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M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. Group: Biochemicals. Alternative Names: Pyrimido[1,2-a]purin-10(3H)-one. Grades: Highly Purified. CAS No. 103408-45-3. Pack Sizes: 25mg. US Biological Life Sciences.
Heterocyclic Organic Compound. CAS No. 115705-71-0. Catalog: ACM115705710.
pyrimidodiazepine synthase
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster. Group: Enzymes. Synonyms: PDA synthase; pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing); pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Enzyme Commission Number: EC 1.5.4.1. CAS No. 93586-06-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1555; pyrimidodiazepine synthase; EC 1.5.4.1; 93586-06-2; PDA synthase; pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing); pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Cat No: EXWM-1555.
10-[(2,3-Dimethyl-1-oxopentyl)amino]-4-oxo-4H-pyrimido[1,2-c]quinazoline-3-carboxylic acid sodium salt
Heterocyclic Organic Compound. CAS No. 100508-89-2. Catalog: ACM100508892.
1,3-Dimethyl-3,4,5,6-tetrahydro-2H-pyrimidone
Dimethyl-3,4,5,6-tetrahydro-2H-pyrimidone. CAS No. 7226-23-5. Categories: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1h)-pyrimidinone.
5g Pack Size. Group: Building Blocks, Organics, Pyrimidines. Formula: C7H13N3. CAS No. 5807-14-7. Prepack ID 18977285-5g. Molecular Weight 139.2. See USA prepack pricing.
Potential tyrosine kinase signal transduction inhibitor. A pyrimido[5,4-d]pyrimidine derivative used as an intermediate in the preparation of nucleoside transporter 1 inhibitors and potential modulators of the activity of antimetabolite antitumor agents. Group: Biochemicals. Alternative Names: Tetrachloropyrimido[5, 4-d]pyrimidine; NSC 96654. Grades: Highly Purified. CAS No. 32980-71-5. Pack Sizes: 500mg, 1g. Molecular Formula: C?Cl?N?, Molecular Weight: 269.9. US Biological Life Sciences.
An antitumor nucleoside pyrimido pyrimidine. Group: Biochemicals. Alternative Names: 2,6-Dichloro-4,8-(di-1-piperidinyl-d10)-pyrimido[5,4-d]pyrimidine. Grades: Highly Purified. CAS No. 1189450-21-2. Pack Sizes: 2.5mg. US Biological Life Sciences.
An antitumor nucleoside pyrimido pyrimidine. Group: Biochemicals. Alternative Names: 2,6-Dichloro-4,8-di-1-piperidinyl-pyrimido[5,4-d]pyrimidine. Grades: Highly Purified. CAS No. 7139-2-8. Pack Sizes: 1g. US Biological Life Sciences.
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2-Chloro-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one
2-Chloro-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one is a general reagent in pharmaceutical syntheses. Group: Biochemicals. Grades: Highly Purified. CAS No. 943995-32-2. Pack Sizes: 50mg, 100mg. Molecular Formula: C6H4ClN3O2, Molecular Weight: 185.57. US Biological Life Sciences.
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2-Isopropyl-6-methyl-4-pyrimidone
2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides. Group: Biochemicals. Grades: Highly Purified. CAS No. 2814-20-2. Pack Sizes: 500mg, 5g. Molecular Formula: C8H12N2O. US Biological Life Sciences.
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2-Isopropyl-6-methyl-4-pyrimidone-d6
Isotope labelled 2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C8H6D6N2O, Molecular Weight: 158.229999999999. US Biological Life Sciences.
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2-Methylthio-4-pyrimidone 99+% (HPLC)
2-Methylthio-4-pyrimidone 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
The major labeled DNA adduct of endogenous carcinogen malondialdehyde. Group: Biochemicals. Alternative Names: M1G-DR. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
The major DNA adduct of endogenous carcinogen malondialdehyde. Uses: The major dna adduct of endogenous carcinogen malondialdehyde. Synonyms: M1G-DR. Grades: 99%. CAS No. 87171-83-3. Molecular formula: C13H13N5O4. Mole weight: 303.27.
(3aR,4R,12R,12aR)-3a,4,12,12a-Tetrahydro-2,2-dimethyl-4,12-epoxy-5H,8H-1,3-dioxolo[4,5-e]pyrimido[2,1-b][1,3]oxazocin-8-one is a potential drug being studied in biomedicine to treat various types of cancer. It has been found to inhibit the enzyme MELK, which is overexpressed in certain cancer cells. Studies have shown promising results in inhibiting the growth of tumors in preclinical models and further research is being conducted to determine its safety and efficacy in humans. Synonyms: 2',3'-O-isopropylidene-5',6-anhydrouridine. CAS No. 3868-21-1. Molecular formula: C12H14N2O5. Mole weight: 266.25.
