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Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma. Group: Biochemicals. Alternative Names: 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; Actimid; CC 4047; IMiD 3. Grades: Highly Purified. CAS No. 19171-19-8. Pack Sizes: 500mg, 1g, 5g. Molecular Formula: C??H??N?O?, Molecular Weight: 273.24. US Biological Life Sciences.
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Pomalidomide
Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-4047. CAS No. 19171-19-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-10984.
Pomalidomide
Promotes degradation of transcription factors SALL4, IKZF1 and IKZF3. Synonyms: CC4047; CC 4047; CC-4047; Pomalidomide. Brand name: Pomalyst. Grades: ≥99% (HPLC). CAS No. 19171-19-8. Molecular formula: C13H11N3O4. Mole weight: 273.24.
Pomalidomide 4'-alkylC4-acid
Pomalidomide 4'-alkylC4-acid (linker16) is a E3 Ligase Ligand-Linker Conjugate. Pomalidomide 4'-alkylC4-acid can be used for conjugation to a target protein ligand [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225940-48-5. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-131886.
Pomalidomide 4'-alkylC5-acid
Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225940-49-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-130737.
Pomalidomide 4'-PEG3-azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach [1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271036-46-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130652.
Pomalidomide-amino-PEG4-NH2 hydrochloride
Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2331259-45-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-138859A.
Pomalidomide-C2-NH2
Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. Synonyms: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride. Grades: > 98%. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.31.
Pomalidomide-C2-NH2 hydrochloride
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 15 hydrochloride. CAS No. 2305369-00-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-128846A.
Pomalidomide-C4-NH2
Pomalidomide-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate that incorporates Pomalidomide-based CRBN ligands and linkers used in PROTAC technology. Synonyms: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2. Grades: ≥95%. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.37.
Pomalidomide Impurity 1
An impurity of Pomalidomide which inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Grades: > 95%. Molecular formula: C16H10N2O6. Mole weight: 326.27.
Pomalidomide Impurity 1
Pomalidomide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 5054-59-1. Molecular Formula: C13H10N2O5. Mole Weight: 274.23. Catalog: APB5054591.
Pomalidomide Impurity 10
An impurity of Pomalidomide which inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Grades: > 95%. Molecular formula: C10H16N2O4. Mole weight: 228.25.
Pomalidomide Impurity 20
Pomalidomide Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1001852-10-3. Molecular Formula: C13H11N3O7. Mole Weight: 321.25. Catalog: APB1001852103.
Pomalidomide Impurity 27
Pomalidomide Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 610-27-5. Molecular Formula: C8H5NO6. Mole Weight: 211.13. Catalog: APB610275.
Pomalidomide Impurity 3
An impurity of Pomalidomide which is a second generation immunomodulator and antineoplastic agent. Synonyms: Isoasparagine; 498-25-9; 3,4-Diamino-4-oxobutanoic acid; DL-Isoasparagine; DL-alpha-Asparagine; H-Asp-NH; H-Isoasn-OH; L-Isoasparagine; H-D-Isoasn-OH; D-Isoasparagine; 3,4-Diamino-4-oxobutyric acid; 3-amino-3-carbamoylpropanoic acid; alpha-asparagine; aspartic 1-amide; H-D-Asp-NH; 3-aminosuccinamic acid; 3,4-Diamino-4-oxobutanoic acid #; NSC528893; Aminobernsteinsaureamid; DL-aspartic 1-amide; aspartic acid 1-amide; NoName_589; Succinamic acid, 3-amino-; SCHEMBL1072994; SCHEMBL11049326; 3-amino-3-carbamoylpropanoicacid; CHEBI:49010; DTXSID90901471; PMLJIHNCYNOQEQ-UHFFFAOYSA-N; Butanoic acid, 3,4-diamino-4-oxo-; AKOS014226960; NSC 528893; NSC-528893; FT-0638751; FT-0697947; EN300-182732; Q27121435. Grades: > 95%. CAS No. 498-25-9. Molecular formula: C5H10N2O3. Mole weight: 146.15.
Pomalidomide Impurity 3
Pomalidomide Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2635-64-5. Molecular Formula: C13H13N3O5. Mole Weight: 291.26. Catalog: APB2635645.
Pomalidomide Impurity 4
An impurity of Pomalidomide which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: DL-GLUTAMINE. Grades: > 95%. CAS No. 585-21-7. Molecular formula: C5H10N2O3. Mole weight: 146.15.
Pomalidomide Impurity 4
Pomalidomide Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 918314-45-1. Molecular Formula: C13H13N3O5. Mole Weight: 291.26. Catalog: APB918314451.
