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| Product | Description | |
|---|---|---|
| PP1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PP1 | PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC 50 of 5 and 6 nM for Lck and Fyn, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGL 1872; EI 275. CAS No. 172889-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13804. |  |
| PP1 | PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 μM), or ZAP-70 (IC50 ≥ 0.6 μM). Synonyms: PP1; PP 1; PP1. Grades: >98%. CAS No. 172889-26-8. Molecular formula: C16H19N5. Mole weight: 281.36. |  |
| PP102 | PP102 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp), and has antibacterial activity against both gram-negative and gram-positive bacteria, but no activity against fungi. Grades: ≥95%. | |
| PP113 | PP113 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp), and has antibacterial activity against both gram-negative and gram-positive bacteria, but no activity against fungi. Grades: >98%. | |
| PP121 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PP121 | PP121 is a multitargeted dual receptor tyrosine kinases inhibitor. PP121 blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases. Synonyms: PP121; PP 121; PP-121. CAS No. 1092788-83-4. Molecular formula: C17H17N7. Mole weight: 319.372. | |
| PP13 | PP13 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp). It has antibacterial activity against E. coli, B. subtilis, S. aureus, S. lutea and B. pumilu (MIC 8-23 μM), but no activity against fungi. Synonyms: Gly-Ala-Ala-Arg-Lys-Ser-Ile-Arg-Leu-His-Arg-Leu-Tyr-Thr-Trp-Lys-Ala-Thr-Ile-Tyr-Thr-Arg. Grades: ≥97%. Molecular formula: C121H197N39O29. Mole weight: 2662.15. | |
| PP1 (4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine) | Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses. Group: Biochemicals. Alternative Names: 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-26-8. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| PP1A, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 | PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases. Group: Fluorescence/luminescence spectroscopy. | |
| PP1 Analog III, 3-MB-PP1 - CAS 956025-83-5 | PP1 Analog III, 3-MB-PP1 primarily used in Inhibition. Group: Fluorescence/luminescence spectroscopy. | |
| PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog) | A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C16H18IN5, Molecular Weight: 407.3. US Biological Life Sciences. | Worldwide |
| PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor) | A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PP1B, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| 1-Naphthyl PP1 | 1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC 50 s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-NA-PP 1. CAS No. 221243-82-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13941. | |
| 1-Naphthyl PP1 | Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 uM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 221243-82-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C19H19N5. US Biological Life Sciences. | Worldwide |
| 1-Naphthyl PP1 hydrochloride | 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC 50 s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-NA-PP 1 hydrochloride. CAS No. 956025-47-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13941B. | |
| 1-Naphthyl PP1 hydrochloride | 1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases, including v-Src and c-Fyn, tyrosine kinase c-Abl and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively. It was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. It was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest. Uses: 1-naphthyl pp1 hydrochloride could potently block prostate cancer cell proliferation by inducing g2/m arrest. Synonyms: 1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride;1-NA-PP 1 hydrochloride. Grades: >98 %. CAS No. 956025-47-1. Molecular formula: C19H20ClN5. Mole weight: 353.85. | |
