Protease Vii Suppliers USA
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Product | Description | |
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Benzamidine hydrochloride Quick inquiry Where to buy Suppliers range | Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). Benzamidine inhibits the autoactivation of human blood coagulation factor VII, useful as a tool for studying the interactions between this and other relevant growth factors. Uses: Serine proteinase inhibitors. Synonyms: Benzenecarboximidamide, hydrochloride (1:1); Benzamidine, monohydrochloride; Benzenecarboximidamide, monohydrochloride; Amidinobenzene hydrochloride; Benzamidinium chloride; Benzimidamide hydrochloride. Grades: ≥98%. CAS No. 1670-14-0. Molecular formula: C7H8N2.HCl. Mole weight: 156.61. | |
E-76 Quick inquiry Where to buy Suppliers range | E-76, a potent anticoagulant, is an inhibitor of coagulation factor VIIa. It acts by binding to an exosite on the VIIa protease domain and non-competitively inhibits the activation of factor X and amide hydrolytic activity. Synonyms: E-76; Acetyl-ALCDDPRVDRWYCQFVEG-amide; Ac-Ala-Leu-D-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bridge: Cys3-Cys13); N-acetyl-L-alanyl-L-leucyl-D-cysteinyl-L-alpha-aspartyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-valyl-L-alpha-aspartyl-L-arginyl-L-tryptophyl-L-tyrosyl-L-cysteinyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-alpha-glutamyl-glycinamide (3->13)-disulfide. Grades: ≥95% by HPLC. CAS No. 1926163-13-4. Molecular formula: C97H139N27O29S2. Mole weight: 2211.47. | |
Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N- (3- (trifluoromethyl) benzyl) -9H-purin-6-amine) Quick inquiry Where to buy Suppliers range | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
MDM2 Inhibitor VII, MEL23 Quick inquiry Where to buy Suppliers range | The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 354.40. Catalog: IAR42410905. Assay: ≥95% (HPLC). | |
MDM2 Inhibitor VII, MEL23 (3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione, MDM2-MDMX E3 Ligase Inhibitor) Quick inquiry Where to buy Suppliers range | A cell-permeable tetrahydro-b-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100uM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc.=14uM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3, MEL23 does not interfere with Mdm2-p53 interaction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PCI-27483 Quick inquiry Where to buy Suppliers range | PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities. FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2). Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells. In addition, this agent inhibits both the extrinsic and intrinsic coagulation cascades, preventing blood clot formation. TF, a blood protein overexpressed on the cell surface of a variety of tumor cell types, may correlate with poor prognosis; PAR-2 (also known as thrombin receptor-like 1) is a G protein-coupled receptor (GPCR) and a protease-activated receptor. PCI-27483 is in a clinical trial for the treatment of advanced pancreatic cancer in combination with Gemcitabine. Synonyms: PCI27483; PCI 27483; (2S) -2-[[2-[3- (6-carbamimidoyl-1H-benzimidazol-2-yl) -4-hydroxy-5- (2-hydroxy-5-sulfamoylphenyl) phenyl]acetyl]amino]butanedioic acid. Grades: ≥98%. CAS No. 871266-63-6. Molecular formula: C26H24N6O9S. Mole weight: 596.6. | |
Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT; 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33 / Ser37 / Thr41 / Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |