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| Product | Description | |
|---|---|---|
| PROSTAGLANDINS | PROSTAGLANDINS. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PROSTAGLANDINS;Einecs 234-237-8. Product Category: Heterocyclic Organic Compound. CAS No. 11000-26-3. Product ID: ACM11000263. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 12(S)-HHTrE | 12(S)-HHTrE is a metabolite of arachidonic acid (A3303), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Grades: Highly Purified. CAS No. 54397-84-1. Pack Sizes: 500ug, 5mg. Molecular Formula: C17H28O3, Molecular Weight: 280.399999999999. US Biological Life Sciences. |  Worldwide |
| 13,14-dehydro-15-oxoprostaglandin 13-reductase | Reduces 13,14-dehydro-15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+. Group: Enzymes. Synonyms: 15-oxo-Δ13-prostaglandin reductase; Δ13-15-ketoprostaglandin reductase; 15-ketoprostaglandin Δ13-reductase; prostaglandin Δ13-reductase; prostaglandin 13-reductase; (5Z)-(15S)-11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase; (5Z)-11α-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Δ13-oxidoreductase. Enzyme Commission Number: EC 1.3.1.48. CAS No. 57406-74-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1320; 13,14-dehydro-15-oxoprostaglandin 13-reductase; EC 1.3.1.48; 57406-74-3; 15-oxo-Δ13-prostaglandin reductase; Δ13-15-ketoprostaglandin reductase; 15-ketoprostaglandin Δ13-reductase; prostaglandin Δ13-reductase; prostaglandin 13-reductase; (5Z)-(15S)-11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase; (5Z)-11α-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Δ13-oxidoreductase. Cat No: EXWM-1320. |  |
| 14,15-Epoxyeicosatrienoic Acid (±14,15-EET) | Epoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,?N'-?dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore. Also, it is derived from Arachidonic Acid, which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Alternative Names: (5Z,8Z,11Z)-13-(3-Pentyl-2-oxiranyl)-5,8,11-tridecatrienoic Acid; 14(15)-EET; 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; (±)14,15-EET; (±)14,15-EpETrE; (all-Z)-13-(3-Pentyloxiranyl)-5,8,11-tridecatrienoic Acid. Grades: Highly Purified. CAS No. 197508-62-6. Pack Sizes: 50ug, 100ug, 500ug. Molecular Formula: C??H??O?, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
| 15-epi-Prostaglandin E1 | 15-epi-Prostaglandin E1 is used in the kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta and the inhibitions of hydroxyprostaglandins dehydrogenase. Also used in the conformational analysis of prostaglandins, studies on active sites and in conformation-action relationship. Group: Biochemicals. Grades: Highly Purified. CAS No. 20897-91-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H34O5, Molecular Weight: 354.48. US Biological Life Sciences. | Worldwide |
| 15-hydroxyprostaglandin-D dehydrogenase (NADP+) | Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)]. Group: Enzymes. Synonyms: prostaglandin-D 15-dehydrogenase (NADP); dehydrogenase, prostaglandin D2; NADP-PGD2 dehydrogenase; dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate); 15-hydroxy PGD2 dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP); NADP-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin . Enzyme Commission Number: EC 1.1.1.196. CAS No. 84399-95-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0099; 15-hydroxyprostaglandin-D dehydrogenase (NADP+); EC 1.1.1.196; 84399-95-1; prostaglandin-D 15-dehydrogenase (NADP); dehydrogenase, prostaglandin D2; NADP-PGD2 dehydrogenase; dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate); 15-hydroxy PGD2 dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP); NADP-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin D2 dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; NADP-linked prostaglandin D2 dehydrogenase; 