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| Product | Description | |
|---|---|---|
| P-gp inhibitor 1 | P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein -mediated multidrug resistance. Uses: Scientific research. Group: Signaling pathways. CAS No. 2050747-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101791. |  |
| Elacridar hydrochloride (GF 120918, P-gp inhibitor, (N-[4-[2- (3, 4-Dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]-9, 10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride) | P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active. Group: Biochemicals. Grades: Highly Purified. CAS No. 143851-98-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Atazanavir | Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor. Atazanavir is a substrate and inhibitor of CYP3A4 , and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: BMS-232632. CAS No. 198904-31-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17367. | |
| Atazanavir sulfate | Atazanavir (BMS-232632) sulfate is a highly selective and orally active HIV-1 protease inhibitor. Atazanavir sulfate is a substrate and inhibitor of CYP3A4 , and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: BMS-232632 sulfate. CAS No. 229975-97-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17367A. | |
| Cepharanthine | Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration ( IC 50 ) and 90% inhibitory concentration ( IC 90 ) values of 1.90 and 4.46?μM [1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model [2] [3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 481-49-2. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N6972. | |
| CP 100356 hydrochloride | The hydrochloride salt form of CP-100356, which has been found to be an inhibitor of MDR1 (P-Gp) and show inactive in inhibiting multidrug resistance-associated protein 2 (MPR2). Synonyms: CP 100356 hydrochloride; CP100356 hydrochloride; CP-100356 hydrochloride; 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 142715-48-8. Molecular formula: C31H36N4O6.HCl. Mole weight: 597.10. |  |
| CP-100356 Hydrochloride | CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM). Group: Biochemicals. Alternative Names: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine Monohydrochloride. Grades: Highly Purified. CAS No. 142715-48-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Elacridar hydrochloride | Elacridar is an orally bioavailable inhibitor of P-glycoprotein (P-gp) and ABCG2. Synonyms: Elacridar HCl; N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide hydrochloride. CAS No. 143851-98-3. Molecular formula: C34H33N3O5.HCl. Mole weight: 600.10. | |
| Encequidar mesylate | Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HM30181; HM-30181; HM 30181; HM-30181 mesylate; Encequidar mesylate. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. Purity: >98%. IUPACName: N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate. Canonical SMILES: O=C(NC1=CC(OC)=C(C=C1C2=NN(N=N2)C3=CC=C(C=C3)CCN4CC5=C(CC4)C=C(C(OC)=C5)OC)OC)C6=CC(C7=C(C=CC=C7)O6)=O.OS(=O)(C)=O. Product ID: ACM849675872. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Genz-123346 Free base | Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function. Synonyms: Genz-123346; Genz123346; Genz 123346. CAS No. 491833-30-8. Molecular formula: C24H38N2O4. Mole weight: 418.57. | |
| Glesatinib | Glasatinib (MGCD265) is a dual MET/SMO inhibitor. Glesatinib is a small molecule, multi-target tyrosine kinase inhibitor with potential anti-tumor activity, which can antagonize P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC). Synonyms: MGCD-265; MGCD 265; MGCD265. Grades: ≥98% by HPLC. CAS No. 936694-12-1. Molecular formula: C31H27F2N5O3S2. Mole weight: 619.7. | |
| Glesatinib hydrochloride | Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent MET/SMO dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MGCD265 hydrochloride. CAS No. 1123838-51-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19642A. | |
| GNE-317 | GNE-317 is a potent and selective PI3K inhibitor with potential anticncer activity. GNE-317 targets the PI3K pathway and can cross the Blood-Brain Barrier. GNE-317 was identified as having physicochemical properties predictive of low efflux by P-gp and BCRP. Studies in transfected MDCK cells showed that GNE-317 was not a substrate of either transporter. GNE-317 markedly inhibited the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals up to 6-hour postdose. GNE-317 was efficacious in the U87, GS2, and GBM10 orthotopic models, achieving tumor growth inhibition of 90% and 50%, and survival benefit, respectively. GNE-317 could be effective in the treatment of GBM. Synonyms: GNE-317; GNE 317; GNE317. Grades: >98%. CAS No. 1394076-92-6. Molecular formula: C19H22N6O3S. Mole weight: 414.48. | |
