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| Product | Description | |
|---|---|---|
| PMAP-36[C/S]-amide (12-35) | PMAP-36[C/S]-amide (12-35) is a fragment of PMAP-36[C/S]-amide, which is an analog of PMAP-36. PMAP-36 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Ac-Lys-Arg-Leu-Lys-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Ser-NH2. Molecular formula: C128H222N34O27. Mole weight: 2669.3. |  |
| PMAP-36[C/S]-amide (16-35) | PMAP-36[C/S]-amide (16-35) is a fragment of PMAP-36[C/S]-amide, which is an analog of PMAP-36. PMAP-36 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Ac-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Ser-NH2. Molecular formula: C104H175N25O23. Mole weight: 2143.6. | |
| PMAP-36 (C/S/amide-Gly) | PMAP-36 (C/S/amide-Gly) is an analog of PMAP-36, which is an antimicrobial peptide produced by Sus scrofa (Pig). PMAP-36 has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Ac-Gly-Arg-Phe-Arg-Arg-Leu-Arg-Lys-Lys-Thr-Arg-Lys-Arg-Leu-Lys-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Ser-NH2. Molecular formula: C191H336N62O39. Mole weight: 4125.1. | |
| 2-PMAP | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Antibacterial peptide PMAP-23 | Antibacterial peptide PMAP-23 is an antimicrobial peptide produced by Sus scrofa (Pig). It has potent antimicrobial activity against Gram-negative and Gram-positive bacteria without hemolytic activity. Synonyms: Myeloid antibacterial peptide 23; PMAP-23; PMAP23; Arg-Ile-Ile-Asp-Leu-Leu-Trp-Arg-Val-Arg-Arg-Pro-Gln-Lys-Pro-Lys-Phe-Val-Thr-Val-Trp-Val-Arg-OH. Grade: ≥95%. Molecular formula: C140H229N43O28. Mole weight: 2962.63. | |
| Antibacterial peptide PMAP-36 | Antibacterial peptide PMAP-36 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Myeloid antibacterial peptide 36; PMAP-36; PMAP36; Gly-Arg-Phe-Arg-Arg-Leu-Arg-Lys-Lys-Thr-Arg-Lys-Arg-Leu-Lys-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Cys-Gly. Grade: 97%. Molecular formula: C191H336N62O39S. Mole weight: 4157.22. | |
| Antibacterial peptide PMAP-37 | Antibacterial peptide PMAP-37 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Myeloid antibacterial peptide 37; PMAP-37; PMAP37; Gly-Leu-Leu-Ser-Arg-Leu-Arg-Asp-Phe-Leu-Ser-Asp-Arg-Gly-Arg-Arg-Leu-Gly-Glu-Lys-Ile-Glu-Arg-Ile-Gly-Gln-Lys-Ile-Lys-Asp-Leu-Ser-Glu-Phe-Phe-Gln-Ser. Grade: >85%. Molecular formula: C192H320N60O56. Mole weight: 4365.02. | |
| Anti-Phospho-PMAT-Y198 antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Azt-pmap | Azt-pmap, an aryl phosphate derivative of AZT, is a nucleoside analogue with anti-HIV activity. Synonyms: 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate; L-Alanine, N-(3'-azido-3'-deoxy-P-phenyl-5'-thymidylyl)-, methyl ester; Thymidine, 3'-azido-3'-deoxy-5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino]phenoxyphosphinyl]-; Methyl (2S)-2-{[{[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)tetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate. Grade: ≥95%. CAS No. 142629-81-0. Molecular formula: C20H25N6O8P. Mole weight: 508.42. | |
| Glycol Ether PMA | Glycol Ether PMA. Category GLYCOL ETHERS. Pack Sizes Drums, Totes, bulk |  |
| Monodisperse PMA Microspheres | Monodisperse PMA Microspheres. Group: Nanospheres. |  |
| Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. |  Worldwide |
| Tamra, PMAP-36 (12-36) | Tamra, PMAP-36 (12-36) is a derivative of PMAP-36 (12-36), a fragment of PMAP-36. PMAP-36 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Tamra-Lys-Arg-Leu-Lys-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Cys-Gly. Molecular formula: C153H244N36O32S. Mole weight: 3132.00. | |
| Tamra, PMAP-36 (16-36) | Tamra, PMAP-36 (16-36) is a derivative of PMAP-36 (16-36), a fragment of PMAP-36. PMAP-36 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Tamra-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Cys-Gly. Molecular formula: C129H197N27O28S. Mole weight: 2606.30. | |
