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100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N2O3S. CAS No. 111025-46-8. Prepack ID 54178163-100mg. Molecular Weight 356.44. See USA prepack pricing.
Pioglitazone
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N2O3S. CAS No. 111025-46-8. Prepack ID 54178163-1g. Molecular Weight 356.44. See USA prepack pricing.
Pioglitazone
25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N2O3S. CAS No. 111025-46-8. Prepack ID 54178163-25mg. Molecular Weight 356.44. See USA prepack pricing.
Pioglitazone
Pioglitazone is a PPAR agonist that exhibits antidiabetic activity in patients with type 2 diabetes mellitus. It has no effect on type 1 diabetes. Synonyms: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. Grades: >98%. CAS No. 111025-46-8. Molecular formula: C19H20N2O3S. Mole weight: 356.44.
Pioglitazone
Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC 50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U 72107. CAS No. 111025-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13956.
Pioglitazone 2-Imine
Pioglitazone impurity. Group: Biochemicals. Alternative Names: 2-Amino-5-[[4-[2- (5-ethyl-2-pyridinyl) ethoxy]phenyl]methyl]-4 (5H) -thiazolone; 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2-imino-4-thiazolidinone. Grades: Highly Purified. CAS No. 105355-26-8. Pack Sizes: 100mg. US Biological Life Sciences.
Cell-permeable. A thiazolidinedione (TZD) derivative that acts as a selective peroxisome proliferator-activated receptor gamma (PPARg) agonist (EC50 = 0.69uM). An antidiabetic agent; improves insulin sensitivity. Group: Biochemicals. Grades: Highly Purified. CAS No. 111025-46-8. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
Pioglitazone Aldehyde HCl
A metabolite of Pioglitazone which is used to lower blood glucose levels in the treatment of diabetes mellitus type 2 (T2DM). Synonyms: Benzaldehyde, 4-[2-(5-ethyl-2-pyridinyl)ethoxy]-, hydrochloride (1:1); SCHEMBL5168951. Grades: > 95%. CAS No. 856255-80-6. Molecular formula: C16H17NO2.HCl. Mole weight: 291.78.
Pioglitazone Bromo Impurity
An impurity of Pioglitazone which is a prescription drug of the thiazolidinedione (TZD) class. Synonyms: 2-[2-(4-Bromophenoxy)ethyl]-5-ethylpyridine Hydrogen Sulfate Salt; 4-[2-(5-Ethyl-2-pyridyl)ethoxy]-1-bromobenzene Hydrogen Sulphate. Grades: > 95%. CAS No. 669716-58-9. Molecular formula: C15H18BrNO5S. Mole weight: 404.2.
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N2O3S · HCl. CAS No. 112529-15-4. Prepack ID 29479163-1g. Molecular Weight 392.9. See USA prepack pricing.
Pioglitazone hydrochloride
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N2O3S · HCl. CAS No. 112529-15-4. Prepack ID 29479163-5g. Molecular Weight 392.9. See USA prepack pricing.
Pioglitazone hydrochloride
Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC 50 s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U 72107A; AD 4833. CAS No. 112529-15-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-14601.
Pioglitazone Hydrochloride
Used as an antidiabetic. Group: Biochemicals. Alternative Names: 5- [ [4- [2- (5-Ethyl-2-pyridinyl] ethoxy] phenyl] methyl] -2, 4-thiazolidinedione Hydrochloride; 5-phenyl]methyl-2,4-thiazolidinedione; AD-4833; Actos; U-72107A. Grades: Highly Purified. CAS No. 112529-15-4; freebase: 111025-46-8. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C19H20N2O3S HCl, Molecular Weight: 392.9. US Biological Life Sciences.
Worldwide
Pioglitazone Imino Impurity
An impurity of Pioglitazone which a thiazolidinedione compound with antiinflammatory and antiarteriosclerotic effects. Synonyms: 5-{4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl}-2-imino-4-thiazolidinedione; EPEBI. Grades: > 95%. CAS No. 105355-26-8. Molecular formula: C19H21N3O2S. Mole weight: 355.46.
