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| Product | Description | |
|---|---|---|
| Protein Tyrosine Phosphatase 1B human | recombinant, expressed in E. coli. Group: Fluorescence/luminescence spectroscopy. |  |
| Protein Tyrosine Phosphatase Substrate Monophosphate | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Protein Tyrosine Phosphatase ? antibody produced in mouse | clone SBK10, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Protein Tyrosine Phosphatase PEST antibody produced in mouse | clone AG25, purified immunoglobulin. Group: Fluorescence/luminescence spectroscopy. | |
| protein-tyrosine-phosphatase | Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase. Group: Enzymes. Synonyms: phosphotyrosine phosphatase; phosphoprotein phosphatase (phosphotyrosine); phosphotyrosine histone phosphatase; protein phosphotyrosine phosphatase; tyrosylprotein phosphatase; phosphotyrosine protein phosphatase; phosphotyrosylprotein phosphatase; tyrosine O-phosphate phosphatase; PPT-phosphatase; PTPase; [phosphotyrosine]protein phosphatase; PTP-phosphatase. Enzyme Commission Number: EC 3.1.3.48. CAS No. 79747-53-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3652; protein-tyrosine-phosphatase; EC 3.1.3.48; 79747-53-8; phosphotyrosine phosphatase; phosphoprotein phosphatase (phosphotyrosine); phosphotyrosine histone phosphatase; protein phosphotyrosine phosphatase; tyrosylprotein phosphatase; phosphotyrosine protein phosphatase; phosphotyrosylprotein phosphatase; tyrosine O-phosphate phosphatase; PPT-phosphatase; PTPase; [phosphotyrosine]protein phosphatase; PTP-phosphatase. Cat No: EXWM-3652. |  |
| Receptor-type tyrosine-protein phosphatase kappa (667-682) | A peptide fragment of Receptor-type tyrosine-protein phosphatase kappa. Receptor-type tyrosine-protein phosphatase kappa is in the regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Synonyms: Protein-tyrosine phosphatase kappa (667-682). |  |
| YOP Protein Tyrosine Phosphatase from Yersinia enterocolitica, Recombinant | Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity. As a consequence, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; EC 3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzym...rentiation, transformation, and synaptic strengthening. Recombinant, expressed in e. coli, > 50 kda unit/ml, buffered aqueous glycerol solution. Applications: Used to release phosphate groups specifically from phosphotyrosine residues in proteins. Group: Enzymes. Synonyms: YOP Protein Tyrosine Phosphatase; Protein tyrosine phosphatase; Tyrosine-specific protein phosphatases; PTPase. PTPase. Activity: > 50,000 unit/mL. Stability: -20°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Yersinia enterocolitica. YOP Protein Tyrosine Phosphatase; Protein tyrosine phosphatase; Tyrosine-specific protein phosphatases; PTPase. Cat No: NATE-0642. | |
| 1,1-Dioxide-5-(4-bromophenyl)-1,2,5-thiadiazolidin-3-one | 1,1-Dioxide-5-(4-bromophenyl)-1,2,5-thiadiazolidin-3-one isused in the preparation of phenyl thiadiazolidinones as inhibitors of protein tyrosine phosphatase 1B (PTP1B) for treatment of diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 692765-79-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C8H7BrN2O3S, Molecular Weight: 291.12. US Biological Life Sciences. |  Worldwide |
| 1-Azido-1-deoxy-β-D-glucopyranoside tetraacetate | 1-Azido-1-deoxy-β-D-glucopyranoside tetraacetate (CAS# 13992-25-1) is an intermediate used for the synthesis of Protein Tyrosine Phosphatase 1B inhibito1. It is used for the preparation of variously coupled conjugates of D-glucose via click chemistry for inhibition of glycogen phosphorylase. Synonyms: 2,3,4,6-Tetra-O-acetyl-1-deoxy-β-D-glucopyranosyl azide; β-D-Glucopyranosyl Azide 2,3,4,6-Tetraacetate; 1-β-Azido-2,3,4,6-tetraacetyl-D-glucopyranose; 2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl azide; NSC 272456; 1-Azido-1-deoxy-beta-D-glucopyranose tetraacetate; (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-azidotetrahydro-2H-pyran-3,4,5-triyl triacetate. Grades: ≥95%. CAS No. 13992-25-1. Molecular formula: C14H19N3O9. Mole weight: 373.32. | |