| 1-NA-PP1 | 1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. Synonyms: 1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-Naphthyl PP1. CAS No. 221243-82-9. Molecular formula: C19H19N5. Mole weight: 317.39. | |
| 1-NM-PP1 | 1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). Synonyms: 1NM-PP1; 1NM PP1; 1NMPP1l PP1 analog II. CAS No. 221244-14-0. Molecular formula: C20H21N5. Mole weight: 331.41424. | |
| 3MB-PP1 | 3MB-PP1 is a bulky purine analog that acts as a selective, ATP-competitive, analog-sensitive polo-like kinase 1 (Plk1) allele inhibitor. Synonyms: 1-Tert-Butyl-3-(3-Methylbenzyl)-1h-Pyrazolo[3,4-D]pyrimidin-4-amine. Grades: ≥98%. CAS No. 956025-83-5. Molecular formula: C17H21N5. Mole weight: 295.4. | |
| 4-Amino-1-tert-butyl-3- (1-naphthylmethyl) pyrazolo[3, 4-d]pyrimidine (1-NMPP1, 1-NM-PP1) | A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NM-PP1. Grades: Highly Purified. CAS No. 221244-14-0. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H21N5, Molecular Weight: 331.41. US Biological Life Sciences. | Worldwide |
| 4-Amino-1-tert-butyl-3-(1-naphthyl)pyrazolo[3,4-d]pyrimidine (1-NA-PP1) | A highly potent (IC-50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NA-PP1. Grades: Highly Purified. CAS No. 2121243-82-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H19N5, Molecular Weight: 317.39. US Biological Life Sciences. | Worldwide |
| InSolution PP1 Analog - CAS 221243-82-9 | A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src compared to wild-type v-Src. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution Src Inhibitor, PP1 | The Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PTK/PI 3-K/mTOR Inhibitor, PP121 - CAS 1092788-83-4 | The PTK/PI 3-K/mTOR Inhibitor, PP121, also referenced under CAS 1092788-83-4, controls the biological activity of PTK/PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Src Inhibitor, PP1 - CAS 172889-26-8 | The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| 4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine | 4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine. Group: Biochemicals. Alternative Names: 2,3-dMB-PP1. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. Molecular Formula: C18H23N5, Molecular Weight: 309.41. US Biological Life Sciences. | Worldwide |
| 4-Amino-1-tert-butyl-3- (3-methylbenzyl) pyrazolo[3, 4-d]pyrimidine | A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-Pyrazolo[3,4-d]pyrimidin-4- amine; 3-MB-PP1. Grades: Highly Purified. CAS No. 956025-83-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Amino-1-tert-butyl-3- (4-methylphenyl) pyrazolo[3, 4-d]pyrimidine | A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; AGL 1872; PP1. Grades: Highly Purified. CAS No. 172889-26-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Amino-1-tert-butyl-3-benzylpyrazolo[3,4-d]pyrimidine | 4-Amino-1-tert-butyl-3-benzylpyrazolo[3,4-d]pyrimidine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(1,1-Dimethylethyl)-3-(phenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-B-PP1. Product Category: Heterocyclic Organic Compound. Appearance: Tan Solid. CAS No. 186895-85-2. Molecular formula: C16H19N5. Mole weight: 281.36. Purity: 0.96. IUPACName: 3-benzyl-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine. Product ID: ACM186895852. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 4-Amino-1-tert-butyl-3-benzylpyrazolo[3,4-d]pyrimidine | A derivative of 4-aminopyrazolo[3,4-d]pyridine, a tyrosine kinase inhibitor. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-(phenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-B-PP1. Grades: Highly Purified. CAS No. 186895-85-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| A431+ Calyculin A (30min) Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 Calyculin A Control Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Active Focal Adhesion Kinase from Human, Recombinant | FAK is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-le...Protein-tyrosine kinase 2; FAK; FADK; FAK1; PTK2; FRNK; PPP1R71; p125FAK. Enzyme Commission Number: EC 2.7.10.2. Purity: Greater than 70% as determined by SDS-PAGE. FAK. Mole weight: 146.7 kDa. Activity: 72 nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate/minute/mg of total protein at 30°C. Stability: Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C to -80°C for longer periods of time. Avoid multiple freeze-thaw cycles. Source: Baculovirus, SF9 insect cells. Species: Human. Focal adhesion kinase 1; EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2; FAK; FADK; FAK1; PTK2; FRNK; PPP1R71; p125FAK. Cat No: NATE-0800. |  |