| HM30181 | HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitax...the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed. Synonyms: 4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-; N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide; Encequidar; HM 30181; HM-30181. Grades: 98%. CAS No. 849675-66-7. Molecular formula: C38H36N6O7. Mole weight: 688.74. | |
| HM-30181 hydrochloride | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 hydrochloride; HM 30181 hydrochloride; HM30181 hydrochloride; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide hydrochloride. Grades: 98%. CAS No. 849675-88-3. Molecular formula: C38H37ClN6O7. Mole weight: 725.20. | |
| HM-30181 mesylate | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 mesylate; HM 30181 mesylate; HM30181 mesylate; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate;849675-88-3 (HM30181 HCl salt);49675-66-7 (HM30181 Free base). Grades: 98%. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. | |
| Iruplinalkib | Iruplinalkib (WX-0593) is an orally active and selective ALK/ROS1 inhibitor. Iruplinalkib can effectively inhibit tyrosine autophosphorylation of ALK and mutant ALK , EGFR , with the IC 50 between 5.38 and 16.74 nM. Iruplinalkib is also a suppressive agent of the transporter MATE1 , MATE2K , P-gp and BCRP. Iruplinalkib can be used in the study of non-small cell lung cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WX-0593. CAS No. 1854943-32-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145574. | |
| Laniquidar | Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters. A study of docetaxel in combination with the new orally administered P-glycoprotein (P-gp) inhibitor R101933showed that this combination was feasible. However, due to the low oral bioavailability ofR101933 and high interpatient variability, no further attempts to increase the level of P-gp inhibition were made. Synonyms: R101933; R 101933; R-101933; methyl 11-(1-(4-(quinolin-2-ylmethoxy)phenethyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carboxylate. CAS No. 197509-46-9. Molecular formula: C37H36N4O3. Mole weight: 584.72. | |
| MC70 | MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC 50 of 0.69 μM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031367-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113805. | |
| MC70 | MC70 is a potent and selective modulator of P-glycoprotein(P-gp) with EC50 value of 0.69 μM. It is also an inhibitor of the ABC transporter ABCB1 (aka MDR1). It potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment. It is potential to be used as novel anticancer agent with both cytostatic and cytotoxic characteristics. Uses: Mc70 is potential to be used as novel anticancer agent. Synonyms: MC-70; MC 70; MC70. 4-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]phenol;MC-70;4'-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-4-ol. Grades: >98 %. CAS No. 1031367-64-2. Molecular formula: C24H25NO3. Mole weight: 375.47. | |
| MC70 hydrochloride | MC70 hydrochloride is the hydrochloride salt form of MC70, which is a potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively). It potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment. It is potential to be used as novel anticancer agent with both cytostatic and cytotoxic characteristics. Uses: Anticancer agent. Synonyms: MC70 hydrochloride; MC 70 hydrochloride; MC-70 hydrochloride; 4-[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]phenol hydrochloride. Grades: 98%. Molecular formula: C24H25NO3.HCl. Mole weight: 411.92. | |
| Norverapamil | Norverapamil is a metabolite of Verapamil. Verapamil is a medication used for the treatment of high blood pressure, chest pain from not enough blood flow to the heart, and supraventricular tachycardia. Norverapamil is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. Uses: Calcium channel blockers. Synonyms: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-benzeneacetonitrile; Verapamil EP Impurity J; Nor Verapamil; NSC672815. Grades: 95%. CAS No. 67018-85-3. Molecular formula: C26H36N2O4. Mole weight: 440.58. | |
| Norverapamil hydrochloride | Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Norverapamil hydrochloride; D591 hydrochloride. CAS No. 67812-42-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-100750. | |
| ONT-093 | ONT-093 (formerly OC-144-093) is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. Phase I trials of ONT-093 in normal human volunteers showed no dose-limiting toxicities at serum concentrations associated with biologic activity achieved with doses ranging from 300 to 500 mg. Synonyms: ONT 093; ONT093; (E)-4,4'-(2-(4-(3-ethoxyprop-1-en-1-yl)phenyl)-1H-imidazole-4,5-diyl)bis(N-isopropylaniline). CAS No. 216227-54-2. Molecular formula: C32H38N4O. Mole weight: 494.68. | |
