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| Product | Description | |
|---|---|---|
| Pomalidomide | Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma. Group: Biochemicals. Alternative Names: 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; Actimid; CC 4047; IMiD 3. Grades: Highly Purified. CAS No. 19171-19-8. Pack Sizes: 500mg, 1g, 5g. Molecular Formula: C??H??N?O?, Molecular Weight: 273.24. US Biological Life Sciences. |  Worldwide |
| Pomalidomide | Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-4047. CAS No. 19171-19-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-10984. |  |
| Pomalidomide 4'-alkylC4-acid | Pomalidomide 4'-alkylC4-acid (linker16) is a E3 Ligase Ligand-Linker Conjugate. Pomalidomide 4'-alkylC4-acid can be used for conjugation to a target protein ligand [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225940-48-5. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-131886. | |
| Pomalidomide 4'-alkylC5-acid | Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225940-49-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-130737. | |
| Pomalidomide 4'-PEG3-azide | Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach [1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271036-46-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130652. | |
| Pomalidomide-amino-PEG4-NH2 hydrochloride | Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2331259-45-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-138859A. | |
| Pomalidomide-C2-NH2 | Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. Synonyms: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride. Grade: > 98%. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.31. |  |
| Pomalidomide-C2-NH2 hydrochloride | Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 15 hydrochloride. CAS No. 2305369-00-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-128846A. | |
| Pomalidomide-C3-adavosertib | Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2414418-49-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-133618. | |
| Pomalidomide-C4-NH2 | Pomalidomide-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate that incorporates Pomalidomide-based CRBN ligands and linkers used in PROTAC technology. Synonyms: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2. Grade: ≥95%. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.37. | |
| Pomalidomide-[d4] | Pomalidomide-[d4] is the labelled analogue of Pomalidomide, which inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Synonyms: Pomalidomide D4; 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione-d4. Grade: 95% by HPLC; 95% atom D. CAS No. 1416575-78-4. Molecular formula: C13H7D4N3O4. Mole weight: 277.27. | |
| Pomalidomide-d5 | Pomalidomide-d5 is a deuterated form of Pomalidomide. Pomalidomide is a third-generation immunomodulatory agent that functions as a molecular glue. It interacts with E3 ligase cereblon and induces the degradation of the essential Ikaros transcription factor. Synonyms: Pomalidomide D5. Grade: 95% by HPLC; 95% atom D. CAS No. 1377838-49-7. Molecular formula: C13H6D5N3O4. Mole weight: 278.27. | |
| Pomalidomide Impurity 20 | Pomalidomide Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1001852-10-3. Molecular formula: C13H11N3O7. Mole weight: 321.25. Catalog: APB1001852103. |  |
| Pomalidomide-PEG1-C2-NH2 | Pomalidomide-PEG1-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG1-NH2; 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-. Grade: ≥95%. CAS No. 2138439-12-8. Molecular formula: C17H20N4O5. Mole weight: 360.36. | |
| Pomalidomide-PEG2-azide | Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology [1]. Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267306-14-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-137537. | |
| Pomalidomide-PEG2-C2-NH2 | Pomalidomide-PEG2-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG2-NH2; 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-({2-[2-(2-Aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-; 4-({2-[2-(2-aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; Thalidomide-NH-PEG2-C2-NH2. Grade: ≥95%. CAS No. 2093416-32-9. Molecular formula: C19H24N4O6. Mole weight: 404.42. | |
| Pomalidomide-PEG3-azide | Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology [1]. Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267306-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-137538. | |
| Pomalidomide-PEG3-C2-NH2 TFA | Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA. CAS No. 2414913-97-4. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g; 2 g. Product ID: HY-128716A. | |
| Pomalidomide-PEG4-azide | Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271036-47-4. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-141015. | |
