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| Product | Description | |
|---|---|---|
| Proteasome inhibitor i | Proteasome inhibitor i. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CARBOBENZOXY-L-ISOLEUCYL-GAMMA-T-BUTYL-L-GLUTAMYL-L-ALANYL-L-LEUCINAL;BENZYLOXYCARBONYL-L-ISOLEUCYL-[(2S)-2-AMINO-4-(T-BUTYLOXYCARBONYL)BUTANOYL]-L-ALANYL-L-LEUCINAL;PROTEASOME INHIBITOR I;PROTEASOME INHIBITOR I (ALDEHYDE);PROTEASOME INHIBITOR PSI;PSI;N-. Product Category: Heterocyclic Organic Compound. CAS No. 158442-41-2. Molecular formula: C32H50N4O8. Mole weight: 618.76. Purity: >90 %. Product ID: ACM158442412. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Proteasome Inhibitor I | The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Proteasome Inhibitor II | The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Proteasome Inhibitor III | The Proteasome Inhibitor III controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Proteasome Inhibitor IV | The Proteasome Inhibitor IV controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Proteasome Inhibitor X, PI-083 - CAS 6298-15-3 | The Proteasome Inhibitor X, PI-083, also referenced under CAS 6298-15-3, controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 | The Proteasome Inhibitor XX, GL5, also referenced under CAS 146304-91-8, controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Proteasome Inhibitor XXI, Z-LLLL-SF (Cbz-Leu-Leu-Leu-Leu-Psi-[CH2SO2]-F, Cbz-Leu4-SF, Cbz-LLLL-SF, Z-Leu4-SF, Z-L4-SF) | A cell-permeable tetrapeptidyl sulfonyl fluoride -based irreversible proteasome inhibitor that selectively inhibits the hydrolysis of Suc-LLVY-AMC by the beta5 chymotrypsin-like activity (IC50 = 7nM using yeast 20S proteasome), while exhibiting much reduced potency against Z-LLE-AMC hydrolysis by the beta1 caspase-like activity or Z-LLR-AMC hydrolysis by the beta2 trypsin-like activity (29% and 75% inhibition, respectively, with 200uM inhibitor). One hour inhibitor treatment at 5uM in HEK cultures is shown to completely abolish beta5 labeling by the proteasome probe MV151, while only partial MV151 blockage is seen with beta1 and beta2 at an inhibitor concentration of 50uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?S. US Biological Life Sciences. |  Worldwide |
| 3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1,3-Bis-(Z-Leu-Leu)-diaminoacetone | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. |  |
| (1R) - (1S, 2S, 3R, 5S) -Pinane diol-N- (N-pyrazinyl phenyl alaninoyl ) -1-aminohexyl -1-boronate | (1R) - (1S, 2S, 3R, 5S) -Pinane diol-N- (N-pyrazinyl phenyl alaninoyl ) -1-aminohexyl -1-boronate is an intermediate in the preparatin of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor. Group: Biochemicals. Alternative Names: N-((S)-1-Oxo-3-phenyl-1-(((R)-1-((3aS, 4S, 6S, 7aR)-3a, 5, 5-trimethylhexahydro-4, 6-methanobenzo[d][1, 3, 2]dioxaborol-2-yl)hexyl)amino)propan-2-yl)pyrazine-2-carboxamide. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (1R) - (1S, 2S, 3R, 5S) -Pinane diol-N- (N-pyrazinyl phenyl alaninoyl ) -1-aminopentyl -1-boronate | (1R) - (1S, 2S, 3R, 5S) -Pinane diol-N- (N-pyrazinyl phenyl alaninoyl ) -1-aminopentyl -1-boronate is an intermediate in the preparatin of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor. Group: Biochemicals. Alternative Names: N-((S)-1-Oxo-3-phenyl-1-(((R)-1-((3aS, 4S, 6S, 7aR)-3a, 5, 5-trimethylhexahydro-4, 6-methanobenzo[d][1, 3, 2]dioxaborol-2-yl)pentyl)amino)propan-2-yl)pyrazine-2-carboxamide. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (1R, 2R) - (1S, 2S, 3R, 5S) -Pinane diol-N- (N-pyrazinyl phenyl alaninoyl ) -1-aminopentyl -1-boronate | (1R, 2R) - (1S, 2S, 3R, 5S) -Pinane diol-N- (N-pyrazinyl phenyl alaninoyl ) -1-aminopentyl -1-boronate is an intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C29H39BN4O4. US Biological Life Sciences. | Worldwide |
