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| Product | Description | |
|---|---|---|
| phospholipase D | Also acts on other phosphatidyl esters. Group: Enzymes. Synonyms: lipophosphodiesterase II; lecithinase D; choline phosphatase. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3723; phospholipase D; EC 3.1.4.4; 9001-87-0; lipophosphodiesterase II; lecithinase D; choline phosphatase. Cat No: EXWM-3723. |  |
| Phospholipase D, Streptomyces chromofuscus | Phospholipase D, Streptomyces chromofuscus (PLD) is an enzyme of the phospholipase superfamily, which widely exists in bacteria, yeast, plants, animals and viruses, and is often used in biochemical research. Phospholipase D can catalyze the hydrolysis of phosphodiester bonds in glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D is involved in a variety of disease-related processes, including diabetes, atherogenesis, obesity, tumorigenesis, immune response, and neuroendocrine function [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLD. CAS No. 9001-87-0. Pack Sizes: 1 KU; 5 KU. Product ID: HY-P2812. |  |
| glycosylphosphatidylinositol phospholipase D | This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes. Group: Enzymes. Synonyms: GPI-PLD; glycoprotein phospholipase D; phosphatidylinositol phospholipase D; phosphatidylinositol-specific phospholipase D. Enzyme Commission Number: EC 3.1.4.50. CAS No. 113756-14-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3733; glycosylphosphatidylinositol phospholipase D; EC 3.1.4.50; 113756-14-2; GPI-PLD; glycoprotein phospholipase D; phosphatidylinositol phospholipase D; phosphatidylinositol-specific phospholipase D. Cat No: EXWM-3733. | |
| N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | This enzyme is involved in the biosynthesis of anandamide. It does not hydrolyse phosphatidylcholine and phosphatidylethanolamine. No transphosphatidation. The enzyme contains Zn2+ and is activated by Mg2+ or Ca2+. Group: Enzymes. Synonyms: NAPE-PLD; anandamide-generating phospholipase D; N-acyl phosphatidylethanolamine phospholipase D; NAPE-hydrolyzing phospholipase D. Enzyme Commission Number: EC 3.1.4.54. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3737; N-acetylphosphatidylethanolamine-hydrolysing phospholipase D; EC 3.1.4.54; NAPE-PLD; anandamide-generating phospholipase D; N-acyl phosphatidylethanolamine phospholipase D; NAPE-hydrolyzing phospholipase D. Cat No: EXWM-3737. | |
| Native Arachis hypogaea (peanut) Phospholipase D | Phospholipase D is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Phospholipase D is involved in conferring drought susceptibility in peanuts, which increases the risk of aflatoxin contamination. Phospholipase d is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Applications: Research has shown adp-ribosylation factor regulation of phospholipase d is important in the release of nascent secretory vesicles from the trans-golgi network. it has also been used in a study to investigate stimulation of na+-ca2+ exchange activity in canine cardiac sarcolemmal vesicals. Group: Enzymes. Synonyms: Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 60 units/mg protein. Storage: -20°C. Form: Partially purified, lyophilized powder containing buffer salts. Source: Arachis hypogaea (peanut). Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Cat No: NATE-0594. | |
| Native Cabbage Phospholipase D | Phospholipase D is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Phospholipase D is involved in conferring drought susceptibility in peanuts, which increases the risk of aflatoxin contamination. Applications: Phospholipase d (pld) is used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld is used in purification and kinetic studies. the enzyme has been used for the preparation of bodipy-phosphatidylcholine during the preparation of fluorescently labelled lipids. Group: Enzymes. Synonyms: Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 100 units/mg solid. Storage: -20°C. Form: lyophilized powder. Source: Cabbage. Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Cat No: NATE-0595. | |
