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| Product | Description | |
|---|---|---|
| Phorbol | 10mg Pack Size. Group: Building Blocks, Organics. Formula: C20H28O6. CAS No. 17673-25-5. Prepack ID 90025150-10mg. Molecular Weight 364.43. See USA prepack pricing. |  |
| Phorbol | Phorbol, derived from the roots of Euphorbia pekinensis Rupr., as a tumor promoter it is able to activate protein kinase C. Synonyms: 4β, 9α, 12β, 13α, 20-Pentahydroxytiglia-1, 6-dien-3-one; 4-alpha-phorbol; 4alpha-phorbol; beta-phorbol; isophorbol; phorbol; phorbol, (1aR-(1aalpha, 1bbeta, 4aalpha, 7aalpha, 7balpha, 8alpha, 9beta, 9bbeta))-isomer. CAS No. 17673-25-5. Molecular formula: C20H28O6. Mole weight: 364.4. |  |
| Phorbol | Phorbol is a highly toxic diterpene, whose esters have important biological properties. Uses: Scientific research. Group: Natural products. Alternative Names: 4β-Phorbol. CAS No. 17673-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N2147. |  |
| Phorbol | Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium. [2][3][4][5][6] The structure of phorbol was determined in 1967.[7][8] It is very soluble in most polar organic solvents, as well as in water. Group: Biochemicals. Alternative Names: 4 β,9α,12 β,13α,20-Pentahydroxytiglia-1,6-dien-3-one. Grades: Highly Purified. CAS No. 17673-25-5. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate, a protein kinase C activator, stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Uses: Carcinogens. Synonyms: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester; 12,13-Dibutyrate, Phorbol; Phorbol 12,13 Dibutyrate; Phorbol 12,13-Dibutyrate; Phorbol-12,13-Dibutyrate. CAS No. 37558-16-0. Molecular formula: C28H40O8. Mole weight: 504.61. | |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 37558-16-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phorbol dibutyrate; PDBu. CAS No. 37558-16-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18985. | |
| Phorbol-12,13-didecanoate | Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 24928-17-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-160070. | |
| Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator [1] [2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells [3] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: PMA; TPA; Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18739. | |
| Phorbol-12-myristate-13-acetate | 1mg Pack Size. Group: Analytical Reagents, Bioactive Small Molecules, Aroma Chemicals, Biochemicals, Building Blocks, Flavours and Fragrance Materials, Organics, Research Organics & Inorganics. Formula: C36H56O8. CAS No. 16561-29-8. Prepack ID 90028661-1mg. Molecular Weight 616.83. See USA prepack pricing. | |
| Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. | Worldwide |
| Phorbol-13-butyrate | Heterocyclic Organic Compound. Alternative Names: PHORBOL 13-BUTYRATE, 4BETA;phorbol 13-butyrate;liquidinampoule;(1aR)-1, 1aα, 1bβ, 4, 4a, 7aα, 7b, 8, 9, 9a-Decahydro-3-(hydroxymethyl)-5-oxo-1, 1, 6, 8α-tetramethyl-5H-cyclopropa[3, 4]benz[1, 2-e]azulene-4aβ, 7bα, 9β, 9aα-tetrol 9a-butyrate. CAS No. 100929-94-0. Molecular formula: C24H34O7. Mole weight: 434.52. Catalog: ACM100929940. |  |
| Phorbol 13-Myristate | Heterocyclic Organic Compound. Alternative Names: PHORBOL 13-MYRISTATE. CAS No. 115905-51-6. Molecular formula: C34H54O7. Mole weight: 574.8. Purity: 0.97. Canonical SMILES: CCCCCCCCCCCCCC (=O)O[C@@]12[C@H] (C1 (C)C)[C@@H]3C=C (C[C@H]4 ([C@H] ([C@H]3 ([C@@H] ([C@H]2O)C)O)C=C (C4=O)C)O)CO. Density: 1.2 g/cm3(Predicted). Catalog: ACM115905516. | |
| phorbol-diester hydrolase | Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil. Group: Enzymes. Synonyms: diacylphorbate 12-hydrolase; diacylphorbate 12-hydrolase; phorbol-12,13-diester 12-ester hydrolase; PDEH. Enzyme Commission Number: EC 3.1.1.51. CAS No. 81181-74-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3479; phorbol-diester hydrolase; EC 3.1.1.51; 81181-74-0; diacylphorbate 12-hydrolase; diacylphorbate 12-hydrolase; phorbol-12,13-diester 12-ester hydrolase; PDEH. Cat No: EXWM-3479. |  |