| Pomalidomide-PEG4-C2-NH2 hydrochloride | Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs. Uses: Scientific research. Group: Signaling pathways. CAS No. 2357105-92-9. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-112599B. | |
| N-Methylated pomalidomide | N-Methylated pomalidomide is an E3 ligase ligand used as a negative control of pomalidomide for PROTAC technology. Synonyms: 4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione. Grade: ≥98%. CAS No. 1352827-50-9. Molecular formula: C14H13N3O4. Mole weight: 287.27. | |
| (±)-Pomalidomide-[d3] (phthalimide-[4,5,6-d3]) | One of the isotopic labelled form of (±)-Pomalidomide, which is a potent TNF-α production inhibitor and could probably used as an antitumor agent. Synonyms: 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione-5,6,7-d3; CC-4047-d3. Grade: 95% by HPLC; 98% atom D. CAS No. 2093128-28-8. Molecular formula: C13H8D3N3O4. Mole weight: 276.27. | |
| (R)-Pomalidomide | The R isometric form of Pomalidomide which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: (R)-pomalidomide; Pomalidomide, (R)-; 202271-90-7; Pomalidomide, (+)-; X9549G9WCL; 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione; (r)-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3R)-2,6-dioxo-3-piperidinyl)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, (R)-; 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3R)-2,6-dioxo-3-piperidinyl)-, (+)-; UNII-X9549G9WCL; SCHEMBL931134; CHEMBL1788309; Q27293711; DUI. Grade: > 95%. CAS No. 202271-90-7. Molecular formula: C13H11N3O4. Mole weight: 273.25. | |
| (S)-Pomalidomide | The S isometric form of Pomalidomide which inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Synonyms: (S)-pomalidomide; 202271-89-4; S-Pomalidomide; Pomalidomide, (S)-; Pomalidomide, (-)-; 2EE4M42K6G; (S)-CC-4047; 4-AMINO-2-[(3S)-2,6-DIOXOPIPERIDIN-3-YL]ISOINDOLE-1,3-DIONE; (S)-4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione; (s)-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3S)-2,6-dioxo-3-piperidinyl)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, (S)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3S)-2,6-dioxo-3-piperidinyl)-, (-)-; Y70; 4ci3; UNII-2EE4M42K6G; SCHEMBL563317; CHEMBL2093113; PD132344; Q27254625; 4-amino-2-[(3S)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione. Grade: > 95%. CAS No. 202271-89-4. Molecular formula: C13H11N3O4. Mole weight: 273.25. | |
| 10-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]decanoic acid | 10-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]decanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C9-COOH. Product Category: PROTAC Library. CAS No. 2243000-24-8. Molecular formula: C23H29N3O6. Mole weight: 443.4929. IUPACName: 10-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]decanoic acid. Product ID: PR2243000248. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione | 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of N-[2-Aminoethyl] Pomalidomide TFA Salt (A6095150. N-[2-Aminoethyl] Pomalidomide TFA is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an anti-inflammatory and anti-tumor agent used in the treatment of multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 835616-60-9. Pack Sizes: 500mg, 1g. Molecular Formula: C13H9FN2O4. US Biological Life Sciences. | Worldwide |
| 2-(2,6-dioxopiperidin-3-yl)-4-[(4-hydroxybutyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-4-[(4-hydroxybutyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C4-OH. Product Category: PROTAC Library. CAS No. 2368940-93-4. Molecular formula: C17H19N3O5. Mole weight: 345.3499. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-4-(4-hydroxybutylamino)isoindole-1,3-dione. Product ID: PR2368940934. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione. Uses: Designed for use in research and industrial production. Product Category: PROTAC Library. CAS No. 2154342-57-9. Molecular formula: C17H18N4O4. Mole weight: 342.3492. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-4-piperazin-1-ylisoindole-1,3-dione. Product ID: PR2154342579. Alfa Chemistry ISO 9001:2015 Certified. Categories: Pomalidomide-piperazine HCl. | |