| 2-(1-Piperidino)aniline | 2-(1-Piperidino)aniline is used to prepare oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. It is also used to synthesize benzimidazole derivatives as AMP-activated protein kinase activators. Group: Biochemicals. Grades: Highly Purified. CAS No. 39643-31-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H16N2. US Biological Life Sciences. | Worldwide |
| 2,3-Dihydrobenzofuran-4-carbaldehyde | 2,3-Dihydrobenzofuran-4-carbaldehyde is used in the synthesis of macroline derivatives as inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B. Group: Biochemicals. Grades: Highly Purified. CAS No. 209256-42-8. Pack Sizes: 250mg, 2.5g. Molecular Formula: C9H8O2, Molecular Weight: 148.16. US Biological Life Sciences. | Worldwide |
| 2,5-Difluorobenzoic acid | 2,5-Difluorobenzoic Acid acts as a reagent in the synthesis of rutaecarpine and analogs used for the removal of caffeine from the body. Prepparation of quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase (Erratum). Preparation, molecular docking, and bioactivity of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. Also used as new passive water tracers for oil field applications. Synonyms: NSC 190310; 5-Difluorobenzoic acid; 2,5-difluorobenzoate. Grades: ≥95%. CAS No. 2991-28-8. Molecular formula: C7H4F2O2. Mole weight: 158.10. | |
| 2',7'-Difluorofluorescein | 2',7'-Difluorofluorescein is a reactant used in the synthesis of biarsenical probes that inhibit protein tyrosine phosphatases. Group: Biochemicals. Grades: Highly Purified. CAS No. 195136-58-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H10F2O5, Molecular Weight: 368.29. US Biological Life Sciences. | Worldwide |
| 2-Bromo-4'-hydroxyacetophenone | A covalent inhibitor of protein tyrosine phosphatases (PTPs). Group: Biochemicals. Alternative Names: 2-Bromo-1- (4-hydroxyphenyl) ethanone; 1-(4-Hydroxyphenyl)-2-bromoethanone; p-Hydroxyphenacyl Bromide; α-Bromo-4'-hydroxyacetophenone; Busan 1130; Busan 90; Butrol 1130. Grades: Highly Purified. CAS No. 2491-38-5. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 2-Bromo-4'-hydroxyacetophenone | PTP Inhibitor I is a cell-permeable inhibitor of protein tyrosine phosphatase (PTP), a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Synonyms: 2-bromo-1-(4-hydroxyphenyl)ethanone; 2-bromo-1-(4-hydroxyphenyl)ethanone. Grades: > 98 %. CAS No. 2491-38-5. Molecular formula: C8H7BrO2. Mole weight: 215.04. | |
| 2-Bromo-4'-methoxyacetophenone | 2-Bromo-4'-methoxyacetophenone is a α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. Group: Biochemicals. Alternative Names: 2-Bromo-1- (4-methoxyphenyl) ethanone; 2-(4-Methoxyphenyl)-2-oxoethyl bromide; 2-Bromo-1-(4-methoxyphenyl)-1-ethanone; 2-Bromo-1-[4- (methyloxy) phenyl]ethanone; 2-Bromo-p-methoxyacetophenone; 4-Methoxy-2'-bromoacetophenone; 4-Methoxyphenacyl Bromide; 4'-Methoxyphenacyl Bromide; Bromomethyl 4-Methoxyphenyl Ketone; Bromomethyl p-Anisyl Ketone; Bromomethyl p-Methoxyphenyl Ketone; NSC 129010; p-Methoxyphenacyl Bromide; α-Bromo-4'-methoxyacetophenone; α-Bromo-p-methoxyacetophenone; ω-Bromo-4'-methoxyacetophenone; ω-Bromo-p-methoxyacetophenone. Grades: Highly Purified. CAS No. 2632-13-5. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2-Chloro-2',4'-difluoroacetophenone | A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. Group: Biochemicals. Alternative Names: 2-Chloro-1- (2, 4-difluorophenyl) ethanone; Chloromethyl 2,4-Difluorophenyl Ketone; α-Chloro-2,4-difluoroacetophenone. Grades: Highly Purified. CAS No. 51336-94-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 2-Chloro-4-nitrophenyl phosphate | 2-Chloro-4-nitrophenyl phosphate, an indispensable compound in the field of biomedicine, possesses extraordinary capabilities in suppressing protein tyrosine phosphatases (PTPs). This fundamental trait renders it a promising avenue for therapeutic intervention against an array of ailments, encompassing malignancies and autoimmune disorders, by selectively targeting PTPs implicated in intricate signal transduction cascades. Synonyms: 2-Chloro-4-nitrophenyl dihydrogen phosphate; 14957-98-3; (2-chloro-4-nitrophenyl) dihydrogen phosphate; AGN-PC-0N3TPY; SCHEMBL1134003; DTXSID40439315; 2-Chloro-4-nitrophenyldihydrogenphosphate; (2-chloro-4-nitrophenoxy)phosphonic acid; A919724. CAS No. 14957-98-3. Molecular formula: C6H5ClNO6P. Mole weight: 253.53. | |
