Prostaglandin E2 Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Prostaglandin E2 Quick inquiry Where to buy Suppliers range | Fluorescence/Luminescence Spectroscopy; Chiral Molecules. Uses: For analytical and research use. Group: reagents. Alternative Names: Dinoprostone, (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid, PGE2. CAS No. 363-24-6. IUPAC Name: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. | |
Prostaglandin E2 Quick inquiry Where to buy Suppliers range | Prostaglandin E2 is a naturally occurring COX product used as a medication in labor induction, bleeding after delivery, and termination of pregnancy. It directly targets muscle stem cells (MuSCs) via EP4 receptor, resulting in MuSC expansion. Uses: Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Synonyms: Dinoprostone; PGE2; Prostin E2; Prepidil. Grades: >98%. CAS No. 363-24-6. Molecular formula: C20H32O5. Mole weight: 352.47. | |
Prostaglandin E2 (Dinoprostone) Quick inquiry Where to buy Suppliers range | The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient. Inhibits NLRP3 by acting through receptor EP4 activation that increases cAMP and phosphorylates NLRP3 at serine 295 through PKA. PKA phosphorylation of NLRP3 inhibits the NLRP3 ATPase activity, which is required for assembly of NLRP3-ASC complexes. Group: Biochemicals. Alternative Names: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid; (-)-Prostaglandin E2; (15S)-Prostaglandin E2; Cervidil; Cerviprime; Cerviprost; Dinoprostone; Minprostin E2; PGE2; Prepidil. Grades: Highly Purified. CAS No. 363-24-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
Prostaglandin E2 ethanolamide Quick inquiry Where to buy Suppliers range | Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 with improved water solubility. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA) and acts as an agonist of E prostanoid (EP) receptors 1-4 with Ki values of 2.45, 0.46, 0.2, and 0.51 μM, respectively. Synonyms: Dinoprostone ethanolamide; PGE2-EA; Prostamide E2; N-(11R,15S-dihydroxy-9-oxo-5Z,13E-prostadienoyl)-ethanolamine; (5Z,11α,13E,15S)-11,15-Dihydroxy-N-(2-hydroxyethyl)-9-oxo-prosta-5,13-dien-1-amide; PGE2 ethanolamide; Prostaglandin E2-EA; N-(2-hydroxyethyl)-9-oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide. Grades: ≥98%. CAS No. 194935-38-1. Molecular formula: C22H37NO5. Mole weight: 395.53. | |
Prostaglandin E2 Ethanolamide-d4 Quick inquiry Where to buy Suppliers range | Prostaglandin E2 Ethanolamide-d4. Group: Biochemicals. Alternative Names: (5Z,11α,13E,15S)-11,15-Dihydroxy-N-(2-hydroxyethyl)-9-oxo-prosta-5,13-dien-1-amide; Prostamide E2; PGE2 ethanolamide. Grades: Highly Purified. Pack Sizes: 50ug. Molecular Formula: C22H33D4NO5, Molecular Weight: 399.56. US Biological Life Sciences. | Worldwide |
Prostaglandin E2-d4 Quick inquiry Where to buy Suppliers range | Prostaglandin E2-d4. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: Dinoprostone-d4, Cerviprime-d4, l-PGE2-d4, (15S)-Prostaglandin E2-d4, 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid-d4, Prostin E2-d4,(5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid-d4, Primiprost-d4, PGE2-d4, (-)-Prostaglandin E2-d4, Cervidil-d4, Prepidil-d4, Minprostin E2-d4, Cerviprost-d4. CAS No. 34210-10-1. IUPAC Name: 9-oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. Molecular formula: C20H28D4O5. Mole weight: 356.50. Catalog: APS34210101. SMILES: O[C@H]1[C@H] (/C=C/[C@@H] (O)CCCCC)[C@@H] (C/C=C\C ([2H]) ([2H])C ([2H]) ([2H])CC (O)=O)C (C1)=O. Format: Neat. Product Type: Stable Isotope Labelled. | |