15-hydroxyprostaglandin-D dehydrogenase (NADP). Cat No: EXWM-0099. | |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) | Acts on prostaglandins E2, F2α and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase. Group: Enzymes. Synonyms: NADP-dependent 15-hydroxyprostaglandin dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; type II 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP). Enzyme Commission Number: EC 1.1.1.197. CAS No. 54989-39-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0100; 15-hydroxyprostaglandin dehydrogenase (NADP+); EC 1.1.1.197; 54989-39-8; NADP-dependent 15-hydroxyprostaglandin dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; type II 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP). Cat No: EXWM-0100. | |
| 15-Keto Prostaglandin E2 | 15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes. Group: Biochemicals. Grades: Highly Purified. CAS No. 26441-05-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C20H30O5, Molecular Weight: 350.45. US Biological Life Sciences. | Worldwide |
| 3-Hydroxymethyl mefenamic acid acyl b-D-glucuronide | 3-Hydroxymethyl mefenamic acid acyl b-D-glucuronide, a remarkable biomedicine compound, holds tremendous promise for combating inflammatory pain and fever associated with diverse ailments, including rheumatoid arthritis and osteoarthritis. With its exceptional analgesic and anti-inflammatory properties, it expertly hampers the production of prostaglandins - the instigators of distress and inflammation. Synonyms: β-D-Glucopyranuronic acid, 1-[2-[[3-(hydroxymethyl)-2-methylphenyl]amino]benzoate]. CAS No. 152832-29-6. Molecular formula: C21H23NO9. Mole weight: 433.41. |  |
| 6-ROX | 6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 6-Carboxy-X-rhodamine. CAS No. 194785-18-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0053. |  |
| a-Glucametacin | a-Glucametacin, the acclaimed anti-inflammatory wonder, showcases its unparalleled efficacy in combating a myriad of inflammatory afflictions, notably arthritis, while effectively tackling postoperative discomfort. By impeding the production of prostaglandins and leukotrienes, this remarkable drug alleviates pain and curtails inflammation. Synonyms: 2-[[[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-a-D-glucopyranose; a-Glucametacine; a-Glucamethacin; α-D-Glucopyranose, 2-[[[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-. CAS No. 871014-84-5. Molecular formula: C25H27ClN2O8. Mole weight: 518.94. | |
| Alprostadil (ProstaglandinE1) | Prostaglandin E1 is a prostaglandins E. It has a role as a platelet aggregation inhibitor, a vasodilator agent, an anticoagulant and a human metabolite. Alternative Names: alprostadil. Prostaglandin E1. PGE1. Edex. CAS No. 745-65-3. Product ID: API745653. Molecular formula: C20H34O5. Mole weight: 354.5. EINECS: 212-017-2. SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O. Appearance: White Solid. Category: Anticoagulant & Antiplatelet APIs. |  |
| Angiotensin I/II (1-7) | Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor, inducing vasorelaxation through release of NO and prostaglandins. Uses: Endogenous peptide fragment. Synonyms: Angiotensin II (1-7) heptapeptide; TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17)H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH. Grade: ≥90%. CAS No. 51833-78-4. Molecular formula: C41H62N12O11. Mole weight: 899. | |
| Apricoxib | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| Arachidonic acid | Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Immunocytophyt. CAS No. 506-32-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109590. | |
| Arachidonic Acid Alkyne | Arachidonic Acid Alkyne is a metabolite of Arachidonic Acid (A3303). Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Grades: Highly Purified. CAS No. 1219038-32-0. Pack Sizes: 100ug, 500ug. Molecular Formula: C20H28O2, Molecular Weight: 300.44. US Biological Life Sciences. | Worldwide |