| 2-Chloro-5-iodobenzoic Acid | 2-Chloro-5-iodobenzoic Acid is a useful synthetic intermediate. It is used to prepare metabotropic glutamate receptor subtype-?2 (mGluR2) positive allosteric modulator (PAM). It is also used to synthesize quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase. Group: Biochemicals. Grades: Highly Purified. CAS No. 19094-56-5. Pack Sizes: 5g, 25g. Molecular Formula: C7H4ClIO2, Molecular Weight: 282.459999999999. US Biological Life Sciences. | Worldwide |
| (2E)-3-Cyclobutyl-2-propenoic Acid | ((2E)-3-Cyclobutyl-2-propenoic Acid is a used in the preparation of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids as peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1355450-70-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H10O2, Molecular Weight: 126.15. US Biological Life Sciences. | Worldwide |
| 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide | 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide is an inhibitor of Protein tyrosine phosphatase 1B (PTP1B). Group: Biochemicals. Grades: Highly Purified. CAS No. 765317-72-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C26H19Br2N3O7S3, Molecular Weight: 741.45. US Biological Life Sciences. | Worldwide |
| 3,5-Dihydroxynapthalene-2-carboxylic Acid | 3,5-Dihydroxynapthalene-2-carboxylic Acid is used as a negative or positive NMDA receptor inhibitor, via allosteric control. NMDA receptors regulate CHN (central nervous system) functions. Also used as a protein tyrosine phosphatase inhibitor due to the benzofuran-like moiety in the substructure. Group: Biochemicals. Alternative Names: UBP551. Grades: Highly Purified. CAS No. 89-35-0. Pack Sizes: 1g, 10g, 50g. Molecular Formula: C11H8O4, Molecular Weight: 204.18. US Biological Life Sciences. | Worldwide |
| 3-Amino-2-methoxycarbonyl thiophene | 3-Amino-2-methoxycarbonyl thiophene is a useful synthetic intermediate. It can be used to synthesize (amino)thienopyridine derivatives as possible inhibitors of VEGFR-2 kinase and EGFR kinase. It can also be used to prepare (carboxyheteroaryl amino) oxalic acids as inhibitors of protein-tyrosine phosphatase 1B. Group: Biochemicals. Grades: Highly Purified. CAS No. 22288-78-4. Pack Sizes: 5g, 25g. Molecular Formula: C6H7NO2S, Molecular Weight: 157.19. US Biological Life Sciences. | Worldwide |
| 3-Carboxypropyl triphenylphosphonium bromide | 3-Carboxypropyl triphenylphosphonium bromide. Uses: (3-carboxypropyl)triphenylphosphonium bromide is used as antimalarial agents, antimycobacterial agents,antifungal agents, inhibitors of protein tyrosine phosphatase. Additional or Alternative Names: (4-Hydroxy-4-oxobutyl)triphenylphosphonium bromide. Product Category: Bromine Series. Appearance: Solid. CAS No. 17857-14-6. Molecular formula: C22H22O2PBr. Mole weight: 429.29. Purity: 0.98. IUPACName: 3-carboxypropyl(triphenyl)phosphanium;bromide. Canonical SMILES: C1=CC=C(C=C1)[P+](CCCC(=O)O)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]. Product ID: ACM17857146-3. