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Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase ( DHFR ) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 500-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0806.
Proguanil hydrochloride
25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics, Testing Standards. Formula: C11H15Cl2N5. CAS No. 537-21-3. Prepack ID 10785411-25mg. Molecular Weight 288.18. See USA prepack pricing.
Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase ( DHFR ) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 637-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0806A.
Proguanil hydrochloride
Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor. Uses: Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. Additional or Alternative Names: Chlorguanide, N1-(4-Chlorophenyl)-N5-isopropylbiguanide, Proguanil hydrochloride. Product Category: Solvents. CAS No. 637-32-1. Molecular formula: C11H17Cl2N5. Mole weight: 290.19. IUPACName: hydrogen 1-({amino[(4-chlorophenyl)amino]methylidene}amino)-N'-(propan-2-yl)methanimidamide chloride. Canonical SMILES: [H+].[Cl-].CC(C)N=C(N)N=C(N)NC1=CC=C(Cl)C=C1. ECNumber: 211-283-7. Product ID: ACM637321. Alfa Chemistry ISO 9001:2015 Certified.
Proguanil hydrochloride
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Proguanil Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Proguanil Related Compound C
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Proguanil Related Compound D
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Proguanil Related Compound E
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Proguanil Related Compound F
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Proguanil Related Compound G
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Chlorguanide Impurity A (Proguanil Impurity A)
An intermediate commonly used for the synthesis of guanide derivatives. An Impurity in the synthesis of Chlorguanide. Synonyms: N-Cyano-N'-(1-methylethyl)guanidine; Isopropyldicyandiamide; 3-Cyano-1-isopropylguanidine; NSC 643485. Grade: > 95%. CAS No. 44830-55-9. Molecular formula: C5H10N4. Mole weight: 126.16.
Chlorguanide-[d4] Hydrochloride
Chlorguanide-[d4] Hydrochloride is the labelled salt of Chlorguanide, which is a medication used to treat and prevent malaria. Synonyms: Chlorguanide-d4 Hydrochloride; N-(4-Chlorophenyl-d4)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride; 1-(p-Chlorophenyl-d4)-5-isopropylbiguanide Hydrochloride; Bigumal-d4; Chlorguanid-d4; Paludrin-d4; Proguanil-d4. Grade: 98%; 98.8% atom D. CAS No. 1189671-34-8. Molecular formula: C11H13D4Cl2N5. Mole weight: 294.22.
Chlorguanide-d4 Hydrochloride
Antimalarial. Group: Biochemicals. Alternative Names: N-(4-Chlorophenyl-d4)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride; 1-(p-Chlorophenyl-d4)-5-isopropylbiguanide Hydrochloride; Bigumal-d4; Chlorguanid-d4; Chloroguanide-d4; Paludrin-d4; Proguanil-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Chlorguanide-d6 Hydrochloride
An isotope labelled derivative of Chlorguanide. Proguanil is a medication used to treat and prevent malaria. Synonyms: N-4-Chlorophenyl-N'-(1-methylethyl-d6)-imidodicarbonimidic Diamide Hydrochloride; Bigumal-d6; Chlorguanid-d6; Chloroguanide-d6; Paludrin-d6; Proguanil-d6. Grade: 95% by HPLC; 98% atom D. Molecular formula: C11H10ClN5D6.HCl. Mole weight: 296.23.
Chlorguanide Hydrochloride
Antimalarial. Group: Biochemicals. Alternative Names: N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride;1-(p-Chlorophenyl)-5-isopropylbiguanide Hydrochloride; Bigumal; Chlorguanid; Chloroguanide; Paludrin; Proguanil; M-4888. Grades: Highly Purified. CAS No. 637-32-1. Pack Sizes: 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
Worldwide
Cycloguanil-[d4] Hydrochloride
Cycloguanil-[d4] Hydrochloride is a labelled analogue of Cycloguanil. Cycloguanidine is a dihydrofolate reductase inhibitor and a metabolite of the antimalarial drug proguanil. Synonyms: Cycloguanil-d4 Hydrochloride. Grade: 98% by HPLC; 98% atom D. CAS No. 1189427-23-3. Molecular formula: C11H11D4Cl2N5. Mole weight: 292.2.
Cycloguanil-[d6]
Cycloguanil-[d6] is a deuterium labelled analogue of Cycloguanil. Cycloguanil is an inhibitor of dihydrofolate reductase and a metabolite of proguanil. Synonyms: Chlorguanide triazine D6. Grade: >98%. Molecular formula: C11H8D6ClN5. Mole weight: 257.76.
Cycloguanil hydrochloride
Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 152-53-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12784A.
Cycloguanil hydrochloride
Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride; BN 2410; Chloroguanide Triazine Hydrochloride; Cycloguanil Hydrochloride; NSC 3074. Product Category: Inhibitors. Appearance: White Solid. CAS No. 152-53-4. Molecular formula: C11H15Cl2N5. Mole weight: 288.18. Purity: 0.96. IUPACName: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride. Canonical SMILES: CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl. Product ID: ACM152534. Alfa Chemistry ISO 9001:2015 Certified.
Cycloguanil hydrochloride
Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Uses: Antimalarials. Synonyms: Chloroguanide Triazine; NSC 3074; 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride. Grade: ≥95%. CAS No. 152-53-4. Molecular formula: C11H14ClN5·HCl. Mole weight: 288.2.
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