6-(2-Deoxy-5-O-DMT-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one is a remarkable biomedical compound, exhibiting exceptional utility in research of an array of malignancies, notably leukemia and solid tumors. Synonyms: 6-(β-D-5-O-(4,4'-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one; 6-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one. Grades: ≥95%. CAS No. 126128-43-6. Molecular formula: C32H33N3O7. Mole weight: 571.62.
6-(b-D-2-Deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one, a versatile drug boasting both antiviral and antitumor properties, has become an invaluable instrument in the medicinal world. Through its DNA synthesis interference, it displays its prowess in staving off viruses and cancerous cells alike, thereby serving as a beacon of hope for those stricken with HIV, leukemia, and solid tumors. Notable for its unique structure and mode of operation, this remarkable molecule has cemented its reputation as a priceless commodity in the realm of biomedical research. Synonyms: 6-((2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one; 6-(2-Deoxy-beta-D-erythro-pentofuranosyl)-4,6-dihydro-1H-pyrimido(4,5-c)(1,2)oxazin-7(3H)-one. Grades: ≥95%. CAS No. 126128-42-5. Molecular formula: C11H15N3O5. Mole weight: 269.25.
An effective inhibitior of ERK5, could probably be used as an antitumor agent. IC50: 0.19μM(EC50 for cellular),of 0.087 μM(for enzymatic) and 0.087 μM(for LRRK2). Uses: An effective inhibitior of erk5 and could probably be used as an antitumor agent. Synonyms: ERK5-IN-1; ERK5 IN 1; ERK5IN1; CHEMBL1673039; SCHEMBL618262; BDBM50337127; ZINC66066276; CS-4938; HY-14403. Grades: 98%. CAS No. 1234479-76-5. Molecular formula: C25H29N7O2. Mole weight: 459.54.
Natural benzodiazepine. Anti-inflammatory. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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b-Catenin/Tcf Inhibitor II, PKF118-310 (1,6-Dimethylpyrimido[5,6-e][1,2,4]triazine-5,7-dione, Wnt Pathway Inhibitor IV)
A synthetic cell-permeable actinobacteria pyrimidotriazine-dione that selectively disrupts b-catenin-Tcf4 interaction (IC50=0.8uM in cell-free binding assays) and inhibits b-catenin-regulated cellular transcription activity (IC50=0.3uM in HCT116-based reporter assays). PKF118-310 is demonstrated to reverse b-catenin, but not siamois, mRNA-induced ventral body axis formation in Xenopus embryos, while direct tumor site injection (1mg/kg/0.5 wk) in HepG2 xenograph mice is shown to increase the number of apoptotic cells and decrease the expression of b-catenin target genes (cyclin D1, c-Myc, survivin) in the tumor mass, resulting in an effective tumor growth retardation (by ~60% after a 4-wk treatment period) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC?? = 0.28uM) that also targets mTOR (IC50 = 5. 3uM), but not PI 3-K in vitro. Induces apoptosis in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 168425-64-7. Pack Sizes: 5mg. US Biological Life Sciences.
A cell-permeable pyrimidoquinoline-dione compound that acts as an efficient Hdm2 E3 ligase inhibitor, prevents Hdm2-mediated p53 ubiquitination and increases the cellular levels of both p53 and Hdm2 (IC50 ~3uM in RPE cells). Shown to selectively arrest the growth of several tumor cells in a p53-dependent manner and display desirable aqueous solubility. Group: Biochemicals. Grades: Highly Purified. CAS No. 502137-98-6. Pack Sizes: 5mg. US Biological Life Sciences.
An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences.
An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity MDGH. Grades: ≥95%. CAS No. 1917333-91-5. Molecular formula: C28H26N6O3. Mole weight: 494.54.
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50=300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.CAS Number:78416-81-6. Group: Biochemicals. Grades: Highly Purified. CAS No. 78416-81-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O? · HCl, Primary Target: cGMP-inhibited phosphodiesterase. US Biological Life Sciences.
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1,3-Dimethyluracil
1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with K i of 316.2 μM and 166.4 μM, respectively [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 874-14-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W008343.
1, 5, 7-Triazabicyclo[4. 4. 0]dec-5-ene
1, 5, 7-Triazabicyclo[4. 4. 0]dec-5-ene. Group: Biochemicals. Alternative Names: 1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine. Grades: Highly Purified. CAS No. 5807-14-7. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C7H13N3. US Biological Life Sciences.