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 5-Carboxypentyl triphenylphosphonium bromide | 5-Carboxypentyl triphenylphosphonium bromide. Uses: (5-carboxypentyl)(triphenyl)phosphonium bromide is used in medicine and as pharmaceutical intermediate. it is also employed as catalyst. reactant for: preparation of inhibitor of protein tyrosine phosphatase 1b for treatment of diabetes and obesity. synthesis of folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. preparation of peptide nucleic acids (pna) with high specific activity. synthesis of roseophilin via wittig/aldol methodology. Additional or Alternative Names: (5-Carboxypentyl)(Triphenyl)Phosphonium Bromide. Product Category: Organic Phosphine Compounds. Appearance: Solid. CAS No. 50889-29-7. Molecular formula: C24H26BrO2P. Mole weight: 457.35. Purity: 0.98. IUPACName: 5-carboxypentyl(triphenyl)phosphanium;bromide. Canonical SMILES: C1=CC=C(C=C1)[P+](CCCCCC(=O)O)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]. Product ID: ACM50889297-3. Alfa Chemistry ISO 9001:2015 Certified. Categories: (5-carboxypentyl)triphenylphosphanium bromide. | |
| A431 Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by Western blotting using anti-Phosphotyrosine. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of A431 cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Acid phosphatase 1 from Human, recombinant | Acid phosphatase 1, also known as ACP1, belongs to the phosphotyrosine protein family. It functions as an acid phosphatase and a protein tyrosine phosphatase (PTPase) and is present in all human tissues, including adipocytes. This enzyme hydrolyzes protein tyrosine phosphate to protein tyrosine and orthophosphate, and also orthophosphoric monoesters to alcohol and orthophosphate. Group: Enzymes. Synonyms: Acid phosphatase 1; soluble isoform b; ACP1; HAAP; LMW-PTP; Red cell acid phosphatase 1; Adipocyte acid phosphatase. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: > 95% by SDS-PAGE. Apase. Mole weight: 20.1 kDa (178 aa, 1-158 aa + NT His-Tag). Activity: > 60,000 unit/mg of protein. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. Acid phosphatase 1; soluble isoform b; ACP1; HAAP; LMW-PTP; Red cell acid phosphatase 1; Adipocyte acid phosphatase; Acid Phosphatase. Cat No: NATE-1672. | |
| Adenosine-5'-(4-fluorosulfonylphenylphosphate) | Adenosine-5'-(4-fluorosulfonylphenylphosphate) is a crucial compound in the biomedical industry. It is extensively utilized for studying the enzymatic activity of protein tyrosine phosphatases (PTPs). Additionally, this product serves as a valuable tool to investigate diseases like cancer, autoimmune disorders, and diabetes where PTP dysregulation plays a role. Its availability ensures accurate analysis and facilitates advancements in biomedicine research. Synonyms: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (4-fluorosulfonylphenyl) hydrogen phosphate;5'-Adenylic acid, mono(4-(fluorosulfonyl)phenyl) ester; 9- (5-O-{[4- (Fluorosulfonyl)phenoxy] (hydroxy)phosphoryl}pentofuranosyl)-9H-purin-6-amine. CAS No. 60397-89-9. Molecular formula: C16H17FN5O9PS. Mole weight: 505.37. | |
| Alendronate sodium (Sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid, trihydrate, MK-217, Fosamax) | Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC?? value of 2nm. Also acts as a farnesyl diphosphate synthase inhibitor (IC?? =460nm) and CD45 protein tyrosine phosphatase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 121268-17-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Alexidine dihydrochloride | Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus. Synonyms: 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2); 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride; Biguanide, 1,1'-hexamethylenebis[5-(2-ethylhexyl)-, dihydrochloride; 1,6-Bis(2-ethylhexylbiguanido)hexane dihydrochloride; Alexidine hydrochloride; Hexamethylenebis(2-ethylhexyl)biguanide dihydrochloride. Grades: >98%. CAS No. 1715-30-6. Molecular formula: C26H58N10Cl2. Mole weight: 581.71. | |
