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| Product | Description | |
|---|---|---|
| Protein Kinase C Peptide Substrate | Protein Kinase C Peptide Substrate targets specific cell compartents and activates G protein-coupled receptors, tyrosine kinase receptors or tyrosine kinase-coupled receptors by relying on second messenger and specific adaptor proteins in response to extracellular signals. Protein Kinase C Peptide Substrate regulates a variety of physiological functions, including nervous, endocrine, exocrine, inflammatory and immune system activation. Synonyms: PKCε; PRKCE; Peptide Epsilon; PKC epsilon; H-Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val-OH; L-alpha-glutamyl-L-arginyl-L-methionyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-glycyl-L-seryl-L-valyl-L-arginyl-L-arginyl-L-arginyl-L-valine. Grades: 95%. CAS No. 120253-69-2. Molecular formula: C83H155N39O21S. Mole weight: 2067.43. |  |
| Protein Kinase C Peptide Substrate acetate | Protein Kinase C Peptide Substrate acetate targets specific cell compartments and activates G protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors by relying on second messenger and specific adaptor proteins in response to extracellular signals. It regulates a variety of physiological functions, including nervous, endocrine, exocrine, inflammatory, and immune system activation. Synonyms: L-α-Glutamyl-L-arginyl-L-methionyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-seryl-L-valyl-L-arginyl-L-arginyl-L-arginyl-L-valine acetate; H-Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val-OH acetate. Grades: ≥95%. Molecular formula: C85H159N39O23S. Mole weight: 2127.52. | |
| Active Focal Adhesion Kinase from Human, Recombinant | FAK is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-le...Protein-tyrosine kinase 2; FAK; FADK; FAK1; PTK2; FRNK; PPP1R71; p125FAK. Enzyme Commission Number: EC 2.7.10.2. Purity: Greater than 70% as determined by SDS-PAGE. FAK. Mole weight: 146.7 kDa. Activity: 72 nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate/minute/mg of total protein at 30°C. Stability: Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C to -80°C for longer periods of time. Avoid multiple freeze-thaw cycles. Source: Baculovirus, SF9 insect cells. Species: Human. Focal adhesion kinase 1; EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2; FAK; FADK; FAK1; PTK2; FRNK; PPP1R71; p125FAK. Cat No: NATE-0800. |  |
| Akt/SKG Substrate Peptide | Akt/SKG Substrate Peptide is a synthetic peptide and used as a substrate for Akt/PKB. It could not be phosphorylated by MAP kinase or p70 S6 kinase activated protein kinase-1. Synonyms: N5-(Diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-alanyl-L-alanyl-L-threonyl-L-phenylalanine. CAS No. 276680-69-4. Molecular formula: C36H59N13O9. Mole weight: 817.95. | |
| AMARA peptide acetate | AMARA peptide acetate is a substrate for salt-induced kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK). Molecular formula: C64H119N27O19S. Mole weight: 1602.89. | |
| AMARA peptide TFA | AMARA peptide TFA is a substrate for salt-induced kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK). Synonyms: Ala-Met-Ala-Arg-Ala-Ala-Ser-Ala-Ala-Ala-Leu-Ala-Arg-Arg-Arg.TFA; L-alanyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-seryl-L-alanyl-L-alanyl-L-alanyl-L-leucyl-L-alanyl-L-arginyl-L-arginyl-L-Arginine trifluoroacetic acid. Grades: >98%. Molecular formula: C62H115N27O17S.C2HF3O2. Mole weight: 1656.83. | |
| Autocamtide 2 | Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II ( CaMKII ). It can be used in the CaMKII activity assay. Uses: Scientific research. Group: Peptides. Alternative Names: Autocamtide II. CAS No. 129198-88-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0225. |  |
| Autocamtide 2 | Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Autocamtide II; H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine. Grades: ≥95%. CAS No. 129198-88-5. Molecular formula: C65H118N22O20. Mole weight: 1527.77. | |
| Autocamtide 2, amide | Autocamtide 2, amide is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-NH2. Grades: ≥95%. Molecular formula: C65H119N23O19. Mole weight: 1526.79. | |
