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PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat [1] [2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. CAS No. 105650-23-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118716.
Shows potent mutagenic activity in the reversion assay of Salmonella typhimurium. Group: Biochemicals. Alternative Names: Nitro-PHIP. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Shows potent mutagenic activity in the reversion assay of Salmonella typhimurium. Group: Biochemicals. Alternative Names: Nitro-PHIP-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A novel analog of the food mutagen and carcinogen PHIP. Group: Biochemicals. Alternative Names: Azido-PHIP. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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4'-Methoxy PhIP
PhIP. Group: Biochemicals. Alternative Names: 4-(2-Amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Fmoc-Asp(O-2-PhiPr)-OH
Quasi-orthogonally-protected Asp derivative.The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Asp(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.This derivative has also been used in solution to prepare bicyclic helix initiating peptides. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Asp(O-2-PhiPr)-OH, N-α-Fmoc-L-aspartic acid β-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 200336-86-3. Mole weight: 473.52. Product ID: ACM200336863-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu-O-2-PhiPr
An excellent tool for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS. The 2-PhiPr group can be selectively removed on the resin with 1% TFA in DCM in the presence of the standard t-butyl-based side-chain protecting groups. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-O-2-PhiPr, N-α-Fmoc-L-glutamic acid α-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 207305-97-3. Mole weight: 487.54. Product ID: ACM207305973-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(O-2-PhiPr)-OH
Quasi-orthogonally-protected Glu derivative. The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Glu(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(O-2-PhiPr)-OH, N-α-Fmoc-L-glutamic acid γ-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 200616-39-3. Mole weight: 487.54. Product ID: ACM200616393-1. Alfa Chemistry ISO 9001:2015 Certified.
The DNA adduct formed from N-Hydroxy-PHIP. Group: Biochemicals. Alternative Names: dG-C8-PHIP. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
1-(2-amino-5-phenylpyridin-3-yl)-1-methylthiourea N- β-D-Glucuronide Methyl Ester Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C26H30N4O9S, Molecular Weight: 574.6. US Biological Life Sciences.
Used in the preparation of PhIP (A617000) metabolites and derivatives. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
1-Deoxy-1-thiocyanato-glucopyranuronic Acidmethyl Ester Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C14H17NO9S, Molecular Weight: 375.35. US Biological Life Sciences.
Worldwide
1-Methyl-2-nitro-6-phenylimidazo[4,5-B]pyridine
1-Methyl-2-nitro-6-phenylimidazo[4,5-B]pyridine. Group: Biochemicals. Alternative Names: Nitro-phIP; 1-Methyl-2-nitro-6-phenyl-1H-imidazo[4,5-b]pyridine. Grades: Highly Purified. CAS No. 129018-59-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C13H10N4O2. US Biological Life Sciences.
Worldwide
2-Amino-1,6-dimethylimidazo[4,5-b]pyridine (DMIP)
A mutagenic cogener of PHIP. Group: Biochemicals. Alternative Names: DMIP. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers. Synonyms: PhIP; 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine. Grades: ≥98%. CAS No. 105650-23-5. Molecular formula: C13H12N4. Mole weight: 224.3.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (2-Amino-1-Me-6-PhIP) N-b-D-glucuronide is an indispensable tool in the realm of biomedicine. This particular chemical derivative assumes a pivotal role in the comprehensive exploration of the intricate processes of metabolism and detoxification surrounding the highly potent mutagen, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - a prevalent entity present in thermally processed meats. Synonyms: 1-Deoxy-1-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]-b-D-glucopyranuronic acid PhIP-N-b-D-glucuronide. CAS No. 133084-70-5. Molecular formula: C19H20N4O6. Mole weight: 400.39.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N-β-D-Glucuronide Sodium Salt
Carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Synonyms: 1-Deoxy-1-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]-β-D-glucopyranuronic Acid Sodium Salt; PhIP-N-β-D-glucuronide Sodium Salt. Grades: 97%. Molecular formula: C19H19N4NaO6. Mole weight: 422.37.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H28N4O9, Molecular Weight: 540.52. US Biological Life Sciences.
Used in the preparation of PhIP (A617000) metabolites and derivatives. Group: Biochemicals. Alternative Names: N3-Methyl-5-(4-methoxyphenyl)-2,3-pyridinediamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
2-Azido-1-methyl-6-phenylimidazo[4,5-b]pyridine
2-Azido-1-methyl-6-phenylimidazo[4,5-b]pyridine. Group: Biochemicals. Alternative Names: Azido-phIP. Grades: Highly Purified. CAS No. 135577-57-0. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C13H10N6. US Biological Life Sciences.