| Tamra, PMAP-36 (7-36) | Tamra, PMAP-36 (7-36) is a derivative of PMAP-36 (7-36), a fragment of PMAP-36. PMAP-36 is an antimicrobial peptide produced by Sus scrofa (Pig). It has antimicrobial activity against Gram-negative and Gram-positive bacteria. Synonyms: Tamra-Arg-Lys-Lys-Thr-Arg-Lys-Arg-Leu-Lys-Lys-Ile-Gly-Lys-Val-Leu-Lys-Trp-Ile-Pro-Pro-Ile-Val-Gly-Ser-Ile-Pro-Leu-Gly-Cys-Gly. Molecular formula: C181H299N49O38S. Mole weight: 3801.90. | |
| THP-1 Nuclear Extract, PMA stimulated (Human Monocyte) | Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| 4α-Phorbol 12,13-didecanoate | 4α-Phorbol 12,13-didecanoate, a substituted diterpene alcohol, is a negative control for phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-didecanoate (PDD). Synonyms: Decanoic acid, 1,1'-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] ester; 1,1'-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] didecanoate; 5. Grade: ≥95%. CAS No. 27536-56-7. Molecular formula: C40H64O8. Mole weight: 672.93. | |
| 4α-Phorbol 12-myristate 13-acetate | 4α-Phorbol 12-myristate 13-acetate is a phorbol ester that is commonly used to activate certain types of PKC, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. And it has the similar chemical structure of 4-Quinolone-3-Carboxamide Furan CB2 Agonist. Synonyms: 4α-PMA. Grade: ≥98%. CAS No. 63597-44-4. Molecular formula: C36H56O8. Mole weight: 616.8. | |
| 7,4'-Dihydroxyflavone | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor ( IC 50 =0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)?paradoxical adverse effects on eotaxin production [1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC 50 value of 1.4 μM [1]. Uses: Scientific research. Group: Natural products. CAS No. 2196-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2609. |  |
| 8(S)-HETE | 8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. Synonyms: 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid. Grade: ≥98%. CAS No. 98462-03-4. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| ARN2966 | ARN2966, also called 2-PMAP, as a Amyloid-β inhibitor, is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: 2-(pyridin-2-ylmethylamino)phenol; 2-PMAP; ARN2966; ARN-2966; Phenol, 2-[(2-pyridinylmethyl)amino]-; 102212-26-0; AGN-PC-0031SD; GTPL7530; 2-(2-Pyridylmethylamino)phenol; SCHEMBL10886688; AOB1080; SYN5152; 2-(pyridin-2-ylmethylamino)phenol; 3970AH; ZINC34411048; AKOS022987680; CS-3335; HY-18292; ARN-2966; CS 3335; HY 18292; ARN 2966; CS3335; HY18292; ARN2966. Grade: > 98%. CAS No. 102212-26-0. Molecular formula: C12H12N2O. Mole weight: 200.24. | |
| (-)-Ascofuranone | (-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 38462-04-3. Pack Sizes: 250ug, 500ug. Molecular Formula: C23H29ClO5, Molecular Weight: 420.93. US Biological Life Sciences. | Worldwide |
| Bryostatin 1 | Bryostatin 1, a structurally unique macrolactone marine natural product, is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Bryostatin 1 fails to mimic many effects caused by PMA and actually blocks some PMA-induced response in a variety of cells and tissues. Animal tests have shown bryostatin 1 may alleviate brain damage after a stroke. Uses: Adjuvants, immunologic. Synonyms: Bryostatin-1; Bryostatin1; NSC-339555; NSC 339555; NSC339555; AC1L8WCW. Grade: ≥99%. CAS No. 83314-01-6. Molecular formula: C47H68O17. Mole weight: 905.04. | |
| Bryostatin 1 (NSC 339555, B705008K112, BRN 4349157) | Bryostatin 1 binds to and activates protein kinase C, but its biological effects differ greatly from those induced by other protein kinase C activators. Bryostatin 1 fails to mimic many effects caused by PMA and actually blocks some PMA-induced response in a variety of cells and tissues. Group: Biochemicals. Grades: Highly Purified. CAS No. 83314-01-6. Pack Sizes: 10ug, 25ug. US Biological Life Sciences. | Worldwide |
| C-178 | C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grade: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27. | |