| 4α-Phorbol 12,13-didecanoate | 4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca 2+ influx [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4αPDD. CAS No. 27536-56-7. Pack Sizes: 1 mg. Product ID: HY-116291. | |
| 4α-Phorbol 12-myristate 13-acetate | 4α-Phorbol 12-myristate 13-acetate is a phorbol ester that is commonly used to activate certain types of PKC, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. And it has the similar chemical structure of 4-Quinolone-3-Carboxamide Furan CB2 Agonist. Synonyms: 4α-PMA. Grades: ≥98%. CAS No. 63597-44-4. Molecular formula: C36H56O8. Mole weight: 616.8. | |
| 1,1,3-Trichloroacetone | 1,1,3-Trichloroacetone is a reagent used to synthesize chlorinated 5-hydroxy-4-methyl-2(5H)-furanones and mucochloric acid. In addition, it can also be used to synthesize (+)-Phorbol. Phorbol derivatives are important for biomedical research and capable of stimulating T-cell activation, proliferation and cytokine production. Group: Biochemicals. Grades: Highly Purified. CAS No. 921-03-9. Pack Sizes: 100mg, 500mg. Molecular Formula: C3H3Cl3O. US Biological Life Sciences. | Worldwide |
| 1,2-Dioctanoyl-sn-glycerol 3-Phosphate Sodium Salt | 1,2-Dioctanoyl-sn-glycerol 3-Phosphate is a derivative of sn-1,2-Dioctanoylglycerol (D481000) which is a cell permeable lipid shown to mimic the effect of tumor-promoting phorbol diesters on mitogenesis and EGF binding and action in intact cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 178603-80-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C19H37O8P xNa, Molecular Weight: US Biological Life Sciences. | Worldwide |
| (+)-[6]-Gingerol | (+)-[6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. (+)-[6]-Gingerol down regulates proinflammatory cytokine release by macrophages. (+)-[6]-Gingerol has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Group: Biochemicals. Alternative Names: (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (5S)-[6]-Gingerol; (S)-(+)-[6]Gingerol; (S)-[6]Gingerol; [6]-Gingerol. Grades: Highly Purified. CAS No. 23513-14-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7,4'-Dihydroxyflavone | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor ( IC 50 =0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)?paradoxical adverse effects on eotaxin production [1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC 50 value of 1.4 μM [1]. Uses: Scientific research. Group: Natural products. CAS No. 2196-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2609. | |
| 7-Oxostaurosporine | It is the oxidised and highly fluorescent analogue of Antibiotic UCN-01 and UCN-02. It is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumour cells lines to UCN-01. Synonyms: 7-Oxostaurosporine; BMY 41950; RK 1409; (9S,10R,11R,13R)-10,11,12,13-Tetrahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,3(2H)-dione; 10, 11, 12, 13-Tetrahydro-10-methoxy-9-methyl-11-(methylamino)-[9S-(9α, 10β, 11β, 13α)]-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonine-1, 3(2H)-dione. Grades: >98% by HPLC. CAS No. 141196-69-2. Molecular formula: C28H24N4O4. Mole weight: 480.52. | |
| 7-Oxostaurosporine (Antibiotic BMY 41950, Antibiotic RK 1409) | 7-Oxostaurosporine is the oxidised and highly fluorescent analogue of Antibiotics UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumor cells lines to Antibiotic UCN-01. Despite its close relationship to Antibiotic UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties. Group: Biochemicals. Alternative Names: Antibiotic BMY 41950, Antibiotic RK 1409. Grades: Highly Purified. CAS No. 141196-69-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CALP1 trifluoroacetate salt | CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. CALP1 is also a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. CALP1 inhibits Ca2+-mediated cytotoxicity and apoptosis with IC50 of 52 μM and activates phosphodiesterase in the presence of calmodulin and absence of calcium. It also decreases radical production induced by phorbol 12-myristate 13-acetate in broncho-alveolar lavage cells. Synonyms: Calcium-like peptide 1. Grades: ≥95%. Molecular formula: C40H75N9O10·xCF3COOH. Mole weight: 842.08. | |