| Native Clostridium perfringens (C. welchII) Phospholipase C | Phospholipase C is induced by thrombin and platelet-activating factor, forming 1,2-diacylglycerol and phosphatidic acid. PLC hydrolyzes the phosphate bond on phosphatidylcholine and other glycerophospholipids yielding diacylglycerol; this enzyme will also hydrolyze the phosphate bonds of sphingomyelin, cardiolipin, choline plasmalogen and ceramide phospholipids. Group: Enzymes. Synonyms: Phospholipase C; PLC; 9001-86-9; lipophosphodiesterase I; lecithinase C; Clostridium welchii α-toxin; Clostridium oede. Enzyme Commission Number: EC 3.1.4.3. CAS No. 9001-86-9. Phospholipase C. Activity: Type I, > 150 units/mg protein; Type II, 10-50 units/mg protein; Type III, Type IV, > 1,000 units/mg protein (Lowry). Storage: -20°C. Form: Type I, Lyophilized powder in buffered salts; Type II, lyophilized powder; Type III, buffered aqueous glycerol solution; Solution in 60% (v/v) glycerol containing 10 mM Tris-HCl, pH 8.0 and 10 mM EDTA; Type IV, lyophilized powder, Contains phosphate buffer salts, EDTA and stabilizer. Source: Clostridium perfringens (C. welchII). Phospholipase C; PLC; 9001-86-9; lipophosphodiesterase I; lecithinase C; Clostridium welchii α-toxin; Clostridium oedematiens β-and γ-toxins; lipophosphodiesterase C; phosphatidase C; heat-labile hemolysin; α-toxin; EC 3.1.4.3. Cat No: NATE-0593. | |
| Native Crotalus durissus terrificus venom Phospholipase A2 | Phospholipase A2 (PLA2) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. It aggressively attacks phospholipids in membranes of intact cells. PLA2 specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Group: Enzymes. Synonyms: Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-84-7. PLA2. Activity: ~200 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing Tris buffer salts. Source: Crotalus durissus terrificus venom. Phospholipases A2; EC 3.1.1.4; 9001-84-7; lecithinase A; phosphatidase; phosphatidolipase; phospholipase A; PLA2; Phosphatidylcholine 2-acylhydrolase; PLA2s. Cat No: NATE-0584. | |
| Native Streptomyces chromofuscus Phospholipase D | Phospholipase D is a phospholipid hydrolyzing enzyme and an important component of receptor-mediated signal transduction responses and regulated secretion. Hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Phospholipase D is involved in conferring drought susceptibility in peanuts, which increases the risk of aflatoxin contamination. Group: Enzymes. Synonyms: Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Mole weight: mol wt ~60 kDa. Activity: Type I, > 50,000 units/mL; Type II, > 150 units/mg solid. Storage: -20°C. Form: Type I, buffered aqueous glycerol solution; Solution in 100 mM Tris/HCl, pH 8.0, 10% glycerol (v/v), and 0.1% Triton X-100 (w/v); Type II, lyophilized powder. Source: Streptomyces chromofuscus. Phospholipase D; EC 3.1.4.4; lipophosphodiesterase II; lecithinase D; choline phosphatase; PLD; 9001-87-0. Cat No: NATE-0596. | |
| Native Streptomyces sp. Phospholipase D | Phospholipase D (PLD) is glycerophospholipid-specific. It is markedly less active on sphingomyelins and lysophospholipids. Phospholipase D hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Applications: Phospholipase d (pld) has been used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to yield the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld has been used in purification and kinetic studies. the enzyme has been used in the translocation of sphingosine kinase 1 (sk1) to membrane fractions under in vitro conditions. it has also been used to produce phosphatidic acid (pa) from phosphatidylcholine (pc) in hl60 permeabilized cells. Group: Enzymes. Synonyms: phospholipase D; lipophosphodiesterase II; lecithinase D;. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 150 units/mg solid. Storage: -20°C. Form: Type VII, lyophilized powder. Source: Streptomyces sp. phospholipase D; lipophosphodiesterase II; lecithinase D; choline phosphatase; phosphatidylcholine phosphatidohydrolase; EC 3.1.4.4; 9001-87-0; PLD. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0597. | |
