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| Product | Description | |
|---|---|---|
| plasma kallikrein | Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg>Lys in P1, in small molecule substrates. Group: Enzymes. Synonyms: serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein. Enzyme Commission Number: EC 3.4.21.34. CAS No. 410538-33-9. Kallikrein. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4128; plasma kallikrein; EC 3.4.21.34; 410538-33-9; serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein. Cat No: EXWM-4128. |  |
| Kallikrein from human plasma | buffered aqueous solution, ?5 units/mg protein. Group: Fluorescence/luminescence spectroscopy. |  |
| 2-(Bromomethyl) Oxazole | 2-(Bromomethyl) Oxazole is used in the synthetic preparation of substituted oxopyridine derivatives as factor XIa and plasma kallikrein inhibitors useful in treating thrombotic or thromboembolic diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1065073-35-9. Pack Sizes: 25mg, 100mg. Molecular Formula: C4H4BrNO, Molecular Weight: 161.979999999999. US Biological Life Sciences. |  Worldwide |
| Avoralstat | Avoralstat, also known as BCX-4161, is an oral plasma kallikrein (PKK) inhibitor and Bradykinin inhibitor, used to treat hereditary angioedema. Synonyms: 3-[2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylic acid; BCX-4161; BCX 4161; BCX4161; Avoralstat. CAS No. 918407-35-9. Molecular formula: C28H27N5O5. Mole weight: 513.54. |  |
| Avoralstat | Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX4161. CAS No. 918407-35-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16735. |  |
| Berotralstat | Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX7353. CAS No. 1809010-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-109127. | |
| Berotralstat dihydrochloride | Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX7353 dihydrochloride. CAS No. 1809010-52-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109127A. | |
| BZ-ILE-GLU-GLY-ARG-PNA | Bz-IEGR-pNA is a substrate for plasma kallikrein and coagulation factor XIIa. Synonyms: Nalpha-Benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine-4-nitroanilide; L-Argininamide, N-benzoyl-L-isoleucyl-L-alpha-glutamylglycyl-N-(4-nitrophenyl)-. CAS No. 59068-47-2. Molecular formula: C32H43N9O9. Mole weight: 697.74. | |
| coagulation factor XIIa | Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator. Enzyme Commission Number: EC 3.4.21.38. CAS No. 75216-42-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4132; coagulation factor XIIa; EC 3.4.21.38; 75216-42-1; Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator. Cat No: EXWM-4132. | |
| D-Pro-Phe-Arg-Chloromethylketone | D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1]. Uses: Scientific research. Group: Peptides. CAS No. 88546-74-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4245. | |
| Gabexate mesylate | Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. Synonyms: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate; Gabexate; Gabexate mesylate; gabexate mesilate. Arodate; Megacart; Megacert; Mesyl Gabexate; Arodate. CAS No. 56974-61-9. Molecular formula: C17H27N3O7S. Mole weight: 417.48. | |
| Gabexate Mesylate | Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Group: Biochemicals. Alternative Names: 4-[[6-[ (Aminoiminomethyl) amino]-1-oxohexyl]oxy]benzoic Acid Ethyl Ester Monomethanesulfonate; Arodate; FOY; FOY 007; FOY-S 983; Gabexate Mesilate; Gabexate Monomethanesulfonate; Megacert; Mesyl Gabexate. Grades: Highly Purified. CAS No. 56974-61-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| H-D-Phe-Phe-Arg-chloromethylketone | H-D-Phe-Phe-Arg-chloromethyl ketone is a potent, specific and irreversible inhibitor of glandular and plasma kallikreins. Uses: Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Synonyms: FFRCK; Phenylalanyl-phenylalanyl-arginine chloromethyl ketone; Phe-phe-arg-CK; 2-Amino-N-[N-(6-carbamimidamido-1-chloro-2-oxohexan-3-yl)phenylalanyl]-3-phenylpropanimidic acid; PPACK II. CAS No. 74392-49-7. Molecular formula: C25H33ClN6O3. Mole weight: 501.02. | |
| H-D-Pro-Phe-Arg-pNA 2HCl | H-D-Pro-Phe-Arg-pNA 2HCl is a chromogenic substrate for the determination of plasma kallikrein-like activity. Synonyms: H-D-PFR-pNA 2HCl; L-Argininamide, D-prolyl-L-phenylalanyl-N-(4-nitrophenyl)-, dihydrochloride; D-Prolyl-L-phenylalanyl-N-(4-nitrophenyl)-L-argininamide hydrochloride (1:2); pFR-pNA dihydrochloride. Grades: 95%. CAS No. 62354-56-7. Molecular formula: C26H34N8O5.2HCl. Mole weight: 611.52. | |