| Arachidonic acid sodium salt | Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Immunocytophyt sodium salt. CAS No. 6610-25-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-109590A. | |
| AX 048 | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grade: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| Canniprene | Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa , is a potent inhibitor of 5-lipoxygenase ( 5-LO ) activity ( IC 50 =0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase ( PGE 2 ; IC 50 =10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins [1]. Uses: Scientific research. Group: Natural products. CAS No. 70677-47-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3535. | |
| carbonyl reductase (NADPH) | Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)]. Group: Enzymes. Synonyms: aldehyde reductase 1; prostaglandin 9-ketoreductase; xenobiotic ketone reductase; NADPH-dependent carbonyl reductase; ALR3; carbonyl reductase; nonspecific NADPH-dependent carbonyl reductase; carbonyl reductase (NADPH2). Enzyme Commission Number: EC 1.1.1.184. CAS No. 89700-36-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0086; carbonyl reductase (NADPH); EC 1.1.1.184; 89700-36-7; aldehyde reductase 1; prostaglandin 9-ketoreductase; xenobiotic ketone reductase; NADPH-dependent carbonyl reductase; ALR3; carbonyl reductase; nonspecific NADPH-dependent carbonyl reductase; carbonyl reductase (NADPH2). Cat No: EXWM-0086. | |
| CAY10397 | Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). CAY10397 is a selective inhibitor of 15-hydroxy PGDH, significantly suppressing endogenous 11-oxo-ETE production with a corresponding increase in 11(R)-HETE. It is a selective inhibitor of 15-hydroxy PGDH with IC50 of 10 μM. Synonyms: CK47A. Grade: ≥98%. CAS No. 78028-01-0. Molecular formula: C17H16N2O5. Mole weight: 328.3. | |
| CAY10410 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. Synonyms: 9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2. Grade: ≥98% (isomer mixture). CAS No. 596104-94-8. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| CAY10650 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grade: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
| (-)-Corey Lactone 4-Phenylbenzoate Alcohol | (-)-Corey Lactone 4-Phenylbenzoate Alcohol is a key intermediate in the synthesis of prostaglandins. Synonyms: (3aR,4S,5R,6aS)-Hexahydro-4-(hydroxymethyl)-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one; Corey Lactone; (3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate; (-)-Corey lactone 4-phenylbenzoate; Corey lactone p-phenylbenzoate alcohol; (3aR,4S,5R,6aS)-[1,1'-Biphenyl]-4-carboxylic acid, hexahydro-4-(methoxymethyl)-2-oxo-2H-cyclopentafuran-5-yl ester; (-)-Corey Lactone 5-(4-Phenylbenzoate); (-)-Corey lactone 4-PBP. Grade: ≥95%. CAS No. 31752-99-5. Molecular formula: C21H20O5. Mole weight: 352.38. | |
| (-)-Corey Lactone 5-(4-Phenylbenzoate) | Key intermediate in the synthesis of prostaglandins. Versatile building block for prostaglandins. Building block for a potent and selective antiglaucoma agent analog of PGF2α. Group: Biochemicals. Alternative Names: (3aR, 4S, 5R, 6aS) -Hexahydro-4- (hydroxymethyl) -5- (4-phenylbenzoyloxy) cyclopenta[b]furan-2-one; (-)-Corey Lactone 4-Phenylbenzoate Alcohol; Corey Lactone. Grades: Highly Purified. CAS No. 31752-99-5. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Cyclooxygenase 1 from Human, Recombinant | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. COX-1. Mole weight: ~70 kDa. Activity: >20,000 units/mg. Stability: > 6 months. Storage: -80°C (as supplied); avoid freeze/thaw cycles by aliquoting protein. Form: 80 mM Tris, pH 8.0, containing 0.1% polysorbate 20, 300 uM DDC, and 10% glycerol. Source: Sf21 cells. Species: Human. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-1237. | |