| α-Oxo-2-furanacetic Acid | α-Oxo-2-furanacetic Acid is an α-ketocarboxylic acid with inhibitory activity against protein tyrosine phosphatases. Group: Biochemicals. Alternative Names: 2-(2-Furyl)-2-oxoacetic acid; 2-(Furan-2-yl)-2-oxoacetic acid; 2-Furanyl(oxo)acetic acid; 2-Furylglyoxylic acid; 2-Oxo-2-(2-furanyl)acetic acid; Furoylformic acid; NSC 59069; 2-Furanglyoxylic acid. Grades: Highly Purified. CAS No. 1467-70-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Antibiotic RK-682 (Antibiotic TAN 1364B, Antibiotic CI 010) | Antibiotic RK-682 is the calcium salt of one of a complex family of tetronic acids isolated from Streptomyces species. The formation of the salt is almost certainly an artefact of silica chromatography. RK-682 is the most extensively studied of the analogues, having been shown to inhibit protein tyrosine phosphatases and heparanase. Pharmacological studies with RK-682 demonstrated enhanced ATP-induced long-term potentiation using guinea-pig hippocampal slices. Investigation of the complex has also shown potent activity against HIV-1 protease. Group: Biochemicals. Alternative Names: Antibiotic TAN 1364B, Antibiotic CI 010. Grades: Highly Purified. CAS No. 154639-24-4(TAN1364B). Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| arsenate reductase (thioredoxin) | The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin. It has no activity with glutaredoxin [cf. EC 1.20.4.1, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC 3.1.3.48, protein-tyrosine-phosphatase. Group: Enzymes. Synonyms: ArsC (ambiguous). Enzyme Commission Number: EC 1.20.4.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1243; arsenate reductase (thioredoxin); EC 1.20.4.4; ArsC (ambiguous). Cat No: EXWM-1243. | |
| bpV(HOpic) potassium salt | BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 4.9 μM and PTP-1βB with IC50 of 25.3 μM. It is reported to function as an insulin mimetic and activate the insulin receptor kinase (IRK). BpV(HOpic) has been shown to activate the insulin receptor kinase of hepatoma cells and enhance PI3K/Akt signaling, which could prevent ischemia-reperfusion (I/R) injury to the myocardium. Synonyms: Bisperoxovanadium(HOpic). Grades: ≥95%. CAS No. 722494-26-0. Molecular formula: C6H4NO8V·2K. Mole weight: 347.2. | |
| bpV(phen) potassium hydrate | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grades: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
| bpV(pic) potassium hydrate | BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium. It is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 31 nM. It is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells and stimulating lipogenesis in adipocytes. BpV(pic) has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells and is also an inhibitor of G6Pase. Synonyms: Bisperoxovanadium(pic). Grades: ≥96%. CAS No. 148556-27-8. Molecular formula: C6H4NO7V·2K·2H2O. Mole weight: 367.3. | |
| BVT-948 | BVT 948 is a non-competitive and cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM). BVT 948 displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP, and enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Some cytochrome P450 isoforms are also suppressed by BVT 948 (IC50 <10 μM). Synonyms: BVT948; BVT-948; BVT 948; SPS8I3; SPS-8I3; SPS 8I3; 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione. Grades: ≥98% by HPLC. CAS No. 39674-97-0. Molecular formula: C14H11NO3. Mole weight: 241.24. | |
| Cdc25 Inhibitor IV, NSC 95397 (2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione, PTP Inhibitor XXIX) | A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki=32nM, 96nM, and 40nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50=1.8uM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. Group: Biochemicals. Grades: Highly Purified. CAS No. 93718-83-3. Pack Sizes: 10mg. Molecular Formula: C??H??O?S?, Molecular Weight: 310.4. US Biological Life Sciences. | Worldwide |
| Cefsulodin sodium | Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein ( PBP ) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB , a virulent phosphatase from Mycobacterium tuberculosis , with an IC 50 value of 16 μM [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCE-129 sodium. CAS No. 52152-93-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-13588. |  |