| 2-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide | 2-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-PEG1-NH2. Product Category: PROTAC Library. CAS No. 2380273-66-3. Molecular formula: C17H18N4O6. Mole weight: 374.348. IUPACName: 2-(2-aminoethoxy)-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide. Product ID: PR2380273663. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid | 3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-PEG3-CO2H; Thalidomide-NH-PEG3-propionic acid. Product Category: PROTAC Library. CAS No. 2138440-82-9. Molecular formula: C22H27N3O9. Mole weight: 477.4645. IUPACName: 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid. Product ID: PR2138440829. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]propanoic acid | 3-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]propanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C2-acid. Product Category: PROTAC Library. CAS No. 2225940-46-3. Molecular formula: C16H15N3O6. Mole weight: 345.3068. Purity: 0.99. IUPACName: 3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propanoic acid. Product ID: PR2225940463. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-(2-Aminoethoxy) Thalidomide SF-1-088 Amide | 3-(2-Aminoethoxy) Thalidomide SF-1-088 Amide is a derivative of Pomalidomide, which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: 2-Methyl-2-propanyl {2-[(4-cyclohexylbenzyl){4-[(2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}ethyl)carbamoyl]-3-hydroxyphenyl}amino]-2-oxoethyl}[(4-methylphenyl)sulfonyl]carbamate; Carbamic acid, N-[2-[[(4-cyclohexylphenyl)methyl][4-[[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethyl]amino]carbonyl]-3-hydroxyphenyl]amino]-2-oxoethyl]-N-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester. Molecular formula: C49H53N5O12S. Mole weight: 936.03. | |
| 3-[4-(Aminomethyl)benzyloxy] Thalidomide | 3-[4-(Aminomethyl)benzyloxy] Thalidomide is a derivative of Pomalidomide, which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: 4-[[4-(aminomethyl)phenyl]methoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; 4-{[4-(Aminomethyl)benzyl]oxy}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[4-(aminomethyl)phenyl]methoxy]-2-(2,6-dioxo-3-piperidinyl)-. Molecular formula: C21H19N3O5. Mole weight: 393.39. | |
| 3-Nitrophthalic acid | An impurity of Pomalidomide which is a derivative of thalidomide with antineoplastic effect. Synonyms: 3-nitrophthalic acid. Grade: 99 %. CAS No. 603-11-2. Molecular formula: C8H5NO6. Mole weight: 211.13. | |
| 4-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]butanoic acid | 4-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]butanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide 4'-alkylC3-acid. Product Category: PROTAC Library. CAS No. 2225940-47-4. Molecular formula: C17H17N3O6. Mole weight: 359.3334. IUPACName: 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid. Product ID: PR2225940474. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C2-NH2. Product Category: PROTAC Library. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.3119. Purity: >98%. IUPACName: 4-(2-aminoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Product ID: PR1957235663. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-[(4-aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(4-aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C4-NH2. Product Category: PROTAC Library. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.3651. Purity: 0.99. IUPACName: 4-(4-aminobutylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Product ID: PR1957236348. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-[(7-aminoheptyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | 4-[(7-aminoheptyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C7-NH2 hydrochloride. Product Category: PROTAC Library. CAS No. 2093387-55-2. Molecular formula: C20H26N4O4. Mole weight: 386.4448. IUPACName: 4-(7-aminoheptylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride. Product ID: PR2093387552. Alfa Chemistry ISO 9001:2015 Certified. | |
| 5-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]pentanoic acid | 5-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]pentanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C4-COOH; Pomalidomide 4'-alkylC4-acid. Product Category: PROTAC Library. CAS No. 2225940-48-5. Molecular formula: C18H19N3O6. Mole weight: 373.36. Purity: 0.95. IUPACName: 5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentanoic acid. Product ID: PR2225940485. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]hexanoic acid | 6-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]hexanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C5-COOH. Product Category: PROTAC Library. CAS No. 2225940-49-6. Molecular formula: C19H21N3O6. Mole weight: 387.3865. IUPACName: 6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexanoic acid. Product ID: PR2225940496. Alfa Chemistry ISO 9001:2015 Certified. | |
| 7-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]heptanoic acid | 7-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]heptanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C6-COOH; Pomalidomide 4'-alkylC6-acid. Product Category: PROTAC Library. CAS No. 2225940-50-9. Molecular formula: C20H23N3O6. Mole weight: 401.4131. Purity: >96%. IUPACName: 7-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]heptanoic acid. Product ID: PR2225940509. Alfa Chemistry ISO 9001:2015 Certified. | |