| C2 Ceramide | C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis , inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ceramide 2. CAS No. 3102-57-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101180. | |
| Cantharidic acid sodium salt | Cantharidic acid is an inhibitor of protein phosphatases, which is first isolated from Chinese blister beetles. Cantharidic acid is a hydrolysis product of cantharidin, it can inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 μM, respectively. Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation. Synonyms: Disodium cantharidin; Cantharidin disodium; 1465-77-6; Disodium cantharidate; 8OIF7X5MK8; Cantharidic Acid (sodium salt); disodium (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate; disodium; (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate; 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, disodium salt, (exo,exo)-; UNII-8OIF7X5MK8. Grades: ≥95%. CAS No. 1465-77-6. Molecular formula: C10H12O5·2Na. Mole weight: 258.2. | |
| Checkpoint Kinase 2, Active Human, Recombinant | CHEK2 is the official symbol for the human gene Checkpoint kinase 2. CHEK2 is located on the the long (q) arm of chromosome 22. CHEK2 is tumor suppressor gene that encodes the protein CHK2, a serine threonine kinase. CHK2 operates in an intricate network of proteins to elicit DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers including breast cancer. Buffered aqueous glycerol solution, recombinant, expressed in e. coli, > 85% (sds-page). Applications: Kinase activity is measured as the molar amount of phosphate incorporated into the chktide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: Checkpoint Kinase 2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; Chek2; Chk2. Purity: > 85% (SDS-PAGE). CHEK2. Mole weight: protein apparent mol wt ~88 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. Checkpoint Kinase 2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; Chek2; Chk2. Cat No: NATE-0122. | |
| Cytostatin | Cytostatin is a potent and selective inhibitor of protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), but it doesn't have effect against PP1, PP2B, or PP5. Synonyms: 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, (5S,6S)-; (5S,6S)-5,6-Dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one; 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl]-5-methyl-, (5S,6S)-; (+)-Cytostatin; Antibiotic MJ 654NF4; NSC 675266. Grades: ≥75%. CAS No. 682329-63-1. Molecular formula: C21H33O7P. Mole weight: 428.46. | |
| Cytostatin sodium salt | Cytostatin is a potent and selective inhibitor of protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), but it doesn't have effect against PP1, PP2B, or PP5. Synonyms: 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, sodium salt (1:1), (5S,6S)-; 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl]-5-methyl-, monosodium salt, (5S,6S)-; (+)-Cytostatin sodium salt; NSC 675266 sodium salt. Grades: ≥75%. CAS No. 457070-06-3. Molecular formula: C21H32NaO7P. Mole weight: 450.44. | |
| DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS | Synonyms: DABCYL-Lys-pp1ab (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS); DABCYL-Lys-ORF1AB (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS). CAS No. 730985-86-1. Molecular formula: C95H141N25O24S2. Mole weight: 2081.42. | |
| Endothall | Endothall (Endothal) is a protein phosphatase 2A ( PP2A ) inhibitor with IC 50 s of 90 nM and 5 μM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Endothal. CAS No. 145-73-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113976A. | |