Pioglitazone Impurity 1
An impurity of Pioglitazone which is a prescription drug of the thiazolidinedione (TZD) class. Synonyms: 3-[2-[(5-Ethyl-2-pyridinyl)ethoxy]phenyl] Pioglitazone Impurity. Grades: > 95%. CAS No. 952187-99-4. Molecular formula: C34H35N3O4S. Mole weight: 581.74.
Pioglitazone Impurity A
Cas No. 625853-74-9.
Pioglitazone Impurity B
Cas No. 136401-69-9.
Pioglitazone Impurity C
Cas No. 952188-00-0.
Pioglitazone Impurity D
Cas No. 868754-41-0.
Pioglitazone Impurity E
Cas No. 868754-42-1.
Pioglitazone Impurity F
An impurity of Pioglitazone which is a thiazolidinedione compound with antiinflammatory and antiarteriosclerotic effects. Synonyms: Pioglitazone bis-Ether Impurity; Bis[4-(5-Thiazolidinedion-yl)methylphenyl] ether; 5-(4-[4-(5-Thiazolidinedion-yl)methylphenoxy]benzyl)thiazolidine-2,4-dione; Des[(5-ethyl-2-pyridinyl)ethyl] Pioglitazone Dimer Ether Impurity; 5,5'-[Oxybis(4,1-phenylenemethylene)]bis(1,3-thiazolidine-2,4-dione); 5, 5'- ( (Oxybis (4, 1-phenylene))bis (methylene))bis (thiazolidine-2, 4-dione). Grades: ≥95%. CAS No. 1391052-15-5. Molecular formula: C20H16N2O5S2. Mole weight: 428.49.
Pioglitazone ketone
Pioglitazone ketone is an active metabolite of the PPARγ agonist pioglitazone. Synonyms: Ketopioglitazone; 5-[[4-[2-(5-acetylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. Grades: ≥98%. CAS No. 146062-45-5. Molecular formula: C19H18N2O4S. Mole weight: 370.42.
Pioglitazone ketone (from M-II)
A metabolite of Pioglitazone which is a PPARγ agonist used as an anti-diabetic drug. Grades: > 95%. Molecular formula: C19H18N2O4S. Mole weight: 370.43.
Pioglitazone Metabolite M1
A metabolite of Pioglitazone which is a PPARγ agonist used as an anti-diabetic drug. Synonyms: Pioglitazone Phenol Impurity ; 5-(4-Hydroxybenzyl)-1,3-thiazolidine-2,4-dione. Grades: > 95%. CAS No. 74772-78-4. Molecular formula: C10H9NO3S. Mole weight: 223.25.
Pioglitazone N-beta-D-Glucuronide (Mixture of Diastereomers)
An impurity of Pioglitazone which is a prescription drug of the thiazolidinedione (TZD) class. Synonyms: Pioglitazone N-β-D-Glucuronide; 1-Deoxy-1-[5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-dioxo-3-thiazolidinyl] β-D-Glucopyranuronic Acid. Grades: > 95%. CAS No. 1296832-75-1. Molecular formula: C25H28N2O9S. Mole weight: 532.57.
Pioglitazone potassium salt
Pioglitazone is a PPARγ agonist (EC50 = ~500-600 nM) with selectivity for PPARγ over PPAR&alpha. It has been used as a medication indicated for the treatment of diabetes mellitus type 2, It works by lowering insulin resistance thus reducing glucose level. Synonyms: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidin-3-ide-2,4-dione potassium salt. Grades: ≥98%. CAS No. 1266523-09-4. Molecular formula: C19H19N2O3S·K. Mole weight: 394.53.
Pioglitazone Related Compound B
An impurity of Pioglitazone which is a thiazolidinedione antidiabetic. Synonyms: Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]; 5-[[4-[2-[5-Ethyl-6-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione. Grades: > 95%. CAS No. 669716-56-7. Molecular formula: C34H35N3O4S. Mole weight: 581.74.
Pioglitazone sulfonic acid impurity
Pioglitazone sulfonic acid impurity. Group: Biochemicals. Alternative Names: a- (Aminocarbonyl) -4- [2- (5-ethyl-2-pyridinyl) ethoxy] benzeneethanesulfonic acid. Grades: Highly Purified. CAS No. 625853-73-8. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C18H22N2O5S. US Biological Life Sciences.