| Cercosporin | Phytotoxin. Potent and specific PKC inhibitor. Competes for the phorbol binding site. Anticancer compound. Cytotoxic. Antiproliferative. Antiparasitic. Antimicrobial. Group: Biochemicals. Alternative Names: NSC 153111. Grades: Highly Purified. CAS No. 35082-49-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C29H26O10. US Biological Life Sciences. | Worldwide |
| CID-755673 | CID-755673 is a selective protein kinase D (PKD) inhibitor. CID-755673 was identified from the National Institutes of Health small molecule repository library of 196,173 compounds. In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibited prostate cancer cell proliferation, cell migration, and invasion. In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential. Synonyms: CID-755673; CID 755673; CID755673. Grades: 0.98. CAS No. 521937-07-5. Molecular formula: C12H11NO3. Mole weight: 217.224. | |
| Curcumin Bis(3-methoxypropanoate) | Curcumin Bis(3-methoxypropanoate) is an intermediate in the synthesis of O,O,C4-Tris[3-N[-(5-methyl-1,3,4-thiadiazol-2-yl)-propionyl]curcumin Derivative of Curcumin (C838500), a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C29H32O10. US Biological Life Sciences. | Worldwide |
| Curcumin-d6 | Labeled Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; C Yellow 15-d6; C.I. 75300-d6; Curcuma-d6; Curcumine-d6; Diferuloylmethane-d6; Haidr-d6; Halad-d6; Haldar-d6; Ukon-d6. Grades: Highly Purified. CAS No. 1246833-26-0. Pack Sizes: 5mg. Molecular Formula: C21H14D6O6, Molecular Weight: 374.42. US Biological Life Sciences. | Worldwide |
| Cyclooxygenase 2 from Human, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. COX-2. Mole weight: 70 kDa. Activity: >8,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Human. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1238. | |
| Cyclooxygenase 2 from Ovine, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Purity: >80% estimated by SDS-PAGE. COX-2. Mole weight: ~70 kDa. Activity: >20,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Ovine. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1239. | |
| Di-(tert-Butyl-dimethylsilyl) Curcumin | Protected Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E, 4Z, 6E) -1, 7-Bis[4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1, 4, 6-heptatrien-3-one. Grades: Highly Purified. CAS No. 1134639-23-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Fmoc-erythro-Sphingosine ( (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol) | The N-Fmoc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Alternative Names: (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| KIN1400 | KIN1400 is an IRF3 activator with antiviral activity. It induces IRF3-dependent innate immune gene expression such as RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA). It also inhibits replication of HCV, West Nile virus, and Paramyxoviridae (RCV, NV). Synonyms: 7- ( (benzo[d]thiazol-2-ylamino) (4- (difluoromethoxy) phenyl) methyl) quinolin-8-ol. Grades: ≥98%. CAS No. 446826-86-4. Molecular formula: C24H17F2N3O2S. Mole weight: 449.5. | |
| KIN1408 | KIN1408 is an IRF3 activator with antiviral activity. It induces innate immune gene expression such as MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA). Synonyms: 7-[[4-(Difluoromethoxy)phenyl]-[(5-methoxy-1,3-benzothiazol-2-yl)amino]methyl]quinolin-8-ol. Grades: ≥98%. CAS No. 1903800-11-2. Molecular formula: C25H19F2N3O3S. Mole weight: 479.5. | |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. | |