| (1R,3S,4S)-tert-Butyl 3-(1H-Benzo[d]imidazol-2-yl)-2-azabicyclo[2. 2. 1]heptane-2-carboxylate | (1R,3S,4S)-tert-Butyl 3-(1H-Benzo[d]imidazol-2-yl)-2-azabicyclo[2. 2. 1]heptane-2-carboxylate can be obtained from (R)-(+)-α-Methylbenzylamine (M288800) which can be used as reactant/reagent in synthesis of urea-containing peptide boronic acids as proteasome inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C18H23N3O2, Molecular Weight: 313.39. US Biological Life Sciences. | Worldwide |
| (1S)-3-Hydroxy Bortezomib | (1S)-3-Hydroxy Bortezomib is a metabolite of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. Bortezomib is a reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C19H25BN4O5, Molecular Weight: 400.24. US Biological Life Sciences. | Worldwide |
| (1S)-3-Hydroxy Bortezomib-d8 | (1S)-3-Hydroxy Bortezomib-d8 is labelled (1S)-3-Hydroxy Bortezomib (H818155) which is a metabolite of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. Bortezomib is a reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C19H17D8BN4O5, Molecular Weight: 408.29. US Biological Life Sciences. | Worldwide |
| [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester | [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester is a reagent in the synthesis of proteasome inhibitor epoxomicin, which has antitumor, antiinflammatory and antibiotic properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 247068-83-3. Pack Sizes: 10mg, 100mg. Molecular Formula: C14H25NO4, Molecular Weight: 271.35. US Biological Life Sciences. | Worldwide |
| [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester-d3 | [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester-d3 is the isotope labelled analog of [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester. [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester is a reagent in the synthesis of proteasome inhibitor epoxomicin, which has antitumor, antiinflammatory and antibiotic properties. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C14H22D3NO4, Molecular Weight: 274.37. US Biological Life Sciences. | Worldwide |
| (1S)-(αR, 3aS, 4S, 6S, 7aR)-Hexahydro-3a, 8, 8-trimethyl-α-pentyl-4, 6-methano-1, 3, 2-benzodioxaborole-2-methanamine Trifluoroacetic Acid Salt | (αR, 3aS, 4S, 6S, 7aR)-Hexahydro-3a, 8, 8-trimethyl-α-pentyl-4, 6-methano-1, 3, 2-benzodioxaborole-2-methanamine is an intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor. Group: Biochemicals. Alternative Names: (αR, 3aS, 4S, 6S, 7aR)-Hexahydro-3a, 5, 5-trimethyl-α-pentyl-4, 6-methano-1, 3, 2-benzodioxaborole-2-methanamine Trifluoroacetic Acid Salt. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2,2-Dimethylpropanoyl Chloride | 2,2-Dimethylpropanoyl Chloride is used in the synthesis of novel guttiferon A derivatives with promising potential to be used in the treatment of malaria. Also used in the synthesis of potent covalent proteasome inhibitors of. Group: Biochemicals. Alternative Names: 1,1-Dimethylethanecarbonyl Chloride; 2,2,2-Trimethylacetyl Chloride; 2,2-Dimethylpropanoyl Chloride; 2,2-Dimethylpropionic Acid Chloride; 2,2-Dimethylpropionyl Chloride; Neopentanoyl Chloride; Pivalic Acid Chloride; Pivalolyl Chloride; Pivalyl Chloride; Trimethylacetyl Chloride; tert-Butyl Chloro Ketone; tert-Butylcarbonyl Chloride. Grades: Highly Purified. CAS No. 3282-30-2. Pack Sizes: 25ml. US Biological Life Sciences. | Worldwide |
| 2-[(2-Pyrazinylcarbonyl)-Bortezomib | 2-[(2-Pyrazinylcarbonyl)-Bortezomib is a derivative of Bortezomib (B675700) which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. Bortezomib is a reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H27BN6O5, Molecular Weight: 490.32. US Biological Life Sciences. | Worldwide |