| Cyclooxygenase 2 from Human, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. COX-2. Mole weight: 70 kDa. Activity: >8,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Human. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1238. | |
| Cyclooxygenase 2 from Ovine, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Purity: >80% estimated by SDS-PAGE. COX-2. Mole weight: ~70 kDa. Activity: >20,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Ovine. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1239. | |
| Diclofenac amide | Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2 , that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15362-40-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-134521. | |
| Diclofenac Potassium | Diclofenac potassium is a nonsteroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. It is a competitive inhibitor of cyclooxygenase (COX) that suppresses the production of prostaglandins. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Uses: Nsaid. Synonyms: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Potassium Salt; [o-(2,6-Dichloroanilino)phenyl]acetic Acid Monopotassium Salt; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monopotassium Salt; Caflam; Cataflam; K-fenak; Potassium diclofenac. Grade: >98%. CAS No. 15307-81-0. Molecular formula: C14H10Cl2KNO2. Mole weight: 334.24. | |
| Etamsylate | Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance and platelet adhesion. Synonyms: E 141; MD 141; E141; MD141; E-141; MD-141; Aglumin; Altodor; Eselin. Grade: >98%. CAS No. 2624-44-4. Molecular formula: C6H6O5S.C4H11N. Mole weight: 263.31. | |
| Ethamsylate | Ethamsylate (Etamsylate) is an orally active anti-hemorrhagic compound. Ethamsylate inhibits biosynthesis and action of prostaglandins. Ethamsylate has the potential to maintain early hemostasis as well as restores capillary resistance. Ethamsylate acts as an antiangiogenic factor, inhibiting wound healing and matrigel tubulogenesis. [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Etamsylate. CAS No. 2624-44-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 10 g. Product ID: HY-B1074. | |
| Felbinac | Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase ( COX ) inhibitor with an IC 50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Biphenylacetic acid. CAS No. 5728-52-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0641. | |
| Flurbiprofen Sodium | Flurbiprofen Sodium is a nonsteroidal anti-inflammatory drug (NSAID) derived from propionic acid. It functions as a potent inhibitor of cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Synonyms: [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, sodium salt (1:1); 2-(2-Fluorobiphenyl-4-yl)propionic acid sodium salt; 2-Fluoro-α-methyl-4-diphenylacetic acid sodium salt; Flurbiprofen sodium salt; Ocufen; Ocuflur; Sodium 3-fluoro-4-phenylhydratropate; Sodium flurbiprofen. Grade: ≥95%. CAS No. 56767-76-1. Molecular formula: C15H12FNaO2. Mole weight: 266.24. | |
| Hydroxy Loxoprofen | An impurity of Loxoprofen. Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduce the synthesis of prostaglandins from arachidonic acid. Synonyms: Benzeneacetic acid, 4-[(2-hydroxycyclopentyl)?methyl]?-α-methyl-. Grade: >95%. CAS No. 83599-40-0. Molecular formula: C15H20O3. Mole weight: 248.32. | |
| Hydroxy Loxoprofen-d6 | Hydroxy Loxoprofen-d6 is a labelled impurity of Hydroxy Loxoprofen. Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduce the synthesis of prostaglandins from arachidonic acid. Grade: > 95%. Molecular formula: C15H14O3D6. Mole weight: 254.36. | |