| Cryptotanshinone | Cryptotanshinone is an inhibitor of oncogenic protein tyrosine phosphatase SHP2. Group: Biochemicals. Alternative Names: (R)-1, 2, 6, 7, 8, 9-Hexahydro-1, 6, 6-trimethylphenanthro[1, 2-b]furan-10, 11-dione; (15R)-Cryptotanshinone; Cryototanshinone; Cryptotanshinon; Tanshinone c. Grades: Highly Purified. CAS No. 35825-57-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg. Molecular Formula: C??H??O?, Molecular Weight: 296.36. US Biological Life Sciences. | Worldwide |
| CX08005 | CX08005 is a competitive inhibitor of PTP1B (IC50 = 0.781 μM). CX08005 binds catalytic P-loop of enzyme. It exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP. Synonyms: 2-[[[2- (Tetradecyl) phenyl]amino]carbonyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1256341-22-6. Molecular formula: C28H39N04. Mole weight: 453.61. | |
| Dephostatin | It is produced by the strain of Streptomyces sp. MJ7420NF5. Dephostatin inhibits the activity of protein tyrosine phosphatase, has an IC50 of 7.7 moL/L against PTPase prepared from human tumor T cell lines, and it inhibits the growth of Jokat cells, and has a weak antibacterial activity (MIC 50~ 100 μg/mL). Synonyms: 1,4-Benzenediol,2-(methylnitrosoamino); 2-(Methylnitrosoamino)-1,4-benzenediol; 2-[(hydroxyamino)-methylamino]cyclohexa-2,5-diene-1,4-dione. Grades: ≥90%. CAS No. 151606-30-3. Molecular formula: C7H8N2O3. Mole weight: 168.15. | |
| Ertiprotafib | Ertiprotafib is an inhibitor of protein tyrosine phosphatase 1B (PTP1B), IkB kinase β (IKK-β), and a dual agonist of PPARα and PPARβ, with IC50s of 1.6 μM and 400 nM for PTP1B and IKK-β, and EC50s of ~1 μM for PPARα/PPAR&beta. It is potentially useful for the treatment of non-insulin dependent diabetes. Synonyms: PTP 112; Benzenepropanoic acid, α-[4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thien-4-yl)-2,6-dimethylphenoxy]-, (αR)-; (2R)-2-(4-(9-Bromo-2,3-dimethylnaphtho(2,3-b)thiophen-4-yl)-2,6-dimethylphenoxy)-3-phenylpropionic acid; (αR)-α-[4-(9-Bromo-2,3-dimethylnaphtho[2,3-b]thien-4-yl)-2,6-dimethylphenoxy]benzenepropanoic Acid. Grades: 98%. CAS No. 251303-04-5. Molecular formula: C31H27BrO3S. Mole weight: 559.52. | |
| HE Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. Human aortic endothelial cells treated with pervanadate for 30 minutes display a significant increase in tyrosine phosphorylation as shown by western. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| HE+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. Human aortic endothelial cells treated with pervanadate for 30 minutes display a significant increase in tyrosine phosphorylation as shown by western. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Jurkat Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of Jurkat cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C. Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Jurkat+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of Jurkat cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C. Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice. Uses: Enzyme inhibitors. Synonyms: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide; BCP32729; EX-A3829. CAS No. 1621673-53-7. Molecular formula: C27H31NO3S2. Mole weight: 481.7. | |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KY-226; KY 226; KY226. Product Category: Inhibitors. Appearance: Fluffy white solid powder. CAS No. 1621673-53-7. Molecular formula: C27H31NO3S2. Mole weight: 481.67. Purity: >97%. IUPACName: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide. Canonical SMILES: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1. Product ID: ACM1621673537. Alfa Chemistry ISO 9001:2015 Certified. Categories: KY 2265. | |
| Lambda Protein Phosphatase (GST), Recombinant | Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. Full-length, recombinant lambda protein phosphatase (l-ppase) with a n- terminal gst-tag, l-ppase is a mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosine. Applications: Phosphatase assays. Group: Enzymes. Synonyms: Protein pho. Purity: Glutathione agarose affinity chromatography. λ-PPase. Storage: 6 months at -70°C. Source: E. coli. Protein phosphatase 1F; PPM1F; CAMKP; CaMKPase; FEM-2; POPX2; hFEM-2; Lambda Protein Phosphatase; λ-Ppase. Cat No: NATE-0856. | |