Worldwide
2-Azido-1-methyl-6-phenylimidazo[4,5-b]pyridine
2-Azido-1-methyl-6-phenylimidazo[4,5-b]pyridine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Azido-PhIP. Product Category: Heterocyclic Organic Compound. Appearance: Light Red Powder. CAS No. 135577-57-0. Molecular formula: C13H10N6. Mole weight: 250.26. Purity: 0.96. IUPACName: 2-azido-1-methyl-6-phenylimidazo[4,5-b]pyridine. Canonical SMILES: CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N=[N+]=[N-]. Density: g/cm³. Product ID: ACM135577570. Alfa Chemistry ISO 9001:2015 Certified.
3-Bromo-5-(4-methoxyphenyl)-2-pyridinamine
Used in the preparation of PhIP (A617000) metabolites and derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 1381938-33-5. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
5-(4-Methoxyphenyl)-2-pyridinamine
Used in the preparation of luciferase inhibitors, substituted triazoles as antifungal agents and PhIP (A617000) metabolites and derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 503536-75-2. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Chlorophyllin sodium copper salt
Chlorophyllin sodium copper salt. Synonyms: Chlorophyllin, coppered trisodium salt. CAS No. 11006-34-1. Pack Sizes: 5, 25, 100 g in glass bottle. Product ID: CDC10-0144. Molecular formula: C34H31CuN4Na3O6. Category: Cosmetic Color Additives. Product Keywords: Cosmetic Ingredients; Cosmetic Color Additives; Chlorophyllin sodium copper salt; CDC10-0144; 11006-34-1; C34H31CuN4Na3O6; Chlorophyllin, coppered trisodium salt; 234-242-5; 11006-34-1. Grade: commercial grade. Purity: 0.99. Color: Dark Green to Black. EC Number: 234-242-5. Physical State: Powder. Solubility: H2O: 100 mg/mL, dark green. Quality Level: 200. Storage: 2-8°C. Application: Chlorophyllin sodium copper salt has been used to study the effect of chlorophyllin against radiation-induced hematopoietic syndrome. It has been used to study the effect of chlorophyllin on the excretion of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its metabolites into the breast-milk of lactating rats. Boiling Point: N/A. Melting Point: >300°C.
Fmoc-Glu-OPp
Fmoc-Glu-OPp is a derivative of Fmoc-Glu used in the synthesis and selective modification of γ-Glu containing peptides. Synonyms: Fmoc-Glu-2-phenylisopropyl ester; Fmoc-Glu-O-2-PhiPr; (S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-((2-phenylpropan-2-yl)oxy)pentanoic acid; Fmoc-Glu-OPis; L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(1-methyl-1-phenylethyl) ester; N-Fmoc-L-glutamic acid 1-(1-methyl-1-phenylethyl) ester. Grades: ≥95%. CAS No. 207305-97-3. Molecular formula: C29H29NO6. Mole weight: 487.55.
Fmoc-L-glutamic acid g -2-phenylisopropyl ester
The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM, making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. Synonyms: Fmoc-L-Glu(2-phenylisopropyloxy)-OH; Fmoc-L-glutamic acid 5-(2-phenylisopropyl) ester; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(2-phenylpropan-2-yloxy)pentanoic acid. Grades: ≥ 99% (Chiral HPLC, HPLC). CAS No. 200616-39-3. Molecular formula: C29H29NO6. Mole weight: 487.56.
N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-β]pyridine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Dguo-phip, dG-C8-Phip, CID132509, N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, Guanosine, 2-deoxy-8-((1-methyl-6-phenyl-1H-imidazo(4,5-b)pyridin-2-yl)amino)-, 142784-25-6. Product Category: Heterocyclic Organic Compound. CAS No. 142784-25-6. Molecular formula: C23H23N9O4. Mole weight: 489.49. Purity: 0.96. IUPACName: 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-[(1-methyl-6-phenylimidazo[4,5-b]pyridin-2-yl)amino]-3H-purin-6-one. Density: 1.77g/cm³. Product ID: ACM142784256. Alfa Chemistry ISO 9001:2015 Certified.
The DNA adduct formed from N-Hydroxy-PHIP. Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV. Synonyms: 2'-Deoxy-8-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]guanosine; dG-C8-PhIP. Grades: 96%. CAS No. 142784-25-6. Molecular formula: C23H23N9O4. Mole weight: 489.49.
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