Proteasome Substrate Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Proteasome Substrate Quick inquiry Where to buy Suppliers range | Proteasome Substrate. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 536.58. Catalog: IAR42415934. Assay: ≥95% (HPLC). | |
Proteasome Substrate II, Fluorogenic Quick inquiry Where to buy Suppliers range | Fluorogenic proteasome substrate. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 664.75. Catalog: IAR42416015. Assay: ≥98% (HPLC). | |
Proteasome Substrate III, Fluorogenic Quick inquiry Where to buy Suppliers range | Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 763.88. Catalog: IAR42416016. Assay: ≥98% (HPLC). | |
7-(N-Benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin Quick inquiry Where to buy Suppliers range | 7-(N-Benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin is a fluorogenic substrate for the chymotrypsin-like activity of the 20S proteasome. Synonyms: 7-Z-Gly-gly-leu-ME; L-Leucinamide, N-[ (phenylmethoxy)carbonyl]glycylglycyl-N- (4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; Z-GGL-AMC. Grades: ≥98%. CAS No. 97792-39-7. Molecular formula: C28H32N4O7. Mole weight: 536.58. | |
Ac-Ala-Asn-Trp-AMC (Ac-ANW-AMC) Quick inquiry Where to buy Suppliers range | Ac-ANW-AMC is a fluorogenic peptide substrate and used for measuring chymotrypsin-like activity of the immunoproteasome.This substrate is specific to the immunoproteasome, and is not hydrolyzed efficiently by the constitutive proteasome. Cleavage of this peptide by the immunoproteasome or other enzymes liberates the fluorophore AMC causing a strong fluorescent signal which is detected at an Excitation wavelength of 345nm and Emission wavelength of 445nm. Uses: Peptide Inhibitors. Product ID: R0951. | |
Ac-Arg-Leu-Arg-AMC Quick inquiry Where to buy Suppliers range | Ac-Arg-Leu-Arg-AMC is a fluorogenic substrate for the determination of the trypsin-like activity of purified proteasomes (Km = 78 μM). Synonyms: Ac-RLR-AMC; N2-Acetyl-L-arginyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-argininamide; L-Argininamide, N2-acetyl-L-arginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-. Grades: ≥95%. CAS No. 929903-87-7. Molecular formula: C30H46N10O6. Mole weight: 642.76. | |
Ac-Nle-Pro-Nle-Asp-AMC Quick inquiry Where to buy Suppliers range | Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes. It can be cleaved by the caspase-like site of proteasome, also known as postglutamyl peptide hydrolase (PGPH). AMC (7-amino-4-methylcoumarin) is released and produces the fluorescence utilized to quantify the caspase-like site activity. Ac-Nle-Pro-Nle-Asp-AMC also inhibits the chymotrypsin-like activity of the proteasome allosterically when bound to the caspase-like site. Synonyms: Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin; Ac-nLPnLD-AMC; N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine; L-α-Asparagine, N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; (3S) -4-Hydroxy-3- ({ (2S) -1-hydroxy-2-[ (hydroxy{ (2S) -1-[N- (1-hydroxyethylidene) -L-norleucyl]-2-pyrrolidinyl}methylene) amino]hexylidene}amino) -4-[ (4-methyl-2-oxo-2H-chromen-7-yl) imino]butanoic acid. Grades: ≥98%. CAS No. 355140-49-7. Molecular formula: C33H45N5O9. Mole weight: 655.74. | |
Ac-RLR-AMC trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-RLR-AMC is a fluorogenic substrate for the 26S proteasome. Ac-RLR-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the trypsin-like activity of 26S proteasomes. Synonyms: Ac-Arg-Leu-Arg-7-amino-4-methylcoumarin; (S)-2-acetamido-5-guanidino-N-((S)-1-(((S)-5-guanidino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)pentanamide, 2,2,2-trifluoroacetate salt. Grades: ≥98%. Molecular formula: C30H46N10O6·CF3COOH. Mole weight: 756.8. | |
Ac-Trp-Leu-Ala-AMC Quick inquiry Where to buy Suppliers range | A fluorogenic peptid substrate used for measuring chymotrypsin-like activity of the proteasome. Hydrolysis of this substrate by the β5 subunit of the 20S proteasome is monitored by observing fluorescence at an Excitation wavelength of 345nm and Emission at 445nm. Uses: Peptide Inhibitors. Product ID: R1034. | |
Ac-WLA-AMC Quick inquiry Where to buy Suppliers range | Ac-WLA-AMC is a fluorogenic substrate for the β5c subunit of the 20S proteasome. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity. Synonyms: Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin; N-acetyl-L-tryptophyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alaninamide. Grades: ≥95%. CAS No. 1104011-59-7. Molecular formula: C32H37N5O6. Mole weight: 587.7. | |
Boc-Leu-Ser-Thr-Arg-AMC Quick inquiry Where to buy Suppliers range | Boc-Leu-Ser-Thr-Arg-AMC is a good fluorescent substrate for activated protein C (Km = 3.3·10-4 M, kcat = 8.4 s-1) and is commonly used to measure tryptic activity of proteasome. Synonyms: Boc-LSTR-AMC; Boc-leucyl-seryl-threonyl-arginine-4-methylcoumaryl-7-amide; Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin. Grades: ≥95%. CAS No. 73554-93-5. Molecular formula: C34H52N8O10. Mole weight: 732.82. | |
