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Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents. Group: Biochemicals. Alternative Names: 5-Phenyl-2,4-thiazolediamine Hydrobromide; Amiphenazole Hydrobromide. Grades: Highly Purified. CAS No. 6020-54-8. Pack Sizes: 25mg. US Biological Life Sciences.
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Ethyl 2-amino-4-phenylthiazole-5-carboxylate
Ethyl 2-amino-4-phenylthiazole-5-carboxylate. Group: Biochemicals. Alternative Names: 2-Amino-4-phenylthiazole-5-carboxylic acid ethyl ester. Grades: Highly Purified. CAS No. 64399-23-1. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC50=16, 19, 39 and 64nM for p110y, PI 4-KIIb, p110a and DNA-PK, respectively). Moderately inhibits p110d, PI 3-KC2b, hsVPS34, ATM, p110b and PI 4-KIIIa (IC50=0.120, 0.140, 0.320, 0.490, 0.590 and 1.1uM, respectively) with minimal inhibition towards a panel of 36-kinases (IC50>10uM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250nM. Group: Biochemicals. Grades: Highly Purified. CAS No. 593960-11-3. Pack Sizes: 5mg. US Biological Life Sciences.
2,2'-Dibromoacetophenone is used in the preparation of 4-phenylthiazol-2(3H)-one derivatives as anticonvulsant agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 49851-55-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H6Br2O, Molecular Weight: 277.94. US Biological Life Sciences.
2-Methoxyphenyl acetonitri le was used in the synthesis of 2- (1-cyano-1- (2-methoxy) phenyl) methylidene-3-phenylthiazolidine-4, 5-dione as possible antibiotic agent. It can also be used to synthesize 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex. Group: Biochemicals. Grades: Highly Purified. CAS No. 7035-3-2. Pack Sizes: 5g, 25g. Molecular Formula: C9H9NO, Molecular Weight: 147.169999999999. US Biological Life Sciences.
A phenylacetamide compound that acts as an allosteric agonist of FFA2 (GPR43), demonstrating a left-shifted acetate dose response (IC50=0.7uM) and 111% efficacy relative to acetate in hFFA2 forskolin-induced cAMP assays. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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KHS101
KHS101 is a selective inducer of neuronal differentiation. Synonyms: N4-Isobutyl-N2-((2-Phenylthiazol-4-Yl)Methyl)Pyrimidine-2,4-Diamine; KHS-101; N4-(2-Methylpropyl)-N2-[(2-Phenyl-1,3-Thiazol-4-Yl)Methyl]Pyrimidine-2,4-Diamine. Grades: 98%. CAS No. 1262770-73-9. Molecular formula: C18H21N5S. Mole weight: 339.5.
KHS 101 hydrochloride
KHS 101 hydrochloride is the hydrochloride salt of KHS 101, which is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo and induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3. It suppresses astrocyte formation. It is a useful intermediate. Synonyms: KHS 101 hydrochloride; KHS-101 hydrochloride; KHS101 hydrochloride; N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride; N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 1784282-12-7. Molecular formula: C18H22ClN5S. Mole weight: 375.92.
PTACH is a SAHA-based novel inhibitor of histone deacetylase (HDAC). It exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1.1 to 9.1 μM. It shows strong activity in cancer cell growth inhibition assay. It inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer. It could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. It upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. It exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. Uses: Ptach exerts potent growth inhibition against various human cancer cells. it could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction. Synonyms: NCH-51; NCH 51; NCH51. PTACH;Cpd 51;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate;S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate;2-Methylpropanethioicacid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester. Grades: >98%. CAS No. 848354-66-5. Molecular formula: C20H26N2O2S2. Mole weight: 390.56.
RCGD423 is a gp130 modulator that prevents the degradation of articular cartilage and promotes repair. Synonyms: N-(4-Bromophenyl)-4-Phenylthiazol-2-Amine; RCGD-423; RCGD 423. Grades: 98%. CAS No. 108237-91-8. Molecular formula: C15H11BrN2S. Mole weight: 331.2.
An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50=3uM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10uM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
TMP269
TMP269 is a highly potent, selective and cell-permeable class IIa HDAC inhibitor with IC50 values of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. Synonyms: TMP269; TMP 269; TMP-269; N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide. Grades: 98%. CAS No. 1314890-29-3. Molecular formula: C25H21F3N4O3S. Mole weight: 514.523.
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