| Fostriecin sodium salt | Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect on topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM). Fostriecin is found in Streptomyces pulveraceous. Uses: Enzyme inhibitors. Synonyms: Fostriecin Sodium; Antibiotic CI 920 sodium salt; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt. Grades: ≥98% by HPLC. CAS No. 87860-39-7. Molecular formula: C19H26O9PNa. Mole weight: 452.37. | |
| Microcystin-LA | Microcystin is a class of cyclic heptapeptide toxins produced by cyanobacteria. Microcystin-LA is an analog of the major microcystin-LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with IC50 value of 0.3 nM. Synonyms: Cyanoginosin-LA; Toxin BE4. Grades: ≥95%. CAS No. 96180-79-9. Molecular formula: C46H67N7O12. Mole weight: 910.06. | |
| Microcystin-LR | Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Uses: Enzyme inhibitors. Synonyms: Microcystin LR; Microcystin; Microcystin-a; MicrocystinLR; Cyanoginosin-LR; Toxin T 17; cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]; 5-L-Arginine-microcystin LA; cyclo(Ala-Leu-MAsp-Arg-Adda-isoGlu-Mdha). Grades: >95%. CAS No. 101043-37-2. Molecular formula: C49H74N10O12. Mole weight: 995.17. | |
| Microcystin-RR | It is produced by the strain of Microcystis aeruginosa. Microcystin-RR inhibits PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively. Synonyms: Cyanoginosin RR; Microcystin-RR; Cyanoginosin-RR; (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid; Cyanoginosin LA, 3-arginyl-5-arginine-; MCYST-RR; MC-RR; Cyanoginosin LA, 3-L-arginyl-5-L-arginine; Cyanoginosin LA, 3-L-arginine-5-L-arginine-; MCRR; Microcystin-RR, Microcystis aeruginosa; Microcystin-RR solution; Microcystin RR from algae. Grades: ≥95%. CAS No. 111755-37-4. Molecular formula: C49H75N13O12. Mole weight: 1038.21. | |
| Native Aspergillus oryzae Ribonuclease T1 | Ribonuclease T1 (RNase T1) from Aspergillus oryzae is an endoribonuclease that hydrolyzes after G residues. Cleavage occurs between the 3-phosphate group of a guanidine ribonucleotide and 5-hydroxyl of the adjacent nucleotide. The initial product is a 2:3 cyclic phosphate nucleoside that is hydrolyzed to the corresponding 3-nucleoside phosphate. It differs from Pancreatic RNase in that it attacks the guanine sites specifically to yield 3'-GMP and oligonucleotides with a 3'-GMP terminal group. Applications: Ribonuclease t1 (rnase t1) from aspergillus oryzae is used to digest denatured rna prior to sequencing and is used for protein folding studies. Group: Enzymes. Synonyms: Ribonuclease T1; EC 3.1.27.3; g. Enzyme Commission Number: EC 3.1.27.3. CAS No. 9026-12-4. Rnase. Activity: 300,000-600,000 units/mg protein. Storage: -20°C. Form: ammonium sulfate suspension; Suspension in 2.8 M (NH4)2SO4 solution. Source: Aspergillus oryzae. Ribonuclease T1; EC 3.1.27.3; guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1; 9026-12-4. Cat No: NATE-0658. | |
| Native Bovine Protein Phosphatase 2A2 | Protein phosphatase 2A (PP2A) is a specific protamine-kinase-inactivating phosphatase, one common physiological form of which is PP2A2. Protein Phosphatase 2A2 from bovine kidney was shown to be a unique inhibitor of protamine kinase while other phosphatases in the same family including PP1, PP2B, PP2C did not show any inhibition. Protein phosphatase 2a (pp2a) is a specific protamine-kinase-inactivating phosphatase, one common physiological form of which is pp2a2. Applications: Protein phosphatase 2a2 has been used in a study to investigate two heat-stable protein inhibitors. it has also been used in a study to describe the purification and properties of a protamine kinase from bovine kidney microsomes. Group: Enzymes. Synonyms: Protein Phosphatase 2A2; PP2A2. Protein Phosphatase. Activity: ~2.0 U/vial. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protein Phosphatase 2A2; PP2A2. Cat No: NATE-0617. | |
