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| Product | Description | |
|---|---|---|
| phosphatidylinositol 3-kinase | One mammalian isoform is known. Group: Enzymes. Synonyms: 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase. Enzyme Commission Number: EC 2.7.1.137. CAS No. 115926-52-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2968; phosphatidylinositol 3-kinase; EC 2.7.1.137; 115926-52-8; 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase. Cat No: EXWM-2968. |  |
| phosphatidylinositol-4,5-bisphosphate 3-kinase | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. Group: Enzymes. Synonyms: type I phosphoinositide 3-kinase. Enzyme Commission Number: EC 2.7.1.153. CAS No. 103843-30-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2983; phosphatidylinositol-4,5-bisphosphate 3-kinase; EC 2.7.1.153; 103843-30-7; type I phosphoinositide 3-kinase. Cat No: EXWM-2983. | |
| phosphatidylinositol-4-phosphate 3-kinase | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. Group: Enzymes. Synonyms: type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase. Enzyme Commission Number: EC 2.7.1.154. CAS No. 141176-94-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2984; phosphatidylinositol-4-phosphate 3-kinase; EC 2.7.1.154; 141176-94-5; type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase. Cat No: EXWM-2984. | |
| 20(R)-Ginsenoside Rg3-d6 | 20(R)-Ginsenoside Rg3-d6 is the labelled version of 20(R)-Ginsenoside Rg3, which causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated, relating to in vivo inhibition of tumor angiogenesis of lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C42H66D6O13, Molecular Weight: 791.05. US Biological Life Sciences. |  Worldwide |
| 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile | 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile is used as a reagent in the preparation of imidazo quinoline derivatives, compounds that act as mammalian target of rapamycin (mTOR) an phosphatidylinositol 3-kinase (PI3K-kinase) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 915019-52-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H17BrN4. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-methylimidazole | 2-Amino-4-methylimidazole is used as a reagent in the synthesis of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel allosteric mGluR5 antagonists. Also used as a reagent in the synthesis of imidazo[1,2-a]pyrimidin-5(1H)-ones as beta isoform selective phosphatidylinositol 3-kinase (PI3K) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6653-42-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C4H7N3, Molecular Weight: 97.12. US Biological Life Sciences. | Worldwide |
| 2-Amino-6-bromo-3-fluoro-benzoic Acid | 2-Amino-6-bromo-3-fluoro-benzoic Acid is an intermediate used to prepare 2, 4-diaminopyrimidinyl aminoethyl quinazolin-4 (3H) -one derivatives as phosphatidylinositol 3-kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1153974-98-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H5BrFNO2, Molecular Weight: 234.02. US Biological Life Sciences. | Worldwide |
| 2-?Amino-?6-?methylpyridine | 2-?Amino-?6-?methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Kα). Group: Biochemicals. Grades: Highly Purified. CAS No. 1824-81-3. Pack Sizes: 5g, 25g. Molecular Formula: C6H8N2, Molecular Weight: 108.14. US Biological Life Sciences. | Worldwide |
| Alpelisib | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. |  |
| Amdizalisib | Amdizalisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, an immunomodulator and an antineoplastic. Synonyms: (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grade: 99% by HPLC. CAS No. 1894229-05-0. Molecular formula: C19H15ClN8. Mole weight: 390.83. | |
| AS-041164 | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a highly potent and selective PI3Kγ inhibitor that inhibits PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ with IC50 values of 240 nM, 1.45 μM, 70 nM and 1.70 μM, respectively. It also blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models. Synonyms: 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione. Grade: ≥98%. CAS No. 6318-41-8. Molecular formula: C11H7NO4S. Mole weight: 249.2. | |