Worldwide
Pioglitazone Sulfonic Impurity
An impurity of Pioglitazone which is a thiazolidinedione antidiabetic. Synonyms: α - (Aminocarbonyl) -4-[2- (5-ethyl-2-pyridinyl) ethoxy]benzeneethanesulfonic Acid. Grades: > 95%. CAS No. 625853-73-8. Molecular formula: C18H22N2O5S. Mole weight: 378.45.
1-Hydroxy Pioglitazone Hydrochloride
Hydroxy Pioglitazone Hydrochloride is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 146062-46-6. Pack Sizes: 500ug, 5mg. Molecular Formula: C19H21ClN2O4S, Molecular Weight: 408.9. US Biological Life Sciences.
Worldwide
2-Hydroxy Pioglitazone Hydrochloride
2-Hydroxy Pioglitazone Hydrochloride is a metabolite of Pioglitazone (P471000), which is used as an antidiabetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 646519-87-1. Pack Sizes: 1mg. Molecular Formula: C19H21ClN2O4S, Molecular Weight: 408.9. US Biological Life Sciences.
A metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: Keto-Pioglitazone. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
A novel intermediate of Pioglitazone. Group: Biochemicals. Alternative Names: 5- [4- [2- (5-Ethylpyridin-2-yl) ethoxy] benzylidene] thiazolidine-2, 4-dione. Grades: Highly Purified. CAS No. 144809-28-9. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
5-Desethyl 5-Carboxy Pioglitazone
A metabolite of Pioglitazone. Antidiabetic. Group: Biochemicals. Alternative Names: 6-[2-[4-[ (2, 4-Dioxo-5-thiazolidinyl) methyl]phenoxy]ethyl]-3-pyridinecarboxylic Acid. Grades: Highly Purified. CAS No. 186751-40-6. Pack Sizes: 1mg. US Biological Life Sciences.
A novel pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative. Group: Biochemicals. Alternative Names: Pioglitazone Impurity E (EP). Grades: Highly Purified. CAS No. 868754-41-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Hydroxy Pioglitazone
Hydroxy pioglitazone is a major metabolite of pioglitazone, a PPARγ agonist. Pioglitazone is a medication indicated for type 2 diabetes. Synonyms: Hydroxypioglitazone; Leriglitazone; 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. Grades: ≥95%. CAS No. 146062-44-4. Molecular formula: C19H20N2O4S. Mole weight: 372.44.
A metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: 5- [ [4- [2- [5- (1-Hydroxyethyl) -2-pyridinyl] ethoxy] phenyl] methyl] -2, 4-thiazolidinedione. Grades: Highly Purified. CAS No. 146062-44-4. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Hydroxypioglitazone (M-IV) hydrochloride
Hydroxypioglitazone (M-IV) hydrochloride is the salt of an active metabolite of Pioglitazone (M-IV), a PPARγ agonist used in the treatment of diabetes mellitus type 2. In comparison with Pioglitazone, it has modest antihyperglycemic activity and more potent stimulating activity in lipid synthesis. Synonyms: 1-Hydroxy Pioglitazone Hydrochloride; 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione hydrochloride. Grades: 99%. CAS No. 146062-46-6. Molecular formula: C19H20N2O4S.HCl. Mole weight: 408.9.
Hydroxy Pioglitazone (M-IV) ß-D-Glucuronide
An impurity of Pioglitazone which a thiazolidinedione compound with antiinflammatory and antiarteriosclerotic effects. Synonyms: 1-[6-[2-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenoxy]ethyl]-3-pyridinyl]ethyl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 625853-76-1. Molecular formula: C25H28N2O10S. Mole weight: 548.56.
Hydroxy pioglitazone(m-vII)
Hydroxy pioglitazone(m-vII). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-[[4-[2-[5-(2-Hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-. Product Category: Heterocyclic Organic Compound. CAS No. 625853-72-7. Molecular formula: C19H20N2O4S. Mole weight: 372.44. Product ID: ACM625853727. Alfa Chemistry ISO 9001:2015 Certified. Categories: Hydroxy Pioglitazone (M-VII).