| Human Factor XII | Factor XII (XII) (Hageman Factor) is a single chain (Mr=78,000) glycoprotein zymogen that circulates in plasma at a concentration of 40 ug/ml. Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation pathway. Surface bound α-XIIa in turn activates factor XI to XIa. Secondary cleavage of α-XIIa by kallikrein yields β-XIIa, which catalyzes solution phase activation of kallikrein, factor VII and the classical complement cascade.The ability of a variety of negatively charged substances, both physiological and nonphysiological to promote XII activation and, thus, initiation of the int...ain (Mr=28,000) contains the catalytic triad (His-40, Asp-89, Ser-191), while the NH2-terminal heavy chain (Mr=52,000) conatins the anionic surface binding portion of the molecule. A secondary cleavage of α-XIIa by kallikrein outside the disulfide bond yields β-XIIa (XIIf, BHFa, HFf, hageman factor fragments) (Mr=28,000), which no longer binds anionic surfaces. β-XIIa can activate prekallikrein, but has little procoagulant activity. Several other minor intermediate forms of XIIa are indicated in the figure above.Inhibitors of XIIa include C1-INH, α2-antiplasmin, α2-macroglobulin and antithrombin III. At physiological concentrations, the relative effectiven | |
| Kallikrein, Porcine pancreas | Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: kininogenase; SK-827. CAS No. 9001-1-8. Pack Sizes: 100 mg; 250 mg. Product ID: HY-P2795. | |
| Lanadelumab | Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SHP643; DX-2930. CAS No. 1426055-14-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99110. | |
| MDI-2268 | MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1609176-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124577. | |
| Nα-Boc-Nω-nitro-D-arginine | Nα-Boc-Nω-nitro-D-arginine is used in the synthesis of selective inactivators of human plasma kallikrein via chloromethyl ketone formation. Nα-Boc-Nω-nitro-D-arginine also produced modest inhibition of the effects acetylcholine in rabbit aorta. Group: Biochemicals. Alternative Names: N2-[ (1, 1-Dimethylethoxy) carbonyl]-N5-[imino (nitroamino) methyl]-D-ornithine; Na-Boc-Nw-nitro-D-arginine; Boc-D-Arg(NO2)-OH. Grades: Highly Purified. CAS No. 50913-12-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Native Human Kallikrein | Plasma kallikrein is an enzyme. This enzyme catalyses the following chemical reaction:Selective cleavage of some Arg-and Lys-bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin. This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Group: Enzymes. Synonyms: serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein; 9001-01-8; EC 3.4.21.34; plasma kallikrein. Enzyme Commission Number: EC 3.4.21.34. CAS No. 9001-1-8. Kallikrein. Activity: Type I, > 5 units/mg protein; Type II, 1-5 units/mg protein. Storage: -20°C. Form: Type I, buffered aqueous solution, Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl; Type II, lyophilized powder. Source: Human plasma. Species: Human. serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein; 9001-01-8; EC 3.4.21.34; plasma kallikrein. Cat No: NATE-0361. | |
| N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride | A chromogenic substrate for plasma kallikrein, cruzipain and trypsin. Synonyms: Bz-Pro-Phe-Arg-Pna hydrochloride; (S)-1-benzoyl-N-((S)-1-((S)-5-guanidino-1-(4-nitrophenylamino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide hydrochloride; Bz-PFR-pNA. Grades: 95%. CAS No. 59188-28-2. Molecular formula: C33H39ClN8O6. Mole weight: 679.17. | |
| PKSI-527 | PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128837-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123133. | |
| PKSI-527 | PKSI-527 is a potent and selective inhibitor of plasma kallikrein with Ki value of 0.81 μM. PKSI-527 may be a useful tool for exploring the mechanism of disseminated intravascular coagulation (DIC) and the accompanying organ failure. Synonyms: 2-[4-[[ (2S) -2-[[4- (aminomethyl) cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]acetic acid hydrochloride. Grades: ≥95%. CAS No. 128837-71-8. Molecular formula: C25H31N3O4·HCl. Mole weight: 474. | |