| 2,5-Dimethylpyrazine | 2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness. Group: Biochemicals. Grades: Highly Purified. CAS No. 123-32-0. Pack Sizes: 5g, 25g. Molecular Formula: C6H8N2. US Biological Life Sciences. | Worldwide |
| 2-Bromo-1,4-dichlorobenzene | 2-Bromo-1,4-dichlorobenzene is a reactant used in the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708. Group: Biochemicals. Grades: Highly Purified. CAS No. 1435-50-3. Pack Sizes: 10g, 25g. Molecular Formula: C6H3BrCl2, Molecular Weight: 225.9. US Biological Life Sciences. | Worldwide |
| 2-Ethyl-2-methyl-1,3-dioxolane | 2-Ethyl-2-methyl-1,3-dioxolane is used as a reagent in the synthesis of Strychnine Hydrochloride (S687710); a compound that acts as an antagonist for cholinesterases and beta amyloid aggregation. Also used as a reagent in the study of the prodrugs of peptide aldehyde as proteasome inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 126-39-6. Pack Sizes: 1g, 10g. Molecular Formula: C6H12O2, Molecular Weight: 116.16. US Biological Life Sciences. | Worldwide |
| (2R)-2-Amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one Trifluoroacetate Salt | (2R)-2-Amino-4-methyl-1-(2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt s an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C11H18F3NO4, Molecular Weight: 285.26. US Biological Life Sciences. | Worldwide |
| (2R)-4-Oxo-2-oxetanecarboxylic Acid | (2R)-4-Oxo-2-oxetanecarboxylic Acid is the R-isomer of 4-Oxo-2-oxetanecarboxylic Acid and is used as a reagent in the synthesis of UCK 14A2 derivatives as proteasome inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 177019-47-5. Pack Sizes: 5mg, 10mg. Molecular Formula: C4H4O4, Molecular Weight: 116.07. US Biological Life Sciences. | Worldwide |
| (2R,4S)-4-((t-Butoxycarbonyl)amino)-1,2-dihydroxy-2,6-dimethyl-3-oxohepan-4-tyl | (2R,4S)-4-((t-Butoxycarbonyl)amino)-1,2-dihydroxy-2,6-dimethyl-3-oxohepan-4-tyl is an intermediate used in the synthesis of Carfilzomib (2S,4S)-Diol (C183495), which is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 1541172-78-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H27NO5, Molecular Weight: 289.37. US Biological Life Sciences. | Worldwide |
| (2R,4S)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate | (2R,4S)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate is an intermediate in synthesizing Carfilzomib (2S,4S)-Diol (C183495), a derivative of Carflizomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H29NO6, Molecular Weight: 331.4. US Biological Life Sciences. | Worldwide |
| (2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate | (2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 247068-85-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C11H18F3NO4, Molecular Weight: 285.26. US Biological Life Sciences. | Worldwide |
| (2S, 3R) -3-Hydroxy-2- (6-phenylpicolinamido) butanoic Acid | (2S, 3R) -3-Hydroxy-2- (6-phenylpicolinamido) butanoic Acid is an intermediate in the synthesis of Delanzomib (D230710), an orally active proteasome inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (2S,4R)-4-((t-Butoxycarbonyl)amino)-1,2-dihydroxy-2,6-dimethyl-3-oxohepan-4-tyl | (2S,4R)-4-((t-Butoxycarbonyl)amino)-1,2-dihydroxy-2,6-dimethyl-3-oxohepan-4-tyl is an intermediate used in the synthesis of Carfilzomib (2S,4R)-Diol (C183500), is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H27NO5, Molecular Weight: 289.37. US Biological Life Sciences. | Worldwide |
| (2S,4R)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate | (2S,4R)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate is an intermediate in synthesizing Carfilzomib (2S,4R)-Diol (C183500), a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H29NO6, Molecular Weight: 331.4. US Biological Life Sciences. | Worldwide |