| Isopropyl Unoprostone | Isopropyl unoprostone is the isopropyl ester of unoprostone. It has a role as an antiglaucoma drug, an antihypertensive agent and a prodrug. It is a prostaglandins Falpha, a ketone and an isopropyl ester. It is functionally related to an unoprostone. Alternative Names: isopropyl unoprostone. Unoprostone isopropyl ester. unoprostone isopropyl. Rescula. CAS No. 120373-24-2. Product ID: API120373242. Molecular formula: C25H44O5. Mole weight: 424.6. SMILES: CCCCCCCC(=O)CCC1C(CC(C1CC=CCCCC(=O)OC(C)C)O)O. Category: Antihypertensive APIs. | |
| Licofelone | Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor ( IC 50 =0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis , and decreases the production of proinflammatory leukotrienes and prostaglandins [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML-3000. CAS No. 156897-06-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1452. | |
| Loxoprofen | Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic Acid; 2-[4-[(2-Oxocyclopentan-1-yl)methyl]phenyl]propionic Acid; 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid. Grade: >98%. CAS No. 68767-14-6. Molecular formula: C15H18O3. Mole weight: 246.3. | |
| Native Crotalus Phospholipase A2 | Phospholipases A2 (PLA2s) EC 3.1.1.4 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators. Phospholipase a2 is a member of the class of heat-stable, calcium-dependent enzymes catalyzing the hydrolysis of the 2-acyl bond of 3-n-phosphoglycerides. a chromatographically purified, dialyzed, lyophilized powder. Group: Enzymes. Synonyms: EC 3.1.1.4; Phospholipases A2; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-86-9. Purity: chromatographically purified, dialyzed. PLA2. Mole weight: 30 kDa (Wells 1969). Activity: > 200 units per mg dry weight. Stability: The enzyme is stable at 90°C and pH 3.0 for at least five minutes. (Uthe 1971; Saito 1962). Storage: Store at 2-8°C. Form: lyophilized powder. Source: Crotalus adamanteus Venom. Species: Crotalus. EC 3.1.1.4; Phospholipases A2; PLA2s. Cat No: NATE-0591. | |
| Native Pineapple Bromelain | Bromelain is a cysteine endopeptidase with broad specificity for cleavage of proteins. Bromelain may be from a stem or piece of fruit. Stem bromelain (SBM) (EC 3.4.22.32), a proteolytic enzyme, is a widely accepted phytotherapeutical drug member of the bromelain family of proteolytic enzymes obtained from Ananas comosus. Some of the therapeutic benefits of SBM are reversible inhibition of platelet aggregation, angina pectoris, bronchitis, sinusitis, surgical traumas, thrombophlebitis, pyelonephritis and enhanced absorption of drugs, particularly of antibiotics. Its anti-metastasis and anti-inflammatory activities are apparently independent of its proteolytic activity. Applications: Bromelain may be used to inhibit the biosysnthesis of proinflammatory prostaglandins. it may be used to reduce clotting efficiency. bromelain, from pineapple stem, has been used to make enzymatic hydrolysates of honeybee-collected pollen. Group: Enzymes. Synonyms: stem bromelain; EC 3.4.22.32; 37189-34-7; bromelain; pineappl. Enzyme Commission Number: EC 3.4.22.32. CAS No. 37189-34-7. Bromelain. Activity: > 3 units/mg protein; 5-15 units/mg protein. Form: Lyophilized powder containing mannitol and potassium phosphate buffer salts. Source: Pineapple stem. Species: Pineapple. stem bromelain; EC 3.4.22.32; 37189-34-7; bromelain; pineapple stem bromelain; SBM. Cat No: NATE-0665. | |
| Native Sheep Cyclooxygenase 1 | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Enzyme Commission Number: EC 1.14.99.1. CAS No. 9055-65-6. Purity: > 95% (SDS-PAGE). COX-1. Mole weight: dimer subunit mol wt 70 kDa. Activity: > 40,000 units/mg protein. Storage: -70°C. Form: aqueous solution. Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN 20 and 300 μM diethyldithiocarbamate. Source: Sheep. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-0149. | |