| CID 2858522 (Selectively Inhibits PKC-induced NF-kB Activation, 1-[3,5-Bis(1,1-dimethylethyl)-4-hyd roxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dime thyl-1H-benzimidazol-1-yl]ethanone) | Selectively inhibits protein kinase C (PKC)-induced activation of the NF-kappaB pathway (IC50 < 0.1um for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-kappaB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-kappaB pathways, including that activated by tumor necrosis factor (TNF). Group: Biochemicals. Grades: Highly Purified. CAS No. 758679-97-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Daphnoretin | Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Hydroxy-6-methoxy-3-[(2-oxo-2H-1-benzopyran 7-yl)-oxy]-2H-1-benzopyran-2-one. Product Category: Inhibitors. Appearance: Powder. CAS No. 2034-69-7. Molecular formula: C19H12O6. Mole weight: 336.29. Purity: 0.98. IUPACName: 7-Hydroxy-6-methoxy-3-(2-oxochromen-7-yl)oxychromen-2-one. Canonical SMILES: COC1=C(C=C2C(=C1)C=C(C(=O)O2)OC3=CC4=C(C=C3)C=CC(=O)O4)O. Density: 1.501 g/ml. Product ID: ACM2034697. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Decynium 22 | Decynium 22 is a potent inhibitor of PMAT and has been found to exhibit activities in inducing apoptosis in cerebellar granule neurons (CGNs). Synonyms: 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide. Grade: ≥98% by HPLC. CAS No. 977-96-8. Molecular formula: C23H23IN2. Mole weight: 454.35. | |
| Decynium 22 (1-Ethyl-2-[(1-ethyl-2(1H)-quinoliny lidene) methyl]quinolinium iodide) | Inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10um). Group: Biochemicals. Grades: Highly Purified. CAS No. 977-96-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Hypothemycin | Hypothemycin, a resorcylic acid lactone antibiotic, was identified as active in a screen for inhibitors of T cell activation. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. This inhibition was partially reversed by exogenous IL-2 indicating that it is not due to non-specific toxicity. Hypothemycin potently suppressed the production of IL-2 (IC50: 9 nM) but affected IL-2-induced proliferation to a lesser extent (IC50: 194 nM). Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. By contrast, it markedly enhanced the production of IL-4, IL-5 and IL-13. These effects were seen both at the mRNA and protein secretion levels. Analysis of the effect of hypothemycin on CD69 induction suggested that it disrupts calcineurin-independent rather than calcineurin-dependent signaling. Furthermore, hypothemycin was able to inhibit the phosphorylation of ERK1/2 induced by PMA treatment of T cells. Therefore, hypothemycin represents an inhibitor of T cell activation with a novel mode of action and unique modulatory activity on cytokine production. Synonyms: Hypothemycin. CAS No. 76958-67-3. Molecular formula: C19H22O8. Mole weight: 378.38. | |
| Ikarugamycin | An unusual pentacyclic tetramic acid produced by streptomyces phaeochromogenes; potent activity against the protozoan, trichomonas vaginalis; demonstrates selective gram positive antibacterial activity, and anti-ulcer activity possibly via inhibition of H. Pylori; inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis; a useful agent for studying the process of endocytosis. Synonyms: 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. Grade: >99% by HPLC. CAS No. 36531-78-9. Molecular formula: C29H38N2O4. Mole weight: 478.62. | |
| Ikarugamycin | Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful. Group: Biochemicals. Grades: Highly Purified. CAS No. 36531-78-9. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Ionomycin (Free Acid) | Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+. Apoptosis inducer. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA. ADAM10 agonist. Potent inducer of shedding CXCL16. TREK-1 channels inhibitor. PPARy ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes. Group: Biochemicals. Alternative Names: SQ 23377; EM 94; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*, 10Z, 12S*, 14S*, 16E, 18S*, 19S*, 20R*, 21R*)]]-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[octahydro-5-(1-hydroxyethyl)-2, 5-dimethyl[2, 2-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic Acid; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*,. Grades: Highly Purified. CAS No. 56092-81-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Isoliquiritin apioside | Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 120926-46-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2497. | |