| Autocamtide 2 TFA | Autocamtide 2 TFA is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH.TFA; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine trifluoroacetic acid; Autocamtide 2 trifluoroacetate salt. Grades: ≥95%. Molecular formula: C67H119F3N22O22. Mole weight: 1641.79. | |
| Calcineurin substrate | Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Synonyms: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH; L-alpha-aspartyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-isoleucyl-L-prolyl-glycyl-L-arginyl-L-phenylalanyl-L-alpha-aspartyl-L-arginyl-L-arginyl-L-valyl-L-seryl-L-valyl-L-alanyl-L-alanyl-L-glutamic acid. Grades: 98%. CAS No. 113873-67-9. Molecular formula: C92H150N28O29. Mole weight: 2112.35. | |
| Calcineurin substrate acetate | Calcineurin substrate acetate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Synonyms: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH.CH3CO2H; L-α-Aspartyl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-isoleucyl-L-prolylglycyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-L-arginyl-L-arginyl-L-valyl-L-seryl-L-valyl-L-alanyl-L-alanyl-L-glutamic acid acetate. Grades: ≥95%. Molecular formula: C94H154N28O31. Mole weight: 2172.40. | |
| CDK2 | CDK2 is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S 0 /T 0 ) in a protein substrate. Uses: Scientific research. Group: Peptides. CAS No. 255064-79-0. Pack Sizes: 5 mg. Product ID: HY-P0235. | |
| Cdk5 Substrate | Cdk5 Substrate is a biological active peptide. (substrate for the cdc2 protein kinase). Uses: Scientific research. Group: Peptides. CAS No. 164669-07-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2668. | |
| cGMP Dependent Kinase Inhibitor Peptide | PKG Inhibitor is a competitive inhibitor of cGMP-dependent protein kinase (PKG). It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: cGMP Dependent Kinase Inhibitor Peptide. Grades: >98%. CAS No. 82801-73-8. Molecular formula: C38H74N18O10. Mole weight: 943.12. | |
| Crosstide | Crosstide, a peptide analog of glycogen synthase kinase α/β fusion protein sequence, acts as a substrate for Akt (PKB) (Km=4μM) and is useful in phosphocellulose kinase assays. Synonyms: H-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH; glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-glycine. Grades: ≥96%. CAS No. 171783-05-4. Molecular formula: C48H77N17O17. Mole weight: 1164.23. | |
| Crosstide | Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. Uses: Scientific research. Group: Peptides. CAS No. 171783-05-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0315. | |
| Crosstide TFA | Crosstide, a peptide analog of glycogen synthase kinase α/β fusion protein sequence, acts as a substrate for Akt (PKB) (Km=4μM) and is useful in phosphocellulose kinase assays. Synonyms: H-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH.TFA; glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-glycine trifluoroacetic acid; Crosstide trifluoroacetate salt. Grades: ≥95%. Molecular formula: C50H78F3N17O19. Mole weight: 1278.25. | |
| DAPK Substrate Peptide | Synthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 μM). Synonyms: AKOS024456611. CAS No. 386769-53-5. Molecular formula: C70H115N25O17. Mole weight: 1578.82. | |
| DNA-PK Substrate | DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11 - 24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.). Uses: Scientific research. Group: Peptides. CAS No. 146064-85-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5429. | |
| Kemptide | Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase ( PKA ). Uses: Scientific research. Group: Peptides. CAS No. 65189-71-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0248. | |
| Kemptide Phospho-Ser5 | Kemptide (Phospho-Ser5), a phosphate acceptor peptide, serves as a specific substrate for cAMP-dependent protein kinase (PKA). Synonyms: Leu-Arg-Arg-Ala-pSer-Leu-Gly; H-Leu-Arg-Arg-Ala-Ser(PO3H2)-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-O-phosphono-L-seryl-L-leucyl-glycine; phosphokemptide; Kinase Domain of Pyruvate Kinase porcine. Grades: ≥95%. Molecular formula: C32H62N13O12P. Mole weight: 851.89. | |
