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| Product | Description | |
|---|---|---|
| Pemetrexed | Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: LY231514; Alimta; LY 231514; LY-231514. Grade: >98%. CAS No. 137281-23-3. Molecular formula: C20H21N5O6. Mole weight: 427.41. |  |
| Pemetrexed | Pemetrexed. Group: Biochemicals. Grades: Highly Purified. CAS No. 137281-23-3. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C20H21N5O6. US Biological Life Sciences. |  Worldwide |
| Pemetrexed | Pemetrexed (LY231514) is an antifolate , the K i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820. |  |
| Pemetrexed-[d5] | Pemetrexed-[d5], is the labelled analogue of Pemetrexed. Pemetrexed is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer. Synonyms: Pemetrexed D5. Grade: 95% by CP; 95% atom D. CAS No. 1129408-57-6. Molecular formula: C20H16D5N5O6. Mole weight: 432.44. | |
| Pemetrexed-d5 Diethyl Ester | Isotope labelled Pemetrexed-d5 Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: Diethyl 2- (4- (2- (2-Amino-4-oxo-4, 7-dihydro-3H-pyrrolo[2, 3-d]pyrimidin-5-yl) ethyl) benzamido) pentanedioate-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed-d5, Disodium Salt (N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d5 Disodium Salt) | Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Antineoplastic. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d5 Disodium Salt. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Pemetrexed Diethyl Ester | Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: Diethyl 2- (4- (2- (2-Amino-4-oxo-4, 7-dihydro-3H-pyrrolo[2, 3-d]pyrimidin-5-yl) ethyl) benzamido) pentanedioate. Grades: Highly Purified. CAS No. 146943-43-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed disodium | Pemetrexed disodium. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid sodium salt. Grades: Highly Purified. CAS No. 150399-23-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C20H19N5Na2O6. US Biological Life Sciences. | Worldwide |
| Pemetrexed disodium | Pemetrexed disodium (LY231514 disodium) is an antifolate, the K i s of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium. CAS No. 150399-23-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10820A. | |
| Pemetrexed Disodium | Pemetrexed Disodium. Uses: For analytical and research use. Group: Impurity standards. CAS No. 150399-23-8. Molecular formula: C20H19N5Na2O6. Mole weight: 471.38. Catalog: APB150399238. |  |
| Pemetrexed disodium hemipentahydrate | Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Synonyms: L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt, hydrate; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt, hydrate (2:4:5); Ciambra; Pemetrexed disodium salt 2.5 hydrate; LY-231514 disodium hemipentahydrate; LY 231514 disodium hemipentahydrate; LY231514 disodium hemipentahydrate; Pemetrexed sodium hydrate (2:4:5); (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid, sodium salt 2.5 hydrate. Grade: >98%. CAS No. 357166-30-4. Molecular formula: C20H19N5Na2O6.5/2H2O. Mole weight: 516.42. | |
| Pemetrexed disodium heptahydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardschiral moleculesenzyme activators, inhibitors & substrateseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: Pemetrexed disodium heptahydrate, L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (9CI), Disodium (2S)-2-[[4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate heptahydrate,L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt, hydrate (1:2:7). | |
| Pemetrexed disodium heptahydrate | Pemetrexed disodium heptahydrate is a novel antifolate , the K i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium heptahydrate. CAS No. 357166-29-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820B. | |
| Pemetrexed Disodium Heptahydrate | Pemetrexed Disodium Heptahydrate. Group: Biochemicals. Alternative Names: N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt Heptahydrate. Grades: Highly Purified. CAS No. 357166-29-1. Pack Sizes: 10mg. Molecular Formula: C20H33N5Na2O13, Molecular Weight: 597.48. US Biological Life Sciences. | Worldwide |
| Pemetrexed Disodium Hydrate | Pemetrexed Disodium Hydrate. Group: Biochemicals. Alternative Names: N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Glutamic Acid Disodium Hydrate. Grades: Highly Purified. CAS No. 357166-30-4. Pack Sizes: 10mg. Molecular Formula: C20H19Na2N5O6 5/2 H2O, Molecular Weight: 471.37. US Biological Life Sciences. | Worldwide |
| Pemetrexed disodium salt | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C20H19N5Na2O6. CAS No. 150399-23-8. Prepack ID 23048138-1g. Molecular Weight 471.37. See USA prepack pricing. |  |
| Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium, LY-231514, Alimta) | Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 357166-29-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed Impurity 3 | Pemetrexed Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 123910-88-3. Molecular formula: C12H16O3. Mole weight: 208.26. Catalog: APB123910883. | |
| Pemetrexed Impurity 8 | Pemetrexed Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1320346-43-7. Molecular formula: C16H16N4O4. Mole weight: 328.33. Catalog: APB1320346437. | |
| Pemetrexed L-Glutamic Acid Benzyl Dimethyl Triester | Protected Pemetrexed L-Glutamic acid (P219530), an impurity of Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-γ-glutamyl-L-glutamic Acid Benzyl Dimethyl Triester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Pemetrexed Methyl Ester | Protected Pemetrexed. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester. Grades: Highly Purified. CAS No. 155405-81-5. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| D-Pemetrexed Dimethyl Diester | D-Pemetrexed dimethyl diester is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Diester. Grade: 98%. CAS No. 1391068-12-4. Molecular formula: C22H25N5O6. Mole weight: 455.46. | |
| D-Pemetrexed Dimethyl Diester | Protected D-Pemetrexed. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Diester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| D-Pemetrexed Hydrate | D-Pemetrexed Hydrate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic Acid Hydrate. Molecular formula: C20H23N5O7. Mole weight: 445.42. | |
| D-Pemetrexed Hydrate | Pemetrexed isomer impurity. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic Acid Hydrate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-Methyl Pemetrexed | N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed, an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; Pemetrexed EP Impurity A. Grades: Highly Purified. CAS No. 869791-42-4. Pack Sizes: 2.5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 441.44. US Biological Life Sciences. | Worldwide |
| N-Methyl Pemetrexed-d3 | N-Methyl Pemetrexed-d3. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d3. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C21H20D3N5O6, Molecular Weight: 444.46. US Biological Life Sciences. | Worldwide |
| 3-Buten-1-ol | An impurity of Pemetrexed, which is used for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: 1-Buten-4-ol; 1-Hydroxy-3-butene; 3-Butenol; 3-Butenyl alcohol; 4-Hydroxy-1-butene; Allylcarbinol; Homoallyl alcohol; NSC 60194; β-Vinylethanol. Grade: ≥95%. CAS No. 627-27-0. Molecular formula: C4H8O. Mole weight: 72.11. | |
| 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid | Used in the preparation of a Pemetrexed (P219500) metabolite. Group: Biochemicals. Grades: Highly Purified. CAS No. 193265-47-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester | 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Benzoic acid, 4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester; Pemetrexed Impurity 63; Methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate; Methyl 4-(2-(2-imino-4,6-dioxo-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate. Grade: ≥95%. CAS No. 1320346-43-7. Molecular formula: C16H16N4O4. Mole weight: 328.32. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid | 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid;4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoic acid (intermediate of pemetrexed);4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-1H-PYMOL[2,3-D]PYRIMODIN-5-. Product Category: Heterocyclic Organic Compound. Appearance: Pale Pink Solid. CAS No. 137281-39-1. Molecular formula: C15H14N4O3. Mole weight: 298.3. Purity: Enterprise Standard. Density: 1.559 g/cm³. Product ID: ACM137281391. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid | An impurity of Pemetrexed which binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid. Grade: > 95%. CAS No. 137281-39-1. Molecular formula: C15H14N4O3. Mole weight: 298.3. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid methyl ester | 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester; 2-Amino-4,7-dihydro-5-[2-[4-(methoxycarbonyl)phenyl]ethyl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine; Pemetrexed Impurity 9. Grade: ≥95%. CAS No. 155405-80-4. Molecular formula: C16H16N4O3. Mole weight: 312.32. | |
