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| Product | Description | |
|---|---|---|
| PyBOP | Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product. May be used in place of BOP in peptide synthesis without loss of coupling efficiency. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: (Benzotriazol-1-Yloxy) Tripyrrolidinophosphonium hexafluorophosphate. CAS No. 128625-52-5. |  Luxembourg Bio Technologies |
| PyBOP | PyBOP. Group: Biochemicals. Grades: Highly Purified. CAS No. 128625-52-5. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C18H28N6OP·PF6, Molecular Weight: 520.39. US Biological Life Sciences. |  Worldwide |
| (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate | PyBOP. CAS No. 128625-52-5. Product ID: 9-10258. Molecular formula: C18H28F6N6OP2. Mole weight: 520.4. Categories: Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate. |  |
| Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate | One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization. Synonyms: PyBOPl; BOPP; (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; bopp; MFCD00077411; PyBOP(R); benzotriazol-1-yl-oxytripyrrolidinphosphonium hexafluorophosphate. Grades: ≥ 99% (HPLC). CAS No. 128625-52-5. Molecular formula: C18H28F6N6OP2. Mole weight: 520.39. |  |
| Fmoc-Arg(Boc)?-OH | An excellent derivative for Fmoc SPPS of Arg-containing peptides. Coupling of this derivative can be effected using standard activation methods, such as PyBOPor TBTU, although longer reaction times may be necessary due to the bulkiness of the side-chain protection. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Arg(Boc)2-OH, N-α-Fmoc-N-ω,N-ωÆ-bis-t-butoxycarbonyl-L-arginine. Product Category: Amino Acids. CAS No. 143824-77-5. Mole weight: 596.67. Product ID: ACM143824775-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fmoc-Asp(OtBu)-(Dmb)Gly-OH | Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction. This derivative also completely inhibits aspartimide formation. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Asp(OtBu)-(Dmb)Gly-OH, N-α-Fmoc-β-O-t.-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)-glycine. Product Category: Amino Acids. CAS No. 900152-72-9. Mole weight: 618.67. Product ID: ACM900152729. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fmoc-Bpa-OH | Fmoc-p-Bz-Phe-OH is a useful tool for preparing photoactivatable peptide-based affinity probes. On photolysis at 366 nm, Benzoylphenylalanine (Bpa) generates a biradical that has a preference for insertion into C-H bonds, particularly those of Leu, Val and Met side chains. The derivative can be introduced using standard coupling method such as PyBOP and is stable to conditions used in peptide chain extension. For the cleavage of Bpa containing peptide from the resin, the use of thiols and silanes should be avoided as dithioketal formation and reduction, respectively, have been observed. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-4-benzoyl-L-phenylalanine. Product Category: Amino Acids. CAS No. 117666-96-3. Molecular formula: C31H25NO5. Mole weight: 491.53. Canonical SMILES: OC(=O)[C@H](Cc1ccc(cc1)C(=O)c2ccccc2)NC(=O)OCC3c4ccccc4-c5ccccc35. Product ID: ACM117666963. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fmoc-Cys(Trt)-OH | High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. The standard derivative for Fmoc SPPS of peptides containing Cys. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP, is to be employed, it is strongly recommended that collidine is used as the base , as this has been shown to significantly reduce loss of optical integrity during coupling. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Cys(Trt)-OH, N-α-Fmoc-S-trityl-L-cysteine. Product Category: Amino Acids. CAS No. 103213-32-7. Molecular formula: C37H31NO4S. Mole weight: 585.71. Product ID: ACM103213327-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fmoc-D-Thr(PO(OBzl)OH)-OH | An excellent building block for the preparation of D-phosphothreonine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Thr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-D-phosphothreonine. Product Category: Amino Acids. CAS No. 937171-63-6. Molecular formula: C26H26NO8P. Mole weight: 511.46. IUPACName: (2R,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[hydroxy(phenylmethoxy)phosphoryl]oxybutanoic acid. Canonical SMILES: CC(C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)OP(=O)(O)OCC4=CC=CC=C4. Density: 1.4±0.1 g/cm3. Product ID: ACM937171636. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fmoc-Sec(pMeOBzl)-OH | Building block for the introduction of selenocysteine during Fmoc SPPS. Selenocysteine derivatives can undergo enantiomerization during coupling and can form dehydroalanine and β-piperidinylalanine containing side products during subsequent chain elongation. Therefore, activation methods, such as HBTU or PyBOP which involve the addition of a tertiary, base should be avoided for addition of the Sec and all subsequent residues. Cleavage and side-chain deprotection of Sec-containing peptides can be effected using tFA-m-cresol-thioanisole-EDT-water (80:5:5:5:5) or TFA-water-DCM-TIS (89:5:51) at 4 °C. As the Se-pMeOBzl bond is stable to TFA, these methods result in the formation of the corresponding Sev(pMeOBzl) peptide. Peptides containing two Sec(pMeOBzl) residues can be oxidized directly to the corresponding selenocystinyl peptides by treatment with 5-10% DMSO in TFA. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Sec(pMeOBzl)-OH, Fmoc-Sec(Mob)-OH, Fmoc-S-4-methoxybenzyl selenocysteine. Product Category: Amino Acids. CAS No. 150308-80-8. Molecular formula: C26H25NO5Se. Mole weight: 510.44. Product ID: ACM150308808. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fmoc-Ser(PO(OBzl)OH)-OH | An excellent building block for the preparation of phosphoserine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods. Applications of this derivative include the preparation of phospholamban , a 52 residue peptide containing both phosphoserine and phosphothreonine, and human salivary statherin, a 42 residue phosphoserine peptide ; for other examples see references.Recently, β-piperidinylalanine formation has been shown to occur during Fmoc deprotection of N-terminal Ser(PO(OBzl)OH), particularly under microwave conditions. This side reaction can be eliminated by using cyclohexylamine or DBU just for this Fmoc deprotection step. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Ser(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-L-phosphoserine. Product Category: Amino Acids. CAS No. 158171-14-3. Molecular formula: C25H24NO8P. Mole weight: 497.43. Product ID: ACM158171143-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[hydroxy(phenylmethoxy)phosphoryl]oxypropanoic acid. | |
| Fmoc-Thr(PO(OBzl)OH)-OH | An excellent building block for the preparation of phosphothreonine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods.A paper describes the use of this derivative in the preparation of phospholamban , a 52 residue peptide containing both phosphoserine and phosphothreonine. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Thr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-L-phosphothreonine. Product Category: Amino Acids. CAS No. 175291-56-2. Molecular formula: C26H26NO8P. Mole weight: 511.46. Product ID: ACM175291562-2. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fmoc-Tyr(PO(OBzl)OH)-OH | An excellent building block for the preparation of phosphotyrosine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. Using this reagent, even peptides containing multiple phosphorylation sites have been prepared efficiently by standard Fmoc SPPS methods. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-L-phosphotyrosine. Product Category: Amino Acids. CAS No. 191348-16-0. Molecular formula: C31H28NO8P. Mole weight: 573.53. Product ID: ACM191348160-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| PyAOP | A phosphonium salt derived from HOAt, is generally more efficient than BOP and PyBOP as coupling reagent. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: (7-Azabenzotriazol-1-Yloxy) Tripyrrolidinophosphonium hexafluorophosphate. CAS No. 156311-83-0. | Luxembourg Bio Technologies |
| PyOxim | PyOxim is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Synonyms: pyoxime; AS-10531; SC-13336; CS-0068035; K-4853; J-009012; (Ethyl cyano(hydroxyimino)acetato)-tri-(1-pyrrolidinyl)-phosphonium hexafluorophosphate; [cyano- (ethoxycarbonyl) methyleneaminooxy]tris (1-pyrrolidinyl) phosphonium hexafluorophosphate; (T-4)-[ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-); (T-4)?-[ethyl 2-cyano-2-[(hydroxy-κO)?imino]?acetato]?tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(?1-). Grades: > 98% (HPLC). CAS No. 153433-21-7. Molecular formula: C17H29F6N5O3P2. Mole weight: 527.38. | |
| PyOxim® | Highly efficient coupling reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: [Ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate. CAS No. 153433-21-7. | Luxembourg Bio Technologies |
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