| Native Baker's yeast (S. cerevisiae) Enolase | Enolase is a metalloenzyme that catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate. Enolase is essential for both glycolysis and gluconeogenesis. Enolase from bakers yeast is a homodimer containing two bound Mg2+ ions. The molecular weight is 93.069 kDa.The peptide consists of 436 amino acids and contains a single cysteine residue. Two of the active site components include His191 and Arg414. The phosphorylated tyrosine residue present in yeast enolase forms a substrate for phosphorylation by tyrosine protein kinase. Apart from Mg2+, the enzyme can be activated by Zn2+, Mn2+, and Cd2+. Applications: Enolase from baker?s yeast has been used in a st...d spectroscopy. it has also been used along with other proteins to study gradient chromatof ocusing-mass spectrometry; a new technique for protein analysis. Group: Enzymes. Synonyms: EC 4.2.1.11; enolase; 2-phosphoglyceRate dehydRatase; 14-3-2-protein; nervous-system specific enolase; phosphoenolpyruvate hydRatase; 2-phosphoglyceRate dehydRatase; 2-phosphoglyceric dehydRatase; 2-phosphoglyceRate enolase; γ-enolase; 2-phospho-D-glyceRate hydro-lyase; 9014-08-8. Enzyme Commission Number: EC 4.2.1.11. CAS No. 9014-8-8. Enolase. Activity: > 50 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing Tris buffer salts. Source: Baker's yeast (S. cerevisiae) | |
| Peptide epsilon | Peptide epsilon. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ERMRPRKRQGSVRRRV;H-GLU-ARG-MET-ARG-PRO-ARG-LYS-ARG-GLN-GLY-SER-VAL-ARG-ARG-ARG-VAL-OH;GLU-ARG-MET-ARG-PRO-ARG-LYS-ARG-GLN-GLY-SER-VAL-ARG-ARG-ARG-VAL;PROTEIN KINASE C (EPSILON);PROTEIN KINASE C-EPSILON, PEPTIDE SUBSTRATE;PROTEIN KINASE CEPSILON PEPTIDE S. Product Category: Heterocyclic Organic Compound. CAS No. 120253-69-2. Molecular formula: C83H155N39O21S. Mole weight: 2067.43. Product ID: ACM120253692. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PKG inhibitor peptide TFA | PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG) with a Ki of 86 μM. It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH.TFA; L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid trifluoroacetic acid; cGMP Dependent Kinase Inhibitor Peptide TFA. Grades: ≥95%. Molecular formula: C40H75F3N18O12. Mole weight: 1057.13. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase ( PKG ). Uses: Scientific research. Group: Peptides. CAS No. 81187-14-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1561. | |
| PKI (5-24) | PKI (5-24) is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. The PKA Inhibitor peptide binds to the catalytic subunit of PKA and displaces the regulatory subunit, and mimics protein substrate by binding to the catalytic site via the Arg-cluster basic residues. Synonyms: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid; PKI (5-24); Protein Kinase A Inhibitor (5-24). CAS No. 99534-03-9. Molecular formula: C94H148N32O31. Mole weight: 2222.4. | |
| Protein Kinase A Catalytic Subunit β, Active human, Recombinant | cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have ...e crebtide substrate peptide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: PKA Catalytic Subunit β, Active human; PKA-Cβ; cAMP-dependent protein kinase; PKACB; PRKACB; PKA C-beta; Protein Kinase A Catalytic Subunit &beta. Purity: > 85% (SDS-PAGE). PKAC. Mole weight: protein apparent mol wt ~65 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected Sf9 cells. Species: Human. PKA Catalytic Subunit β, Active human; PKA-Cβ; cAMP-dependent protein kinase; PKACB; PRKACB; PKA C-beta; Protein Kinase A Catalytic Subunit &beta. Cat No: NATE-0572. | |
| Protein Kinase C 19-31 | Protein Kinase C (19-31) is a peptide inhibitor of protein kinase C (PKC) originating in the pseudo-substrate regulatory domain of PKCA (residues 19-31). Synonyms: PKC (19-31); Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val; Pseudosubstrate; L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysyl-glycyl-L-alanyl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparagyl-L-valine. Grades: 95%. CAS No. 121545-65-1. Molecular formula: C67H118N26O16. Mole weight: 1543.82. | |