| 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid | Pemetrexed intermediate. Group: Biochemicals. Alternative Names: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid. Grades: Highly Purified. CAS No. 137281-39-1. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester | 4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is an intermediate of Pemetrexed, which is used as a single agent or in combination with other chemotherapeutic agents for the treatment of several types of cancer. Synonyms: Pemetrexed Impurity; Benzoic acid, 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, 2,5-dioxo-1-pyrrolidinyl ester; 2,5-Dioxo-1-pyrrolidinyl 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate; 2,5-Pyrrolidinedione, 1-[[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]oxy]-; 2,5-Dioxopyrrolidin-1-yl 4-(2-(2-imino-4-oxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate; 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester; 1-[[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]oxy]-2,5-pyrrolidinedione. Grade: ≥95%. CAS No. 204257-65-8. Molecular formula: C19H17N5O5. Mole weight: 395.38. | |
| 4-[2- (7-Deazaguanine) ethyl]benzoic Acid N-Hydroxysuccinimide Ester | Intermediate in the preparation of Pemetrexed. Group: Biochemicals. Alternative Names: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester; 1-[[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]oxy]-2,5-pyrrolidinedione. Grades: Highly Purified. CAS No. 204257-65-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate; N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid; 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl-L-glutamic acid diethyl ester p-toluenesulfonate salt. Grade: > 98%. CAS No. 165049-28-5. Molecular formula: C31H37N5O9S. Mole weight: 655.72. | |
| (-)-LY-338979 | (-)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5R)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5R)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| (+)-LY-338979 | (+)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5S)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5S)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| LY 338979 | LY 338979 is a metabolite of the antifolate Pemetrexed. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid. Grades: Highly Purified. CAS No. 193281-00-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| LY 338979 Dimethyl Ester | Protected LY 338979 (L486650), a metabolite of the antifolate Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester. Grades: Highly Purified. CAS No. 1320346-45-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| LY 368962 Dimethyl Ester | Protected LY 368962 (L486705), a metabolite of the antifolate Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid Dimethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid | N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM). Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; NSC 698037; Pemetrexed. Grades: Highly Purified. CAS No. 137281-23-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic aciddisodium salt hydrate | N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic aciddisodium salt hydrate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic aciddisodium salt hydrate;Pemetrexed disodium hepthydrate;PeMetrexed disodiuM 7-hydrate;L-GlutaMic acid, N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-, disodiuM salt, heptahydrate;Pemetrexed for system suitability;Pemetrexed (sodium salt hydrate);N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hepthydrate. CAS No. 357166-29-1. Molecular formula: C20H19N5Na2O6.7(H2O). Mole weight: 489.38958. Purity: 0.98. IUPACName: disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;heptahydrate. Canonical SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.O.O.[Na+].[Na+]. ECNumber: 604-733-2. Product ID: ACM357166291. Alfa Chemistry ISO 9001:2015 Certified. | |
| Native Pseudomonas sp. Carboxypeptidase G | Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group.1 Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions. Applications: Carboxypeptidase g from pseudomonas sp., or γ-glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin cooh-terminus in p-450cam (cytochrome m) hydroxylations. carboxypeptidase g from pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via no-cgmp signaling in lung adenocarcinoma cells. Group: Enzymes. Synonyms: γ-Glutamyl hydrolase; EC 3.4.17.11; 9074-87-7; glutamate carboxypeptidas. Enzyme Commission Number: EC 3.4.17.11. CAS No. 9074-87-7. Carboxypeptidase G. Activity: > 3 units/mg protein. Storage: -20°C. Form: lyophilized powder contains sodium acetate salt. Source: Pseudomonas sp. γ-Glutamyl hydrolase; EC 3.4.17.11; 9074-87-7; glutamate carboxypeptidase; carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Cat No: NATE-0102. |  |
| (S)-dimethyl 2-(4-(4-oxobutyl)benzamido)pentanedioate | (S)-dimethyl 2-(4-(4-oxobutyl)benzamido)pentanedioate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed Impurity 10. CAS No. 1081974-98-2. Molecular formula: C18H23NO6. Mole weight: 349.38. | |
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