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| Product | Description | |
|---|---|---|
| 1-(tert-Butoxycarbonyl)-2-oxoindolin-5-ylboronic acid | Heterocyclic Organic Compound. CAS No. 1256345-64-8. Molecular formula: C13H16BNO5. Purity: 0.97. Catalog: ACM1256345648. |  |
| 2-(1-Methyl-2-oxoindolin-5-yl)-2-oxoacetic Acid | 2-(1-Methyl-2-oxoindolin-5-yl)-2-oxoacetic Acid is a derivative of 1-Methyl-2-indolone (M305490), a reactant for preparation of fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching, irreversible Nek2 Kinase Inhibitors and anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 1152495-80-1. Pack Sizes: 100mg, 1g. Molecular Formula: C11H9NO4, Molecular Weight: 219.19. US Biological Life Sciences. |  Worldwide |
| 4-Chloro-2-oxoindoline-3-carbaldehyde | 4-Chloro-2-oxoindoline-3-carbaldehyde. Group: Biochemicals. Grades: Highly Purified. CAS No. 23872-23-3. Pack Sizes: 100mg, 250mg, 500mg, 1g. US Biological Life Sciences. | Worldwide |
| 4-Chloro-2-oxoindoline-3-carbaldehyde ≥95% (NMR) | 4-Chloro-2-oxoindoline-3-carbaldehyde ≥95% (NMR). Group: Biochemicals. Grades: Reagent Grade. CAS No. 23872-23-3. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences. | Worldwide |
| 5-Fluoro-2-oxoindoline | 5-Fluoro-2-oxoindoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 56341-41-4. Pack Sizes: 25 g. Product ID: HY-W002914. |  |
| 5-Methoxy-2-oxoindoline-3-carbaldehyde | 5-Methoxy-2-oxoindoline-3-carbaldehyde. Group: Biochemicals. Grades: Highly Purified. CAS No. 52508-88-0. Pack Sizes: 500mg, 1g. US Biological Life Sciences. | Worldwide |
| 5-Methoxy-2-oxoindoline-3-carbaldehyde ≥95% (NMR) | 5-Methoxy-2-oxoindoline-3-carbaldehyde ≥95% (NMR). Group: Biochemicals. Grades: Reagent Grade. CAS No. 52508-88-0. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| 6-Chloro-2-oxoindoline | 6-Chloro-2-oxoindoline. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Dimethyl 3, 3'- ( ( ( ( (2, 2'- (piperazine-1, 4-diyl)bis (acetyl))bis (methylazanediyl))bis (4, 1-phenylene))bis (azanediyl))bis (phenylmethanylylidene)) (3Z, 3'E)-bis (2-oxoindoline-6-carboxylate) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity 50. Grades: ≥95%. CAS No. 2410284-90-9. Molecular formula: C56H52N8O8. Mole weight: 965.08. |  |
| (E)-6-bromo-3-(6-bromo-1-(2-octyldodecyl)-2-oxoindolin-3-ylidene)-1-(2-octyldodecyl)indolin-2-one | (E)-6-bromo-3-(6-bromo-1-(2-octyldodecyl)-2-oxoindolin-3-ylidene)-1-(2-octyldodecyl)indolin-2-one. Group: Organic light-emitting diode (oled) materials. Product ID: (3E)-6-bromo-3-[6-bromo-1-(2-octyldodecyl)-2-oxoindol-3-ylidene]-1-(2-octyldodecyl)indol-2-one. Molecular formula: 981.1g/mol. Mole weight: C56H88Br2N2O2. CCCCCCCCCCC (CCCCCCCC)CN1C2=C (C=CC (=C2)Br)C (=C3C4=C (C=C (C=C4)Br)N (C3=O)CC (CCCCCCCC)CCCCCCCCCC)C1=O. InChI=1S / C56H88Br2N2O2 / c1-5-9-13-17-21-23-27-31-35-45 (33-29-25-19-15-11-7-3) 43-59-51-41-47 (57) 37-39-49 (51) 53 (55 (59) 61) 54-50-40-38-48 (58) 42-52 (50) 60 (56 (54) 62) 44-46 (34-30-26-20-16-12-8-4) 36-32-28-24-22-18-14-10-6-2 / h37-42, 45-46H, 5-36, 43-44H2, 1-4H3 / b54-53+. IBVJZYTVOIAPRS-DBFBYELTSA-N. |  |
| (E)-6-bromo-3-(6-bromo-1-octyl-2-oxoindolin-3-ylidene)-1-octylindolin-2-one | (E)-6-bromo-3-(6-bromo-1-octyl-2-oxoindolin-3-ylidene)-1-octylindolin-2-one. Group: Organic light-emitting diode (oled) materials. Product ID: 6-bromo-3-(6-bromo-1-octyl-2-oxoindol-3-ylidene)-1-octylindol-2-one. Molecular formula: 644.5g/mol. Mole weight: C32H40Br2N2O2. CCCCCCCCN1C2=C (C=CC (=C2)Br)C (=C3C4=C (C=C (C=C4)Br)N (C3=O)CCCCCCCC)C1=O. InChI=1S / C32H40Br2N2O2 / c1-3-5-7-9-11-13-19-35-27-21-23 (33) 15-17-25 (27) 29 (31 (35) 37) 30-26-18-16-24 (34) 22-28 (26) 36 (32 (30) 38) 20-14-12-10-8-6-4-2 / h15-18, 21-22H, 3-14, 19-20H2, 1-2H3. MLSKVFFBSGZTFD-UHFFFAOYSA-N. | |
