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| Product | Description | |
|---|---|---|
| Prostaglandin A2 | PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It shows some antiviral/antitumor activity. Synonyms: (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic Acid; 7-[2-(3-Hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl]-5-heptenoic Acid; (+)-Prostaglandin A2; (15S)-PGA2; 15(S)-Hydroxy-9-oxo-5-cis- 10,13-trans-prostatrienoic Acid; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostenoic Acid; 15(S)-Prostaglandin A2; 15α-Hydroxy-9-oxo-cis-5,10,trans- 13-prostatrienecarboxylic Acid; 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienoic Acid; 5,6-cis-PGA2; Medullin; NSC 165561; PGA2. Grades: > 95%. CAS No. 13345-50-1. Molecular formula: C20H30O4. Mole weight: 334.46. |  |
| Prostaglandin A2 | Prostaglandin A2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. Prostaglandin A2 is generally not present in mammals. Prostaglandin A2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity. Prostaglandin A2 has also been shown to act as a vasodilator with natriuretic properties. Group: Biochemicals. Alternative Names: (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic Acid; 7-[2-(3-Hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl]-5-heptenoic Acid; (+)-Prostaglandin A2; (15S)-PGA2; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostatrienoic Acid; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostenoic Acid; 15(S)-Prostaglandin A2; 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienecarboxylic Acid; 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienoic Acid; 5,6-cis-PGA2; Medullin; NSC 165561; PGA2. Grades: Highly Purified. CAS No. 13345-50-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Prostaglandin A2 methyl ester | Prostaglandin A2 (PGA2) methyl ester is a lipophilic analog of PGA2. PGA2 is a prostaglandin formed by the dehydration of PGE2. PGA2 was shown to block the cell cycle progression of NIH 3T3 cells at G1 and G2/M. Synonyms: Medullin methyl ester; PGA2 methyl ester; 15S-Hydroxy-9-oxo-methyl ester-prosta-5Z,10,13E-trien-1-oic acid; Methyl (Z)-7-[(1R,2S)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-en-1-yl]hept-5-enoate. Grades: ≥98%. CAS No. 31753-19-2. Molecular formula: C21H32O4. Mole weight: 348.5. | |
| 16,16-Dimethyl prostaglandin A2 | 16,16-Dimethyl prostaglandin A2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. Synonyms: 16,16-dimethyl PGA2; (Z)-7-[(1R,2S)-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid. Grades: ≥98%. CAS No. 41691-92-3. Molecular formula: C22H34O4. Mole weight: 362.5. | |
| 16,16-Dimethyl Prostaglandin A2 | 16,16-dimethyl Prostaglandin A2 is a PGA2 analog studied for its antiproliferative properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 41691-92-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C22H34O4, Molecular Weight: 362.5. US Biological Life Sciences. | Worldwide |
| AX 048 | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grades: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
| CAY10650 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grades: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
| Dimethyl (3-phenoxy-2-oxoproyl)phosphonate | Dimethyl (3-phenoxy-2-oxoproyl)phosphonate Travopropst (T715600), a selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma. Used in the synthesis ofnovel prostanoid thromboxane A2 agonists. Group: Biochemicals. Alternative Names: P- (2-oxo-3-Phenoxypropyl) phosphonic Acid Dimethyl Ester; (2-oxo-3-Phenoxypropyl) phosphonic Acid Dimethyl Ester; (2-Oxo-3-phenoxypropyl) phosphonic Acid Dimethyl Ester; Dimethyl (2-oxo-3-phenoxypropyl) phosphonate; Dimethyl (3-Phenoxyacetonyl) phosphonate; Dimethyl 3-{Phenoxy-2-oxopropylphosphonate. Grades: Highly Purified. CAS No. 40665-68-7. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| Epoprostenol Sodium | Epoprostenol Sodium is the sodium salt form of epoprostenol, which is a synthetic prostacyclin. It has vasodilatory and anticoagulant activity. It is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It prevents the formation of platelet plugs and is an effective vasodilator. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. It directly simulates prostaglandin receptors in arterial vascular smooth muscle, thereby causing vasodilatation. lt is also used for the treatment of pulmonary hypertension. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. It is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract. It was developed by GlaxoSmithKline and has been listed. Uses: Epoprostenol sodium has vasodilatory and anticoagulant activity. it prevents the formation of platelet plugs and is an effective vasodilator. lt is also used for the treatment of pulmonary hypertension. Synonyms: Prostacyclin Sodium Salt; (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-Dihydroxy-prosta-5,13-dien-1-oic Acid Sodium Salt; Flolan. Grades: >99 %. CAS No. 61849-14-7. Molecular formula: C20H31O5Na. Mole weight: 374.45. | |
| Ifetroban | Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291. CAS No. 143443-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218. |  |
| Ifetroban | Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials for the treatment of Asthma, Hepatorenal syndrome, Portal hypertension and Systemic scleroderma is on-going. Uses: Asthma; hepatorenal syndrome; portal hypertension; systemic scleroderma. Synonyms: Ifetroban; BMS 180291-02; BMS-180291; BMS180291; CHEMBL283100; BMS-180291;SCHEMBL9589119;3-[2-[[3-[4-(pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]propanoic acid. Grades: 98%. CAS No. 143443-90-7. Molecular formula: C25H32N2O5. Mole weight: 440.54. | |
| Ifetroban sodium | Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291 sodium. CAS No. 156715-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218A. | |
| Native Crotalus Phospholipase A2 | Phospholipases A2 (PLA2s) EC 3.1.1.4 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators. Phospholipase a2 is a member of the class of heat-stable, calcium-dependent enzymes catalyzing the hydrolysis of the 2-acyl bond of 3-n-phosphoglycerides. a chromatographically purified, dialyzed, lyophilized powder. Group: Enzymes. Synonyms: EC 3.1.1.4; Phospholipases A2; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-86-9. Purity: chromatographically purified, dialyzed. PLA2. Mole weight: 30 kDa (Wells 1969). Activity: > 200 units per mg dry weight. Stability: The enzyme is stable at 90°C and pH 3.0 for at least five minutes. (Uthe 1971; Saito 1962). Storage: Store at 2-8°C. Form: lyophilized powder. Source: Crotalus adamanteus Venom. Species: Crotalus. EC 3.1.1.4; Phospholipases A2; PLA2s. Cat No: NATE-0591. |  |
| thromboxane-A synthase | A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2. Group: Enzymes. Synonyms: thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase. Enzyme Commission Number: EC 5.3.99.5. CAS No. 61276-89-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5513; thromboxane-A synthase; EC 5.3.99.5; 61276-89-9; thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase. Cat No: EXWM-5513. | |
| U 46619 | U 46619 is a PGH2 (TXA2) analog that is reported to be a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U 46619 has been shown to stimulate TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. U 46619 also activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors. Synonyms: U46619, U-46619, U 46619; (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid. Grades: ≥98% by HPLC. CAS No. 56985-40-1. Molecular formula: C21H34O4. Mole weight: 350.5. | |
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