| phosphoinositide phospholipase C | These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four Δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found. Group: Enzymes. Synonyms: triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Enzyme Commission Number: EC 3.1.4.11. CAS No. 63551-76-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3711; phosphoinositide phospholipase C; EC 3.1.4.11; 63551-76-8; triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Cat No: EXWM-3711. | |
| sPLA2-IIA Inhibitor II, KH064 ( (S) -5- (4- (benzyloxy) phenyl) -4- (7-phenylheptanamido) pentanoic Acid, Phospholipase A2 Group IIA Inhibitor II, PLA2g2a Inhibitor II) | A reversible, potent, and selective sPLA2-IIA/PLA2g2a (phospholipase A2 group IIA) inhibitor (IC50 = 29nM) that displays much reduced potency against sPLA2-V/PLA2g5 (PLA2 group V; IC50 = 2uM) and is reported not to affect the activity of cytosolic cPLA2, Ca2+-independent iPLA2, 30 human GPCRs, and 25 other enzymes. In addition to being useful in studying PLA2g2a-mediated cellular responses in cultures in vitro (100% inhibition of LPS-induced PGE2 production in HMC-1 cells; 15 min 10uM pretreatment), KH064 is orally available in rats and efficacious in various rat disease models in vivo (5mg/kg p.o.), including adjuvant-induced arthritis, spontaneous hypertension, high fat diet-induced metabolic disorders. Comparing to the substrate-competitive inhibitor c(2NapA)LS(2NapA)R, KH064 also effectively chelates sPLA2-IIA active site Ca2+ in addition to targeting the enzyme's N-terminal lipid substrate binding site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 1, 12-Dodecanediylbis (tributylphosphonium) Dibromide | An antigungal agent that is a potent inhibitor of phospholipases from the fungal pathogen Cryptococcus neoformans. Group: Biochemicals. Grades: Highly Purified. CAS No. 99372-74-4. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl lysophosphatidic acid | 1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase. Synonyms: 1-Oleoyl-sn-glycerol 3-phosphate; Oleoyl LPA; 18:1 LPA; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate; LysoPA(18:1). Grades: ≥95%. CAS No. 65528-98-5. Molecular formula: C21H41O7P. Mole weight: 436.50. |  |
| 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol Sodium Salt | Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues generated by substitution of ethanol for the lipid headgroup by the phospholipase D enzyme. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is theoretically 100%. Group: Biochemicals. Grades: Highly Purified. CAS No. 322647-55-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C39H74NaO8P, Molecular Weight: 724.96. US Biological Life Sciences. | Worldwide |
| 2,2,2-Trifluoroethanol-1,1-d2 | Isotope labelled 2,2,2-Trifluoroethanol (T790175), is used in the synthesis of competitive inhibitors for phospholipase A2. Used in the preparation of a key Efavirenz (E425000) intermediate, a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 132248-58-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C2HD2F3O, Molecular Weight: 102.05. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1,3,2-dioxaphospholane-2-oxide | 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α -naphthyl phosphoryl choline as a method to detect phospholipase C activity. Group: Biochemicals. Alternative Names: Ethylene phosphorochloridate; Phosphorochloridic Acid, Cyclic Ethylene Ester; 2-Chloro-2-oxido-1,3,2-dioxaphospholane; 2-Chloro-2-oxo-1,3,2-dioxaphospholane; Cyclic ethylene phosphorochloridate; Ethylene Chlorophosphate. Grades: Highly Purified. CAS No. 6609-64-9. Pack Sizes: 5g, 25g. Molecular Formula: C?H?ClO?P, Molecular Weight: 142.48. US Biological Life Sciences. | Worldwide |
| 2-Nitro-4-carboxyphenyl N,N-Diphenylcarbamate | 2-Nitro-4-carboxyphenyl N,N-Diphenylcarbamate is an inhibitor of Phospholipase C. Also functions in the inhibition of blood coagulation factors II, VII, IX, and X, serine esterase inhibition, and plant-growth regulator. Group: Biochemicals. Grades: Highly Purified. CAS No. 10556-88-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C20H14N2O6, Molecular Weight: 378.33. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4-phenyl-2-butanone | 3-Bromo-4-phenyl-2-butanone is used as a reagent in the synthesis of indolizine and indene derivatives which are potent inhibitors of secretory phospholipase A2 (sPLA2). Group: Biochemicals. Grades: Highly Purified. CAS No. 55985-68-7. Pack Sizes: 1g, 10g. Molecular Formula: C10H11BrO, Molecular Weight: 227.1. US Biological Life Sciences. | Worldwide |