| Multiflorenol | Multiflorenol is a triterpenoid found in the geranium family and other flowering plants. It inhibits histamine release induced by antigen-antibody reaction and inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate (TPA) in a concentration-dependent manner. Synonyms: 26-Norolean-7-en-3-ol, 13-methyl-, (3β,13α,14β)-; (3β)-D:C-Friedoolean-7-en-3-ol; (14β)-13α-methyl-26-norolean-7-en-3β-ol; 26-Norolean-7-en-3-ol, 13-methyl-, (3beta,13alpha,14beta)-; (3S,4aR,6aS,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,7,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-ol. Grades: ≥95% by HPLC. CAS No. 2270-62-4. Molecular formula: C30H50O. Mole weight: 426.72. | |
| Native Rat Protein Kinase C Catalytic Subunit | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and &theta. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Does not require ca2+ or phosphatidylserine for its activity. Group: Enzymes. Synonyms: PKC-M, PKM; PKCM; Protein Kinase C Catalytic Subunit. Purity: > 90% (SDS-PAGE). PKC. Activity: > 800 units/mg protein. Stability: -70°C. Source: rat brain. Species: Rat. PKC-M, PKM; PKCM; Protein Kinase C Catalytic Subunit. Pack: vial of 200 ng. Cat No: NATE-0578. | |
| N-Boc-erythro-sphingosine-13C2,D2 | Labelled N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Boc-erythro-sphingosine ((2S,3R,4E)-2-tert-Butyloxycarbonylamino-4-octadecen-1,3-diol) | The N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Alternative Names: (2S,3R,4E)-2-tert-Butyloxycarbonylamino-4-octadecen-1,3-diol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
| Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| O-tert-Butyl-dimethylsilyl Curcumin | Protected Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E, 4Z, 6E) -ethyl) dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1- (4-hydroxy-3-methoxyphenyl) -1, 4, 6-heptatrien-3-one. Grades: Highly Purified. CAS No. 911292-36-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| PDDHV | PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat vanilloid receptor VR1 (TRPV1). It evoked 45Ca2+-uptake by rat dorsal root ganglion neurons in culture. Synonyms: Phorbol 12,13-didecanoate 20-homovanillate. Grades: ≥99%. CAS No. 179469-40-0. Molecular formula: C49H72O11. Mole weight: 837.1. | |
| PMA | PMA, extracted from seeds of Euphorbia lathyris L, is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC), including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. Synonyms: Phorbol-12-Myristate-13-Acetate; 12-O-Tetradecanoylphorbol 13-acetate, 4β, 9α, 12β, 13α, 20-Pentahydroxytiglia-1, 6-dien-3-one 12-tetradecanoate; 12 Myristoyl 13 acetylphorbol; 12 O Tetradecanoyl Phorbol 13 Acetate; 12-Myristoyl-13-acetylphorbol; 12-O-Tetradecanoyl Phorbol 13-Acetate; 13-Acetate, 12-O-Tetradecanoyl Phorbol; Acetate, Phorbol Myristate; Acetate, Tetradecanoylphorbol; Myristate Acetate, Phorbol; Phorbol 13-Acetate, 12-O-Tetradecanoyl; Phorbol Myristate Acetate; Tetradecanoylphorbol Acetate; Tetradecanoylphorbol Acetate, 4a alpha Isomer; Tetradecanoylphorbol Acetate, 4a alpha-Isomer. Grades: ≥95%. CAS No. 16561-29-8. Molecular formula: C36H56O8. Mole weight: 616.83. | |
| PPAHV | PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM), and is agonist at rat VR1(TRPV1) (EC50 between 3 and 10 μM) but virtually inactive at human VR1(TRPV1) (EC50>10 μM). It displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Synonyms: [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9-[phenylacetyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester benzeneacetic acid; Phorbol 12-phenylacetate 13-acetate 20-homovanillate. Grades: ≥98% by HPLC. CAS No. 175796-50-6. Molecular formula: C39H44O11. Mole weight: 688.77. | |
| Prostratin | Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). It is an unusual non-tumorigenic phorbol ester and is found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). It has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells. It exhibits promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. It inhibits growth and induces differentiation of AML cell lines. It inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Uses: Prostratin has potential to be useful in the treatment of hiv. it exhibits promising therapeutic potential against other diseases such as cancer and alzheimer's disease. Synonyms: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one;13-O-Acetylphorbol;NSC 623310;(1aR)-1, 1aα, 1bβ, 4, 4a, 7aα, 7b, 8, 9, 9a-Decahydro-4a. Grades: 95%. CAS No. 60857-08-1. Molecular formula: C22H30O6. Mole weight: 390.47. | |