| (E)-6-bromo-3-(6-bromo-2-oxoindolin-3-ylidene)indolin-2-one | (E)-6-bromo-3-(6-bromo-2-oxoindolin-3-ylidene)indolin-2-one. Group: Organic light-emitting diode (oled) materials. Product ID: 6-bromo-3-(6-bromo-2-hydroxy-1H-indol-3-yl)indol-2-one. Molecular formula: 420.05g/mol. Mole weight: C16H8Br2N2O2. C1=CC2=C (C=C1Br)NC (=C2C3=C4C=CC (=CC4=NC3=O)Br)O. InChI=1S/C16H8Br2N2O2/c17-7-1-3-9-11 (5-7)19-15 (21)13 (9)14-10-4-2-8 (18)6-12 (10)20-16 (14)22/h1-6, 19, 21H. FMIGDKYPJSFPDF-UHFFFAOYSA-N. | |
| Methyl 1-Acetyl-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: 1-acetyl-2-oxo-3H-indole-6-carboxylic acid methyl ester; methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate. CAS No. 676326-36-6. Molecular formula: C12H11NO4. Mole weight: 233.22. | |
| Methyl 2-oxoindoline-5-carboxylate | Methyl 2-oxoindoline-5-carboxylate. Group: Biochemicals. Alternative Names: 2-Oxo-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester. Grades: Highly Purified. CAS No. 199328-10-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| Methyl 2-oxoindoline-5-carboxylate ≥97% | Methyl 2-oxoindoline-5-carboxylate ≥97%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate; Nintedanib Impurity 06. CAS No. 2093243-16-2. Molecular formula: C17H13NO4. Mole weight: 295.29. | |
| N-methyl-N- (3- ( (2- (2-oxoindolin-5-ylamino) -5- (trifluoromethyl) pyrimidin-4-ylamino) methyl) pyridin-2-yl) methanesulfonamide benzenesulfonate | N-methyl-N- (3- ( (2- (2-oxoindolin-5-ylamino) -5- (trifluoromethyl) pyrimidin-4-ylamino) methyl) pyridin-2-yl) methanesulfonamide benzenesulfonate. Group: Biochemicals. Grades: Highly Purified. CAS No. 939791-38-5. Pack Sizes: 250ug, 500ug, 1mg, 2mg, 5mg. Molecular Formula: C27H26F3N7O6S2. US Biological Life Sciences. | Worldwide |
| Oxytocin Receptor Antagonist, MSC1630296 (OT-R Antagonist, 3- (4- (N- (4-chlorophenyl) -N- (2-oxo-2- (2- (2-oxoindolin-3-ylidene) hydrazinyl) ethyl) sulfamoyl) phenyl) -N- (3- (dimethylamino) propyl) propanamide, Fumarate Salt) | A tertiary sulfonamide-based compound that acts as a high-affinity oxytocin (OT) receptor-selective antagonist (Ki = 650 and 670pM in 125I-OVTA-competitive binding assays using human and rat OT-R, respectively), while displaying 65-, 245-, and 23,000-fold reduced affinity, respectively, toward human vassopressin receptors V1a, V2, and V1b. Shown to effectively inhibit OT- (10nM) induced Ca2+ mobilization in hOT-R-expressing HEK293-EBNA cells (IC50 = 14nM) in vitro and OT-stimulated uterine contractions in rats (1.4 -10mg/kg p.o. or 30mg/kg p.o.) in vivo. Product is supplied as a fumarate salt for enhanced aqueous solubility (20 and 10mg/ml, respectively, in water and HBSS). Group: Biochemicals. Grades: Purified. Pack Sizes: 2mg. Molecular Formula: C??H??ClN?O?S.C?H?O?. US Biological Life Sciences. | Worldwide |
| Trk Inhibitor III, GNF-5837 ( (Z) -1- (3- ( (3- ( (1H-Pyrrol-2-yl) methylene) -2-oxoindolin-6-yl) amino) -4-methylphenyl) -3- (2-fluoro-5- (trifluoromethyl) phenyl) urea) | An orally bioavailable oxindole compound that and acts as a potent, reversible and type II DFG-out inhibitor of pan-Trk activity (IC50=8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC50=11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC50=42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC50=1 and 0.5uM) and Ba/F3-Tel-R and wt-Ba/F3 cells (IC50=3.0 and 5.6uM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1033769-28-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib metabolite M3; Nintedanib impurity I; 1H-Indole-6-carboxylic acid, 2, 3-dihydro-3- [ [ [4- [methyl [2- (1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-, methyl ester, (3Z)-. Grades: ≥95%. CAS No. 334951-61-0. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| 2,3-Dihydro-2-oxo-1H-indole-5-sulfonamide | 2,3-Dihydro-2-oxo-1H-indole-5-sulfonamide. Group: Biochemicals. Alternative Names: 2-Oxo-2,3-dihydro-1H-indole-5-sulfonamide; 2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide; 2-Oxoindoline-5-sulfonamide; 5-Aminosulfonyl-2-indolinone; 5-Aminosulfonyl-2-oxindole. Grades: Highly Purified. CAS No. 175075-24-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2H-Indol-2-one,5-(2-bromoacetyl)-1,3-dihydro- | Heterocyclic Organic Compound. Alternative Names: 5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 97;5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE;5-(BROMOACETYL)-2-OXOINDOLINE;5-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one 97%;5-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one(5-(bromoacetyl)-2-oxoindoline). CAS No. 105316-98-1. Molecular formula: C10H8BrNO2. Mole weight: 254.08002. Purity: 0.96. IUPACName: 5-(2-bromoacetyl)-1,3-dihydroindol-2-one. Canonical SMILES: C1C2=C(C=CC(=C2)C(=O)CBr)NC1=O. Density: 1.631g/cm³. Catalog: ACM105316981. | |
| 5-Chloro-2-oxindole | 5-Chloro-2-oxindole is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Alternative Names: 5-Chloro-1,3-dihydro-2H-indol-2-one; 5-Chloro-1,3-dihydroindol-2-one; 5-Chloro-2,3-dihydroindol-2-one; 5-Chloro-2-indolinone; 5-Chloro-2-oxindole; 5-Chloro-2-oxoindoline; 5-Chloroindol-2-one; 5-Chlorooxindole. Grades: Highly Purified. CAS No. 17630-75-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| BI-847325 | BI-847325 is an orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling. BI 847325 also binds to and inhibits the activity of the Aurora kinases A, B and C which may disrupt the assembly of the mitotic spindle apparatus, prevent chromosome segregation, and inhibit both cellular division and proliferation in Aurora kinase-overexpressing tumor cells. Group: Inhibitors. Alternative Names: BI-847325; BI 847325; BI847325. CAS No. 1207293-36-4. Molecular formula: C29H28N4O2. Mole weight: 464.57. Appearance: Solid powder. Purity: >98%. IUPACName: (Z)-3- (3- ( (4- ( (dimethylamino)methyl)phenylamino) (phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide. Canonical SMILES: O=C (NCC)C#CC1=CC (NC/2=O)=C (C=C1)C2=C (NC3=CC=C (CN (C)C)C=C3)/C4=CC=CC=C4. Catalog: ACM1207293364-1. | |
| BIX 02189 | BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. Synonyms: BIX02189; BIX-02189; (Z)-3- ( (3- ( (dimethylamino)methyl)phenylamino) (phenyl)methylene)-N, N-dimethyl-2-oxoindoline-6-carboxamide. Grades: >98%. CAS No. 1094614-85-3. Molecular formula: C27H28N4O2. Mole weight: 440.54. | |
| Desmethyl Nintedanib | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: Nintedanib Impurity G; 2, 3-Dihydro-3- [ [ [4- [ [ (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-methyl Ester-1H-indole-6-carboxylic Acid; (Z)-Methyl 3- ( ( (4- (2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate. CAS No. 894783-61-0. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| methyl 1-(2-chloroacetyl)-2-oxo-3H-indole-6-carboxylate | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/66 nM. Synonyms: 1160293-25-3; methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl estermethyl 1-(2-chloroacetyl)-2-oxo-3H-indole-6-carboxylate1H-Indole-6-carboxylic acid, 1-(2-chloroacetyl)-2,3-dihydro-2-oxo-, methyl ester. Grades: 95%. CAS No. 1160293-25-3. Molecular formula: C12H10ClNO4. Mole weight: 267.66. | |
| Nintedanib Impurity 1 (Intedanib Impurity 1) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/74 nM. Synonyms: Dimethyl 2-oxoindoline-3,6-dicarboxylate; 3,6-dimethyl 2-oxo-2,3-dihydro-1H-indole-3,6-dicarboxylate. Grades: > 95%. Molecular formula: C12H11NO5. Mole weight: 249.23. | |
| Nintedanib Impurity 26 | Nintedanib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3Z,3'Z)-dimethyl 3, 3'- ( ( ( ( (2, 2'- (piperazine-1, 4-diyl)bis (acetyl))bis (methylazanediyl))bis (4, 1-phenylene))bis (azanediyl))bis (phenylmethanylylidene))bis (2-oxoindoline-6-carboxylate). Molecular Formula: C56H52N8O8. Mole Weight: 965.06. Catalog: APB01463. |  |
| Nintedanib Impurity 49 | Nintedanib Impurity 49. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: dimethyl 2-oxoindoline-3,6-dicarboxylate. Molecular Formula: C12H11NO5. Mole Weight: 249.22. Catalog: APB01462. | |