11Beta-prostaglandin e2 Quick inquiry Where to buy Suppliers range | A solution in methyl acetate. Group: Heterocyclic Organic Compound. Alternative Names: 9-OXO-11BETA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;11BETA-PROSTAGLANDIN E2;(5Z,11S,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid;(5Z,13E,15S)-11β,15-Dihydroxy-9-oxo-5,13-prostadiene-1-oic acid;(5Z,13E,15S)-9-Oxo-11β,15-dihydroxyprosta-5. CAS No. 38310-90-6. Molecular formula: C20H32O5. Mole weight: 352.47. | |
11-deoxy-16,16-dimethyl prostaglandin E2 Quick inquiry Where to buy Suppliers range | AY 24609 is an analogue of PGE2 and a selective EP2 and EP3 receptors agonist. It also inhibits gastric acid secretion and ulcer formation in rat. Synonyms: AY 24609; 11-deoxy-16,16-dimethyl PGE2; (Z)-7-[(1R,2R)-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 53658-98-3. Molecular formula: C22H36O4. Mole weight: 364.5. | |
11-Deoxy prostaglandin e2 Quick inquiry Where to buy Suppliers range | A crystalline solid. Group: Heterocyclic Organic Compound. Alternative Names: 11-DEOXY PROSTAGLANDIN E2;9-OXO-15S-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID. Grades: >99%. CAS No. 35536-53-9. Molecular formula: C20H32O4. Mole weight: 336.47. | |
15-Keto-prostaglandin e2 Quick inquiry Where to buy Suppliers range | White solid. Group: Heterocyclic Organic Compound. Alternative Names: 15-KETO PROSTAGLANDIN E2;9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;(E)-7-[(1R,2S,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid;11-Hydroxy-9,15-dioxo-[5Z,11α,13E]-prosta-5,13-dien-1-oic acid: 15-Dehydroprostagla. Grades: 96%. CAS No. 26441-05-4. Molecular formula: C20H30O5. Mole weight: 350.45. IUPAC Name: (Z)-7-[(1R,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid. Exact Mass: 350.20900. Boiling Point: 534.4ºC at 760 mmHg. Flash Point: 291ºC. Density: 1.144g/cm3. SMILES: CCCCCC (=O)C=CC1C (CC (=O)C1CC=CCCCC (=O)O)O. InChIKey: YRTJDWROBKPZNV-KMXMBPPJSA-N. H-Bond Donor: 2. H-Bond Acceptor: 5. | |
15-Keto prostaglandin E2 Quick inquiry Where to buy Suppliers range | 15-Keto prostaglandin E2 is a metabolite of PGE2 formed by 15-hydroxy PGDH. Synonyms: 15-keto PGE2; 15-Oxo-PGE2. Grades: ≥95%. CAS No. 26441-05-4. Molecular formula: C20H30O5. Mole weight: 350.5. | |
15-Keto Prostaglandin E2 Quick inquiry Where to buy Suppliers range | 15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes. Group: Biochemicals. Grades: Highly Purified. CAS No. 26441-05-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C20H30O5, Molecular Weight: 350.45. US Biological Life Sciences. | Worldwide |
16,16-Dimethyl Prostaglandin E2 Quick inquiry Where to buy Suppliers range | 16,16-Dimethyl Prostaglandin E2, a prostaglandin E2 derivative, could induce an increase in hematopoietic stem cell (HSC) numbers in mouse model. Uses: Anti-ulcer agents. Synonyms: 16,16-Dimethyl-pge2; 16,16-dimethylprostaglandin E2; 16,16-Dimethyl-prostaglandin E2; dmpge2; (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Grades: >98%. CAS No. 39746-25-3. Molecular formula: C22H36O5. Mole weight: 380.52. | |
16,16-Dimethyl Prostaglandin E2 Quick inquiry Where to buy Suppliers range | Synthetic derivative of prostaglandin E2. Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos. Group: Biochemicals. Grades: Highly Purified. CAS No. 39746-25-3. Pack Sizes: 1mg. Molecular Formula: C22H36O5. US Biological Life Sciences. | Worldwide |
17-Phenyl trinor prostaglandin E2 Quick inquiry Where to buy Suppliers range | 17-Phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist. Synonyms: 17-phenyl trinor PGE2; 17-phenyl-trinor-prostaglandin E2. Grades: ≥98%. CAS No. 38315-43-4. Molecular formula: C23H30O5. Mole weight: 386.5. | |