| Native Rabbit Protein Phosphatase 1C | Protein Phosphatase 1 is a growth factor stimulated, divalent cation-independent serine/threonine protein phosphatase involved in regulating numerous cellular processes such as glycogen metabolism, mitosis, and meiosis. Protein phosphatase 1c (pp1c) is expressed in the dendrites of retinal bipolar cells where it was found to bind to group i metabotropic glutamate receptors indicating a function for pp1c in glutamatergic signal transduction. >90% (sds-page), buffered aqueous glycerol solution. Applications: Protein phosphatase-1c has been used in a study to investigate why two metabolites of microcystin-lr glutathione conjugate and microcystin-cysteine conjugate, as well as microcystin-rr are less toxic than microcystin-lr. Group: Enzymes. Synonyms: Protein Phosphatase 1C; PP1C. Purity: >90% (SDS-PAGE). Protein Phosphatase. Activity: > 1500 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Rabbit muscle. Species: Rabbit. Protein Phosphatase 1C; PP1C. Cat No: NATE-0615. | |
| Nodularin | Nodularin is a pentapeptide toxin produced by the cyanobacterium Nodularia spumigena. It acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. Synonyms: Nodularin; Nodularin R; Nodularin-R; UNII-0979BIK2QU; 0979BIK2QU; HSDB 7749; DTXSID60880022; (2Z,5R,6S,9S,12S,13S,16R)-9-[3-(diaminomethylideneamino)propyl]-2-ethylidene-12-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid; Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl); Nodularin, cyanotoxin. Grades: ≥95%. CAS No. 118399-22-7. Molecular formula: C41H60N8O10. Mole weight: 825. | |
| Nodularin (in ethanol) | Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026nm, respectively. It inhibits PP2B only at higher concentrations (IC50=1.8uM). Group: Biochemicals. Alternative Names: Cyclo[(2S, 3S, 4E, 6E, 8S, 9S)-3-amino-9-methoxy-2, 6, 8-trimethyl-10-phenyl-4, 6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D- β-aspartyl-L-arginyl]; Cyclo[(Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D- β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-γ-glutamyl]; 1, 4, 8, 11, 15-Pentaazacyclononadecan e Cyclic Peptide Deriv.; Nodularin R. Grades: Highly Purified. CAS No. 118399-22-7. Pack Sizes: 100ug. Molecular Formula: C??H??N?O??, Molecular Weight: 824.96. US Biological Life Sciences. | Worldwide |
| Norcantharidin | It is an antitumor drug and a PP1 and PP2A inhibitor. It is a modified product of the natural antitumor drug cantharidin. It reduces its urinary system toxicity but not its antitumor efficacy after is demethylated. It induces cell apoptosis and acts as an antineoplastic. Synonyms: rel-(3aR,4S,7R,7aS)-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; 7-Oxabicyclo[2.2.1]heptane-exo-cis-2,3-dicarboxylic anhydride; Demethylcantharidin; Isocantharidin; NSC 59023; NCTD; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (3aR,4S,7R,7aS)-rel-; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (3aα, 4β, 7β, 7aα)-; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride, exo-; exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid anhydride. Grades: ≥98%. CAS No. 29745-04-8. Molecular formula: C8H8O4. Mole weight: 168.15. | |
| Okadaic acid | Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A ( IC 50 =0.1-0.3 nM), and inhibits PP1 ( IC 50 =15-50 nM), PP3 ( IC 50 =3.7-4 nM), PP4 ( IC 50 =0.1 nM), PP5 ( IC 50 =3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 78111-17-8. Pack Sizes: 25 μg (124.2 μM * 250 μL in Ethanol). Product ID: HY-N6785. | |
| Okadaic Acid | Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1, both isoforms of PP2A and PP3. It is a very weak inhibitor of PP2B and does not inhibit PP2C or other phosphatases. Synonyms: AA8227800; 9,10-Deepithio-9,10-didehydroacanthifolicin. Grades: 95% by HPLC. CAS No. 78111-17-8. Molecular formula: C44H68O13. Mole weight: 805.00. | |
| Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
| Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Perfluoroperhydrofluorene | Perfluoroperhydrofluorene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PERFLUOROFLUORENE;PERFLUOROPERHYDROFLUORENE;FLUTEC PP10;FLUTECR PP10;Perfluoroperhydrofluorene,tech.;Perfluoroperhydrofluorene80%;Docosafluorododecahydro-9H-fluorene;Dodecahydrodocosafluoro-9H-fluorene. Product Category: Heterocyclic Organic Compound. CAS No. 307-08-4. Molecular formula: C13F22. Mole weight: 574.1. Purity: 0.96. IUPACName: 1,1,2,2,3,3,4,4,4a,4b,5,5,6,6,7,7,8,8,8a,9,9,9a-docosafluorofluorene. Density: 1.89g/cm³. Product ID: ACM307084. Alfa Chemistry ISO 9001:2015 Certified. | |