| AS-605240 potassium salt | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grade: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
| BGT226 | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BGT-226; BGT 226; BGT-226 free base; BGT226 free base; NVP-BGT226; 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-2H-imidazo[4,5-c]quinolin-2-one. Grade: 98%. CAS No. 915020-55-2. Molecular formula: C32H29F3N6O6. Mole weight: 534.54. | |
| Bilobalide | Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 33570-04-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C15H18O8. US Biological Life Sciences. | Worldwide |
| Biotin Phosphatidylinositol 3,4-bisphosphate | Biotin Phosphatidylinositol 3,4-bisphosphate is a water-soluble analog of PI(3,4)P2 labelled with biotin at the sn-1 position. PI(3,4)P2 is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. Synonyms: Biotin PI(3,4)P2. Grade: >95%. Molecular formula: C37H62N4Na5O22P3S. Mole weight: 1153.84. | |
| Biotin Phosphatidylinositol 4,5-bisphosphate | Biotin Phosphatidylinositol 4,5-bisphosphate is a water-soluble analog of PI(4,5)P2 labelled with biotin at the sn-1 position. PI(4,5)P2 has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. Synonyms: Biotin PI(4,5)P2. Grade: >95%. Molecular formula: C37H62N4Na5O22P3S. Mole weight: 1154.84. | |
| Biotin PI(3,4,5)P3 | Biotin PI(3,4,5)P3 is a water-soluble analog of PI(3,4,5)P2 (PIP3) labelled with biotin at the sn-1 position. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 through phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Synonyms: Biotin Phosphatidylinositol 3,4,5-trisphosphate. Grade: >95%. Molecular formula: C37H61N4Na7O25P4S. Mole weight: 1278.78. | |
| CAY10505 | CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor, was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505, may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction. Synonyms: CAY10505; CAY 10505; CAY-10505. Grade: 0.98. CAS No. 1218777-13-9. Molecular formula: C14H8FNO3S. Mole weight: 289.28. | |
| CAY10626 | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grade: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
| Dactolisib | Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; NVP-BEZ235; NVP-BEZ-235; NVP-BEZ 235; Dactolisib. Grade: 0.98. CAS No. 915019-65-7. Molecular formula: C30H23N5O. Mole weight: 469.548. | |
| Demethoxyviridiol | It is a mycotoxin produced by the strain of Nodulisporium hinnuleum. It is a fungal metabolite belonging to the wortmannin and viridin classes and an inhibitor of phosphatidylinositol 3-kinase. It affects phospholipid signalling and proliferation of swiss 3T3 cells. Synonyms: Desmethoxyviridiol; Cyclopenta(7,8)phenanthro(10,1-bc)furan-6,9-dione, 1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methyl-, (1R-(1-alpha,3-alpha,11b-alpha))-; (1R,3S,11bR)-1,2,3,7,8,11b-Hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione; [1R-(1α,3α,11bα)]-1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione. Grade: >95% by HPLC. CAS No. 56617-66-4. Molecular formula: C19H16O5. Mole weight: 324.33. | |
| D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium salt | The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents. Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Grade: ≥98%. Molecular formula: C6H12O21P5·5Na. Mole weight: 689.96. | |
| DNA-PK Inhibitor IV | DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK). It also inhibits the phosphatidylinositol 3-kinase (PI3K) isoforms p110β, p110δ, and p110γ but not p110α or class II PI3Ks, PI4Kβ, ATM, ATR, mTOR, CK2, or GRK2. Synonyms: 2-hydroxy-4-(4-morpholinyl)-benzaldehyde. Grade: ≥98%. CAS No. 70362-07-1. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