17-Phenyl-trinor-prostaglandin E2 Quick inquiry Where to buy Suppliers range | 17-Phenyl-trinor-prostaglandin E2 is a synthetic analog of PGE2 and an agonist at the EP1 and EP3 receptor (1). Prostaglandin E2(PGE2) regulates neuroinflammatory responses and is upregulated in brain injury by cyclooxygenase 2 (COX-?2) and membrane-bound PGE synthase. 17-Phenyl-trinor-prostaglandin E2 can be used to investigate inflammatory signaling pathways (2). Group: Biochemicals. Grades: Highly Purified. CAS No. 38315-43-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H30O5, Molecular Weight: 386.48. US Biological Life Sciences. | Worldwide |
17-Phenyl trinor prostaglandin E2 ethyl amide Quick inquiry Where to buy Suppliers range | 17-Phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). Synonyms: 17-phenyl trinor PGE2 ethyl amide; (Z)-N-ethyl-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamide. Grades: ≥98%. CAS No. 1219032-20-8. Molecular formula: C25H35NO4. Mole weight: 413.6. | |
19(R)-Hydroxy prostaglandin E2 Quick inquiry Where to buy Suppliers range | 19(R)-Hydroxy-prostaglandin E2 is a PGE2 metabolite that acts as a potent smooth muscle relaxant and a selective EP2 receptor agonist, contrary to PGE2, which can activate a variety of prostanoid receptor types. Synonyms: 19(R)-hydroxy PGE2; 19(R)-OH PGE2; 19(R)-hydroxy Prostaglandin E2. Grades: ≥98%. CAS No. 64625-54-3. Molecular formula: C20H32O6. Mole weight: 368.5. | |
19(R)-Hydroxy-prostaglandin E2 Quick inquiry Where to buy Suppliers range | 19(R)-hydroxy Prostaglandin E2 is a selective EP2 receptor agonist and a smooth muscle relaxant (1,2). Group: Biochemicals. Grades: Highly Purified. CAS No. 64625-54-3. Pack Sizes: 50ug, 100ug. Molecular Formula: C20H32O6, Molecular Weight: 368.46. US Biological Life Sciences. | Worldwide |
2-Amino-4-(1-naphthyl)thiazole Quick inquiry Where to buy Suppliers range | 2-Amino-4-(1-naphthyl)thiazole is a reagent used in the synthesis of 2-substituted ethenesulfonic acid ester derivatives as PTP1B inhibitors. Also used as a reagent in the preparation of pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors for the treatment of inflammation and various cancers. Group: Biochemicals. Grades: Highly Purified. CAS No. 56503-96-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10N2S, Molecular Weight: 226.3. US Biological Life Sciences. | Worldwide |
2-Amino-4-chlorobenzenethiol Quick inquiry Where to buy Suppliers range | 2-Amino-4-chlorobenzenethiol is used as reagent in the synthesis of several organic compounds including that of MHY908 which is an inhibitor of melanogenesis and can potentially be used in the prevention and treatment of pigmentation disorders. Also used in the synthesis of γ-lactam analogs of prostaglandin E2 which may act as EP4 agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1004-00-8. Pack Sizes: 5g, 10g. Molecular Formula: C6H6ClNS. US Biological Life Sciences. | Worldwide |
2-Formyl-1,1'-biphenyl Quick inquiry Where to buy Suppliers range | 2-Formyl-1,1'-biphenyl is a reactant used in the preparation of imidazoquinoline derivatives, a class of microsomal prostaglandin E2 synthase-1 inhibitors. 2-Formyl-1,1'-biphenyl is also used in the preparation of phenoxybenzylamino carboline derivatives as potential antitumor drugs targeting α-tubulin. Group: Biochemicals. Alternative Names: 2-Formylbiphenyl; 2-Phenylbenzaldehyde; 2-Biphenylcarboxalde hyde; [1,1'-Biphenyl]-2-carboxaldehyde. Grades: Highly Purified. CAS No. 1203-68-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