| Nintedanib Impurity 6 (Intedanib Impurity 6) | BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Synonyms: BIBF-1202; BIBF 1202; BIBF1202. (3Z) -2, 3-Dihydro-3- [ [ [4- [methyl [ (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. Grades: >98%. CAS No. 894783-71-2. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| Nintedanib Impurity 9 (Intedanib Impurity 9) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/86 nM. Synonyms: (Z)-methyl 3- ( ( (4- (N-methyl-2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-7-carboxylate. Grades: > 95%. Molecular formula: C32H37N5O4. Mole weight: 555.68. | |
| Nintedanib Impurity A (Intedanib Impurity A) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/66 nM. Synonyms: (Z)-3- ( ( (4- (2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylic acid. Grades: > 95%. Molecular formula: C29H29N5O4. Mole weight: 511.59. | |
| Nintedanib impurity C | Nintedanib impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-methyl 3- ( ( (4- (N-methyl-2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-7-carboxylate. Molecular Formula: C31H33N5O4. Mole Weight: 539.62. Catalog: APB01470. | |
| Nintedanib impurity E | Nintedanib impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-methyl 3- ( ( (4- (methylamino)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate. CAS No. 1987887-92-2. Molecular Formula: C24H21N3O3. Mole Weight: 399.44. Catalog: APB1987887922. | |
| Nintedanib impurity F | Nintedanib impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-methyl 3- ( ( (4- (2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate. CAS No. 894783-61-0. Molecular Formula: C30H31N5O4. Mole Weight: 525.60. Catalog: APB894783610. | |
| Nintedanib Impurity H | Nintedanib Impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-ethyl 1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate. Molecular Formula: C21H19NO5. Mole Weight: 365.38. Catalog: APB01469. | |
| Nintedanib Impurity H (Intedanib Impurity H) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: (E)-1- (2- ( (4- ( ( (6- (methoxycarbonyl)-2-oxoindolin-3-ylidene) (phenyl)methyl)amino)phenyl) (methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide. Grades: > 95%. Molecular formula: C31H33N5O6. Mole weight: 571.64. | |
| Nintedanib Impurity I | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate; NINTEDANIB IMPURITY I; 3TK2E45UHG; BIBF1053; Nintedanib metabolite M3 (m/Z 526); (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate ( Nintedanib Impurity); 1H-Indole-6-carboxylic acid, 2, 3-dihydro-3- ( ( (4- (methyl (2- (1-piperazinyl) acetyl) amino) phenyl) amino) phenylmethylene) -2-oxo-, methyl ester, (3Z)-; methyl 2-hydroxy-3-[N-[4-[methyl-(2-piperazin-1-ylacetyl)amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate. Grades: ≥95%. Molecular formula: C14H22N4O2. Mole weight: 278.36. | |
| Nintedanib Impurity N | Nintedanib Impurity N. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-ethyl 3- ( ( (4- ( (methyl (3- (4-methylpiperazin-1-yl)-2-oxopropyl)amino)methyl)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate. Molecular Formula: C34H39N5O4. Mole Weight: 581.7. Catalog: APB01464. | |
| Nintedanib Impurity O | Nintedanib Impurity O. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate. CAS No. 334951-61-0. Molecular Formula: C30H31N5O4. Mole Weight: 525.60. Catalog: APB334951610. | |
| Orantinib | Orantinib is a multiple receptor tyrosine kinase inhibitor with IC50s of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively. It has greatest potency against PDGFR autophosphorylation. Synonyms: 3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic Acid; 3-[2,4-Dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propionic Acid; 3-[4-(2-Carboxyethyl)-3,5-dimethylpyrrol-2-methylidenyl]-2-indolinone; 5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid; NSC 702827; SU 6668; TSU-68. Grades: ≥98%. CAS No. 252916-29-3. Molecular formula: C18H18N2O3. Mole weight: 310.35. | |