| Lambda Protein Phosphatase, Recombinant | λ Protein Phosphatase (λ-PPase) is a Mn+2-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosine and histidine residues. It is the 221 amino-acid product of ORF221 open reading frame on bacteriophage lambda (1, 2). λ-PPase was expressed as a recombinant protein in E.coli and highly purified (2). This product is an intact enzyme of high quality without tag. Applications: Λ-ppase can be used to release phosphate groups from phosphorylated serine, threonine, tyrosine and histidine residues in proteins (2). it should be noted that different proteins are dephosphorylated at different rates. optimal reaction temperature is 30°c. inclusion of protease inhibitor cocktail and shortest incubation time is desired when assays are done with crude samples. Group: Enzymes. Synonyms: Protein phosphatase 1F; PPM1F; CAMKP; CaMKPase; FEM-2; POPX2; hFEM-2; Lambda Protein. Purity: >98% by SDS-PAGE. λ-PPase. Activity: 400,000 U/mg (400 U/ul). Storage: Store at -80°C. Avoid repeating freeze-thaw cycles. Form: 400 U/ul λ-PPase in 50mM HEPES (pH 7.5), 100mM NaCl, 2mM dithiothreitol, 0.1 mM MnCl2, 0.1mM EDTA, 50% glycerol, 0.01% Brij 35. Source: E. coli. Protein phosphatase 1F; PPM1F; CAMKP; CaMKPase; FEM-2; POPX2; hFEM-2; Lambda Protein Phosphatase; λ-PPase. Cat No: NATE-0990. | |
| Licochalcone C | Licochalcone C could inhibit α-glucosidase , with IC 50 s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. Uses: Scientific research. Group: Natural products. CAS No. 144506-14-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0374. | |
| LYP Inhibitor II, LTV-1 (Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E) -3- ( (4- ( (4, 6-Dioxo-2-thioxo-1-o-tolyltetra hydropyrimidin-5 (6H) -ylide ne ) methyl ) phenoxy) methyl ) benzoic Acid) | A cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50=508nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki=384nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50=1.52, 1.59, 7.56, 23.2, 30.1, and 100uM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MSI-1436 | MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B) , with an IC 50 of appr 1 μM, 200-fold preference over TCPTP (IC 50 , 224 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trodusquemine; Aminosterol-1436. CAS No. 186139-09-3. Pack Sizes: 500 μg. Product ID: HY-12219. | |
| MSI-1436 lactate | MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B ( PTP1B ), with an IC 50 of 1 μM, 200-fold preference over TCPTP ( IC 50 of 224 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trodusquemine lactate; Aminosterol-1436 lactate. CAS No. 1309370-86-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12219A. | |
| N-Acetyl-DL-Tyrosine | N-Acetyl-dl-tyrosine is a biologically active form of tyrosine that inhibits the activity of protein tyrosine phosphatases. CAS No. 87-32-1. Product ID: PAP-0016. Molecular formula: C11H13NO4. Category: Amino acid. Product Keywords: Amino Acid Series; N-Acetyl-DL-Tyrosine; PAP-0016; Amino acid; C11H13NO4; 87-32-1. EC Number: 201-739-3. Solubility: Slightly soluble in water, very soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides. Storage: 2-8°C. Applications: N-Acetyl-DL-Tyrosine has also been used as a part of standard diet in animal models. Boiling Point: 389.26°C (rough estimate). Melting Point: 204-206 °C (dec.) (lit.). Density: 1.1855 (rough estimate). Product Description: N-Acetyl-DL-Tyrosine has also been used as a part of standard diet in animal models. |  |