Hydroxy pioglitazone (M-VII)
Hydroxy pioglitazone (M-VII). Group: Biochemicals. Alternative Names: 5- [ [4- [2- [5- (2-Hydroxyethyl) -2-pyridinyl] ethoxy] phenyl] methyl] -2, 4-thiazolidinedione. Grades: Highly Purified. CAS No. 625853-72-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C19H20N2O4S. US Biological Life Sciences.
Worldwide
Hydroxy Pioglitazone (M-VII)
A metabolite of Pioglitazone which is a thiazolidinedione compound with antiinflammatory and antiarteriosclerotic effects. Synonyms: Hydroxy Pioglitazone (M-VII); 625853-72-7; 5-[[4-[2-[5-(2-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; 5-[(4-{2-[5-(2-Hydroxyethyl)pyridin-2-yl]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione; Hydroxy pioglitazone(m-vII); SCHEMBL5805283; DTXSID10849604; 5-[[4-[2-[5-(2-Hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione; FT-0670010. Grades: > 95%. CAS No. 625853-72-7. Molecular formula: C19H20N2O4S. Mole weight: 372.45.
Hydroxy pioglitazone (M-VII) b-D-glucuronide
Hydroxy pioglitazone (M-VII) b-D-glucuronide is a biomedical compound used in the treatment of diabetes. It acts as a metabolite of pioglitazone, an oral antidiabetic medication, and functions by enhancing insulin sensitivity. This product aids in maintaining blood sugar levels and managing complications associated with diabetes, promoting overall well-being. Synonyms: 2-[6-[2-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenoxy]ethyl]-3-pyridinyl]ethyl b-D-glucopyranosiduronic acid. CAS No. 625853-75-0. Molecular formula: C25H28N2O10S. Mole weight: 548.56.
Keto Pioglitazone-d4 (M-III-d4)
A labeled metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: 5-[[4-[2-(5-Acetyl-2-pyridinyl)ethoxy-d4]phenyl]methyl]-2,4-thiazolidinedione; Keto-Pioglitazone (M-III)-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Keto Pioglitazone (M-III)
A metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: 5-[[4-[2- (5-Acetyl-2-pyridinyl) ethoxy]phenyl]methyl]-2, 4thiazolidinedione; Keto-Pioglitazone (M-III). Grades: Highly Purified. CAS No. 146062-45-5. Pack Sizes: 1mg. US Biological Life Sciences.
Pioglitazone impurity. Group: Biochemicals. Alternative Names: 5-[[4-[2- (5-Ethyl-2-pyridinyl) ethoxy]phenyl]methyl]-3-[2- (5-ethyl-2-pyridinyl) ethyl]-2, 4-thiazolidinedione; Pioglitazone Impurity. Grades: Highly Purified. CAS No. 952188-00-0. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
1-(6-Methyl-1,6-dihydropyridin-3-yl)ethanol
1-(6-Methyl-1,6-dihydropyridin-3-yl)ethanol is an analogue of 1-(6-Methyl-3-pyridinyl)ethanol (M326310), An intermediate used in the synthesis of metabolites of the antidiabetic, antihyperglycemic agent Pioglitazone (P471000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500mg, 5g. Molecular Formula: C8H13NO, Molecular Weight: 139.19. US Biological Life Sciences.
Worldwide
2-(2-(4-Bromophenoxy)ethyl)-3-methylpyridine
2-(2-(4-Bromophenoxy)ethyl)-3-methylpyridine is an intermediate in the synthesis of 5- (4- (2- (3-Methylpyridin-2-yl) ethoxy) benzyl) thiazolidine-2, 4-dione (M320850), which is used in the synthesis of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinedione derivatives as antidiabetic agents, such as Pioglitazone (P471000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C14H14BrNO, Molecular Weight: 292.17. US Biological Life Sciences.
Worldwide
2-(3-Methylpyridin-2-yl)ethanol
2-(3-Methylpyridin-2-yl)ethanol is a reactant in the preparation of Pioglitazone analogues as antidiabetic agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 4723-26-6. Pack Sizes: 250mg, 2.5g. Molecular Formula: C8H11NO, Molecular Weight: 137.18. US Biological Life Sciences.