Pomalidomide Impurity 5
An impurity of Pomalidomide which inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Synonyms: 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione; 4-Nitrothalidomide; 3-Nitrothalidomide; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-nitro-; 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindole-1,3-dione; Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-nitro-; OH13HKS17A; CHEMBL370441; C13H9N3O6; MFCD01748356; 2-(2,6-Dioxo-3-piperidinyl)-4-nitro-1H-isoindole-1,3(2H)-dione; 2-(2,6-dioxopiperidin-3-yl)-4-nitro-1H-isoindole-1,3(2H)-dione; N-(2,6-Dioxo-3-piperidyl)-3-nitrophthalimide; Nitrothalidomide; 3-(1',3'-Dioxo-4'-nitroisoindolinyl-2')-2,6-dioxopiperidine. Grades: > 95%. CAS No. 19171-18-7. Molecular formula: C13H9N3O6. Mole weight: 303.23.
Pomalidomide Impurity 6
An impurity of Pomalidomide which a derivative of thalidomide with antineoplastic effect. Grades: > 95%. Molecular formula: C21H14N4O6. Mole weight: 418.37.
Pomalidomide Impurity 7
An impurity of Pomalidomide which is a second generation immunomodulator and antineoplastic agent. Synonyms: Hydrolyzed Pomalidomide M10; 4-Amino-γ-(aminocarbonyl)-1,3-dihydro-1,3-dioxo-2H-isoindole-2-butanoic Acid. Grades: > 95%. CAS No. 918314-45-1. Molecular formula: C13H13N3O5. Mole weight: 291.27.
Pomalidomide Impurity 8
Pomalidomide Impurity 8 is an impurity of pomalidomide, which is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma. Synonyms: CC-8017; CC 8017; CC8017; 2-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid. Grades: >98%. CAS No. 2635-64-5. Molecular formula: C13H13N3O5. Mole weight: 291.26.
Pomalidomide Impurity 9
An impurity of Pomalidomide which a derivative of thalidomide with antineoplastic effect. Grades: > 95%. Molecular formula: C10H18N2O5. Mole weight: 246.27.
Pomalidomide-PEG1-C2-NH2
Pomalidomide-PEG1-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG1-NH2; 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-. Grades: ≥95%. CAS No. 2138439-12-8. Molecular formula: C17H20N4O5. Mole weight: 360.36.
Pomalidomide-PEG2-azide
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology [1]. Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267306-14-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-137537.
Pomalidomide-PEG2-C2-NH2
Pomalidomide-PEG2-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG2-NH2; 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-({2-[2-(2-Aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-; 4-({2-[2-(2-aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; Thalidomide-NH-PEG2-C2-NH2. Grades: ≥95%. CAS No. 2093416-32-9. Molecular formula: C19H24N4O6. Mole weight: 404.42.
Pomalidomide-PEG3-azide
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology [1]. Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267306-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-137538.
Pomalidomide-PEG3-C2-NH2 hydrochloride
Pomalidomide-PEG3-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate containing a cereblon ligand based on Pomalidomide and a PEG linker of 3 O(CH2)2 units with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride. CAS No. 2446474-09-3. Molecular formula: C21H29ClN4O7. Mole weight: 484.93.
Pomalidomide-PEG3-C2-NH2 TFA
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA. CAS No. 2414913-97-4. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g; 2 g. Product ID: HY-128716A.
Pomalidomide-PEG4-azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271036-47-4. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-141015.
Pomalidomide-PEG4-C2-NH2 hydrochloride
Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs. Uses: Scientific research. Group: Signaling pathways. CAS No. 2357105-92-9. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-112599B.
Pomalidomide-PEG5-CO2H
Pomalidomide-PEG5-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid. Grades: ≥98%. CAS No. 2139348-63-1. Molecular formula: C26H35N3O11. Mole weight: 565.57.
(R)-Pomalidomide
The R isometric form of Pomalidomide which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: (R)-pomalidomide; Pomalidomide, (R)-; 202271-90-7; Pomalidomide, (+)-; X9549G9WCL; 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione; (r)-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3R)-2,6-dioxo-3-piperidinyl)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, (R)-; 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3R)-2,6-dioxo-3-piperidinyl)-, (+)-; UNII-X9549G9WCL; SCHEMBL931134; CHEMBL1788309; Q27293711; DUI. Grades: > 95%. CAS No. 202271-90-7. Molecular formula: C13H11N3O4. Mole weight: 273.25.