| N-Acetyl-L-cysteine methyl ester | N-Acetyl-L-cysteine methyl ester is used in the preparation of benzyl mono-fluorophosphonate and benzyl penta-fluorophosphate anions as physiologically stable phosphotyrosine mimetics and inhibitors of protein tyrosine phosphatases. It can also be used in the preparation of anthracene derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 7652-46-2. Pack Sizes: 500mg, 1g. Molecular Formula: C6H11NO3S, Molecular Weight: 177.22. US Biological Life Sciences. | Worldwide |
| NSC87877 | NSC87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 with IC50 values of 355nm and 318 nM, respectively. It shows effective growth inhibition and induction of apoptosis in NB cell lines. It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. It blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes. Synonyms: NSC-87877; 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-; (E)-8-hydroxy-7-((6-sulfonaphthalen-2-yl)diazenyl)quinoline-5-sulfonic acid. Grades: >98 %. CAS No. 56990-57-9. Molecular formula: C19H13N3O7S2. Mole weight: 459.45. | |
| NSC 95397 | NSC 95397 is a 1,4-naphthoquinone-based irreversible inhibitor of Cdc25 dual-specificity phosphatases (Ki = 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). NSC 95397 exhibits 125-180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Synonyms: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone; NSC-95397; NSC95397; NSC 95397. Grades: ≥97% by HPLC. CAS No. 93718-83-3. Molecular formula: C14H14O4S2. Mole weight: 310.38. | |
| Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
| Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic Acid, Prorocentrum sp. (OA) | An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50=10-15nM) and protein phosphatase 2A (IC50=0.1nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. Group: Biochemicals. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| O-Sulfonato-L-tyrosine sodium salt | O-Sulfonato-L-tyrosine sodium salt, an amino acid derivative utilized in biomedical research, presents itself as a valuable asset. Its application as a protein tyrosine phosphatase and kinase specificity substrate highlights its pertinence in the industry. Excitingly, it has been researched extensively for its anti-inflammatory attributes and could potentially offer new remedies for autoimmune diseases. Synonyms: H-Tyr(SO3H)-OH, sodium salt. Grades: 95%. CAS No. 98930-06-4. Molecular formula: C9H10NNaO6S. Mole weight: 283.24. | |
| Pentamidine | Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC 50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis , antimony-resistant leishmaniasis , and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MP-601205. CAS No. 100-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0537. | |
| Pentamidine | Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,4'-(pentamethylenedioxy)dibenzamidine;4,4'-diamidino-alpha,omega-diphenoxypentane;4,4'-diamidinodiphenoxypentane;p,p'-(pentamethylene-dioxy)bis-benzamidine;p,p'-(pentamethylenedioxy)dibenzamidine;4,4-[1,5-PENTANEDIYLBIS(OXY)]BIS-BENZENECARBOXIMIDAMIDE;PENTAMIDINE;4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamid. Product Category: Inhibitors. CAS No. 100-33-4. Molecular formula: C19H24N4O2. Mole weight: 340.42. Product ID: ACM100334. Alfa Chemistry ISO 9001:2015 Certified. | |
| Pentamidine isethionate | Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC 50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis , antimony-resistant leishmaniasis , and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MP-601205 isethionate. CAS No. 140-64-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0537B. | |
| PHPS1 | PHPS1 is a cell-permeable inhibitor of the protein tyrosine phosphatase Shp2, a positive modulator of growth factor signaling. It is selective for Shp2 over ECPTP, PTP1B, Shp1, and mycobacterium MptpA. Synonyms: Phenylhydrazonopyrazolone sulfonate 1; Protein Tyrosine Phosphatase Inhibitor V; PTP Inhibitor V; [4-[[5-[4-(nitromethyl)phenyl]-3-oxo-2-phenyl-1H-pyrazol-4-yl]diazenyl]phenyl]methanesulfonic acid. Grades: ≥98%. CAS No. 314291-83-3. Molecular formula: C21H15N5O6S. Mole weight: 465.4. | |
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