| S-49076 | This active molecular is a Axl receptor tyrosine kinase inhibitor, Proto oncogene protein c met inhibitor, Type-1, Type-2 and Type-3 fibroblast growth factor receptor antagonist originated by Servier. S49076 blocked cellular phosphorylation of MET, AXL and FGFRs and inhibited downstream signaling in vitro and in vivo. Clinical trials in Phase I/II for the treatment of Glioblastoma and Non-small cell lung cancer is on-going. Prexclinical trials for Hepatocellular carcinoma is on-going. Uses: Glioblastoma; non-small cell lung cancer. Synonyms: S-49076; S49076; S 49076; (Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;EBP 883; BMS 790052. Grades: 98%. CAS No. 1265965-22-7. Molecular formula: C22H22N4O4S. Mole weight: 438.50. | |
| SU4984 | SU4984 is a protein tyrosine kinase inhibitor used in cancer research with an IC50 of 10-20 μM against fibroblast growth factor receptor 1 (FGFR1). It also inhibits platelet-derived growth factor receptor and insulin receptor. Synonyms: SU-4984; SU 4984; 1-Piperazinecarboxaldehyde, 4-[4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]phenyl]-; 4-{4-[(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-1-piperazinecarbaldehyde; 4-(4-((2-Oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde. Grades: ≥95%. CAS No. 186610-89-9. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| Sumatriptan Impurity 1 | One of the impurities of Sumatriptan that is a 5-HT receptro agonist. Synonyms: Sumatriptan Impurity 1; Sumatriptan Hydroxy-Oxindole Impurity; 1-(3-(2-(Dimethylamino)ethyl)-3-hydroxy-2-oxoindolin-5-yl)-N-methylmethane. Grades: > 95%. Molecular formula: C14H21N3O4S. Mole weight: 327.41. | |
| Sunitinib Impurity B | Sunitinib Impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-N,N-diethyl-2-(5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamido)ethanamine oxide. CAS No. 356068-99-0. Molecular Formula: C22H27FN4O3. Mole Weight: 414.47. Catalog: APB356068990. | |
| TSU-68 | TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 towards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses. Group: Biochemicals. Alternative Names: (Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic Acid; 3-[2,4-Dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propionic Acid; 3-[4-(2-Carboxyethyl)-3,5-dimethylpyrrol-2-methylidenyl]-2-indolinone; 5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid; NSC 702827; Orantinib; SU 6668. Grades: Highly Purified. CAS No. 252916-29-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ziprasidone N-Oxide | Ziprasidone N-Oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(benzo[d]isothiazol-3-yl)-1-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)piperazine 1-oxide. CAS No. 188797-76-4. Molecular Formula: C21H21ClN4O2S. Mole Weight: 428.94. Catalog: APB188797764. | |
| Ziprasidone N-Oxide Impurity 2 | Ziprasidone N-Oxide Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(benzo[d]isothiazol-3-yl)-4-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)piperazine 1-oxide. Molecular Formula: C21H21ClN4O2S. Mole Weight: 428.94. Catalog: APB01833. | |
| Ziprasidone N-Oxide Impurity 3 | Ziprasidone N-Oxide Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(benzo[d]isothiazol-3-yl)-4-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)piperazine 1,4-dioxide. Molecular Formula: C21H21ClN4O3S. Mole Weight: 444.93. Catalog: APB01829. | |
| Ziprasidone Oxide Impurity 4 | Ziprasidone Oxide Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)-1-(1-oxidobenzo[d]isothiazol-3-yl)piperazine 1-oxide. Molecular Formula: C21H21ClN4O3S. Mole Weight: 444.93. Catalog: APB01830. | |
| Ziprasidone Oxide Impurity 5 | Ziprasidone Oxide Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)-4-(1-oxidobenzo[d]isothiazol-3-yl)piperazine 1,4-dioxide. Molecular Formula: C21H21ClN4O4S. Mole Weight: 460.93. Catalog: APB01827. | |
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