| Nordihydroguaiaretic acid | NDGA (Nordihydroguaiaretic acid), also known as masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase. Synonyms: 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol. Grade: > 98 %. CAS No. 500-38-9. Molecular formula: C18H22O4. Mole weight: 302.36. | |
| Pranoprofen | Pranoprofen is a non-steroidal anti-inflammatory agent ( NSAID ) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 52549-17-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0336. | |
| Prost-13-en-1-oic acid,9,11,15-trihydroxy-,(9a,11a,13e,15s)- | Prost-13-en-1-oic acid,9,11,15-trihydroxy-,(9a,11a,13e,15s)-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: prostaglandinf1; PGF1; PROSTAGLANDIN F1A; prostaglandin F1alpha; PGF1ALPHA; protaglandinf1; syntheticwhitecrystallinesolid; PROSTAGLANDINS F1ALPHA; PROSTAGLANDIN F1ALPHA. Product Category: Heterocyclic Organic Compound. CAS No. 745-62-0. Molecular formula: C20H36O5. Mole weight: 356.56. Purity: 0.96. IUPACName: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]heptanoic acid. Canonical SMILES: CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O. Density: 1.136 g/cm³. Product ID: ACM745620. Alfa Chemistry ISO 9001:2015 Certified. | |
| Prostaglandin E2 (Dinoprostone) | The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient. Inhibits NLRP3 by acting through receptor EP4 activation that increases cAMP and phosphorylates NLRP3 at serine 295 through PKA. PKA phosphorylation of NLRP3 inhibits the NLRP3 ATPase activity, which is required for assembly of NLRP3-ASC complexes. Group: Biochemicals. Alternative Names: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid; (-)-Prostaglandin E2; (15S)-Prostaglandin E2; Cervidil; Cerviprime; Cerviprost; Dinoprostone; Minprostin E2; PGE2; Prepidil. Grades: Highly Purified. CAS No. 363-24-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Prostaglandin F2α Tromethamine Salt | One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both. Group: Biochemicals. Alternative Names: (5Z, 9α, 11α, 13E, 15S)-9, 11, 15-Trihydroxyprosta-5, 13-dien-1-oic Acid 2-Amino-2-(hydroxymethyl)-1,3-propanediol; 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic Acid Tromethamine; (+)-Prostaglandin F2α Tromethamine; 9α, 11α, 15(S)-Trihydroxy-5-cis-13-trans-prostadienoic Acid Tromethamine; 9α,11α-PGF2 Tromethamine; 9α,11α-PGF2α Tromethamine; Prostaglandin F2α-tham; THAM PGF2α; Tromethamine Prostaglandin F2α; U 14583E; U 14585. Grades: Highly Purified. CAS No. 38562-01-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Prostaglandin H2 | Prostaglandin H2 (PGH2), a potent vasoconstrictor, is produced by the conversion of Arachidonic acid (AA). Prostaglandin H2 is asubstrate for the production of Prostaglandins (PGs) and thromboxanes (TXs) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PGH2. CAS No. 42935-17-1. Pack Sizes: 10 μg (283.71 μM * 100 μL in Acetone); 50 μg (283.71 μM * 500 μL in Acetone); 100 μg (283.71 μM * 1 mL in Acetone). Product ID: HY-136500. | |
| unspecific monooxygenase | A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH-hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here. Group: Enzymes. Synonyms: microsomal monooxygenase; xenobiotic monooxygenase; aryl-4-monooxygenase; aryl hydrocarbon hydroxylase; microsomal P-450; flavoprotein-linked monooxygenase; flavoprotein monooxygenase; substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hy. Enzyme Commission Number: EC 1.14.14.1. CAS No. 9038-14-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0906; unspecific monooxygenase; EC 1.14.14.1; 9038-14-6; microsomal monooxygenase; xenobiotic monooxygenase; aryl-4-monooxygenase; aryl hydrocarbon hydroxylase; microsomal P-450; flavoprotein-linked monooxygenase; flavoprotein monooxygenase; substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing). Cat No: EXWM-0906. | |