| 4-Aminophenyl a-D-mannopyranoside 6-phosphate | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Synonyms: 4-Aminophenyl 6-phospho-alpha-mannopyranoside; 4-Aminophenyl 6-phospho-alpha-D-mannopyranoside. CAS No. 74160-60-4. Molecular formula: C12H18NO9P. Mole weight: 351.25. | |
| 4-Methylumbelliferyl phosphocholine | 4-Methylumbelliferyl phosphocholine, a highly sought-after fluorescent substrate within the biomedical industry, boasts immense significance in elucidating the intricacies surrounding phosphocholine-hydrolyzing enzymes. Touted for its efficacy in ascertaining the activity of microbial phospholipases, pivotal actors in the realm of bacterial and fungal pathogenesis, this substrate undeniably opens Pandora's box of insights into the multifaceted mechanics governing diverse infectious diseases. CAS No. 97055-84-0. Molecular formula: C15H20NO6P. Mole weight: 341.30. | |
| 5-Methoxy-2-methylindoline | Used in the preparation of indole-3-acetamides, inhibitors of phospholipase A2. Group: Biochemicals. Alternative Names: 2-Methyl-5-methoxyindoline; 2,3-Dihydro-5-methoxy-2-methyl-1H-indole. Grades: Highly Purified. CAS No. 41568-27-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 740 Y-P | 740 Y-P is a cell-permeable phosphopeptide activator of PI3K. It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. And it displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro. Synonyms: PDGFR 740Y-P; H-Arg-Gln-aIle-Lys-aIle-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-Tyr(PO3H2)-Met-Asp-Met-Ser-OH. Grades: 98.38 %. CAS No. 1236188-16-1. Molecular formula: C141H222N43O39PS3. Mole weight: 3270.70. | |
| AACOCF3 | AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl trifluoromethyl ketone. CAS No. 149301-79-1. Pack Sizes: 5 mg (28.05 mM * 500 μL in Ethanol); 10 mg (28.05 mM * 1 mL in Ethanol). Product ID: HY-108611. | |
| acyloxyacyl hydrolase | The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms. It consists of diglucosamine, β-D-GlcN-(1? 6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue. Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3. The enzyme from human leucocytes detoxifies the lipid by hydrolysing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS). It also possesses a wide range of phospholipase and acyltransferase activities [e.g. EC 3.1.1.4 (phospholipase A2), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.32 (phospholipase A1) and EC 3.1.1.52 (phosphatidylinositol deacylase)], hydrolysing diacylglycerol and phosphatidyl compounds, but not triacylglycerols. It has a preference for saturated C12-C16 acyl groups. Group: Enzymes. Enzyme Commission Number: EC 3.1.1.77. CAS No. 110277-64-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3505; acyloxyacyl hydrolase; EC 3.1.1.77; 110277-64-0. Cat No: EXWM-3505. | |
| AG 879 - CAS 148741-30-4 | A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC?? = 10 μM) as well as NGF-induced phospholipase C-?1 phosphorylation. Group: Fluorescence/luminescence spectroscopy. |  |
| Alexidine dihydrochloride | Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus. Synonyms: 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2); 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride; Biguanide, 1,1'-hexamethylenebis[5-(2-ethylhexyl)-, dihydrochloride; 1,6-Bis(2-ethylhexylbiguanido)hexane dihydrochloride; Alexidine hydrochloride; Hexamethylenebis(2-ethylhexyl)biguanide dihydrochloride. Grades: >98%. CAS No. 1715-30-6. Molecular formula: C26H58N10Cl2. Mole weight: 581.71. | |
| Aristolochic acid C | Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A 2 ( PLA2 ) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis [1]. Uses: Scientific research. Group: Natural products. CAS No. 4849-90-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1450. | |
| ARN19874 | ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 μM. ARN19874 is the first selective, cell-active inhibitor of NAPE-PLD. It is significantly less potent on the Q320A mutant, and it can cause a substantial accumulation of non-metabolized NAPE species iuman HEK-293 cells at 50 uM. Uses: Enzyme inhibitors. Synonyms: 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide. Grades: ≥98%. CAS No. 2190502-57-7. Molecular formula: C19H14N4O4S. Mole weight: 394.41. | |