| protein kinase C | A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters. Group: Enzymes. Synonyms: calcium-dependent protein kinase C; calcium-independent protein kinase C; calcium/phospholipid dependent protein kinase; cPKCα; cPKCβ; cPKCγ; nPKCΔ; nPKCε; nPKC; nPKC; PKC; PKCα; PKCβ; PKCγ; PKCΔ; PKCε; PKCζ; Pkc1p; protein kinase Cε; STK24. Enzyme Commission Number: EC 2.7.11.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3132; protein kinase C; EC 2.7.11.13; calcium-dependent protein kinase C; calcium-independent protein kinase C; calcium/phospholipid dependent protein kinase; cPKCα; cPKCβ; cPKCγ; nPKCΔ; nPKCε; nPKC; nPKC; PKC; PKCα; PKCβ; PKCγ; PKCΔ; PKCε; PKCζ; Pkc1p; protein kinase Cε; STK24. Cat No: EXWM-3132. | |
| Protein kinase Cα isozyme human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second...third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. > 70% (sds-page), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution. Group: Enzymes. Synonyms: PRKCA; protein kinase C, alpha; PKCA; protein kinase C alpha type; PKC-A; PKCα; AAG6; PKC-alpha; PRKACA. Purity: > 70% (SDS-PAGE). PKC. Mole weight: mol wt 80-81 kDa by SDS-PAGE. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. PRKCA; protein kinase C, alpha; PKCA; protein kinase C alpha type; PKC-A; PKCα; AAG6; PKC-alpha; PRKACA. Cat No: NATE-0574. | |
| Protein Kinase CβII isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec... esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: calculated mol wt 76.9 kDa; mol wt 80 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Cat No: NATE-0622. | |
| Protein Kinase CβI isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec...ted by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: > 95% (SDS-PAGE). PKC. Mole weight: apparent mol wt 79-80 kDa. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Cat No: NATE-0621. | |
| Protein Kinase Cδ isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec...DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCD; protein kinase C, delta; protein kinase C delta type; ALPS3; CVID9; MAY1; PKCD; nPKC-delta; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: mol wt 74-79 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCD; protein kinase C, delta; protein kinase C delta type; ALPS3; CVID9; MAY1; PKCD; nPKC-delta; EC 2.7.1.37. Cat No: NATE-0623. | |
| Protein Kinase Cε isozyme human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the secon...tein kinase C, epsilon; protein kinase C epsilon type; PKCE; nPKC-epsilon; Ca2+-activated phospholipid-dependent serine-threonine kinase, ε isozyme human; PKCε human; PKCε; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: apparent mol wt 89-96 kDa. Storage: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. PRKCE; protein kinase C, epsilon; protein kinase C epsilon type; PKCE; nPKC-epsilon; Ca2+-activated phospholipid-dependent serine-threonine kinase, ε isozyme human; PKCε human; PKCε; EC 2.7.1.37. Cat No: NATE-0575. | |
| Protein Kinase Cη isozyme human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second ...nd include PKCξ, μ, and &Iota. > 90% (sds-page), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution. Group: Enzymes. Synonyms: PRKCH; Ca2+-activated phospholipid-dependent serine-threonine kinase η isozyme human; PKCη human; PKCH; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: > 90% (SDS-PAGE). PKC. Mole weight: mol wt 82-84 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. PRKCH; Ca2+-activated phospholipid-dependent serine-threonine kinase η isozyme human; PKCη human; PKCH; EC 2.7.1.37. Cat No: NATE-0576. | |