2- (5- (1- (Methoxymethoxy) ethyl) pyridin-2-yl) ethanol is a reactant in the synthesis of Pioglitazone(P471000) metabolites. Group: Biochemicals. Grades: Highly Purified. CAS No. 146062-58-0. Pack Sizes: 100mg, 1g. Molecular Formula: C11H17NO3, Molecular Weight: 211.26. US Biological Life Sciences.
Worldwide
4-[2- (5-Ethyl-2-pyridinyl) ethoxy]benzaldehyde
An intermediate of Pioglitazone. Group: Biochemicals. Alternative Names: 4-[2- (5-Ethyl-3-pyridyl) ethoxy]benzaldehyde. Grades: Highly Purified. CAS No. 114393-97-4. Pack Sizes: 50mg. US Biological Life Sciences.
Pioglitazone intermediate. Group: Biochemicals. Alternative Names: U 92231. Grades: Highly Purified. CAS No. 144842-17-1. Pack Sizes: 25mg. US Biological Life Sciences.
An intermediate for the synthesis of the metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: 5-[[4-[2-[5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinyl]ethoxy-d4]phenyl]methyl]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
An intermediate for the preparation of the metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: 5-[[4-[2-[5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinyl]ethoxy-d4]phenyl]methylene]-2,4-thiazolidinedione. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
5- (4-Hydroxybenzyl) thiazolidine-2, 4-dione
A metabolite of Pioglitazone. Group: Biochemicals. Alternative Names: 5-[(4-Hydroxyphenyl)methyl]-. Grades: Highly Purified. CAS No. 74772-78-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
5-Ethyl-2-pyridineethanol Tosylate
Intermediate in the preparation of Pioglitazone impurities. Group: Biochemicals. Alternative Names: 5-Ethyl-2-pyridineethanol 2- (4-Methyl Benzene sulfonate) ; 2-(5-Ethyl-2-pyridyl)ethyl Tosylate; Toluene-4-sulfonic Acid 2-(5-Ethylpyridin-2-yl)ethyl Ester. Grades: Highly Purified. CAS No. 144809-27-8. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Balaglitazone
The Rs for the separations were 3.5 for balaglitazone enantiomers, 3.5 for pioglitazone enantiomers, and 3.7 for rosiglitazone. The squared correlation coefficients (r2) were found to be 0.999 for all three compounds. Balaglitazone treated groups shown significantly reduce of HbA1c (%), FSG (mmol/L), postprandial glucose as comparison to pioglitazone. Balaglitazone 10 mg and 20 mg show the similar magnitudes of the effects which comparable to the effects seen in the pioglitazone 45 mg group. The incidence of fluid retention and fat accumulation fewer than those observed with pioglitazone 45 mg. Sixty male dio induced obese rats were divided into five categories: vehicle, pioglitazone 10 mg/kg, pioglitazone 30 mg/kg, balaglitazone 5 mg/kg, balaglitazone 10 mg/kg. At day -7, 21 and 42 fasting serum samples were collected and whole body tissue composition was evaluated by MR scanning. Synonyms: DRF-2593; NN-2344; DRF2593; NN2344; DRF 2593; NN 2344. Grades: >98%. CAS No. 199113-98-9. Molecular formula: C20H17N3O4S. Mole weight: 395.43.
A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50=0.9uM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4uM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25uM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
MSDC-0160
MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. Synonyms: Mitoglitazone; CAY10415; 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione; Pioglitazone Ketone; 5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione; 5-{4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]benzyl}-1,3-thiazolidine-2,4-dione. Grades: >98%. CAS No. 146062-49-9. Molecular formula: C19H18N2O4S. Mole weight: 370.42.
A metabolite of Pioglitazone which is a metabolite of Pioglitazone, a prescription drug of the thiazolidinedione (TZD) class. Synonyms: 5-(4-Fluorobenzyl)-2,4-thiazolidinedione. Grades: > 95%. CAS No. 291536-42-0. Molecular formula: C10H8FNO2S. Mole weight: 225.24.
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