| PGP-4008 | PGP-4008 is a selective P-glycoprotein (P-gp) inhibitor without modulating multidrug resistance-related protein 1 (MRP1). In combination with doxorubicin, PGP-4008 inhibited tumor growth in a murine syngeneic Pgp-mediated MDR solid tumor model. Synonyms: N-(1-Benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide. Grades: ≥95%. CAS No. 365565-02-2. Molecular formula: C26H23N3O. Mole weight: 393.5. | |
| Phenformin | Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenethylbiguanide. CAS No. 114-86-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16397. | |
| Reversan | Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (Mdr-1) and P-glycoprotein (P-gp), which may be clinically useful for the treatment of neuroblastoma. Synonyms: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide. Grades: ≥99% by HPLC. CAS No. 313397-13-6. Molecular formula: C26H27N5O2. Mole weight: 441.52. | |
| Tariquidar dihydrochloride | Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Tariquidar was found to reverse drug resistance in multiple MDR cell lines. Tariquidar binds to the p-glycoprotein transporter, and inhibits transmembrane transport of anticancer drugs, leading to increased concentrations and enhanced cytotoxic effects of anticancer drugs. Synonyms: N-[2-[[[4-[2- (3, 4-dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]amino]carbonyl]-4, 5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1992047-62-7. Molecular formula: C38H38N4O6.2HCl. Mole weight: 719.66. | |
| Tridecafluorohexane sulfonic Acid Potassium Salt | Tridecafluorohexane sulfonic Acid is a perfluorinated compound that has been identified to be a p-glycoprotein (p-gp) inhibitor and therefore, a chemosensitizer. Tridecafluorohexane sulfonic Acid is part of a new class of global environmental pollutant; they bioaccumulate and are persistent in the environment and wildlife. Group: Biochemicals. Alternative Names: 1, 1, 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 6-Tridecafluoro-1-hexanesulfonic Acid Potassium Salt; Tridecafluoro-1-hexanesulfonic Acid Potassium Salt; Potassium (Perfluorohexyl) sulfonate; Potassium Perfluoro-1-hexanesulfonate; Potassium Perfluorohexane sulfonate; Potassium Tridecafluorohexane-1-sulfonate. Grades: Highly Purified. CAS No. 3871-99-6. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| Verapamil | Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Verapamil; CP-16533-1. CAS No. 52-53-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-14275. | |
| Verapamil hydrochloride | Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Verapamil hydrochloride; CP-16533-1 hydrochloride. CAS No. 152-11-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-A0064. | |
| Vismodegib | Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC 50 of 3 nM. Vismodegib also inhibits P-gp , ABCG2 with IC 50 values of 3.0 μM and 1.4 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0449. CAS No. 879085-55-9. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10440. | |
| Vismodegib | Vismodegib (GDC-0449) is a potent, novel and specific inhibitor of hedgehog with IC50 of 3 nM and also inhibitor of P-gp with IC50 of 3.0 μM. Synonyms: Code name: GDC-0449; GDC 0449; GDC0449; RG3616; RG 3616; RG-3616. trade name: Erivedge. Grades: 0.99. CAS No. 879085-55-9. Molecular formula: C19H14Cl2N2O3S. Mole weight: 421.292. | |
| Zosuquidar | Zosuquidar, also called as LY335979, a cyclopropyldibenzosuberane, was developed as an inhibitor of P-glycoprotein (P-gp). It is undergoing testing in a phase I/II trial clinical study in acute myeloid leukaemia. Synonyms: (2R)-anti-5-(3-(4-(10,11-difluoromethanodibenzo-suber-5-yl)piperazin-1-yl)2-hydroxypropoxy)quinoline trihydrochlorideLY 335979; LY-335979LY335979RS 33295-198RS-33295-198zosuquidar trihydrochloride. CAS No. 167354-41-8. Molecular formula: C32H31F2N3O2. Mole weight: 527.60. | |
| Zosuquidar | Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor ( K i =59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RS 33295-198; LY-335979. CAS No. 167354-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-15255. | |
| Zosuquidar Trihydrochloride | Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer). Group: Biochemicals. Alternative Names: (α R) -4- [ (1aα , 6α , 10bα ) -1, 1-Difluoro-1, 1a, 6, 10b-tetrahydrodibenzo [a, e]cyclopropa [c]cyclohepten-6-yl]-α - [ (5-quinolinyloxy) methyl]-1-piperazineethanol Hydrochloride; Zosuquidar Hydrochloride. Grades: Highly Purified. CAS No. 167465-36-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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