| GDC-0879 | GDC-0879, a highly selective, potent, and orally bioavailable RAF small-molecule inhibitor. In GDC-0879-treated mice, both cell line- and patient-derived BRAF(V600E) tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors. Despite the involvement of activated RAF signaling in RAS-induced tumorigenesis, decreased time to progression was observed for some KRAS-mutant tumors following GDC-0879 administration. Moreover, striking differences were noted for RAF and MEK inhibition across a panel of 130 tumor cell lines. Whereas GDC-0879-mediated efficacy was associated strictly with BRAF(V600E) status, MEK inhibition also attenuated proliferation and tumor growth of cell lines expressing wild-type BRAF (81% KRAS mutant, 38% KRAS wild type). The responsiveness of BRAF(V600E) melanoma cells to GDC-0879 could be dramatically altered by pharmacologic and genetic modulation of phosphatidylinositol 3-kinase pathway activity. These data suggest that GDC-0879-induced signaling changes are dependent on the point of oncogenic activation within the RAS network. Taken together, these studies increase our understanding of the molecular determinants for antitumor efficacy resulting from RAF pathway inhibition and have implications for therapeutic intervention in the clinic. Synonyms: GDC0879; GDC-0879; GDC 0879. CAS No. 905281-76-7. Molecular formula | |
| GDC-0941 Bimesylate | Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K). Group: Biochemicals. Alternative Names: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine Methanesulfonate. Grades: Highly Purified. CAS No. 957054-33-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GDC-0941, Free Base, PI3K Inhibitor | GDC-0941 is a potent inhibitor of p110a and p110d (IC?? = 3nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer." J. Med. Chem. 51: 5522-5532 (2008).GDC-0941 inhibited the growth of >70% ...I., et al. "Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941." Mol. Cancer Ther. 8: 1725-1738 (2009). Group: Biochemicals. Alternative Names: 2- (1H-indazol-4-yl) -6- ( (4- (methylsulfonyl) piperazin-1-yl) methyl) -4-morpholinothieno[3, 2-d]pyrimidine; 4-[2- (1H-Indazol-4-yl) -6-[[4- (methylsulfonyl) piperazin-1-yl]methyl]thieno[3, 2-d]pyrimidin-4-yl]morpholine; GDC 0941; GDC 941; GNE 0941; Pictilisib; Pictrelisib. Grades: Highly Purified. CAS No. 957054-30-7. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 513.64. US Biological Life Sciences. | Worldwide |
| GloPIPs Biotin-PI(3,4,5)P3 | GloPIPs Biotin-PI(3,4,5)P3 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. Phosphatidylinositol 3,4,5-trisphosphate, formed from PI(4,5)P2 through phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. Grade: >95%. Molecular formula: C31H51N4Na7O23P4S. Mole weight: 1164.64. | |
| GloPIPs Biotin-PI(3,4)P2 | GloPIPs Biotin-PI(3,4)P2 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. PI(3,4)P2 is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. Grade: >95%. Molecular formula: C31H52N4Na5O20P3S. Mole weight: 1040.69. | |
| InSolution Wortmannin | Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase). Group: Fluorescence/luminescence spectroscopy. |  |
| Luteolin (3',4',5,7-Tetrahydroxyflavone, Luteolol, BRN 0292084, C.I. Natural Yellow 2, Digitoflavone, Flacitran, Flavopurpol, Daphneflavonol, Argemexitin) | Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-y. inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 (PDE1-5). PKC(e) and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator. Phosphatidylinositol 3-kinase (PI3K) / Akt signaling inhibitor. p90 ribosomal S6 kinase (RSK1/RSK2) kinase activity inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-70-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H10O6. US Biological Life Sciences. | Worldwide |
| NVP-BEZ 235 | Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Group: Biochemicals. Alternative Names: 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile; 2-Methyl-2- [4- [3-methyl-2-oxo-8- (quinolin-3-yl) -2, 3-dihydroimidazo [4, 5-c] quinolin-1-yl] phenyl] propionitrile; BEZ 235. Grades: Highly Purified. CAS No. 915019-65-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4). The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. Group: Enzymes. Synonyms: SHIP1; SHIP2; SHIP; p150Ship. Enzyme Commission Number: EC 3.1.3.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3692; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; EC 3.1.3.86; SHIP1; SHIP2; SHIP; p150Ship. Cat No: EXWM-3692. | |