2-Formyl-1,1'-biphenyl-13C6 Quick inquiry Where to buy Suppliers range | 2-Formyl-1,1'-biphenyl-13C6 is a reactant used in the preparation of labelled imidazoquinoline derivatives, a class of microsomal prostaglandin E2 synthase-1 inhibitors. 2-Formyl-1,1'-biphenyl is also used in the preparation of phenoxybenzylamino carboline derivatives as potential antitumor drugs targeting α-tubulin. Group: Biochemicals. Alternative Names: 2-Formylbiphenyl-13C6; 2-Phenylbenzaldehyde-13C6; 2-Biphenylcarboxaldehyde-13C6; [1,1'-Biphenyl]-2-carboxaldehyde-13C6. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
2-Iodobenzotrifluoride Quick inquiry Where to buy Suppliers range | 2-Iodobenzotrifluoride acts as a reagent in the preparation, cyclooxygenase-1 inhibitory activity, and docking studies of aminoalkoxyphenyl benzamide s. Prepartion and SAR of tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 444-29-1. Pack Sizes: 1g, 5g. Molecular Formula: C7H4F3I, Molecular Weight: 272.01. US Biological Life Sciences. | Worldwide |
4',5'-Dihydro-8-Hydroxy Psoralen Quick inquiry Where to buy Suppliers range | 4',5'-Dihydro-8-hydroxypsoralen is a furancouramin with inhibitory activity on CYP3A4 as well as inhibitory effects on prostaglandin E2 production. 4',5'-Dihydro-8-hydroxypsoralen is an impurity of 8-Methoxypsoralen , also known as Methoxsalen. Group: Biochemicals. Alternative Names: 2,3-Dihydro-9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one; 2,3-Dihydro-6,7-dihydroxy-5-benzofuranacrylic Acid δ-Lactone; 2,3-Dihydroxanthotoxol. Grades: Highly Purified. CAS No. 68123-30-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
AAT-008 Quick inquiry Where to buy Suppliers range | AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4; IC50 = 16.3 nM in a human EP4 functional assay). Synonyms: 4-[(1S)-1-[[5-chloro-2-(3-fluorophenoxy)pyridine-3-carbonyl]amino]ethyl]benzoic acid. Grades: ≥98%. CAS No. 847727-81-5. Molecular formula: C21H16ClFN2O4. Mole weight: 414.8. | |
AX 048 Quick inquiry Where to buy Suppliers range | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grades: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
CAY10580 Quick inquiry Where to buy Suppliers range | Prostaglandin E2 is a naturally occurring prostaglandin which is used as a medication. As a medication it is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor with Ki of 35 nM. Synonyms: CAY 10580; CAY-10580. Grades: ≥96%. CAS No. 64054-40-6. Molecular formula: C19H35NO4. Mole weight: 341.5. | |
CAY10684 Quick inquiry Where to buy Suppliers range | Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans. EP4 is a G protein-coupled receptor, which plays important roles in bone formation and resorption. CAY10684 is an EP4 receptor agonist. It displays more than 1,000-fold selectivity for EP4 over other EP receptors. Synonyms: CAY 10684; CAY-10684; 7-((2R)-2-((E)-3-(4'-Chloro-2'-methyl-[1,1'-biphenyl]-3-yl)-3-hydroxyprop-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoic acid. Grades: ≥98%. CAS No. 493035-81-7. Molecular formula: C27H32ClNO4. Mole weight: 470. | |
Chebulagic acid Quick inquiry Where to buy Suppliers range | Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Uses: Topoisomerase i inhibitors. Synonyms: β-D-glucopyranose; Cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); Cyclic 2?2:4?1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid. Grades: ≥98%. CAS No. 23094-71-5. Molecular formula: C41H30O27. Mole weight: 954.66. | |