Worldwide
15-Lipoxygenase Inhibitor 1
15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 μM. Synonyms: 15-LO Inhibitor 1; 4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine. Grades: ≥95%. CAS No. 928853-86-5. Molecular formula: C16H19N5S. Mole weight: 313.4.
(1α, 3α, 5α)-3, 5-dihydroxy-cyclohexanecarboxylic Acid Methyl Ester can be used as a starting material to synthesize pyrimido[4,5-d]pyrimidinones as selective inhibitors of both KDR and FGFR kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 156526-48-6. Pack Sizes: 500mg, 5g. Molecular Formula: C8H14O4, Molecular Weight: 174.19. US Biological Life Sciences.
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1-Methyl-1H-indole-3-carbonyl Chloride
1-Methyl-1H-indole-3-carbonyl Chloride has been used as a reactant in the preparation of indolo[2,3-a]pyrimido[5,4-c]carbazole derivatives as anti-cancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 126921-19-5. Pack Sizes: 50mg, 500mg. Molecular Formula: C10H8ClNO, Molecular Weight: 193.63. US Biological Life Sciences.
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2,3'-Anhydrothymidine
2,3'-Anhydrothymidine, a biomedical compound, emerges as a promising therapeutic agent against viral infections caused by thymidine kinase-dependent DNA viruses, including herpes simplex viruses and varicella-zoster virus. Its distinctive ability lies in its interference with viral DNA synthesis, thus showcasing potent antiviral activity. Uses: An intermediate in the preparation of thymidine derivatives. Synonyms: 2'-Deoxy-3',2-anhydro-5-methyluridine; Anhydrothymidine; O2,3'-Cyclothymidine; 2,3'-O-Cyclothymidine; NSC 144601; (2R,3R,5R)-2,3-Dihydro-3-(hydroxymethyl)-8-methyl-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one; 2,3'-Anhydro-1-(2'-deoxy-β-D-threo-pentofuranosyl)thymine. Grades: ≥95%. CAS No. 15981-92-7. Molecular formula: C10H12N2O4. Mole weight: 224.21.
2,4,5-Triamino-6-hydroxypyrimidine-13C2 Sulfate Salt
2,4,5-Triamino-6-hydroxypyrimidine-13C2 Sulfate Salt is an intermediate used in the preparation of labelled 2-Amino-6,8-dihydroxypurine Hydrochloride (A604920). A labelled substituted 5-aminopyrimidines with antioxidative activity. Group: Biochemicals. Alternative Names: 4,5-Triamino-6-pyrimidinol-13C2 Sulfate Salt; 2,4,5-Triaminopyrimidin-6(1H)-one-13C2 Sulfate Salt; 2,5,6-Triamino-4(1H)-pyrimidone-13C2 Sulfate Salt; 2,5,6-Triamino-4-hydroxypyrimidine-13C2 Sulfate Salt; 2,5,6-Triamino-4-oxopyrimidine-13C2 Sulfate Salt; 2,5,6-Triamino-4-pyrimidinol-13C2 Sulfate Salt; 2,5,6-Triamino-4-pyrimidinone-13C2 Sulfate Salt; 2,5,6-Triaminopyrimidin-4(1H)-one;-13C2 Sulfate Salt; 2,5,6-Triaminopyrimidin-4(3H)-one-13C2 Sulfate Salt; 4-Hydroxy-2,5,6-triaminopyrimidine-13C2 Sulfate Salt; 6-Hydroxy-2,4,5-triaminopyrimidine-13C2 Sulfate Salt; NSC 9313-13C2 Sulfate Salt. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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2,4,5-Triamino-6-hydroxypyrimidine sulfate
2,4,5-Triamino-6-hydroxypyrimidine sulfate. Group: Biochemicals. Alternative Names: 2,5,6-Triamino-4-pyrimidol sulfate. Grades: Highly Purified. CAS No. 35011-47-3,39267-74-8. Pack Sizes: 50g, 100g, 250g, 500g, 1Kg. Molecular Formula: C4H7N5OH2SO4. US Biological Life Sciences.
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2-(4-Bromophenyl)-acetamidine
2-(4-Bromophenyl)-acetamidine is a bromo-substituted analog of 2-Phenylacetamidine; a useful synthetic intermediate used in the synthesis of non-nucleoside reverse transcriptase inhibitors. 2-Phenylacetamidine is also used to prepare naltrexone-derived pyrido- and pyrimidomorphinans. Group: Biochemicals. Grades: Highly Purified. CAS No. 59104-21-1. Pack Sizes: 1g, 10g. Molecular Formula: C8H9BrN2, Molecular Weight: 213.07. US Biological Life Sciences.
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