| Magnesium Bis(trifluoromethane Sulfone)imide | Magnesium Bis(trifluoromethane Sulfone)imide is a salt that is used in the synthesis of a polymeric gel electrolyte system. Coupled with poly(ethylene oxide)-modified polymethacrylate (PEO-PMA), the gel electrolyte exhibits great characteristics such as flexibility and mechanical strength. Group: Biochemicals. Grades: Highly Purified. CAS No. 133395-16-1. Pack Sizes: 250mg, 500mg. Molecular Formula: C4F12MgN2O8S4, Molecular Weight: 584.59. US Biological Life Sciences. | Worldwide |
| NF-kB Activation Inhibitor VIII, EVP4593 (SOC Inhibitor, Neuronal Store-Operated Calcium Entry Inhibitor, N4- (4-phenoxyphenethyl) quinazoline-4, 6-diamine, TRPC1 Inhibitor) | A cell-permeable quinazoline derivative that blocks PMA/PHA-induced NF-kB activation in Jurkat cells (IC50=11nM), but has no effect on PKC kinase, and exhibits an anti-inflammatory effect on carrageenin-induced paw edema in rats (1mg/kg, i.p.). In addition, it is shown to inhibit the store-operated calcium entry (SOC) pathway possibly by targeting TRPC1 containing heteromeric channels in Huntington Disease (HD) neurons (SK-N-SH cells transfected with mutant Huntingtin Htt-138Q) at 300nM. It displays neuroprotective effects in YAC128 MSN mice neurons from glutamate toxicity dose-dependently from 30nM to 3uM, which is consistent with TRPC1 knocown effects, and attenuates the progressive decline in the climbing speed of the HD Drosophila, dose-dependently from 100uM to 400uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator [1] [2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells [3] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: PMA; TPA; Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18739. | |
| PIP3 Antagonist II, DM-PIT-1, N- ( (2-Hydroxy-5-nitrophenyl) carbamothioyl) -3, 5-dimethylbenzamide, N- ( ( (2-Hydroxy-5-nitrophenyl) amino) thioxomethyl) -3, 5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI) | A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 for binding PH domains of Akt1 (IC50 >31uM), ARNO, GRP1, and P1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100uM for 3d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1h 100uM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-delta and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1mg/kg micelles-formulated or 0.4mg/kg free drug daily i.v., respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 701947-53-7. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 345.4. US Biological Life Sciences. | Worldwide |
| PNU-120596 | PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC 50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 216666. CAS No. 501925-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12152. | |
| Poly(methyl acrylate) solution | The polymer product is a hydrophobic material that is insoluble in water or other polar solvents. Uses: Pma/methylamine borane (meab) composites, prepared by solution blending process finds uses as a hydrogen storage material with better dehydrogenation property compared to meab. Group: Hydrophobic polymers. Alternative Names: Methyl acrylate homopolymer, Acrylic acid methyl ester polymer. CAS No. 9003-21-8. Pack Sizes: 50, 100 g in glass bottle. Molecular formula: average Mw ~40,000 by GPC. Mole weight: (C4H6O2)n. COC(=O)C=C. | |