(S)-Pomalidomide
The S isometric form of Pomalidomide which inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Synonyms: (S)-pomalidomide; 202271-89-4; S-Pomalidomide; Pomalidomide, (S)-; Pomalidomide, (-)-; 2EE4M42K6G; (S)-CC-4047; 4-AMINO-2-[(3S)-2,6-DIOXOPIPERIDIN-3-YL]ISOINDOLE-1,3-DIONE; (S)-4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione; (s)-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3S)-2,6-dioxo-3-piperidinyl)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, (S)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3S)-2,6-dioxo-3-piperidinyl)-, (-)-; Y70; 4ci3; UNII-2EE4M42K6G; SCHEMBL563317; CHEMBL2093113; PD132344; Q27254625; 4-amino-2-[(3S)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione. Grades: > 95%. CAS No. 202271-89-4. Molecular formula: C13H11N3O4. Mole weight: 273.25.
10-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]decanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C9-COOH. Product Category: PROTAC Library. CAS No. 2243000-24-8. Molecular formula: C23H29N3O6. Mole weight: 443.4929. IUPACName: 10-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]decanoic acid. Product ID: PR2243000248. Alfa Chemistry ISO 9001:2015 Certified.
2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of N-[2-Aminoethyl] Pomalidomide TFA Salt (A6095150. N-[2-Aminoethyl] Pomalidomide TFA is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an anti-inflammatory and anti-tumor agent used in the treatment of multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 835616-60-9. Pack Sizes: 500mg, 1g. Molecular Formula: C13H9FN2O4. US Biological Life Sciences.
2-(2,6-dioxopiperidin-3-yl)-4-[(4-hydroxybutyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C4-OH. Product Category: PROTAC Library. CAS No. 2368940-93-4. Molecular formula: C17H19N3O5. Mole weight: 345.3499. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-4-(4-hydroxybutylamino)isoindole-1,3-dione. Product ID: PR2368940934. Alfa Chemistry ISO 9001:2015 Certified.
2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione. Uses: Designed for use in research and industrial production. Product Category: PROTAC Library. CAS No. 2154342-57-9. Molecular formula: C17H18N4O4. Mole weight: 342.3492. IUPACName: 2-(2,6-dioxopiperidin-3-yl)-4-piperazin-1-ylisoindole-1,3-dione. Product ID: PR2154342579. Alfa Chemistry ISO 9001:2015 Certified. Categories: Pomalidomide-piperazine HCl.
2-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-PEG1-NH2. Product Category: PROTAC Library. CAS No. 2380273-66-3. Molecular formula: C17H18N4O6. Mole weight: 374.348. IUPACName: 2-(2-aminoethoxy)-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide. Product ID: PR2380273663. Alfa Chemistry ISO 9001:2015 Certified.
3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-PEG3-CO2H; Thalidomide-NH-PEG3-propionic acid. Product Category: PROTAC Library. CAS No. 2138440-82-9. Molecular formula: C22H27N3O9. Mole weight: 477.4645. IUPACName: 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid. Product ID: PR2138440829. Alfa Chemistry ISO 9001:2015 Certified.
3-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]propanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C2-acid. Product Category: PROTAC Library. CAS No. 2225940-46-3. Molecular formula: C16H15N3O6. Mole weight: 345.3068. Purity: 0.99. IUPACName: 3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propanoic acid. Product ID: PR2225940463. Alfa Chemistry ISO 9001:2015 Certified.
3-(2-Aminoethoxy) Thalidomide SF-1-088 Amide
3-(2-Aminoethoxy) Thalidomide SF-1-088 Amide is a derivative of Pomalidomide, which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: 2-Methyl-2-propanyl {2-[(4-cyclohexylbenzyl){4-[(2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}ethyl)carbamoyl]-3-hydroxyphenyl}amino]-2-oxoethyl}[(4-methylphenyl)sulfonyl]carbamate; Carbamic acid, N-[2-[[(4-cyclohexylphenyl)methyl][4-[[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethyl]amino]carbonyl]-3-hydroxyphenyl]amino]-2-oxoethyl]-N-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester. Molecular formula: C49H53N5O12S. Mole weight: 936.03.
3-[4-(Aminomethyl)benzyloxy] Thalidomide
3-[4-(Aminomethyl)benzyloxy] Thalidomide is a derivative of Pomalidomide, which is an immunomodulatory antineoplastic agent for the treatment of multiple myeloma. Synonyms: 4-[[4-(aminomethyl)phenyl]methoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; 4-{[4-(Aminomethyl)benzyl]oxy}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[4-(aminomethyl)phenyl]methoxy]-2-(2,6-dioxo-3-piperidinyl)-. Molecular formula: C21H19N3O5. Mole weight: 393.39.
3-Nitrophthalic acid
An impurity of Pomalidomide which is a derivative of thalidomide with antineoplastic effect. Synonyms: 3-nitrophthalic acid. Grades: 99 %. CAS No. 603-11-2. Molecular formula: C8H5NO6. Mole weight: 211.13.