| 11-beta-Prostaglandin E1 | 11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. Prostaglandin E1 is a naturally occurring prostaglandin. It is used to treat erectile dysfunction. Synonyms: 9-oxo-11β,15S-dihydroxy-prost-13E-en-1-oic acid. Grade: > 95%. CAS No. 24570-01-2. Molecular formula: C20H34O5. Mole weight: 354.49. | |
| 11β-Prostaglandin E1 | 11β-Prostaglandin E1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-oxo-11β,15S-dihydroxy-prost-13E-en-1-oic acid. Appearance: Crystalline solid. CAS No. 24570-01-2. Molecular formula: C20H34O5. Mole weight: 354.5. Purity: 0.95. Product ID: ACM24570012. Alfa Chemistry ISO 9001:2015 Certified. | |
| 11-deoxy-16,16-dimethyl prostaglandin E2 | AY 24609 is an analogue of PGE2 and a selective EP2 and EP3 receptors agonist. It also inhibits gastric acid secretion and ulcer formation in rat. Synonyms: AY 24609; 11-deoxy-16,16-dimethyl PGE2; (Z)-7-[(1R,2R)-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Grade: ≥98%. CAS No. 53658-98-3. Molecular formula: C22H36O4. Mole weight: 364.5. | |
| 11-Deoxy-16,16-dimethyl prostaglandin e2 | 11-Deoxy-16,16-dimethyl prostaglandin e2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-OXO-15R-HYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID;11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2. Product Category: Heterocyclic Organic Compound. Appearance: A solution in methyl acetate. CAS No. 53658-98-3. Molecular formula: C22H36O4. Mole weight: 364.52. Purity: 0.96. IUPACName: 7-[(1R,2R)-2-[(3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Canonical SMILES: CCCCC(C)(C)C(C=CC1CCC(=O)C1CC=CCCCC(=O)O)O. Product ID: ACM53658983. Alfa Chemistry ISO 9001:2015 Certified. Categories: 11-deoxy-16,16-dimethyl-PGE2. | |
| 11-Deoxy prostaglandin E1 | 11-Deoxy prostaglandin E1 is a synthetic analog of PGE1. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively. Uses: Anti-ulcer agents. Synonyms: 11-deoxy PGE1; 7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid. Grade: ≥96%. CAS No. 37786-00-8. Molecular formula: C20H34O4. Mole weight: 338.5. | |
| 11-Deoxy Prostaglandin E2 | 11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC 50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35536-53-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114910. | |
| 11-Epiprostaglandin E1 | 11-Epiprostaglandin E1 is used for the studies of various prostaglandin analogs. Group: Biochemicals. Grades: Highly Purified. CAS No. 24570-01-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H34O5, Molecular Weight: 354.48. US Biological Life Sciences. | Worldwide |
| 11-Keto fluprostenol | 11-Keto fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Synonyms: Fluprostenol Prostaglandin D2; (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid. Grade: ≥98%. CAS No. 62145-07-7. Molecular formula: C23H27F3O6. Mole weight: 456.5. | |
| 12(S)-HHTrE | 12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets. It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. Synonyms: 12(S)-HHT; 12-hydroxyheptadecatrienoic acid. Grade: ≥95%. CAS No. 54397-84-1. Molecular formula: C17H28O3. Mole weight: 280.4. | |
| 12(S)-hydroxy-16-heptadecynoic acid | 12(S)-hydroxy-16-heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM. Synonyms: 16-Heptadecynoic acid,12-hydroxy-, (S)- (9CI); 12-Hydroxy-heptadec-16-ynoic acid. Grade: ≥98%. CAS No. 148019-74-3. Molecular formula: C17H30O3. Mole weight: 282.4. | |
| 13,14-Dihydro-15-keto-PGD2 | 13,14-Dihydro-15-keto-PGD2 is a metabolite of prostaglandin D2 and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59894-07-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H32O5, Molecular Weight: 352.47. US Biological Life Sciences. | Worldwide |