| Poly(methyl methacrylate) | PMMA is a transparent plastic that offers incredible strength and stiffness and can be optically clear. This transparency makes it easy for advanced vision systems or employees performing physical visual inspections to analyze and monitor food product quality throughout transportation. Uses: Pmma is often used to store milk and other dairy products, oils, and feed for animals. acrylic is also used to create mixing bowls, where transparency can aid mixing and other cooking process applications. pmma is bpa-free and non-toxic when solid, and its so biocompatible that acrylic is frequently used in dentures and cavity fillings. Group: 3d printing materials bioelectronic materials hydrophobic polymersself assembly and lithographyorganic field effect transistor (ofet) materials polymersfood grade plastic. Alternative Names: Poly(methyl methacrylate), Methyl methacrylate resin, Perspex. CAS No. 9011-14-7. Pack Sizes: 25 g in poly bottle. Product ID: Poly(methyl 2-methylpropenoate). Molecular formula: average Mw ~350000 by GPC. Mole weight: [CH2C(CH3)(CO2CH3)]n. 1S/C5H9O2/c1-4(2)5(6)7-3/h1-3H3. PMAMJWJDBDSDHV-UHFFFAOYSA-N. | |
| Propidium monoazide | Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR [1]. Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Fluorescent dye. CAS No. 91416-20-5. Pack Sizes: 1 mg. Product ID: HY-D1444. | |
| RSK2 Inhibitor, RMM-46 ((E)-2-Cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide, RMM46, RSK Inhibitor IV) | A cell-permeable cyanoacrylamide compound that acts as a potent, reversible, and selective inhibitor of ribosomal S6 kinase 2 (RSK2; IC50 = 12 and 2.5nM for wild-type and T493M RSK2, respectively). Shown to act by covalently modifying Cys436 at the ATP-binding site. Exhibits good selectivity over NEK2 and PLK1 (IC50 = 530nM and 2.2uM) and does not affect the activity of a panel of 26 other protein kinases. Also shown to block phosphorylation of mitogen and stress activated kinases (MSK) 1, 2, and 3 in PMA-stimulated COS7 cells (IC50 ~100nM) and CREB phosphorylation in PMA- or UV-stimulated HeLa cells (IC50 ~300nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| S6K1 Inhibitor, PF-4708671 ((2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole, p70 Ribosomal S6 Kinase 1 Inhibitor) | A cell-permeable piperazinyl-pyrimidine compound that acts as an inhibitor against S6K1 (Ki=20nM; IC50=160nM) and MSK1 (IC50=950nM) kinase activity, exhibiting little or much reduced potency against 85 other protein and lipid kinases ( IC50=4.7, 9.2, 65uM, respectively, against RSK1, RSK2, and S6K2; <27% inhibition of the rest at 1uM). Shown to selectively inhibit IGF1- and PMA-stimulated S6K1 substrates phosphorylation in HEK-293 cells in a dose-dependent manner (up to 10uM) in vitro and alleviate heart remodeling and functional damage in a MI (myocardial infarction) model in mice in vivo (75/mg/kg/daily i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?, Molecular Weight: 390.4. US Biological Life Sciences. | Worldwide |
| Staurosporin | Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurospores and is a super-potent, cell permeable PKC inhibitor (IC50=0.7); at higher concentrations Staurosporine inhibits other protein kinases: CDK2/cyclin A (IC50=7uM) and CDK4/cyclin D (IC50=3-10uM). At a concentration of 50-100nM it is a functional neurotrophins agonist promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. Staurosporine inhibits a variety of kinases including PKA, PKG, MLCK, CaMK, tyrosine kinases, and phosphorylase kinase. This compound displays selectivity toward the PKC isoforms, inhibiting PKCα, PKC β, PKCγ, PKCδ, and PKCε, but not PKC?, and induces PKC translocation. Staurosporine also inhibits topoisomerase II directly by interaction with the ATP binding site, augments PMA-induced ornithine decarboxylase, and activates a bcl-2-regulated apoptosis pathway. Source:Streptomyces staurosporeus. Group: Biochemicals. Alternative Names: Antibiotic AM2282; Antibiotic 230; CCRIS 3272. Grades: Highly Purified. CAS No. 62996-74-1. Pack Sizes: 100ug, 1mg, 5mg, 10mg. Molecular Formula: C28H26N4O3, Molecular Weight: 466.53. US Biological Life Sciences. | Worldwide |
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