| Protein Kinase C 19-31 acetate | Protein Kinase C 19-31 acetate is a peptide inhibitor of protein kinase C (PKC) originating in the pseudo-substrate regulatory domain of PKCA (residues 19-31). It is used as a protein kinase C substrate peptide for testing the protein kinase C activity. Synonyms: PKC (19-31) acetate; H-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-OH.CH3CO2H; L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysyl-glycyl-L-alanyl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparagyl-L-valine acetic acid. Grades: ≥95%. Molecular formula: C69H122N26O18. Mole weight: 1603.90. | |
| Protein Kinase CΙ, Active human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second...activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Recombinant, expressed in e. coli, > 85% (sds-page), buffered aqueous glycerol solution. Applications: Kinase activity is measured as the molar amount of phosphate incorporated into the crebtide substrate peptide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: PKCL; Protein Kinase C Lambda/Iota; PKC&Iota. Purity: > 85% (SDS-PAGE). PKC. Mole weight: apparent mol wt ~98 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. PKCL; Protein Kinase C Lambda/Iota; PKC&Iota. Cat No: NATE-0577. | |
| SAMS | SAMS peptide is a specific substrate for the AMP-activated protein kinase ( AMPK ). Uses: Scientific research. Group: Peptides. CAS No. 125911-68-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0136. | |
| Syntide 2 | Syntide 2, a synthetic peptide, is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) (Ki= 12 μM) and protein kinase C (Km = 11 μM). Synonyms: Calmodulin-Dependent Protein Kinase Substrate; Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys; L-prolyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-valyl-L-alanyl-glycyl-L-leucyl-L-prolyl-glycyl-L-lysyl-L-lysine; Syntide-2; Syntide2. Grades: ≥97% by HPLC. CAS No. 108334-68-5. Molecular formula: C68H122N20O18. Mole weight: 1507.82. | |
| Syntide 2 acetate | Syntide-2 acetate, a synthetic peptide, is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) (Ki = 12 μM) and protein kinase C (Km = 11 μM). Synonyms: H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH.CH3CO2H; L-prolyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-valyl-L-alanyl-glycyl-L-leucyl-L-prolyl-glycyl-L-lysyl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C70H126N20O20. Mole weight: 1567.85. | |
| UPC-K-005 | UPC-K-005 is a novel small-molecule inhibitor of a new allosteric site in p38α (IC50 = 13 mcM), which is the binding site for MAPK-activated protein kinase 2 (MK2). Researchers found that UPC-K-005 inhibits both the p38α peptide substrate and ATF2 protein substrate in a dose-response manner, which indicated that they are more universal inhibitors. Uses: Inhibitor of a new allosteric site in p38&alpha. Synonyms: UPC-K-005; 896842-60-7; SCHEMBL17903201; AKOS005505861. Molecular formula: C21H25N7OS. Mole weight: 423.5. | |
| caspase-9 | Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63). Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage. Procaspase-3 is the enzyme's physiological substrate. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3. Enzyme Commission Number: EC 3.4.22.62. CAS No. 180189-96-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4238; caspase-9; EC 3.4.22.62; 180189-96-2; CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3. Cat No: EXWM-4238. | |
| Peptidyl-Prolyl Cis/Trans Isomerase from Human, Recombinant | Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like b-Catenin, c-Jun, and the tumor...ase Pin1; DOD; UBL5; PIN1; PPIase. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. Peptidylprolyl Isomerase. Mole weight: 18.2 kDa. Activity: > 162 nmoles/min/ug. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. Appearance: Sterile filtered colorless solution. Source: E. coli. Species: Human. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; EC 5.2.1.8; Rotamase Pin1; PPIase Pin1; DOD; UBL5; PIN1; PPIase. Cat No: NATE-0910. | |
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