CP-533536 Quick inquiry Where to buy Suppliers range | CP-533536, also called as Evatanepag, a 3-pyridyl sulfonamide compound, demonstrated excellent in vitro potency against prostaglandin E2 (PGE2) (induces local bone formation with EC50= 0.3 nM) and selectivity against a broad panel of other targets. Synonyms: 2- [3- [ [ (4-tert-butylphenyl) methyl-pyridin-3-ylsulfonylamino] methyl] phenoxy] acetic acid(3-((4-tert-butylbenzyl)-(pyridine-3-sulfonylamino)methyl)phenoxy)acetic acidCP-533536; CP 533536; CP533536; Evatanepag. Grades: 95%. CAS No. 223488-57-1. Molecular formula: C25H28N2O5S. Mole weight: 468.56. | |
Dinoprostone impurity C Quick inquiry Where to buy Suppliers range | Dinoprostone impurity C. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: (E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(S,E)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl}hept-5-enoic acid, (5E)-PGE2, (E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid, 5,6-trans-PGE2, 5-trans-PGE2, 5-trans-PGE2, 5-trans-Prostaglandin E2, Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5E,11alpha,13E,15S)-, (5E,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid, trans-Dinoprostone, Dinoprostone EP impurity C. CAS No. 36150-00-2. IUPAC Name: (E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Molecular formula: C20H32O5. Mole weight: 352.47. Catalog: APS36150002. SMILES: CCCCC[C@H] (O)\C=C\[C@H]1[C@H] (O)CC (=O)[C@@H]1C\C=C\CCCC (=O)O. Format: Neat. Product Type: Impurity. Shipping: Ice pack (-20°C). | |
E7046 Quick inquiry Where to buy Suppliers range | E7046 is an orally bioavailable and specific type 4 prostaglandin E2 (PGE2) receptor EP antagonist (IC50= 13.5 nM) (Ki= 23.14 nM), with anti-tumor activities. Synonyms: E7046; E-7046; E 7046. 4-[(1S)-1-[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid. CAS No. 1369489-71-3. Molecular formula: C22H18F5N3O4. Mole weight: 483.39. | |
GW2580 Quick inquiry Where to buy Suppliers range | GW2580 is an orally bioavailable inhibitor of cFMS kinase. GW2580 was found to completely inhibit human cFMS kinase in vitro at 0.06 microM and was inactive against 26 other kinases. GW2580 at 1 microM completely inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes and completely inhibited bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone. In contrast, GW2580 did not affect the growth of mouse NS0 lymphoblastoid cells, human endothelial cells, human fibroblasts, or five human tumor cell lines. GW2580 also did not affect lipopolysaccharide (LPS)-induced TNF, IL-6, and prostaglandin E2 production in freshly isolated human monocytes and mouse macrophages. After oral administration, GW2580 blocked the ability of exogenous CSF-1 to increase LPS-induced IL-6 production in mice, inhibited the growth of CSF-1-dependent M-NFS-60 tumor cells in the peritoneal cavity, and diminished the accumulation of macrophages in the peritoneal cavity after thioglycolate injection. Unexpectedly, GW2580 inhibited LPS-induced TNF production in mice, in contrast to effects on monocytes and macrophages in vitro. In conclusion, GW2580's selective inhibition of monocyte growth and bone degradation is consistent with cFMS kinase inhibition. The ability of GW2580 to chronically inhibit CSF-1 signaling through cFMS kinase in normal and tumor cells in vivo makes GW2580 a useful tool in assessing the role of cFMS kinase in normal and disease processes. Synonyms: GW 2580; GW-2580; GW2580. Grades: 0.98. CAS No. 870483-87-7. Molecular formula: C20H22N4O3. Mole weight: 366.421. | |
GYY-4137 Morpholine salt Quick inquiry Where to buy Suppliers range | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Synonyms: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt;(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine;ZYJ1122 morpholine salt;ZYJ-1122 morpholine salt. Grades: ≥95%. CAS No. 106740-09-4. Molecular formula: C15H25N2O3PS2. Mole weight: 376.47. | |