4-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]butanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide 4'-alkylC3-acid. Product Category: PROTAC Library. CAS No. 2225940-47-4. Molecular formula: C17H17N3O6. Mole weight: 359.3334. IUPACName: 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid. Product ID: PR2225940474. Alfa Chemistry ISO 9001:2015 Certified.
4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C2-NH2. Product Category: PROTAC Library. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.3119. Purity: >98%. IUPACName: 4-(2-aminoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Product ID: PR1957235663. Alfa Chemistry ISO 9001:2015 Certified.
4-[(4-aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C4-NH2. Product Category: PROTAC Library. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.3651. Purity: 0.99. IUPACName: 4-(4-aminobutylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Product ID: PR1957236348. Alfa Chemistry ISO 9001:2015 Certified.
4-[(7-aminoheptyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C7-NH2 hydrochloride. Product Category: PROTAC Library. CAS No. 2093387-55-2. Molecular formula: C20H26N4O4. Mole weight: 386.4448. IUPACName: 4-(7-aminoheptylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride. Product ID: PR2093387552. Alfa Chemistry ISO 9001:2015 Certified.
5-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]pentanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C4-COOH; Pomalidomide 4'-alkylC4-acid. Product Category: PROTAC Library. CAS No. 2225940-48-5. Molecular formula: C18H19N3O6. Mole weight: 373.36. Purity: 0.95. IUPACName: 5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentanoic acid. Product ID: PR2225940485. Alfa Chemistry ISO 9001:2015 Certified.
6-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]hexanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C5-COOH. Product Category: PROTAC Library. CAS No. 2225940-49-6. Molecular formula: C19H21N3O6. Mole weight: 387.3865. IUPACName: 6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexanoic acid. Product ID: PR2225940496. Alfa Chemistry ISO 9001:2015 Certified.
7-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]heptanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C6-COOH; Pomalidomide 4'-alkylC6-acid. Product Category: PROTAC Library. CAS No. 2225940-50-9. Molecular formula: C20H23N3O6. Mole weight: 401.4131. Purity: >96%. IUPACName: 7-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]heptanoic acid. Product ID: PR2225940509. Alfa Chemistry ISO 9001:2015 Certified.
8-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]octanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pomalidomide-C7-COOH. Product Category: PROTAC Library. CAS No. 2225940-51-0. Molecular formula: C21H25N3O6. Mole weight: 415.4397. IUPACName: 8-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]octanoic acid. Product ID: PR2225940510. Alfa Chemistry ISO 9001:2015 Certified.
CC-12074
A Metabolite of Pomalidomide. Uses: Pomalidomide metabolite. Synonyms: CC-12074; CC12074; CC 12074; Pomalidomide metabolite M19; UNII-A480CC1Z8I; SCHEMBL3742152.4-amino-2-(5-hydroxy-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Grades: ≥98%. CAS No. 460741-57-5. Molecular formula: C13H11N3O5. Mole weight: 289.24.
CC-17368
CC-17368 is a hydroxyisoindole derivative and metabolite of pomalidomide that has potential activity in anticancer study like multiple myeloma. Synonyms: CC 17368; CC17368; Pomalidomide metabolite M17; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-. Grades: 98%. CAS No. 1547162-41-3. Molecular formula: C13H11N3O5. Mole weight: 289.25.
CC-17369
CC-17369, a hydroxyisoindole derivative, is a metabolites of pomalidomide and has potential activity in anticancer study like multiple myeloma. Synonyms: CC-17369; CC 17369; CC17369; Pomalidomide metabolite M16; M16(CC-17369); SCHEMBL15439588; 4-amino-2-(2,6-dioxopiperidin-3-yl)-7-hydroxyisoindole-1,3-dione. Grades: 98%. CAS No. 1547162-46-8. Molecular formula: C13H11N3O5. Mole weight: 289.25.
E3 ligase Ligand-Linker Conjugates 30
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47.
(s)-6-amino-5-(4-amino-1,3-dioxoisoindolin-2-yl)-6-oxohexanoic acid is an impurity of Pomalidomide, a thalidomide derivative with antitumor effects. CAS No. 918314-44-0. Molecular formula: C14H15N3O5. Mole weight: 305.29.
TFC 007
TFC-007 is a selective inhibitor of hematopoietic prostaglandin D synthase (H-PGDS), with high inhibitory activity against the H-PGDS enzyme (IC50 value of 83 nM). TFC-007 can be used to construct a H-PGDS degrader inducer PROTAC(H-PGDS)-1, where TFC-007 binds to H-PGDS and Pomalidomide binds to cereblon. Synonyms: TFC-007; TFC 007; TFC007; N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 927878-49-7. Molecular formula: C27H29N5O4. Mole weight: 487.55.
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