| (2S,4R)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate Trifluoroacetate Salt | (2S,4R)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate Trifluoroacetate Salt is an intermediate in synthesizing Carfilzomib (2S,4R)-Diol (C183500), a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H21NO4; (C2HF3O2), Molecular Weight: 231.2911402. US Biological Life Sciences. | Worldwide |
| (2S,4S)-4-Amino-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate TFA Salt | (2S,4S)-4-Amino-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate TFA Salt is an intermediate used in the synthesis of Carfilzomib (2S,4S)-Diol (C183495), which is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H21NO4; C2HF3O2, Molecular Weight: 231.2911402. US Biological Life Sciences. | Worldwide |
| (2S,4S)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate | (2S,4S)-4-((t-Butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl Acetate is an intermediate in synthesizing Carfilzomib (2S,4S)-Diol (C183495), a derivative of Carflizomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H29NO6, Molecular Weight: 331.4. US Biological Life Sciences. | Worldwide |
| (3aS,4S,6S,7aR)-2-Butylhexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborole | (3aS,4S,6S,7aR)-2-Butylhexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborole is an intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor. Group: Biochemicals. Alternative Names: [3aS-(3aα,4 β,6 β,7aα)]-2-Butylhexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborole. Grades: Highly Purified. CAS No. 85167-10-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| (3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-2-pentyl-4,6-methano-1,3,2-benzodioxaborole | (3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-2-pentyl-4,6-methano-1,3,2-benzodioxaborole is an intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 476335-09-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 8-Hydroxyquinoline Hemisulfate Salt Hemihydrate | 8-Hydroxyquinoline Hemisulfate Salt Hemihydrate is a 20S proteasome inhibitor. It can be used in pharmacological activity and biological study of treatment of drug-resistant bacterial and fungal infections with metal chelating compounds such as clioquinol analogs and combination with other antibiotics in relation to β lactamase. Group: Biochemicals. Grades: Highly Purified. CAS No. 207386-91-2. Pack Sizes: 100g, 250g. Molecular Formula: C9H11NO6S, Molecular Weight: 261.25. US Biological Life Sciences. | Worldwide |
| AAF-CMK trifluoroacetate salt | AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome function, and reversibly inhibits Cln2 (TPPI). Synonyms: N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase Inhibitor II; L-Alaninamide,L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-. Grades: ≥95%. CAS No. 184901-82-4. Molecular formula: C18H23ClF3N3O5. Mole weight: 453.84. | |
| AdaAhx?L?VS - CAS 389064-25-9 | A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 μM), and PGPH (0.5-1 μM) activities of the 20S proteasome. Group: Fluorescence/luminescence spectroscopy. | |
| Alloxan hydrate | Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244-11-3. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-W017227. |  |
| (αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetate | Bortezomib intermediate. A boronic acid dipeptide derivative as proteasome inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 179324-87-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| AM-114 | AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome. In addition, AM-114 shows anticancer activity, It can inhibit cell growth in human colon cancer HCT116 p53+/+ cells. Uses: Anticancer. Synonyms: AM-114; AM 114; AM114; Proteasome Inhibitor IX; ( (1Z, 1'Z)- (1-methyl-4-oxopiperidine-3, 5-diylidene)bis (methanylylidene))bis (4, 1-phenylene))diboronic acid. Grades: 98%. CAS No. 856849-35-9. Molecular formula: C20H21B2NO5. Mole weight: 377.01. | |