| ASB14780 | ASB14780 is a potent and oral inhibitor of cytosolic phospholipase A2α (cPLA2α; IC50 = 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay) with anti-inflammatory property in ear edema and asthma models. ASB14780 has the potential for the treatment of nonalcoholic fatty liver diseases including fatty liver and hepatic fibrosis. ASB14780 significantly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA and TGFb1 in the liver, as well as the expression of monocyte/macrophage markers. Synonyms: ASB14780; ASB 14780; ASB-14780; 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol; 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol. Grades: 99%. CAS No. 1069046-00-9. Molecular formula: C31H27NO3.C4H11NO3. Mole weight: 582.69. | |
| Avarol | Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Group: Biochemicals. Alternative Names: NSC 306951. Grades: Highly Purified. CAS No. 55303-98-5. Pack Sizes: 1mg. Molecular Formula: C21H30O2. US Biological Life Sciences. | Worldwide |
| AX 048 | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grades: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
| Benzylideneacetone | Benzylideneacetone (Benzalacetone) is an orally active antibiotic , tyrosinase inhibitor, phospholipase A 2 inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Benzalacetone. CAS No. 122-57-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W012595. | |
| BMS-229724 | BMS-229724 is a selective tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2) in that it did not inhibit secreted phospholipase A2 in vitro, nor phospholipase C and phospholipase D in cells. BMS-22972 acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. Synonyms: 4-[4-[2-[2-[bis (4-chlorophenyl) methoxy]ethylsulfonyl]ethoxy]phenyl]-1, 1, 1-trifluorobutan-2-one; 4- (4- (2- (2- (bis (4-chlorophenyl) methoxy) ethylsulfonyl) ethoxy) phenyl) -1, 1, 1-trifluoro-2-butanone; BMS-229724; BMS 229724; BMS229724; 42AD6D8ECA; SCHEMBL3304414; LS-46643; UNII-42AD6D8ECA. Grades: >98%. CAS No. 221914-85-8. Molecular formula: C27H25Cl2F3O5S. Mole weight: 589.45. | |
| Bromoenol lactone | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
| BW-B 70C | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
| C16 Ceramide-1-phosphate (d18:1/16:0) ammonium salt | C16 Ceramide-1-phosphate (C16 C1P) is one of the main forms of C1P found in cells. It is created by phosphorylation of by ceramide kinase. It activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells. Synonyms: C16 C1P; C16 Ceramide-1-phosphate; N-(hexadecanoyl)-sphing-4-enine-1-phosphate; CerP(d18:1/16:0). Grades: ≥98%. CAS No. 1246303-22-9. Molecular formula: C34H71N2O6P. Mole weight: 634.91. | |
| Caloporoside | Caloporoside is a phospholipase C inhibitor produced by Caloporus dichrous. It has only weak antifungal and bacterial activity, and has the effect of selectively inhibiting phospholipase C. Synonyms: 2-O-Acetyl-5-O-(2-O-acetylhexopyranosyl)-2-C-[17-(2-carboxy-3-hydroxyphenyl)heptadecan-2-yl]hexonic acid; D-Mannonic acid, 5-O-(2-O-acetyl-beta-D-mannopyranosyl)-, 16-(2-carboxy-3-hydroxyphenyl)-1-methylhexadecyl ester, 2-acetate, (R)-. CAS No. 160471-36-3. Molecular formula: C40H64O17. Mole weight: 816.92. | |
| Calphostin C (UCN 1028C, PKF115-584, Cal-C) | Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion. Source:Cladosporium cladosporioides sp. Group: Biochemicals. Grades: Highly Purified. CAS No. 121263-19-2. Pack Sizes: 100ug, 1mg. Molecular Formula: C44H38O14 , Molecular Weight: ~790.8. US Biological Life Sciences. | Worldwide |
| CAY10502 | Phospholipases A2 (PLA2s) are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule. It catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively. Synonyms: CAY10502; CAY-10502. Grades: ≥98% (mixture of isomers). CAS No. 888320-29-4. Molecular formula: C30H37NO7. Mole weight: 523.6. | |