Mf-63 Quick inquiry Where to buy Suppliers range | Mf-63 is a selective Microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Its IC50 value is 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. It displays greater than 1,000-fold selectivity over other prostanoid synthases. It strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme in rodent species. It did not cause NSAID-like gastrointestinal toxic effects that is caused by non-selective COX inhibitors, although it markedly suppresses PGE2 synthesis in the stomach. It prevents LPS-induced hyperglasia. It has anti-inflammatory, analgesic and anti-cancer agent. Uses: Mf-63 has anti-inflammatory, analgesic and anti-cancer agent. Synonyms: 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;MF-63; MF63; MF 63. Grades: >98%. CAS No. 892549-43-8. Molecular formula: C23H11ClN4. Mole weight: 378.81. | |
Nocistatin (bovine) Quick inquiry Where to buy Suppliers range | Nocistatin (bovine) is a peptide derived from the same precursor as nociceptin, and acts as a negative control of nociceptin. It blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2. Synonyms: Nocistatin (bovine); 208253-85-4; AKOS024456394; NCGC00167175-01; PD079088. CAS No. 208253-85-4. Molecular formula: C82H135N21O32. Mole weight: 1927.07. | |
PF 4693627 Quick inquiry Where to buy Suppliers range | PF 4693627 is a potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) that has the potential to treat inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). Uses: Potential treatment of inflammation. Synonyms: PF-4693627; PF 4693627; PF4693627. 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide. Grades: 99%. CAS No. 1312815-93-2. Molecular formula: C26H29Cl2N3O3. Mole weight: 502.43. | |
Pirinixic acid aminothiazole Quick inquiry Where to buy Suppliers range | Pirinixic acid aminothiazole is a dual inhibitor of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase 1 (mPGES-1) with IC50 values of 0.4 and 0.2 μM, respectively. It also weakly inhibits COX-1 and -2. Synonyms: 2-[4-Chloro-6-[4-(2-naphthyl)-2-thiazolylamino]-2-pyrimidinylthio]octanoic acid. Grades: ≥98%. CAS No. 1492060-44-2. Molecular formula: C25H25ClN4O2S2. Mole weight: 513.1. | |
Prostaglandin EP2 Receptor Antagonist, TG6-10-1 ( (E) -N- (2- (2- (trifluoromethyl) -1H-indol-1-yl) ethyl) -3- (3, 4, 5-trimethoxyphenyl) acrylamide, EP2 Antagonist, TG6-10-1) Quick inquiry Where to buy Suppliers range | A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (10uM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
Prostaglandin F2α Tromethamine Salt Quick inquiry Where to buy Suppliers range | One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both. Group: Biochemicals. Alternative Names: (5Z, 9α, 11α, 13E, 15S)-9, 11, 15-Trihydroxyprosta-5, 13-dien-1-oic Acid 2-Amino-2-(hydroxymethyl)-1,3-propanediol; 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic Acid Tromethamine; (+)-Prostaglandin F2α Tromethamine; 9α, 11α, 15(S)-Trihydroxy-5-cis-13-trans-prostadienoic Acid Tromethamine; 9α,11α-PGF2 Tromethamine; 9α,11α-PGF2α Tromethamine; Prostaglandin F2α-tham; THAM PGF2α; Tromethamine Prostaglandin F2α; U 14583E; U 14585. Grades: Highly Purified. CAS No. 38562-01-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(R)-Butaprost Quick inquiry Where to buy Suppliers range | Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: (±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester; 15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester; TR 4978; 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid methyl ester. Grades: ≥98%. CAS No. 69648-38-0. Molecular formula: C24H40O5. Mole weight: 408.6. | |
