis of peptides and receptor targeting ligands. Synonyms: Fmoc-Ile-Ser[Psi(Me,Me)Pro]-OH; (S)-3-[N-(9-Fluorenylmethyloxycarbonyl)-L-isoleucinyl]-2,2-dimethyloxazolidine-4-carboxylic acid; Fmoc-Ile-Ser(Psime,Mepro)-OH; 6904AH; (4S)-3-[(2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid. Grades: 99-101% (Assay by titration). CAS No. 1147996-34-6. Molecular formula: C27H32N2O6. Mole weight: 480.56.
GW6471
GW6471 is a PPARα antagonist (IC50 = 0.24 μM). GW6471 enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Synonyms: GW-6471; GW 6471; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; N-[ (2S) -2-[[ (1Z) -1-Methyl-3-oxo-3-[4- (trifluoromethyl) phenyl]-1-propen-1-yl]amino]-3-[4-[2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy]phenyl]propyl]propanamide; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propenyl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide. Grades: ≥95%. CAS No. 880635-03-0. Molecular formula: C35H36F3N3O4. Mole weight: 619.67.
GW 6471
GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Group: Biochemicals. Alternative Names: N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propen-1-yl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide; N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propenyl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide. Grades: Highly Purified. CAS No. 880635-03-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
MK-3328
This molecular has a favorable potency versus human β-amyloid plaque and has been radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. Studies led to the identification of MK-3328 as a candidate PET ligand for the clinical assessment of β-amyloid plaque load. In Aug 2009, Phase-I clinical trials in Alzheimer's disease in Belgium was on-going, but no recent reported has been published yet. Uses: Alzheimer's disease. Synonyms: MK3328; MK 3328; MK-3328; 5-fluoro-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)oxazolo[5,4-b]pyridine. Grades: 98%. CAS No. 1201323-97-8. Molecular formula: C14H9FN4O. Mole weight: 268.25.
2-[N-(Dicyclopropylmethyl)amino]oxazoline. I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine. CAS No. 54187-04-1. Product ID: 1-01046. Molecular formula: C10H16N2O 0.5 C4H4O4. Mole weight: 238.29. Properties: water soluble. Reference: TIPS, 13, 369, 1992; Brit. J. Pharm. 117, 1744, 1996.
Rilmenidine hemifumarate
Rilmenidine hemifumarate, a centrally acting antihypertensive agent, is an I1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Rilmenidine targets the nonadrenergic imidazoline-binding site I1 receptor with a Ki value of 7.1 nM and demonstrates weaker affinity for the I2 receptor with a Ki value of 5.2 μM. Synonyms: 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate; Oxaminozoline; S 3341. Grades: ≥99% by HPLC. CAS No. 207572-68-7. Molecular formula: C10H16N2O.1/2C4H4O4. Mole weight: 238.29.
RO5166017
RO5166017 is a highly potent, selective, and orally active agonist for the trace amine-associated receptor 1(TAAR1) with no significant activity at other targets. It is weak and rapidly metabolized (endogenous ligands). It has strong pharmacological activity at other targets. Uses: Ro5166017 has strong pharmacological activity. Synonyms: RO5166017; RO 5166017; RO-5166017; (4S)-4-[(N-ethylanilino)methyl]-4,5-dihydro-1,3-oxazol-2-amine;RO-5166017;(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine. Grades: >98 %. CAS No. 1048346-74-2. Molecular formula: C12H17N3O. Mole weight: 219.29.
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