| 8-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]octanoic acid | 8-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]octanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C7-COOH. Product Category: PROTAC Library. CAS No. 2225940-51-0. Molecular formula: C21H25N3O6. Mole weight: 415.4397. IUPACName: 8-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]octanoic acid. Product ID: PR2225940510. Alfa Chemistry ISO 9001:2015 Certified. | |
| CC-12074 | A Metabolite of Pomalidomide. Uses: Pomalidomide metabolite. Synonyms: CC-12074; CC12074; CC 12074; Pomalidomide metabolite M19; UNII-A480CC1Z8I; SCHEMBL3742152.4-amino-2-(5-hydroxy-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Grade: ≥98%. CAS No. 460741-57-5. Molecular formula: C13H11N3O5. Mole weight: 289.24. | |
| CC-17368 | CC-17368 is a hydroxyisoindole derivative and metabolite of pomalidomide that has potential activity in anticancer study like multiple myeloma. Synonyms: CC 17368; CC17368; Pomalidomide metabolite M17; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-. Grade: 98%. CAS No. 1547162-41-3. Molecular formula: C13H11N3O5. Mole weight: 289.25. | |
| CC-17369 | CC-17369, a hydroxyisoindole derivative, is a metabolites of pomalidomide and has potential activity in anticancer study like multiple myeloma. Synonyms: CC-17369; CC 17369; CC17369; Pomalidomide metabolite M16; M16(CC-17369); SCHEMBL15439588; 4-amino-2-(2,6-dioxopiperidin-3-yl)-7-hydroxyisoindole-1,3-dione. Grade: 98%. CAS No. 1547162-46-8. Molecular formula: C13H11N3O5. Mole weight: 289.25. | |
| E3 ligase Ligand-Linker Conjugates 30 | E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grade: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47. | |
| FC-11 | FC-11 is a PROTAC FAK degrader ( DC 90 : 1 nM). FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271035-37-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139344. | |
| FOSL1 degrader 1 | FOSL1 degrader 1 (4) is a T-5224-PROTAC, potently degrade FOSL1 (AP-1) to suppress cancer stemness gene expression in HNSCC. FOSL1 degrader 1 (4) effectively eliminate HNSCC cancer stem cells to inhibit tumor growth through degrading FOSL1. FOSL1 degrader 1 (4) displays around 30- to 100-fold increased potency over T-5224 (Pink: T-5224 (HY-12270); Black: Linker (HY-130200); Blue: Pomalidomide (HY-10984))[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162723. | |
| HDAC6 degrader-1 | HDAC6 degrader-1 (Compound NP8) is the PROTAC degrader for HDAC6 with a DC50 of 3.8 nM in cell MM.1S[1].(Blue: ligand for E3 ligase Pomalidomide (HY-10984); Black: linker (HY-140213); Pink: ligand for target protein Nexturastat A (HY-16699)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2439058-23-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-132998. | |
| PROTAC Bcl2 degrader-1 | PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 ?M; DC50, 3.0 ?M) and Mcl-1 (IC50, 11.81 ?M) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1] (Blue: CRBN ligand, Black: linker?Pink: Mcl-1/Bcl-2 inhibitor, Nap-1). Uses: Scientific research. Group: Signaling pathways. CAS No. 2378801-85-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-125876. | |
| PROTAC BRAF-V600E degrader-1 | PROTAC BRAF-V600E degrader-1 (compound 23) is a potent PROTAC BRAF-V600E degrader whlie no degradation activity against BRAF-WT. PROTAC BRAF-V600E degrader-1 exhibits Kd values of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS) and inhibits the growth of melanoma cells[1]. (In the molecular structure, target protein ligand: BI-882370 (HY-107779), red part; E3 ubiquitin enzyme ligand: Pomalidomide (HY-10984), blue part; PROTAC linker: G007-LK (HY-12438), black part. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417296-84-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-137487. | |
| QC-01-175 | QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267290-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134850. | |
| (s)-6-amino-5-(4-amino-1,3-dioxoisoindolin-2-yl)-6-oxohexanoic acid | (s)-6-amino-5-(4-amino-1,3-dioxoisoindolin-2-yl)-6-oxohexanoic acid is an impurity of Pomalidomide, a thalidomide derivative with antitumor effects. CAS No. 918314-44-0. Molecular formula: C14H15N3O5. Mole weight: 305.29. | |
| SJ988497 | SJ988497 is a PROTAC JAK2 degrader. SJ988497 potently inhibits CRLF2-rearranged (CRLF2r) cell proliferation and degrades the CRBN neosubstrate GSPT1. SJ988497 consists of a Ruxolitinib (HY-50856) derivative, linker, and CRBN ligand Pomalidomide. SJ988497 can be used in the research of acute lymphoblastic leukemia (ALL)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2595365-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151902. | |
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