(R)-Butaprost (free acid) Quick inquiry Where to buy Suppliers range | Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Synonyms: (±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1; 15-deoxy-16R-hydroxy-17-cyclobutyl PGE1; 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid. Grades: ≥98%. CAS No. 215168-33-5. Molecular formula: C23H38O5. Mole weight: 394.6. | |
SC-51089 Quick inquiry Where to buy Suppliers range | A selective EP1 prostanoid receptor antagonist that attenuates prostaglandin E2-induced neuronal cell death in vitro and slows tumor growth in vivo. Its neuroprotective effect may potentially have therapeutic application in human stroke. Group: Biochemicals. Alternative Names: 8-Chloro-dibenz[b, f][1, 4]oxazepine-10(11H)-carboxylic Acid 2-[1-Oxo-3- (4-pyridinyl) propyl]hydrazide Hydrochloride; SC 51089. Grades: Highly Purified. CAS No. 146033-02-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
TG6-10-1 Quick inquiry Where to buy Suppliers range | TG6-10-1, a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, has been shown antagonist activity at human EP2 receptor expressed in rat C6 cells. It shows low-nanomolar antagonist activity against EP2 (>300-fold selectivity ov. Synonyms: (E)-N-[2-[2-(trifluoromethyl)indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamideTG6-10-1; TG 6-10-1; TG-6-10-1; TP6101; TP-6101; TP 6101. CHEMBL32642041415716-58-3C23H23F3N2O4BDBM50016950AKOS0274399 55CS-4637; AK-499428; HY-16978; CS 4637; AK 499428; HY 16978; CS4637; AK499428; HY16978(E)-N-(2-(2-(Trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trime. CAS No. 1415716-58-3. Molecular formula: C23H23F3N2O4. Mole weight: 448.43. | |
Tylvalosin Quick inquiry Where to buy Suppliers range | Tylvalosin, a macrolide antibiotic, is active against S. aureus, E. coli, and P. multocidas with MICs of 2, 128, and 128 μg/mL, respectively. Tylvalosin (5 and 10 μg/mL) reduces LPS-induced production of proinflammatory cytokines, prostaglandin E2 (PGE2) and nitric oxide in RAW 264.7 cells. Preparations containing tylvalosin have been used for the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs. Synonyms: 3-Acetate 4B-(3-methylbutanoate)-tylosin; 3-O-Acetyl-4''-O-isovaleryltylosin; Acetylisovaleryltylosin; 3-Acetyl-4''-isovaleryltylosin; AIV-tylosin; Tylosin acetate isovalerte; Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 4-(acetyloxy)-15-[[(6-deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methyl-1-oxobutyl)-α-L-ribo-hexopyranosyl]-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-16-ethyl-5,9,13-trimethyl-2,10-dioxo-, (4R,5S,6S,7R,9R,11E,13E,15R,16R)-. Grades: ≥95%. CAS No. 63409-12-1. Molecular formula: C53H87NO19. Mole weight: 1042.25. | |
URB937 Quick inquiry Where to buy Suppliers range | URB937 is a potent, peripheral fatty acid amide hydrolase (FAAH) inhibitor with IC50 value of 26.8 nM. It was shown to reduce prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats. Synonyms: URB-937; URB 937; [3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate. Grades: ≥95%. CAS No. 1357160-72-5. Molecular formula: C20H22N2O4. Mole weight: 354.4. | |
Viridicatol Quick inquiry Where to buy Suppliers range | Viridicatol is a fungal metabolite found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. Synonyms: 2(1H)-Quinolinone, 3-hydroxy-4-(3-hydroxyphenyl)-; Carbostyril, 3-hydroxy-4-(m-hydroxyphenyl)-; 3-hydroxy-4-(3-hydroxyphenyl)carbostyril; 4-(3-Hydroxyphenyl)-2,3-quinolinediol. Grades: ≥95%. CAS No. 14484-44-7. Molecular formula: C15H11NO3. Mole weight: 253.25. |