| PI-103 | PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PI103; PI-103; PI 103. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 371935-74-9. Molecular formula: C19H17ClN4O3. Mole weight: 384.82. Purity: >98%. IUPACName: 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol. Canonical SMILES: OC1=CC=CC(C2=NC(N3CCOCC3)=C(OC4=NC=CC=C45)C5=N2)=C1. Product ID: ACM371935749. Alfa Chemistry ISO 9001:2015 Certified. Categories: PS-100 Karachi East-IV. |  |
| PI-103 (3-(4-(4-Morpholinyl)pyrido[3, 2:4, 5]furo[3, 2-d]pyrimidin-2-yl)phenol) | A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2 β, p110δ, mTORC2, p110 β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo. Group: Biochemicals. Alternative Names: 3-(4-(4-Morpholinyl)pyrido[3, 2:4, 5]furo[3, 2-d]pyrimidin-2-yl)phenol. Grades: Highly Purified. CAS No. 371935-74-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Sonolisib | Sonolisib, also known as PX-866, is a small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor PX-866 inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Uses: Potential anti-cancer agent. Synonyms: PX-866; PX866; PX 866. Grade: >98%. CAS No. 502632-66-8. Molecular formula: C29H35NO8. Mole weight: 525.59. | |
| Viridiol | Steroidal antibiotic. Belongs to the Viridin family, including Wortmannin. Antifungal. Phytotoxin. Shows necrotic activity on plants. Phosphatidylinositol 3-kinase (PI3K) inhibitor. Group: Biochemicals. Alternative Names: NSC 658706, 3beta-Alcohol-Viridin. Grades: Highly Purified. CAS No. 23820-80-6. Pack Sizes: 250ug, 1mg. Molecular Formula: C20H18O6. US Biological Life Sciences. | Worldwide |
| Wortmannin | Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19545-26-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C23H24O8. US Biological Life Sciences. | Worldwide |
| Zandelisib | Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC 50 of 3.5 nM. Zandelisib functions as an antineoplastic [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ME-401; PWT-143. CAS No. 1401436-95-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109198. |  |
| Apitolisib | Apitolisib, also known as GDC-0980 and RG7422; or GNE390, is a dual PI3 kinase/mTOR inhibitor, is also an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor GDC-0980 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion. Synonyms: GDC-0980; GDC0980; GDC 0980; RG7422; RG-7422; RG 7422; GNE 390; GNE390; GNE-390; Apitolisib. CAS No. 1032754-93-0. Molecular formula: C23H30N8O3S. Mole weight: 498.606. | |
| GSK-2269557 HCl salt | GSK-2269557 is a selective Phosphatidylinositol 3 kinase delta inhibitor originated by GlaxoSmithKline. GSK-2269557 is highly selective for PI3Kδ over the closely related isoforms and is active in a animal model of Th2-driven lung inflammation. Treatment for Asthma and Chronic obstructive pulmonary disease(COPD) is in clinical trials Phase II. Uses: Asthma; chronic obstructive pulmonary disease. Synonyms: GSK-2269557 HCl salt; GSK 2269557 HCl salt; GSK2269557 HCl salt; 6-(1H-indol-4-yl)?-4-[5-[[4-(1-methylethyl)?-1-piperazinyl]?methyl]?-2-oxazolyl]?-1H-indazole, monohydrochloride; 1254036-71-9(free base). Grade: 98%. CAS No. 1254036-77-5. Molecular formula: C26H28N6O; HCl. Mole weight: 477.01. | |
| GSK2292767 | GSK2292767 is a Phosphatidylinositol 3 kinase delta inhibitor applicated for the treatment of respiratory diseases including asthma and COPD in clinical trials. GSK2292767 is highly selective for PI3Kδ over the closely related isoforms and is really active in the animal model of Th2-driven lung inflammation. Uses: Asthma and copd. Synonyms: GSK2292767; GSK-2292767; GSK 2292767. N-[5-[4-[5-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]-1,3-oxazol-2-yl]-1H-indazol-6-yl]-2-methoxypyridin-3-yl]methanesulfonamide; SCHEMBL173490; ZINC95938263; KB-78330; 1254036-66-2; Methanesulfonamide,N-[5-[4-[5-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-methoxy-3-pyridinyl]. Grade: 98%. CAS No. 1254036-66-2. Molecular formula: C24H28N6O5S. Mole weight: 512.58. | |
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