Chlorotoxin Quick inquiry Where to buy Suppliers range | A fluorogenic peptide substrate that can be used to monitor 20S Immunoproteasome activity, which is excited at 345 nm and emits at 445 nm. This substrate is specific to the immunoproteasome, and is not hydrolyzed efficiently by the constitutive proteasome. Uses: Peptide Inhibitors. CAS No. 163515-35-3. Product ID: R1032. | |
DUB Inhibitor IV, b-AP15 (NSC687852, 3, 5-bis ( (4-Nitrophenyl) methylidene) -1-prop-2-enoylpiperidin-4-one, (3E, 5E) -1-Acryloyl-3, 5-bis (4-nitrobenzylidene) piperidin-4-one, USP14 Inhibitor III, UCH-L5/UCH37 Inhibitor II) Quick inquiry Where to buy Suppliers range | A cell-permeable bis-nitrobenzylidene-piperidinone compound that acts as a potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitylating enzymes (DUBs) UCH-L5 and USP-14 (IC50=2.1uM against Ub-AMC substrate), with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. Shown to prevent proteasomal degradation (IC50=0.8uM in MelJuSo-UbG76V-YFP cells), and cause accumulation of higher molecular weights polyubiquitinated proteins in HCT-116 cells. Preferentially induces cell-cycle arrest and apoptosis in several colon cancer and in CNS cells, and effectively suppresses tumor growth in various mouse model (5mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 419.4. US Biological Life Sciences. | Worldwide |
MG-115 Substrate Inhibitor, Z-LLNVa-CHO (Z-Leu-Leu-NVa-CHO) Quick inquiry Where to buy Suppliers range | A potent, reversible proteasome inhibitor with Ki of 21nM for 20S proteasome and 35nM for 26S proteasome. The inhibition of proteasome was through specific inhibition of chymotrypsin-like activity of the proteasome. Also shown to induce apoptosis in Rat-1 and PC12 cells via a p3-independent pathway. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
ML241 Quick inquiry Where to buy Suppliers range | ML241 is a selective p97 ATPase inhibitor and IC50 value is 100 nM. It can inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the treatment of cancer. Uses: Anticancer. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine; ML241; ML-241; ML 241. Grades: 98%. CAS No. 1346528-06-0. Molecular formula: C23H24N4O. Mole weight: 372.46. | |
ML241 HCl Quick inquiry Where to buy Suppliers range | ML241 is identified as a potent and selective inhibitors of p97 ATPase (IC(50)= 100 nM). ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 could impair the endoplasmic-reticulum-associated degradation (ERAD) pathway. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine hydrochloride; ML241; ML-241; ML 241; ML241 HCl; ML241 hydrochloride. CAS No. 2070015-13-1. Molecular formula: C23H25ClN4O. Mole weight: 408.93. | |
Suc-Leu-Leu-Val-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate of calpains and 20S proteasome. Synonyms: Suc-LLVY-AMC; Proteasome substrate (fluorogenic); Calpain substrate (fluorogenic). Grades: >97%. CAS No. 94367-21-2. Molecular formula: C40H53N5O10. Mole weight: 763.89. | |
Suc-Leu-Leu-Val-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate of calpains and 20S proteasome and used to study the activity of calpains and proteosomal degradation. It is also a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain. Uses: Peptide Inhibitors. CAS No. 94367-21-2. Product ID: R0808. | |
Suc-Leu-Leu-Val-Tyr-pNA Quick inquiry Where to buy Suppliers range | Suc-Leu-Leu-Val-Tyr-pNA is a chromogenic substrate analogue to the proteasome substrate Suc-LLVY-AMC. Synonyms: Suc-LLVY-pNA; N-(3-Carboxypropanoyl)-L-leucyl-L-leucyl-L-valyl-N-(4-nitrophenyl)-L-tyrosinamide; L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-nitrophenyl)-. Grades: ≥90%. CAS No. 1926163-44-1. Molecular formula: C36H50N6O10. Mole weight: 726.83. | |
Suc-Leu-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease), and used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm). Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli. Uses: Peptide Inhibitors. CAS No. 94367-20-1. Product ID: R0810. | |
Z-Leu-Leu-Glu-AMC Quick inquiry Where to buy Suppliers range | An excellent fluorogenic substrate for measuring the peptidylglutamyl-peptide-hydrolyzing (PGPH) activity of the 20S proteasome, which is excited at 340-360 nm and emits at 440-460 nm. It is typically used in cell lysates after experimental treatment. Uses: Peptide Inhibitors. CAS No. 348086-66-8. Product ID: R1025. | |
Z-LLE-AMC Quick inquiry Where to buy Suppliers range | Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. AMC (7-amino-4-methylcoumarin) is released to quantify the caspase-like hydrolase activity. Synonyms: Proteasome Substrate III, Fluorogenic. Grades: >95%. CAS No. 348086-66-8. Molecular formula: C35H44N4O9. Mole weight: 664.76. | |
Z-Val-Lys-Met 7-amido-4-methylcoumarin Quick inquiry Where to buy Suppliers range | Synonyms: Fluorogenic Proteasome Substrate; Z-VKM-AMC. Grades: ≥98% (HPLC). CAS No. 141223-71-4. Molecular formula: C34H45N5O7S. Mole weight: 667.82. |