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| Product | Description | |
|---|---|---|
| Primary Amyl Acetate | Primary Amyl Acetate. Synonyms: PAA. CAS: 628-63-7. Packing: Metal Drums. |  New Jersey NJ |
| Amyl Acetate Primary FCC | Amyl Acetate Primary FCC (Mixed Isomers 35/65). CAS No. ISOMER MIXTURE. Kosher: Y. VIGON Item # 500790. Categories: Speciality Ingredients Suppliers, Flavors, Fragrances, Perfumers. |  America & Internationally |
| Amyl Alcohol Primary | Amyl Alcohol Primary (Mixed Isomers 35/65). CAS No. ISOMER MIXTURE. Kosher: Y. VIGON Item # 500596. Categories: Speciality Ingredients Suppliers, Flavors, Fragrances, Perfumers. | America & Internationally |
| Amyloid β-Peptide (1-43) (human) | Amyloid β-Peptide (1-43) (human) is the minor component of neuritic plaques, which is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. It is neurotrophic and neurotoxic. Synonyms: β-Amyloid (1-43); Amyloid β-Protein Fragment 1-43; H-DL-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-D-Glu-D-Asp-D-Val-Gly-D-Ser-D-Asn-D-Lys-Gly-D-Ala-D-xiIle-D-xiIle-Gly-D-Leu-D-Met-D-Val-Gly-Gly-D-Val-D-Val-D-xiIle-D-Ala-D-xiThr-OH. CAS No. 134500-80-4. Molecular formula: C207H318N56O62S. Mole weight: 4615.19. |  |
| BACE-1 Inhibitor | BACE-1 Inhibitor is a potent, selective and cell-permeable inhibitor of human β-secretase (BACE-1) binding to the active site of BACE-1. It inhibits secretion of amyloid-β (Aβ) precursor protein (APP; IC50 = 29 nM) in HEK293T cells and also suppresses formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively). Synonyms: BACE-1 Inhibitor; BACE 1 Inhibitor; BACE1 Inhibitor; Beta-Secretase Inhibitor IV; β-Secretase Inhibitor IV; N1-[(1S,2R)-3-(Cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-N3-[(1R)-1-phenylethyl]-1,3-benzenedicarboxamide; Axon 1125. Grades: 98%. CAS No. 797035-11-1. Molecular formula: C31H38N4O5S. Mole weight: 578.72. | |
| bis(7)-Tacrine | Acetylcholinesterase (AChE) is the primary cholinesterase in the body. It is an enzyme catalyzing the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), which has been proposed as a clinical treatment for Alzheimer's disease. Bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine. It is thought to have multiple mechanisms of action including inhibition of AChE, and inihbititon of the amyloid precursor protein/beta-amyloid cascade. It has been shown to inhibit the formation of Aβ1-42 oligomers and reduce the amount of pre-formed Aβ1-42 oligomers. Synonyms: 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine. Grades: ≥98%. CAS No. 224445-12-9. Molecular formula: C33H40N4·2HCl. Mole weight: 565.6. | |
| CHF 5074 | CHF 5074 is a novel γ-secretase modulator. It reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM respectively. It protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. Uses: Chf5074 induces microglia alternative activation in plaque-free tg2576 mice and primary glial cultures exposed to beta-amyloid. it restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque tg2576 mice. it is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of alzheimer's disease. it significantly reduces the apoptosis in hippocampal neurons exposed to ogd, as revealed by cleaved-caspase-3 immunoreactivity and tunel staining. Synonyms: CHF-5074; Itanapraced; 1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid. Grades: >98%. CAS No. 749269-83-8. Molecular formula: C16H11Cl2FO2. Mole weight: 325.16. | |
| Fulvestrant | Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor α (ERα).1,2 It binds to rat uterine ER with an IC50 value of 44.8nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06mg/kg per day) but has no effect on uterine weight alone.3 It also decreases uterine weight in adult rats without affecting the production of luteinizing and follicle-stimulating hormones and prolactin. Fulvestrant inhibits the growth of ER-positive MCF-7 human breast cancer cells but not ER-negative BT-20 cells when used at a concentration of 1ug/ml. It also prevents tumor growth in MCF-7 and Br10 breast cancer mouse xenograft models when used at a single dose of 5mg per animal. Fulvestrant is neuroprotective in vitro against neurotoxicity induced by glutamate- and amyloid- β (1-42) (A β42) in primary rat hippocampal cells.4 Formulations containing fulvestrant have been used in the treatment of estro Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol; Faslodex; Fulvestrant; ICI 182780; ZD 182780; ZD 9238; ZM 182780. Grades: Highly Purified. CAS No. 129453-61-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C??H??F?O?S, Molecular Weight: 606.77. US Biological Life Sciences. |  Worldwide |
| ReACp53 | ReACp53 is a cell-permeable inhibitor of p53 amyloid formation that targets mutant p53 protein in primary prostate cancer. Synonyms: H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-OH; L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-isoleucyl-L-leucyl-L-threonyl-L-arginyl-L-isoleucyl-L-threonyl-L-leucyl-L-glutamic acid. Grades: ≥95%. Molecular formula: C108H206N52O24. Mole weight: 2617.13. | |
| Native Human Cathepsin S | Cathepsin S is a lysosomal cysteine protease found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides. Applications: Cathepsin s from human spleen has been used in a study to assess the sequence identification, tissue distribution and polymorphism of the porcine cathepsin d (ctsd) gene. cathepsin s from human spleen has also been used in a study to investigate a new promising camptothecin analogue-polysaccharide conjugate. Group: Enzymes. Synonyms: CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886. Enzyme Commission Number: EC 3.4.22.27. CTSS. Storage: -70°C. Form: lyophilized powder. Lyophilized from 100 mM sodium acetate, pH 5.5, and 1 mM EDTA. Source: Human spleen. Species: Human. CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886. Cat No: NATE-0178. |  |
| (Val34)-Amyloid β-Protein (1-40) | Cerebral amyloid angiopathy (CAA) is a common manifestation of Alzheimer's disease, characterized by amyloid-Aβ vascular deposition in >80% of cases. Mutations at sites 21-23 (such as the Dutch mutation E22Q) are primarily associated with CAA, although they present with significantly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant lies outside this hot spot, showing a similar bleeding phenotype, though less aggressive than the widely studied Dutch variant. Synonyms: Amyloid β-Protein (1-40) L34V; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Val-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 1678415-83-2. Molecular formula: C193H293N53O58S. Mole weight: 4315.84. | |
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