| PPACKII trifluoroacetate salt | PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins. Human tissue kallikreins (hKs) are a class of secreted serine proteases that is involved in the release of vasodepressor peptides or kinins from a plasma substrate. Synonyms: H-D-Phe-Phe-Arg-Chloromethyl Ketone; (2R)-2-amino-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide trifluoroacetate salt. Grades: ≥95%. CAS No. 649748-23-2. Molecular formula: C25H33ClN6O3·2CF3COOH. Mole weight: 729.1. | |
| Pro-Phe-Arg-7-amido-4-methylcoumarin | PFR-AMC is a highly sensitive, fluorogenic substrate for plasma as well as pancreatic and urinary kallikreins. Synonyms: PFR-NMec. CAS No. 65147-21-9. Molecular formula: C30H37N7O5. Mole weight: 575.66. | |
| Sebetralstat | Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KVD900. CAS No. 1933514-13-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132830. | |
| semenogelase | A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by α1-antichymotrypsin. Group: Enzymes. Synonyms: prostate-specific antigen; α-seminoprotein; seminin; P-30 antigen; antigen (human clone HPSA-1 prostate-specific protein moiety reduced); γ-seminoglycoprotein (human protein moiety reduced); γ-SM; antigen PSA (human prostate-specific); human glandular kallikrein; antigen PSA (human clone 5P1 protein moiety reduced). Enzyme Commission Number: EC 3.4.21.77. CAS No. 110157-83-0, 95829-41-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4169; semenogelase; EC 3.4.21.77; 110157-83-0, 95829-41-7; prostate-specific antigen; α-seminoprotein; seminin; P-30 antigen; antigen (human clone HPSA-1 prostate-specific protein moiety reduced); γ-seminoglycoprotein (human protein moiety reduced); γ-SM; antigen PSA (human prostate-specific); human glandular kallikrein; antigen PSA (human clone 5P1 protein moiety reduced). Cat No: EXWM-4169. | |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| Suramin | Suramin, also called as Germanin, has been demonstrated to inhibit a large variety of enzymes including urease, hexokinase, succinic dehydrogenase, p-glucuronidase, acid phosphatase, lysozyme, thrombin, plasma kallikrein, (Na'-K')-activated ATPase, plasmi. Uses: Antineoplastic agents. Synonyms: suramin; Germanin; Naganol; Naphuride; Belganyl; Suramine. Grades: 95%. CAS No. 145-63-1. Molecular formula: C51H40N6O23S6. Mole weight: 1297.29. | |
| Trypsin Inhibitor (soybean) | Trypsin Inhibitor (soybean) is a peptide inhibitor of serine proteases that reduces trypsin, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases. Synonyms: Kunitz Trypsin Inhibitor; MR 20; SBTI. CAS No. 9035-81-8. | |
| u-plasminogen activator | Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26. Group: Enzymes. Synonyms: urokinase; urinary plasminogen activator; cellular plasminogen activator; urokinase-type plasminogen activator; double-chain urokinase-type plasminogen activator; two-chain urokinase-type plasminogen activator; urokinase plasminogen activator; uPA; u-PA; abbokinase; urinary esterase A. Enzyme Commission Number: EC 3.4.21.73. CAS No. 9039-53-6. uPA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4165; u-plasminogen activator; EC 3.4.21.73; 9039-53-6; urokinase; urinary plasminogen activator; cellular plasminogen activator; urokinase-type plasminogen activator; double-chain urokinase-type plasminogen activator; two-chain urokinase-type plasminogen activator; urokinase plasminogen activator; uPA; u-PA; abbokinase; urinary esterase A. Cat No: EXWM-4165. | |
| Z-L-tyrosine 4-nitrophenyl ester | A substrate for human plasma and urinary kallikreins and for human leukocyte elastase. Synonyms: Z-L-Tyr-Onp; (S)-4-Nitrobenzyl 2-(((Benzyloxy)Carbonyl)Amino)-3-(4-Hydroxyphenyl)Propanoate; 4-Nitrophenyl N-[(Benzyloxy)Carbonyl]-L-Tyrosinate. Grades: ≥ 97%. CAS No. 3556-56-7. Molecular formula: C23H20N2O7. Mole weight: 436.40. | |
| Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride - CAS 70382-26-2 | Substrate for fluorogenic assay of plasma and glandular kallikreins. Group: Fluorescence/luminescence spectroscopy. | |
| Z-Phe-Arg-AMC HCl | Fluorogenic substrate for plasma kallikrein and soybean trypsin-like enzyme. Synonyms: Z-FR-AMC.HCl; CBZ-FR-AMCC.HCl; Z-Phe-Arg-Amc Hydrochloride; Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride; 7-(Nalpha-carbobenzoxy-L-phenylalanyl-L-arginyl)amino-4-methylcoumarin Hydrochloride. Grades: ≥95%. CAS No. 65147-22-0. Molecular formula: C33H36N6O6.HCl. Mole weight: 649.14. | |
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