| PP 3 | PP 3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2. It inhibits EGFR kinase (IC50 = 2.7 μM). Synonyms: PP 3; PP3; PP-3; 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 5334-30-5. Molecular formula: C11H9N5. Mole weight: 211.22. | |
| Protein Phosphatase-1 Catalytic Subunit, α-Isoform from Human, Recombinant | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene. The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies a...e alternatively spliced transcript variants encoding different isoforms have been found for this gene. Applications: Sds-page; wb; elisa; ip. Group: Enzymes. Synonyms: PPP1CA; protein phosphatase 1; PP-1A; PP1A; PP1alpha; PPP1A. Purity: > 95%. Protein Phosphatase. Mole weight: 41.1kDa. Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Form: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative. Source: E.coli. Species: Human. PPP1CA; protein phosphatase 1; PP-1A; PP1A; PP1alpha; PPP1A. Cat No: NATE-1243. | |
| Protein Phosphatase-1 Catalytic Subunit, α-Isoform from rabbit, Recombinant | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene. The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. 5 kda-15 kda units/mg protein, recombinant, expressed in e. coli, lyophilized powder. Group: Enzymes. Synonyms: PPP1CA; protein phosphatase 1; PP-1A; PP1A; PP1alpha; PPP1A. Protein Phosphatase. Mole weight: mol wt 37.5 kDa. Activity: 5,000-15,000 units/mg protein. Stability: -20°C. Form: lyophilized powder. Source: E. coli. Species: Rabbit. PPP1CA; protein phosphatase 1; PP-1A; PP1A; PP1alpha; PPP1A. Pack: Package size based on protein content. Cat No: NATE-0614. | |
| Protein phosphatase 1 regulatory subunit 3B (172-180) | Protein phosphatase 1 regulatory subunit 3B (172-180) is a peptide derived from Protein phosphatase 1 regulatory subunit 3B. Protein phosphatase 1 regulatory subunit 3B facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity as a glycogen-targeting subunit for phosphatase PP1. Synonyms: Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL (172-180); Protein phosphatase 1 regulatory subunit 4 (172-180); Protein phosphatase 1 subunit GL (172-180). | |
| ribonuclease T1 | Formerly EC 2.7.7.26 and EC 3.1.4.8. Group: Enzymes. Synonyms: guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1. Enzyme Commission Number: EC 3.1.27.3. CAS No. 9026-12-4. Rnase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3601; ribonuclease T1; EC 3.1.27.3; 9026-12-4; guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1. Cat No: EXWM-3601. | |
| Rubratoxin A | Mycotoxin. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. Antitumor agent. Antimetastatic. Group: Biochemicals. Alternative Names: BRN 1633008; HSDB 3532, (4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione. Grades: Highly Purified. CAS No. 22467-31-8. Pack Sizes: 250ug, 500ug. Molecular Formula: C??H??O??. US Biological Life Sciences. | Worldwide |
| Sephin 1 | Sephin 1 is a selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin 1 selectively disrupted the PPP1R15A-PP1c complex, thus prolonging eIF2α phosphorylation after stress, delaying translation recovery, and attenuated expression of stress genes such as the pro-apoptotic protein CHOP. In mice, Sephin 1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases. Uses: Potential treatment of protein misfolding disease. Synonyms: Sephin1; Sephin-1. Grades: 99%. CAS No. 951441-04-6. Molecular formula: C8H9ClN4. Mole weight: 196.64. | |
| Tautomycetin | Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 = 1.6 and 62 nM for PP1 and PP2, respectively) used as an immunosuppressive agent. Tautomycetin induces apoptosis in activated T cells, and inhibits PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Synonyms: (1R, 2S, 3R, 6S, 7S, 10S, 12R, 15E, βR, 3R)-16-Ethyl-3, 7-dihydroxy-1, 2, 6, 10, 12-pentamethyl-5, 14-dioxo-15, 17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester. Grades: ≥95% by HPLC. CAS No. 119757-73-2. Molecular formula: C33H50O10. Mole weight: 606.75. | |
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