| 13,14-dihydro-15-keto prostaglandin D2 | 13,14-dihydro-15-keto prostaglandin D2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. It has been recently identified as a selective agonist for the DP2 receptor. Additionally, 13,14-dihydro-15-keto Prostaglandin D2 has been shown to inhibit ion flux in canine colonic mucosa preparation. Synonyms: 13,14-dihydro-15-keto PGD2; 11,15-dioxo-9S-hydroxy-5Z-prostenoic acid; (Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid. Grade: ≥95%. CAS No. 59894-07-4. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| 13,14-Dihydro-15-keto prostaglandin e1 | 13,14-Dihydro-15-keto prostaglandin e1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1;9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID. Product Category: Heterocyclic Organic Compound. Appearance: A solution in methyl acetate. CAS No. 5094-14-4. Molecular formula: C20H34O5. Mole weight: 354.48. Product ID: ACM5094144. Alfa Chemistry ISO 9001:2015 Certified. | |
| 13,14-Dihydro-15-keto Prostaglandin F2α | 13,14-Dihydro-15-keto Prostaglandin F2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 13,14-Dihydro-15-keto-PGF2α. CAS No. 27376-76-7. Pack Sizes: 1 mg (28.21 mM * 100 μL in Methyl acetate); 5 mg. Product ID: HY-113208. | |
| 13,14-Dihydro Bimatoprost | 13,14-Dihydro Bimatoprost is an impurity of Bimatoprost, which is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Synonyms: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethyl-5-heptenamide; N-Ethyl-9-alpha,11-alpha,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-amide; Latanoprost ethyl amide; LAT-NET. Grade: 98%. CAS No. 607351-44-0. Molecular formula: C25H39NO4. Mole weight: 417.58. | |
| 13-trans-Latanoprost | 17-phenyl trinor PGF2α is a potent FP receptor agonist. Synonyms: Bimatoprost isopropyl ester; 17-phenyl-18,19,20-trinor-prostaglandin F2 alpha-1-isopropyl ester; 17-phenyl-18,19,20-trinor-PGF2alpha-1-isopropyl ester; 13,14-dehydro-latanoprost; Bimatoprost isopropyl ester; 17-phenyl trinor PGF2α-iPr; 17-phenyl trinor PGF2α isopropyl ester; 17-Phenyl trinor Pgf2alpha-Iprdehydrolatanoprost; 17-Phenyl trinor prostaglandin F2α isopropyl ester. Grade: ≥ 90%. CAS No. 130209-76-6. Molecular formula: C26H38O5. Mole weight: 430.58. | |
| 14-Methyl Prostaglandin E1 | 14-Methyl Prostaglandin E1 is used for studies on 15-hydroxyprostaglandin dehydrogenase with various prostagladin analogs. Also, the acts as a reagent for the synthesis of prostaglandin analogs, which functions as anticoagulants, bronchidilators, hypotensives e.t.c. Group: Biochemicals. Grades: Highly Purified. CAS No. 41692-11-9. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H36O5, Molecular Weight: 368.51. US Biological Life Sciences. | Worldwide |
| 15-Cyclohexyl pentanor prostaglandin F2α | 15-cyclohexyl pentanor PGF2α is an analog of PGF2α with resistance to 15-hydroxy PGDH metabolism. Synonyms: 15-cyclohexyl pentanor PGF2α; (Z)-7-[(1R,2R,3R,5S)-2-[(E,3S)-3-cyclohexyl-3-hydroxyprop-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid. Grade: ≥96%. CAS No. 58611-97-5. Molecular formula: C21H34O5. Mole weight: 366.5. | |
| 15-deoxy-Δ12,14-Prostaglandin D2 | 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation ( EC 50 =8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 ( SRC-1 ) to peroxisome proliferator-activated receptor γ ( PPARγ ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells ( IC 50 =0.3 μg/ml) and inhibits ADP-induced platelet aggregation ( IC 50 =320 ng/mL). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 15-Deoxy-Δ12,14-PGD2. CAS No. 85235-11-6. Pack Sizes: 1 mg (2.99 mM * 1 mL in Methyl acetate). Product ID: HY-116028. | |
| 15-deoxy-Δ-12,14-Prostaglandin J2 | Selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 87893-55-8. Pack Sizes: 1mg. Molecular Formula: C20H28O3, Method for Determining. US Biological Life Sciences. | Worldwide |
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