| CAY10590 | Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. There are three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2). CAY10590 is a selective and potent inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2. Synonyms: CAY 10590; CAY-10590. Grades: ≥98%. CAS No. 1101136-50-8. Molecular formula: C21H33NO3. Mole weight: 347.5. | |
| CAY10594 | CAY10594 is a potent phospholipase D2 inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. CAY10594 administration markedly blocked the acute liver injury in a dose-dependent manner, showing almost complete inhibition with 8 mg/kg of CAY10594. CAY10594 administration strongly blocked GSK-3β (Serine 9)/JNK phosphorylation in the APAP-induced acute liver injury model. Consistently, sustained JNK activation in the cytosol and mitochondria from hepatocytes were also decreased in CAY10594-treated mice. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CAY10594; CAY-10594; CAY 10594. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.54. Purity: >98%. IUPACName: N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide. Canonical SMILES: O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(C4=CC=CC=C4)CN5)C5=O. Product ID: ACM1130067343. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CAY10594 | Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. There are two mammalian isoforms of PLD, which are PLD1 and PLD2. CAY10594 is a potent phospholipase D2 inhibitor (PLD2), which also prevents the invasive migration of breast cancer cells. It ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Synonyms: CAY 10594; CAY-10594. Grades: ≥98%. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.5. | |
| CAY10650 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grades: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
| Cgp-33304 | Cgp-33304 is a dual phospholipase A2 inhibiting agent and leukotriene receptor antagonists. It may prevent hypoxia secondary to leukotriene induced bronchoconstriction in shock states. It has potential to be an useful therapeutic agent in acute ischemic disorders including traumatic shock. Uses: Cgp-33304 has potential to be an useful therapeutic agent in acute ischemic disorders including traumatic shock. Synonyms: Cgp 33304; Cgp33304; Cgp-33304; 1H-Tetrazole-5-carboxamide, N-(5-(3-(4-acetyl-3-hydroxy-2-propylphenox y)propoxy)-4-bromo-2-methylphenyl)-, monosodium salt;CGP33304;N-(3-(3-(4-Acetyl-3-hydroxy-2-n-propylphenoxy)propoxy)-4-bromo-6-methylphenyl)-1H-tetrazole-5-carboxamide sodium;Sodium 5-((5-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-bromo-2-methylphenyl)carbamoyl)tetrazol-1-ide. Grades: >98%. CAS No. 111130-14-4. Molecular formula: C23H25BrN5NaO5. Mole weight: 554.38. | |
| Cgp-35949 | Cgp-35949 is an LTD4 antagonist which has phospholipase inhibitory activity. It represents a new approach to the treatment of asthma. Uses: Cgp-35949 represents a new approach to the treatment of asthma. Synonyms: Cgp 35949; Cgp-35949; Cgp35949; 1H-Tetrazole-5-carboxamide, N-(5-(3-(4-acetyl-3-hydroxy-2-propylphenox y)propoxy)-4-chloro-2-methylphenyl)-, monosodium salt;CGP35949;N-(5-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-chloro-2-methylphenyl)-1H-tetrazole-5-carboxamide monosodium salt;Sodium N-[5-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-chloro-2-methylphenyl]-1,2,3-triaza-4-azanidacyclopenta-2,5-diene-5-carboxamide;Sodium 5-((5-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-chloro-2-methylphenyl)carbamoyl)tetrazol-1-ide. Grades: >98%. CAS No. 111130-13-3. Molecular formula: C23H25ClN5NaO5. Mole weight: 509.92. | |
| Choline tosylate | Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Choline p-toluenesulfonate. CAS No. 55357-38-5. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-W100403. | |
| Cinnamycin | It is an antibiotic produced by several species of streptoverticillium. It is a potent indirect inhibitor of phospholipase A2 by specifically sequestering phosphatidylethanolamine (PE). It has antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells. It is also an immunopotentiator. Synonyms: Lanthiopeptin; Ro 09-0198; NSC 71936; Antibiotic NSC-71936; Antibiotic Ro 09-0198; L-cysteinyl-L-arginyl-L-glutaminyl-D-cysteinyl-L-cysteinyl-3-aminoalanyl-L-phenylalanylglycyl-L-prolyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-L-valyl-L-cysteinyl-(3R)-3-hydroxy-L-a-aspartylglycyl-L-asparaginyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-lysine, cyclic (1?18), (4?14), (5?11)-tris(thioether), cyclic (6?19)-imine. Grades: >98% by HPLC. CAS No. 110655-58-8. Molecular formula: C89H125N25O25S3. Mole weight: 2041.29. | |