| Protein kinase Cγ isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec...vated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCG; protein kinase C, gamma; protein kinase C gamma type; PKC-gamma; PKCC; PKCG; SCA14; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: mol wt 77-84 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 250 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCG; protein kinase C, gamma; protein kinase C gamma type; PKC-gamma; PKCC; PKCG; SCA14; EC 2.7.1.37. Cat No: NATE-0624. | |
| Protein Kinase CΙ, Active human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second...activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Recombinant, expressed in e. coli, > 85% (sds-page), buffered aqueous glycerol solution. Applications: Kinase activity is measured as the molar amount of phosphate incorporated into the crebtide substrate peptide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: PKCL; Protein Kinase C Lambda/Iota; PKC&Iota. Purity: > 85% (SDS-PAGE). PKC. Mole weight: apparent mol wt ~98 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. PKCL; Protein Kinase C Lambda/Iota; PKC&Iota. Cat No: NATE-0577. | |
| Protein Kinase Cζ isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the seco...Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCZ; protein kinase C, zeta; protein kinase C zeta type; PKC2; PKC-ZETA; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: > 75% (SDS-PAGE). PKC. Mole weight: mol wt 76-80 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous solution; Solution in 20 mM HEPES, pH 7.5; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 250 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCZ; protein kinase C, zeta; protein kinase C zeta type; PKC2; PKC-ZETA; EC 2.7.1.37. Cat No: NATE-0625. | |
| RO31-8220 | Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate or diacylglycerols by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells. Uses: Enzyme inhibitors. Synonyms: RO31-8220; RO 31-8220; RO-31-8220; RO318220. Grades: 0.98. CAS No. 125314-64-9. Molecular formula: C25H23N5O2S. Mole weight: 457.552. | |
| Safingol | Safingol is a lyso-sphingolipid protein kinase C (PKC) inhibitor. It binds to and inhibits the regulatory phorbol-binding domain of PKC. It has the potential for the treatment of solid tumors. Synonyms: L-threo-Dihydrosphingosine; L-threo-Sphinganine; L-threo-2-Amino-1,3-octadecanediol; (2S,3S)-2-aminooctadecane-1,3-diol. Grades: ≥98%. CAS No. 15639-50-6. Molecular formula: C18H39NO2. Mole weight: 301.51. | |
| sn-1,2-Dioctanoylglycerol (DOG) | Cell permeable lipid shown to mimic the effect of tumor-promoting phorbol diesters on mitogenesis and EGF binding and action in intact cells. Group: Biochemicals. Alternative Names: DOG. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Sphingosine (D-erythro-Sphingosine) | Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine. Group: Biochemicals. Alternative Names: (2S,3R,4E)-2-Aminooctadec-4-ene-1,3-diol; trans-D-erythro-2-Amino-4-octadecene-1,3-diol; 4-Sphingenine; D-erythro-Sphingosine. Grades: Highly Purified. CAS No. 123-78-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??NO?, Molecular Weight: 299.49. US Biological Life Sciences. | Worldwide |
| ST638 | ST638 is a tyrosine kinase inhibitor and PLD inhibitor. It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts. Uses: Enzyme inhibitors. Synonyms: (Z)-2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide. Grades: ≥98%. CAS No. 107761-24-0. Molecular formula: C19H18N2O3S. Mole weight: 354.4. | |
| TAPI-2 | TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE; ADAM17), other ADAMs and matrix metalloproteinases (MMPs). It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit. Synonyms: TNF Protease Inhibitor 2; N-[(2S)-1-[[(2S)-1-(2-Aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide. Grades: ≥95%. CAS No. 187034-31-7. Molecular formula: C19H37N5O5. Mole weight: 415.5. | |
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