| Autophagy Compound Library | A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Autophagy inducers, Autophagy inhibitors, Proteasome, HIF, HDAC, Aurora Kinase, E3 Ligase, mTOR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3200. Categories: Autophagy Compounds Libraries. |  |
| B2 | B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). B2 promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. B2 prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. Synonyms: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline; CPNQ. Grades: ≥98% by HPLC. CAS No. 115687-05-3. Molecular formula: C20H17ClN4O3. Mole weight: 396.83. | |
| Baceridin | Baceridin, a cyclic hexapeptide isolated from the culture medium of a plant-related bacillus strain, shows moderate cytotoxicity and weak activity against Staphylococcus aureus. In addition, it is a proteasome inhibitor that inhibits cell cycle progression and induces tumor cell apoptosis through a p53-independent pathway. Synonyms: Cyclo(D-alanyl-L-tryptophyl-L-leucyl-D-leucyl-L-valylisoleucyl); Cyclo(-D-Ala-D-allo-Ile-Val-D-Leu-Leu-Trp); cyclo[D-alanyl-L-tryptophyl-L-leucyl-D-leucyl-L-valyl-(3S)-DL-isoleucyl]. Grades: ≥95%. CAS No. 1622872-91-6. Molecular formula: C37H57N7O6. Mole weight: 695.89. | |
| b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal inhibition on recombinant and cytosolic nonproteasomal cysteine deubiquitinases. Synonyms: b-AP15; b-AP15; b-AP-15; USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. Grades: >98%. CAS No. 1009817-63-3. Molecular formula: C22H17N3O6. Mole weight: 419.39. | |
| Boc-L-Valine | Boc-L-Valine is used in amino acid conjugates as proteasome inhibitors. Group: Biochemicals. Alternative Names: N-[ (1, 1-dimethylethoxy) carbonyl]-L-valine; (2S) -2- (tert-Butoxycarbonylamino) -3-methylbutanoic Acid; (2S) -2-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-3-methylbutanoic Acid; (S)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic Acid; (S)-N-tert-Butoxycarbonylvaline; BOC-valine; Boc-L-valine; N-BOC-L-valine; N-BOC-valine; N-tert-Butoxycarbonyl-L-valine; N-tert-Butoxycarbonylvaline; N-tert-Butyloxycarbonyl-L-valine; N-tert-Butyl oxycarbonyl valine; N-α-tert-Butoxycarbonyl-L-valine; NSC 197197; t-Butoxycarbonyl-L-valine; tert-Butoxycarbonyl-L-valine. Grades: Highly Purified. CAS No. 13734-41-3. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| Bortezomib | Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome ( K i =0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PS-341; LDP-341; NSC 681239. CAS No. 179324-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10227. | |
| Bortezomib | selective proteasome inhibitor. CAS No. 179324-69-7. Product ID: 2-08399. Molecular formula: C19H25BN4O4. Mole weight: 384.24. Reference: Clin. Cancer Res., 16, 4978, 2010. |  |
| Bortezomib, deuterated (Velcade-deuterated, [ (1R) -3-Methyl-1- [ [ (2S) -1-oxo-3-phenyl-2- [ (pyrazinylcarbonyl) amino] propyl] amino] butyl] -boronic Acid-deuterated) | Bortezomib is the first proteasome inhibitor to be approved b the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Group: Biochemicals. Alternative Names: Velcade-deuterated, [ (1R) -3-Methyl-1- [ [ (2S) -1-oxo-3-phenyl-2- [ (pyrazinylcarbonyl) amino] propyl] amino] butyl] -boronic Acid-deuterated. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bortezomib, Free Base (Velcade, MG-341, PS-341, [ (1S) -3-methyl-1- [ [ (2R) -3-phenyl-2- (pyrazine-2-carbonylamino) propanoyl] amino] butyl] boronic Acid) | Bortezomib is the active ingredient in the drug sold under the trade name Velcade®. This drug has been approved in at least one country to treat multiple myeloma. It is a potent (Ki, 0.6nM), specific and reversible proteasome inhibitor. There is not any significant inhibitory activity against other enzymes or receptors. In a study with the National Cancer Institute's panel of 60 human cell lines, Bortezomib showed a mean IC50 of 7nM as tested by SRB analysis. Group: Biochemicals. Grades: Highly Purified. CAS No. 179324-69-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Bortezomib Impurity 9 | Bortezomib Impurity 9 is an impurity of Bortezomib and a tripeptide boronic acid proteasome inhibitor used as an antitumor agent. Synonyms: N-(2-Pyrazinylcarbonyl)-L-phenylalanyl-N-[(1R)-1-borono-3-methylbutyl]-L-phenylalaninamide ; ( (R) -3-Methyl-1- ( (S) -3-phenyl-2- ( (S) -3-phenyl-2- (pyrazine-2-carboxamido) propanamido) propanamido) butyl) boronic Acid. Grades: > 95%. CAS No. 1194235-41-0. Molecular formula: C28H34BN5O5. Mole weight: 531.42. | |
| Bortezomib Liposome (PEGylated) | Bortezomib (BTZ) is a proteasome inhibitor used to treat various malignancies, including lung cancer, prostate cancer, colorectal cancer, breast cancer, etc. This product is a pre-formulated liposome encapsulating Bortezomib. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. |  |
| BSc2118 | BSc2118 is a potent proteasome inhibitor. BSc2118 shows significant antimyeloma activity and may be considered as a promising agent in cancer drug development. BSc2118 is also a promising new candidate for stroke therapy, which may in addition alleviate recombinant tissue-plasminogen activator-induced brain toxicity. Synonyms: BSc-2118; BSc 2118. Grades: 98%. CAS No. 863924-64-5. Molecular formula: C28H43N3O7. Mole weight: 533.66. | |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Carfilzomib | Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Alternative Names: (α S) -α - [ [2- (4-Morpholinyl) acetyl] amino] benzenebutanoyl-L-leucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyl-2-oxiranyl] carbonyl] butyl] -L-phenylalaninamide; (α S) -α - [ (4-Morpholinylacetyl) amino] benzenebutanoyl-L-leucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-phenylalaninamide; PR 171. Grades: Highly Purified. CAS No. 868540-17-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C40H57N5O7, Molecular Weight: 719.91. US Biological Life Sciences. | Worldwide |
| Carfilzomib | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Synonyms: Kyprolis; PR171; PR-171; PR 171; (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide. Grades: ≥98%. CAS No. 868540-17-4. Molecular formula: C40H57N5O7. Mole weight: 719.9. | |
| Carfilzomib | Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC 50 of 5 nM in ANBL-6 and RPMI 8226 cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PR-171. CAS No. 868540-17-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10455. | |
| Carfilzomib Impurity 13 hydrochloride | Carfilzomib is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It is a second-generation and peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome with IC50 of 5.2 nM. Carfilzomib impurity 13 hydrochloride is a potential impurity found in commercial carfilzomib preparations. Grades: ≥95%. CAS No. 2319881-95-1. Molecular formula: C16H22N2O4·HCl. Mole weight: 342.8. | |
| Carfilzomib Impurity 2 | Carfilzomib (2R,4S)-Diol is a derivative of Carflizomib , a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Synonyms: (α S) ?-α -[[2- (4-Morpholinyl) ?acetyl]?amino]?benzenebutanoyl-L-leucyl-N-[ (1S, ?3R) ?-3, ?4-dihydroxy-3-methyl-1- (2-methylpropyl) ?-2-oxobutyl]?-L-phenylalaninamide. Grades: > 95%. CAS No. 1541172-75-1. Molecular formula: C40H59N5O8. Mole weight: 737.94. | |