| Compound 48/80 | Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Poly-p-methoxyphenethylmethylamine. CAS No. 94724-12-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-115768. | |
| Compound 48/80 hydrochloride | Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells. Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C. Synonyms: 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine trihydrochloride. Grades: ≥95%. CAS No. 848035-21-2. Molecular formula: C32H45N3O3·3HCl. Mole weight: 629.1. | |
| CRM-51005 | It is a phospholipase C (PLC) inhibitor originally isolated from fungal MT51005. Synonyms: Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-((1E)-1-methyl-1-pentenyl)-; Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-(1-methyl-1-pentenyl)-, (E)-; 3-ethyl-6-[(E)-hex-2-en-2-yl]-2,4-dihydroxybenzaldehyde. CAS No. 203051-01-8. Molecular formula: C15H20O3. Mole weight: 248.32. | |
| Cyclooctatin | It is produced by the strain of Sreptomyces melanosporofaciens M1614-43F2. It can inhibit the hemolysis phospholipase [EC 3.1.1.5] (Lyso-PL) activity. Terpentecin as substrates, it inhibits Lyso-PL, PL-A2, PL-C and PL-D with IC50 of 2.9 μg/mL, 65.0 μg/mL, 70.0 μg/mL and >100 μg/mL, respectively. Ki is 4.8 X 10-6 mol/L. Synonyms: Dicyclopenta(a,d)cyclooctene-3,4-diol,1,2,3,3a,4,5,7,8,9,9a,10,10a-dodecahydro-4,9a-dimethyl-1-(hydroxymethyl)-7-(1-methylethyl)-; 1-(Hydroxymethyl)-7-isopropyl-4, 9a-dimethyl-1, 2, 3, 3a, 4, 5, 7, 8, 9, 9a, 10, 10a-dodecahydrodicyclopenta[a, d]cyclooctene-3, 4-diol. CAS No. 139552-97-9. Molecular formula: C20H34O3. Mole weight: 322.49. | |
| D609 | D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor and is antiviral and antitumor agent. It suppresses LPS- and IFNγ-induced NO production and blocks oxidative glutamate toxicity in nerve cells. Synonyms: D-609; D 609; D609; D-609 free. Grades: >98%. CAS No. 83373-60-8. Molecular formula: C11H15KOS2. Mole weight: 266.46. | |
| D609, Potassium Salt - CAS 83373-60-8 | Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 μM). Group: Fluorescence/luminescence spectroscopy. | |
| Darapladib | Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Synonyms: SB-480848; SB 480848; SB480848; Darapladib. Grades: >98%. CAS No. 356057-34-6. Molecular formula: C36H38F4N4O2S. Mole weight: 666.77. | |
| des-His1-[Glu9]-Glucagon (1-29) amide | A glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes) that displays no agonist activity. It binds to glucagon receptors to stimulate breakdown of inositol phospholipids by phospholipase C. It was shown to potentiate glucose-stimulated pancreatic insulin release in vitro. It blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats. Synonyms: (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine); H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2; L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threoninamide. Grades: ≥95%. CAS No. 110084-95-2. Molecular formula: C148H221N41O47S. Mole weight: 3358.68. | |
| [Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grades: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
| DHPG | DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs [1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (RS)-3,5-DHPG. CAS No. 146255-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12598A. | |
| Difluprednate | Difluprednate is a topical corticosteroid, which is thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). Difluprednate is used for the symptomatic treatment of inflammation and pain associated with ocular surgery. Uses: Scientific research. Group: Signaling pathways. CAS No. 23674-86-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-17569. | |
| D-myo-Inositol-1,4,5-triphosphate potassium salt | D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium. Synonyms: D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE TRIPOTASSIUM SALT; tripotassium; [ (1R, 2S, 3R, 4R, 5S, 6R)-2, 3, 5-trihydroxy-4, 6-bis[[hydroxy (oxido)phosphoryl]oxy]cyclohexyl] hydrogen phosphate; D-Myo-inositol-1,2,5-tris(dihydrogen phosphate), tripotassium salt; PD020902; D-myo-Inositol 1,4,5-triphosphate tripotassium salt, >=95% (HPLC). Grades: ≥98%. CAS No. 141611-11-2. Molecular formula: C6H12O15P3·3K. Mole weight: 534.4. | |
| D-myo-Inositol-1,4,5-triphosphate sodium salt | D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium. Grades: ≥98%. CAS No. 141611-10-1. Molecular formula: C6H12O15P3·3Na. Mole weight: 486. | |
| D-myo-Inositol 1,4,5-trisphosphate tripotassium | D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca 2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Inositol 1,4,5-trisphosphate tripotassium; Ins(1,4,5)-P3 tripotassium. CAS No. 141611-11-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-150135B. | |
| D-myo-Inositol-2,4,5-triphosphate sodium salt | D-myo-Inositol-2,4,5-triphosphate sodium salt is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3. Synonyms: Ins(2,4,5)P3 sodium salt; 2,4,5-IP3 sodium salt; D-myo-inositol-2,4,5-tris(hydrogen phosphate), trisodium salt. Grades: ≥98%. Molecular formula: C6H12O15P3·3Na. Mole weight: 486. | |
| Duramycin B | Duramycins B is a new lanthionine containing antibiotic, has been isolated from Streptoverticillium strain R2075. Duramycins B is a potent inhibitor of human phospholipase A2. It exhibits only a weak antibacterial activity against B.subtilis, and does not display antimicrobial activity against S.aureus, S.mitis, E.coli, K.pneumoniae, P.vulgaris and C.albicans. Grades: ≥98%. CAS No. 132246-31-2. Molecular formula: C86H127N25O25S3. Mole weight: 2007.27. | |
| Duramycin C | Duramycin C is a new lanthionine containing antibiotic, has been isolated from Streptomyces griseoluteus (R2107). Duramycin C is a potent inhibitor of human phospholipase A2. It exhibits only a weak antibacterial activity against B.subtilis, and does not display antimicrobial activity against S.aureus, S.mitis, E.coli, K.pneumoniae, P.vulgaris and C.albicans. Grades: ≥98%. CAS No. 132268-38-3. Molecular formula: C82H115N23O27S3. Mole weight: 1951.12. | |
| EA4 | EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grades: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8. | |
| Edelfosine | Edelfosine, an orally administered antileishmanial drug, has anti-metastasis effect in experimental tumors. Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. Uses: Phosphodiesterase inhibitors. Synonyms: ALP; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-OMe; ET 18-OCH3; rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine; NSC-324368; (±)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium hydroxide inner salt 4-oxide. Grades: ≥95%. CAS No. 70641-51-9. Molecular formula: C27H58NO6P. Mole weight: 523.73. | |
| Elaidamide | Elaidamide has been found in the cerebrospinal fluid of sleep-deprived cats. Elaidamide is a fatty acid amide that inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM) and porcine pancreatic and human synovial phospholipase A2 (PLA2). Uses: Food additives. Synonyms: Elaidoylamide; (E)-9,10-Octadecenamide; 9E-octadecenamide. Grades: ≥95%. CAS No. 4303-70-2. Molecular formula: C18H35NO. Mole weight: 281.5. | |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Synonyms: 5-Fluoro-2-Indolyl des-Chlorohalopemide; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide; 5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide. Grades: >98 %. CAS No. 939055-18-2. Molecular formula: C23H24FN5O2. Mole weight: 421.47. | |
| FIPI hydrochloride | FIPI hydrochloride is an inhibitor of phospholipase D (PLD) (IC50 values of 20-25 nM for both PLD1 and PLD2), which is an enzyme catalyzing the hydrolysis of phosphatidylcholine to form phosphatidic acid. FIPI blocks in vivo phosphatidic acid (PA) production with subnanomolar potency. FIPI is a candidate therapeutic for autoimmunity and cancer metastasis. Uses: Potential treatment of autoimmunity and cancer metastasis. Synonyms: AOB33782; AKOS024457709; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride; 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1781834-93-2. Molecular formula: C23H24FN5O2.HCl. Mole weight: 457.93. | |
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