| CB5083 | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models. CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. Synonyms: CB5083; CB-5083; CB 5083. Grades: >98%. CAS No. 1542705-92-9. Molecular formula: C24H23N5O2. Mole weight: 413.4. | |
| Cdc25A (80-93) (human) | Cdc25A abundance fluctuates periodically during the cell division cycle and is mainly regulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, which later promote complex/cyclosome and Skp1/Cul1/F-box proteins. Due to the presence of the destruction motif (KEN-box) in Cdc25A, ubiquitination and degradation occur at the mitotic outlet and G1, while phosphorylation events modulate the stability of Cdc25A protein in the S phase, both in undisturbed cells and in cells exposed to DNA damage agents or DNA replication inhibitors. Synonyms: H-Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp-OH. Grades: ≥95%. CAS No. 851538-67-5. Molecular formula: C60H90N14O24S. Mole weight: 1423.52. | |
| Celastrol | Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC 50 of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Tripterine; Tripterin. CAS No. 34157-83-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13067. | |
| CEP-1612 | CEP-1612, a dipeptidyl proteasome inhibitor, induces apoptosis and inhibits tumor growth of the human lung cancer cell line A-549 in an in vivo model. Synonyms: N-[(2S)-5-[[amino(nitramido)methylidene]amino]-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]-2-cyclopentyl-10-(1,3-dioxoisoindol-2-yl)decanamide; CEP-1612; CEP 1612; CEP1612; UNII-9K6U075027. Grades: >98%. CAS No. 189036-01-9. Molecular formula: C35H53N7O7. Mole weight: 683.84. | |
| CEP-7055 | CEP-18770 is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Synonyms: CEP 7055; CEP7055; 3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-12-yl)propyl 2-dimethylaminoacetate. CAS No. 402857-58-3. Molecular formula: C32H35N3O4. Mole weight: 525.65. | |
| CFLZ-171 formic acid salt | CFLZ-171 is an important intermediate to synthesis carfilzomib which is an anti-cancer drug acting as a selective proteasome inhibitor. Synonyms: CFLZ-171 formic acid salt; CFLZ 171 formic acid salt; CFLZ171 formic acid salt; carfilzomib intermediate molecule weight 171. 1Pentanone 2amino4methyl1(2R)2methyl2oxiranyl (2S) 222trifluoroacetate (1:1); 1Pentanone 2amino4methyl1(2R)2methyloxiranyl (2S) trifluoroacetate (9CI);S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one 2,2,2-trifluoroacetate. Grades: 98%. CAS No. 1140908-93-5. Molecular formula: C9H17NO2.CH2O2. Mole weight: 217.27. | |
| CFLZ-567 | CFLZ-567 is a key intermediate for making carfilzomib. carfilzomib is a selective proteasome inhibitor as an anti-cancer drug. Uses: Key intermediate for making carfilzomib. Synonyms: carfilzomib intermediate molecule weight 567; LPhenylalanine (S) 2 (4morpholinyl) acetylaminobenzenebutanoylLleucyl; LPhenylalanine (S) (4morpholinylacetyl) aminobenzenebutanoylLleucyl (9CI);(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic acid. Grades: 98%. CAS No. 868540-16-3. Molecular formula: C31H42N4O6. Mole weight: 566.69. | |
| Clasto-lactacystin (beta-Clastolactacystin, Clasto-lactacystin b-Lactone, Omuralide) | Cell-permeable. A highly specific, potent and irreversible proteasome inhibitor. Lactacystin acts as a precursor for clasto-lactacystin beta-lactone and the latter compound is at least 10 times more active than the parent Lactacystin. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| clasto-Lactacystin β-lactone | Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces , acts as an irreversible 20S proteasome inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: Omuralide; β-Clastolactacystin. CAS No. 154226-60-5. Pack Sizes: 50 μg (2.34 mM * 100 μL in Methyl acetate). Product ID: HY-108549. | |
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